A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures
出版年份 2017 全文链接
标题
A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures
作者
关键词
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出版物
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Volume 93, Issue 9, Pages 851-869
出版商
Informa UK Limited
发表日期
2017-06-27
DOI
10.1080/09553002.2017.1332438
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Minipigs as models in drug discovery
- (2016) Vijay K. Singh et al. Expert Opinion on Drug Discovery
- Medical countermeasures for unwanted CBRN exposures: part II radiological and nuclear threats with review of recent countermeasure patents
- (2016) Vijay K. Singh et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Radioprotective Efficacy of Gamma-Tocotrienol in Nonhuman Primates
- (2016) Vijay K. Singh et al. RADIATION RESEARCH
- Understanding the Pathophysiology and Challenges of Development of Medical Countermeasures for Radiation-Induced Vascular/Endothelial Cell Injuries: Report of a NIAID Workshop, August 20, 2015
- (2016) Merriline M. Satyamitra et al. RADIATION RESEARCH
- Targeting of Chk2 as a countermeasure to dose-limiting toxicity triggered by topoisomerase-II (TOP2) poisons
- (2016) Prashanth Gokare et al. Oncotarget
- Key mechanisms involved in ionizing radiation-induced systemic effects. A current review
- (2016) Ifigeneia V. Mavragani et al. Toxicology Research
- Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): A review
- (2015) Vijay K. Singh et al. CYTOKINE
- Medical Countermeasures for Radiation Exposure and Related Injuries
- (2015) Vijay K. Singh et al. HEALTH PHYSICS
- Combined immunomodulator and antimicrobial therapy eliminates polymicrobial sepsis and modulates cytokine production in combined injured mice
- (2015) Thomas B. Elliott et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Development of a minipig model for lung injury induced by a single high-dose radiation exposure and evaluation with thoracic computed tomography
- (2015) Jong-Geol Lee et al. JOURNAL OF RADIATION RESEARCH
- Ciprofloxacin Therapy Results in Mitigation of ATP Loss after Irradiation Combined with Wound Trauma: Preservation of Pyruvate Dehydrogenase and Inhibition of Pyruvate Dehydrogenase Kinase 1
- (2015) Joshua M. Swift et al. RADIATION RESEARCH
- Pegfilgrastim Improves Survival of Lethally Irradiated Nonhuman Primates
- (2015) Kim G. Hankey et al. RADIATION RESEARCH
- New Approaches to Radiation Protection
- (2015) Eliot M. Rosen et al. Frontiers in Oncology
- Human Ghrelin Mitigates Intestinal Injury and Mortality after Whole Body Irradiation in Rats
- (2015) Zhimin Wang et al. PLoS One
- Hemorrhage Exacerbates Radiation Effects on Survival, Leukocytopenia, Thrombopenia, Erythropenia, Bone Marrow Cell Depletion and Hematopoiesis, and Inflammation-Associated microRNAs Expression in Kidney
- (2015) Juliann G. Kiang et al. PLoS One
- The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates
- (2015) Vadim I. Krivokrysenko et al. PLoS One
- Recombinant interleukin-12, but not granulocyte-colony stimulating factor, improves survival in lethally irradiated nonhuman primates in the absence of supportive care: Evidence for the development of a frontline radiation medical countermeasure
- (2014) Zoya Gluzman-Poltorak et al. AMERICAN JOURNAL OF HEMATOLOGY
- Radiation countermeasure agents: an update (2011 – 2014)
- (2014) Vijay K Singh et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Overview of Use of G-CSF and GM-CSF in the Treatment of Acute Radiation Injury
- (2014) Glen Reeves HEALTH PHYSICS
- Preclinical Development of a Bridging Therapy for Radiation Casualties
- (2014) Vijay K. Singh et al. HEALTH PHYSICS
- 2013 Dade W. Moeller Lecture
- (2014) John E. Moulder HEALTH PHYSICS
- Evidence for Radiation-Induced Disseminated Intravascular Coagulation as a Major Cause of Radiation-Induced Death in Ferrets
- (2014) Gabriel S. Krigsfeld et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Randomized comparison of single dose of recombinant human IL-12 versus placebo for restoration of hematopoiesis and improved survival in rhesus monkeys exposed to lethal radiation
- (2014) Zoya Gluzman-Poltorak et al. Journal of Hematology & Oncology
- Protective effect and the therapeutic index of indralin in juvenile rhesus monkeys
- (2014) Mikhail V. Vasin et al. JOURNAL OF RADIATION RESEARCH
- Safety and Otoprotection of Metformin in Radiation-Induced Sensorineural Hearing Loss in the Guinea Pig
- (2014) Mario A. Mujica-Mota et al. OTOLARYNGOLOGY-HEAD AND NECK SURGERY
- Ghrelin Therapy Improves Survival after Whole-Body Ionizing Irradiation or Combined with Burn or Wound: Amelioration of Leukocytopenia, Thrombocytopenia, Splenomegaly, and Bone Marrow Injury
- (2014) Juliann G. Kiang et al. Oxidative Medicine and Cellular Longevity
- Pegylated G-CSF Inhibits Blood Cell Depletion, Increases Platelets, Blocks Splenomegaly, and Improves Survival after Whole-Body Ionizing Irradiation but Not after Irradiation Combined with Burn
- (2014) Juliann G. Kiang et al. Oxidative Medicine and Cellular Longevity
- Progenitors Mobilized by Gamma-Tocotrienol as an Effective Radiation Countermeasure
- (2014) Vijay K. Singh et al. PLoS One
- Model Development and Use of ACE Inhibitors for Preclinical Mitigation of Radiation-Induced Injury to Multiple Organs
- (2014) Meetha Medhora et al. RADIATION RESEARCH
- Development of a New Minipig Model to Study Radiation-Induced Gastrointestinal Syndrome and its Application in Clinical Research
- (2014) Sehwan Shim et al. RADIATION RESEARCH
- Radiation Combined Injury Models to Study the Effects of Interventions and Wound Biomechanics
- (2014) Janice A. Zawaski et al. RADIATION RESEARCH
- Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis
- (2013) Nian-Hua Ding et al. CURRENT DRUG TARGETS
- Effects of ionizing radiation on mitochondria
- (2013) Winnie Wai-Ying Kam et al. FREE RADICAL BIOLOGY AND MEDICINE
- Survival Efficacy of the PEGylated G-CSFs Maxy-G34 and Neulasta in a Mouse Model of Lethal H-ARS, and Residual Bone Marrow Damage in Treated Survivors
- (2013) Hui Lin Chua et al. HEALTH PHYSICS
- The Delayed Pulmonary Syndrome Following Acute High-dose Irradiation
- (2013) Michael Garofalo et al. HEALTH PHYSICS
- A Pilot Study in Rhesus Macaques to Assess the Treatment Efficacy of a Small Molecular Weight Catalytic Metalloporphyrin Antioxidant (AEOL 10150) in Mitigating Radiation-induced Lung Damage
- (2013) Michael C. Garofalo et al. HEALTH PHYSICS
- The Gottingen Minipig Is a Model of the Hematopoietic Acute Radiation Syndrome: G-Colony Stimulating Factor Stimulates Hematopoiesis and Enhances Survival From Lethal Total-Body γ-Irradiation
- (2013) Maria Moroni et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures
- (2013) Vijay K. Singh et al. JOURNAL OF RADIATION RESEARCH
- Whole Brain Radiation-Induced Vascular Cognitive Impairment: Mechanisms and Implications
- (2013) Junie P. Warrington et al. JOURNAL OF VASCULAR RESEARCH
- Effects of Solar Particle Event Proton Radiation on Parameters Related to Ferret Emesis
- (2013) J. K. Sanzari et al. RADIATION RESEARCH
- Enalapril Mitigates Focal Alveolar Lesions, A Histological Marker of Late Pulmonary Injury by Radiation to the Lung
- (2013) Feng Gao et al. RADIATION RESEARCH
- Curcumin for Radiation Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Thirty Breast Cancer Patients
- (2013) Julie L. Ryan et al. RADIATION RESEARCH
- Renin-angiotensin System Blockers and Modulation of Radiation-Induced Brain Injury
- (2012) M. E. Robbins et al. CURRENT DRUG TARGETS
- Acute Gastrointestinal Syndrome in High-Dose Irradiated Mice
- (2012) Catherine Booth et al. HEALTH PHYSICS
- A Nonhuman Primate Model of the Hematopoietic Acute Radiation Syndrome Plus Medical Management
- (2012) Ann M. Farese et al. HEALTH PHYSICS
- A Preclinical Rodent Model of Radiation-induced Lung Injury for Medical Countermeasure Screening in Accordance With the FDA Animal Rule
- (2012) Isabel L. Jackson et al. HEALTH PHYSICS
- A Synthetic Superoxide Dismutase/Catalase Mimetic EUK-207 Mitigates Radiation Dermatitis and Promotes Wound Healing in Irradiated Rat Skin
- (2012) Susan R. Doctrow et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Dose-modifying factor for captopril for mitigation of radiation injury to normal lung
- (2012) M. Medhora et al. JOURNAL OF RADIATION RESEARCH
- Angiotensin Converting Enzyme Inhibitors Mitigate Collagen Synthesis Induced by a Single Dose of Radiation to the Whole Thorax
- (2012) Lakhan KMA et al. JOURNAL OF RADIATION RESEARCH
- Autologous Adipocyte Derived Stem Cells Favour Healing in a Minipig Model of Cutaneous Radiation Syndrome
- (2012) Fabien Forcheron et al. PLoS One
- HemaMax™, a Recombinant Human Interleukin-12, Is a Potent Mitigator of Acute Radiation Injury in Mice and Non-Human Primates
- (2012) Lena A. Basile et al. PLoS One
- Development and Licensure of Medical Countermeasures to Treat Lung Damage Resulting from a Radiological or Nuclear Incident
- (2012) Andrea L. DiCarlo et al. RADIATION RESEARCH
- Plerixafor, a CXCR4 Antagonist, Mitigates Skin Radiation-Induced Injury in Mice
- (2012) Jae Ho Kim et al. RADIATION RESEARCH
- Pegfilgrastim Administered in an Abbreviated Schedule, Significantly Improved Neutrophil Recovery after High-Dose Radiation-Induced Myelosuppression in Rhesus Macaques
- (2012) A. M. Farese et al. RADIATION RESEARCH
- Animal Models and Medical Countermeasures Development for Radiation-Induced Lung Damage: Report from an NIAID Workshop
- (2012) Jacqueline P. Williams et al. RADIATION RESEARCH
- Efficacy of Radiation Countermeasures Depends on Radiation Quality
- (2012) Lynnette H. Cary et al. RADIATION RESEARCH
- ROS-Scavenger and Radioprotective Efficacy of the New PrC-210 Aminothiol
- (2012) Daniel D. Peebles et al. RADIATION RESEARCH
- Short-Term Treatment with a SOD/Catalase Mimetic, EUK-207, Mitigates Pneumonitis and Fibrosis after Single-Dose Total-Body or Whole-Thoracic Irradiation
- (2012) Feng Gao et al. RADIATION RESEARCH
- Filgrastim Improves Survival in Lethally Irradiated Nonhuman Primates
- (2012) Ann M. Farese et al. RADIATION RESEARCH
- Wound trauma alters ionizing radiation dose assessment
- (2012) Juliann G Kiang et al. Cell and Bioscience
- Acute radiation syndrome caused by accidental radiation exposure - therapeutic principles
- (2011) Harald Dörr et al. BMC Medicine
- Death by protein damage in irradiated cells
- (2011) Michael J. Daly DNA REPAIR
- Rifaximin diminishes neutropenia following potentially lethal whole-body radiation
- (2011) Christopher D Jahraus et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute
- (2011) Vijay K. Singh et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Fibroblast Growth Factor-Peptide Improves Barrier Function and Proliferation in Human Keratinocytes After Radiation
- (2011) Kunzhong Zhang et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Mitigation of Late Renal and Pulmonary Injury After Hematopoietic Stem Cell Transplantation
- (2011) Eric P. Cohen et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- RhG-CSF Improves Radiation-induced Myelosuppression and Survival in the Canine Exposed to Fission Neutron Irradiation
- (2011) Zu-Yin YU et al. JOURNAL OF RADIATION RESEARCH
- Hematological Changes as Prognostic Indicators of Survival: Similarities Between Gottingen Minipigs, Humans, and Other Large Animal Models
- (2011) Maria Moroni et al. PLoS One
- Bone Marrow Stromal Cell Transplantation Mitigates Radiation-Induced Gastrointestinal Syndrome in Mice
- (2011) Subhrajit Saha et al. PLoS One
- Laminin 332 Deposition is Diminished in Irradiated Skin in an Animal Model of Combined Radiation and Wound Skin Injury
- (2011) M. M. Jourdan et al. RADIATION RESEARCH
- The Association of Inbreeding with Lung Fibrosis Incidence in Beagle Dogs That Inhaled238PuO2or239PuO2
- (2011) Dulaney A. Wilson et al. RADIATION RESEARCH
- A Further Comparison of Pathologies after Thoracic Irradiation among Different Mouse Strains: Finding the Best Preclinical Model for Evaluating Therapies Directed Against Radiation-Induced Lung Damage
- (2011) Isabel L Jackson et al. RADIATION RESEARCH
- Hematopoietic Radiation Syndrome in the Gottingen Minipig
- (2011) Maria Moroni et al. RADIATION RESEARCH
- Literature Review and Global Consensus on Management of Acute Radiation Syndrome Affecting Nonhematopoietic Organ Systems
- (2011) Nicholas Dainiak et al. Disaster Medicine and Public Health Preparedness
- First Global Consensus for Evidence-Based Management of the Hematopoietic Syndrome Resulting From Exposure to Ionizing Radiation
- (2011) Nicholas Dainiak et al. Disaster Medicine and Public Health Preparedness
- Multipotent mesenchymal stem cell grafting to treat cutaneous radiation syndrome: Development of a new minipig model
- (2010) Diane Agay et al. EXPERIMENTAL HEMATOLOGY
- RADIATION COMBINED INJURY: OVERVIEW OF NIAID RESEARCH
- (2010) Andrea L. DiCarlo et al. HEALTH PHYSICS
- EUROPEAN CONSENSUS ON THE MEDICAL MANAGEMENT OF ACUTE RADIATION SYNDROME AND ANALYSIS OF THE RADIATION ACCIDENTS IN BELGIUM AND SENEGAL
- (2010) Patrick Gourmelon et al. HEALTH PHYSICS
- Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus
- (2010) Kenneth A Jenrow et al. Radiation Oncology
- Wound Trauma Increases Radiation-Induced Mortality by Activation of iNOS Pathway and Elevation of Cytokine Concentrations and Bacterial Infection
- (2010) Juliann G. Kiang et al. RADIATION RESEARCH
- Life Span and Thymic Lymphoma Incidence in High- and Low-Dose-Rate Irradiated AKR/J Mice and Commonly Expressed Genes
- (2010) Suk Chul Shin et al. RADIATION RESEARCH
- Animal Models for Medical Countermeasures to Radiation Exposure
- (2010) Jacqueline P. Williams et al. RADIATION RESEARCH
- Emerging therapy for improving wound repair of severe radiation burns using local bone marrow-derived stem cell administrations
- (2010) Eric Bey et al. WOUND REPAIR AND REGENERATION
- Intravenous administration of mesenchymal stem cells genetically modified with extracellular superoxide dismutase improves survival in irradiated mice
- (2009) A. S. Abdel-Mageed et al. BLOOD
- Radiation countermeasure agents: an update
- (2009) Francis Dumont et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- History and development of radiation-protective agents
- (2009) Joseph F. Weiss et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Renin-Angiotensin System Suppression Mitigates Experimental Radiation Pneumonitis
- (2009) Swarajit N. Ghosh et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Pravastatin Limits Radiation-Induced Vascular Dysfunction in the Skin
- (2009) Valerie Holler et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- COX-2 Inhibitors Are Contraindicated for Treatment of Combined Injury
- (2009) W. Jiao et al. RADIATION RESEARCH
- Revisiting Strain-Related Differences in Radiation Sensitivity of the Mouse Lung: Recognizing and Avoiding the Confounding Effects of Pleural Effusions
- (2009) Isabel L. Jackson et al. RADIATION RESEARCH
- Effects of Radiation on Protein Oxidation and Lipid Peroxidation in the Brain Tissue
- (2009) O. Gulbahar et al. TRANSPLANTATION PROCEEDINGS
- Radiologic and nuclear events: contingency planning for hematologists/oncologists
- (2008) D. M. Weinstock et al. BLOOD
- Coagulation values in normal ferrets (Mustela putorius furo) using selected methods and reagents
- (2008) Keith G. Benson et al. VETERINARY CLINICAL PATHOLOGY
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