A common genetic variant in zinc transporter ZnT2 (Thr288Ser) is present in women with low milk volume and alters lysosome function and cell energetics

ZnT2 is an electroneutral proton-coupled vesicular antiporter displaying an apparent stoichiometry of two protons per zinc ion

(2019) Yarden Golan et al.   PLoS Computational Biology

Milk-derived miRNA profiles elucidate molecular pathways that underlie breast dysfunction in women with common genetic variants in SLC30A2

(2019) Shannon L. Kelleher et al.   Scientific Reports

ZnT2 is critical for lysosome acidification and biogenesis during mammary gland involution

(2018) Olivia C Rivera et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

A genetic variant in SLC30A2 causes breast dysfunction during lactation by inducing ER stress, oxidative stress and epithelial barrier defects

(2018) Sooyeon Lee et al.   Scientific Reports

Th-POK regulates mammary gland lactation through mTOR-SREBP pathway

(2018) Rui Zhang et al.   PLoS Genetics

High proportion of transient neonatal zinc deficiency causing alleles in the general population

(2018) Yarden Golan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes

(2018) Peace Atakpa et al.   Cell Reports

Zinc transporter 2 interacts with vacuolar ATPase and is required for polarization, vesicle acidification, and secretion in mammary epithelial cells

(2017) Sooyeon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of the zinc transporter SLC30A2/ZnT2 in transient neonatal zinc deficiency

(2017) Yarden Golan et al.   Metallomics

Distinct kinetics of serine and threonine dephosphorylation are essential for mitosis

(2017) Jamin B. Hein et al.   NATURE CELL BIOLOGY

A mutation in the viral sensor 2’-5’-oligoadenylate synthetase 2 causes failure of lactation

(2017) Samantha R. Oakes et al.   PLoS Genetics

Biological underpinnings of breastfeeding challenges: the role of genetics, diet, and environment on lactation physiology

(2016) Sooyeon Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness

(2016) Christina McGuire et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Molecular Basis of Transient Neonatal Zinc Deficiency

(2016) Yarden Golan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer

(2016) Paige Chandler et al.   Molecular Cancer

Novel mutations in SLC30A2 involved in the pathogenesis of transient neonatal zinc deficiency

(2016) Naoya Itsumura et al.   PEDIATRIC RESEARCH

Lysosome triggered near-infrared fluorescence imaging of cellular trafficking processes in real time

(2016) Marco Grossi et al.   Nature Communications

Essential Role for Zinc Transporter 2 (ZnT2)-mediated Zinc Transport in Mammary Gland Development and Function during Lactation

(2015) Sooyeon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly

(2015) Laura A. Stransky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TNFα Post-Translationally Targets ZnT2 to Accumulate Zinc in Lysosomes

(2015) Stephen R. Hennigar et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Exome Sequencing of SLC30A2 Identifies Novel Loss- and Gain-of-Function Variants Associated with Breast Cell Dysfunction

(2015) Samina Alam et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival

(2015) Nai Yang Fu et al.   NATURE CELL BIOLOGY

AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer

(2015) Shao-hua Fan et al.   Oncotarget

V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy

(2015) Nathalie Meo-Evoli et al.   Oncotarget

ZnT2 is a critical mediator of lysosomal-mediated cell death during early mammary gland involution

(2015) Stephen R. Hennigar et al.   Scientific Reports

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

(2014) Chen-Song Zhang et al.   Cell Metabolism

Prolactin (PRL)-stimulated Ubiquitination of ZnT2 Mediates a Transient Increase in Zinc Secretion Followed by ZnT2 Degradation in Mammary Epithelial Cells

(2014) Young Ah Seo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zn2+ efflux through lysosomal exocytosis prevents Zn2+-induced toxicity

(2014) I. Kukic et al.   JOURNAL OF CELL SCIENCE

V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activationin vivo

(2013) Rebekka Kubisch et al.   INTERNATIONAL JOURNAL OF CANCER

Effects of AMP-activated protein kinase (AMPK) signaling and essential amino acids on mammalian target of rapamycin (mTOR) signaling and protein synthesis rates in mammary cells

(2013) J.A.D.R.N. Appuhamy et al.   JOURNAL OF DAIRY SCIENCE

The Biology of Zinc Transport in Mammary Epithelial Cells: Implications for Mammary Gland Development, Lactation, and Involution

(2013) Nicholas H. McCormick et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Compound Heterozygous Mutations in SLC30A2/ZnT2 Results in Low Milk Zinc Concentrations: A Novel Mechanism for Zinc Deficiency in a Breast-Fed Infant

(2013) Naoya Itsumura et al.   PLoS One

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

(2013) S. A. Kang et al.   SCIENCE

Protein Folding in the Endoplasmic Reticulum

(2013) I. Braakman et al.   Cold Spring Harbor Perspectives in Biology

ATP is released from autophagic vesicles to the extracellular space in a VAMP7-dependent manner

(2012) Claudio Marcelo Fader et al.   Autophagy

Breastfeeding Frequency, Milk Volume, and Duration in Mother–Infant Dyads with Persistent Nipple Pain

(2012) Holly L. McClellan et al.   Breastfeeding Medicine

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

A Dominant Negative Heterozygous G87R Mutation in the Zinc Transporter, ZnT-2 (SLC30A2), Results in Transient Neonatal Zinc Deficiency

(2012) Inbal Lasry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Marginal Maternal Zinc Deficiency in Lactating Mice Reduces Secretory Capacity and Alters Milk Composition

(2012) Colleen Dempsey et al.   JOURNAL OF NUTRITION

Breastfeeding and the Use of Human Milk

(2012)   PEDIATRICS

A histidine-rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial function

(2011) Young Ah Seo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of autophagy by lysosomal positioning

(2011) Viktor I. Korolchuk et al.   Autophagy

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Role and regulation of autophagy in the development of acinar structures formed by bovine BME-UV1 mammary epithelial cells

(2011) Agnieszka Sobolewska et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Stat3 controls lysosomal-mediated cell death in vivo

(2011) Peter A. Kreuzaler et al.   NATURE CELL BIOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Functional analysis of two single nucleotide polymorphisms in SLC30A2 (ZnT2): implications for mammary gland function and breast disease in women

(2010) Young Ah Seo et al.   PHYSIOLOGICAL GENOMICS

Zinc transporter-2 (ZnT2) variants are localized to distinct subcellular compartments and functionally transport zinc

(2009) Veronica Lopez et al.   BIOCHEMICAL JOURNAL

Why Mothers Stop Breastfeeding: Mothers' Self-reported Reasons for Stopping During the First Year

(2008) Ruowei Li et al.   PEDIATRICS