期刊
HEALTH PHYSICS
卷 103, 期 4, 页码 463-473出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HP.0b013e31826386ef
关键词
lungs; rodent; modeling; dose assessment; radiation; medical; radiation damage
类别
资金
- National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN266200500043C]
The purpose of preclinical murine model development is to establish that the pathophysiological outcome of the rodent model of radiation-induced lung injury is sufficiently representative of the anticipated pulmonary response in the human population. This objective is based on concerns that the C57BL/6J strain may not be the most appropriate preclinical model of lethal radiation lung injury in humans. In this study, the authors assessed this issue by evaluating the relationship between morbidity (pulmonary function, histopathologic damage) and mortality among three strains of mice: C57BL/6J, CBA/J, and C57L/J. These different strains display variations in latency and phenotypic expression of radiation-induced lung damage. By comparing the response of each strain to the human pulmonary response, an appropriate animal model(s) of human radiation-induced pulmonary injury was established. Observations in the C57L/J and CBA/J murine models can be extrapolated to the human lung for evaluation of the mechanisms of action of radiation as well as future efficacy testing and approving agents that fall under the Animal Rule of the U. S. Food and Drug Administration (FDA) (21 CFR Parts 314 and 601). Health Phys. 103(4):463-473;2012
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