Article
Gastroenterology & Hepatology
Ruiqiao He, Pan Li, Jinfeng Wang, Bota Cui, Faming Zhang, Fangqing Zhao
Summary: Fecal microbiota transplantation is a promising treatment for microbiota dysbiosis associated diseases. This study investigated the effect of different types of donor-derived microbiota on FMT efficacy. The research found two dominant types of microbiota in CDI and IBD patients, and observed the interaction between recipient and donor-derived microbiota during FMT.
Article
Gastroenterology & Hepatology
Aki Ronkainen, Imran Khan, Eva Krzyzewska-Dudek, Kaisa Hiippala, Tobias L. Freitag, Reetta Satokari
Summary: Fecal microbiota transplantation (FMT) is commonly used to treat recurrent Clostridioides difficile infection (rCDI) and is being investigated for the treatment of other gut microbiota-related conditions. This study found that selected Bifidobacterium strains from FMT donors, such as DX_pv23, have the potential to colonize the recipient's gut and restore antibiotic-disturbed microbiota. The study also revealed that DX_pv23 expressed genes related to adherence and pilus formation, which may contribute to its therapeutic effects.
Review
Food Science & Technology
Yuhan Zhao, Mengjie Li, Yanan Wang, Ruixuan Geng, Jingjing Fang, Qing Liu, Seong-Gook Kang, Wei Cai Zeng, Kunlun Huang, Tao Tong
Summary: This article discusses the relationship between diet and gut microbiota, the mechanism linking diabetes and gut dysbiosis, and the effects of dietary components on diabetes from the perspective of modulating gut microbiota. It provides compelling evidence that targeting gut microbiota through dietary interventions is a promising strategy for the clinical management of diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Sona Ciernikova, Aneta Sevcikova, Lubos Drgona, Michal Mego
Summary: Treatment resistance and adverse effects are important issues in cancer patient management. The use of microbiome in oncology is showing promising results. Favorable bacterial species and gut diversity are associated with increased treatment efficacy, while alterations in gut microbiome contribute to intestinal dysbiosis and treatment-induced toxicity.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Gastroenterology & Hepatology
Prashant Singh, Eric J. Alm, John M. Kelley, Vivian Cheng, Mark Smith, Zain Kassam, Judy Nee, Johanna Iturrino, Anthony Lembo
Summary: Fecal microbiota transplantation is an effective strategy to correct microbial dysbiosis in diarrhea-predominant irritable bowel syndrome. For patients with IBS-D, FMT with antibiotic pretreatment significantly reduces bacterial engraftment.
Article
Clinical Neurology
Carlo Romano Settanni, Gianluca Ianiro, Stefano Bibbo, Giovanni Cammarota, Antonio Gasbarrini
Summary: This article discusses the role of gut microbiota in maintaining central and peripheral functions as well as mental health, and the association between dysbiosis and psychiatric disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Gastroenterology & Hepatology
Shaghayegh Habibi, Armin Rashidi
Summary: Disruptions to the gut microbiota have been linked to adverse outcomes after hematopoietic cell transplantation and cellular therapy. Fecal microbiota transplantation (FMT) is a potential therapeutic intervention, but more research is needed before it can be considered a standard treatment. This review examines the evidence for microbiota-outcome associations, highlights the main FMT trials, and suggests future paths for research.
Article
Microbiology
Haiming Fang, Tingting Yao, Wanli Li, Na Pan, Hang Xu, Qian Zhao, Yuan Su, Kangwei Xiong, Jiajia Wang
Summary: This study evaluated the efficacy and safety of fecal microbiota transplantation (FMT) for adult chronic insomnia. The results showed that FMT significantly improved the insomnia, anxiety, depression, and quality of life in patients with chronic insomnia. The study also found that the increase in certain bacteria was positively correlated with the efficacy of FMT.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Clinical Neurology
Herbert L. DuPont, Jessika Suescun, Zhi-Dong Jiang, Eric L. Brown, Heather T. Essigmann, Ashley S. Alexander, Andrew W. DuPont, Tehseen Iqbal, Netanya S. Utay, Michael Newmark, Mya C. Schiess
Summary: This pilot clinical study investigated the safety and efficacy of fecal microbiota transplantation (FMT) in patients with Parkinson's disease. The results showed that FMT treatment increased the diversity of the intestinal microbiome and improved constipation and gut function associated with Parkinson's disease. This suggests that the intestinal microbiome may play a significant role in the pathogenesis of Parkinson's disease and offers new opportunities for treatment.
FRONTIERS IN NEUROLOGY
(2023)
Article
Allergy
Tihong Shao, Ronald Hsu, Camelia Hacein-Bey, Weici Zhang, Lixia Gao, Mark J. Kurth, Huanhuan Zhao, Zongwen Shuai, Patrick S. C. Leung
Summary: The gut microbiota plays important physiological roles and maintaining immune homeostasis. Imbalanced gut microbiome is associated with various diseases, and fecal microbiota transplantation (FMT) has shown efficacy in restoring normal gut microbiota homeostasis. This review aims to increase our understanding of the mechanisms and efficacies of FMT in human diseases, discussing its application, limitations, safety, and suggested mechanisms in recurrent Clostridioides difficile infection (rCDI), autoimmune diseases, and cancer. Future perspectives of FMT in human medicine are also addressed.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)
Article
Physiology
Yun Ju Choi, Ji Eun Kim, Su Jin Lee, Jeong Eun Gong, Hong Joo Son, Jin Tae Hong, Dae Youn Hwang
Summary: The study found significant alterations in fecal microbiota composition in C3 KO mice with constipation, indicating a key role in the induction and regulation of defecation delay.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Bhupinder Kapoor, Monica Gulati, Reena Gupta, Rajeev K. Singla
Summary: Dysregulated immune system, in which self-antigens are not recognized properly, is a common pathogenesis in autoimmune diseases. Environmental factors, such as disturbed gut microbiota, have been found to play a crucial role. Recent studies have shown that dysbiosis of gut microbiota is associated with the development of myasthenia gravis (MG), a rare autoimmune disease of the neuromuscular junction. The modulation of gut microbiota through interventions like probiotics, prebiotics, and fecal microbiota transplantation (FMT) is considered a promising approach for the management of MG.
AUTOIMMUNITY REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Howard Junca, Dietmar H. Pieper, Eva Medina
Summary: The human microbiome has been widely studied for its potential clinical interventions, and disruptions in the microbiota have been associated with various pathological conditions. Microbiome transplantation, such as fecal microbiome transplantation, has shown success in treating certain diseases and is being explored in other areas, such as vaginal disorders and skin pathologies.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Immunology
Hongtao Liu, Ping Gao, Baoqian Jia, Na Lu, Baoli Zhu, Fuping Zhang
Summary: The Atg16L1T300A polymorphism impacts the commensal bacterial flora in the intestine, leading to an increase in certain bacteria abundance, a decrease in mucin secretion, resulting in defective autophagy and more severe inflammation response.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Adrian Boicean, Victoria Birlutiu, Cristian Ichim, Paula Anderco, Sabrina Birsan
Summary: Inflammatory bowel diseases (IBD) are complex diseases characterized by chronic inflammation in the gastrointestinal tract. Fecal microbiota transplantation (FMT) has shown increasing effectiveness and safety in treating recurrent Clostridium difficile infection (CDI) and co-infection of SARS-CoV-2 and CDI. By modifying the gut microbiota, FMT offers an alternative approach to indirectly influence the host's immune system in a safe way, improving clinical symptoms and endoscopic findings in IBD patients. Further validation is needed to establish a clinical protocol for FMT in IBD.
Article
Biochemical Research Methods
Adam M. Farkas, Casandra Panea, Yoshiyuki Goto, Gaku Nakato, Marta Galan-Diez, Seiko Narushima, Kenya Honda, Ivaylo I. Ivanov
JOURNAL OF IMMUNOLOGICAL METHODS
(2015)
Article
Multidisciplinary Sciences
Yoshiyuki Goto, Aayam Lamichhane, Mariko Kamioka, Shintaro Sato, Kenya Honda, Jun Kunisawa, Hiroshi Kiyono
SCIENTIFIC REPORTS
(2015)
Article
Cell Biology
Casandra Panea, Adam M. Farkas, Yoshiyuki Goto, Shahla Abdollahi-Roodsaz, Carolyn Lee, Balazs Koscso, Kavitha Gowda, Tobias M. Hohl, Milena Bogunovic, Ivaylo I. Ivanov
Review
Immunology
Yoshiyuki Goto, Satoshi Uematsu, Hiroshi Kiyono
Article
Immunology
Takashi Ito, Koichi Hirose, Aiko Saku, Kenta Kono, Hiroaki Takatori, Tomohiro Tamachi, Yoshiyuki Goto, Jean-Christophe Renauld, Hiroshi Kiyono, Hiroshi Nakajima
JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Article
Immunology
Yosuke Kurashima, Yoshiyuki Goto, Hiroshi Kiyono
EUROPEAN JOURNAL OF IMMUNOLOGY
(2013)
Article
Immunology
Yoshiyuki Goto, Casandra Panea, Gaku Nakato, Anna Cebula, Carolyn Lee, Marta Galan Diez, Terri M. Laufer, Leszek Ignatowicz, Ivaylo I. Ivanov
Review
Immunology
Yoshiyuki Goto, Hiroshi Kiyono
IMMUNOLOGICAL REVIEWS
(2012)
Review
Cell Biology
Yoshiyuki Goto, Ivaylo I. Ivanov
IMMUNOLOGY AND CELL BIOLOGY
(2013)
Article
Immunology
Takuma Shibata, Naoki Takemura, Yuji Motoi, Yoshiyuki Goto, Thangaraj Karuppuchamy, Kumi Izawa, Xiaobing Li, Sachiko Akashi-Takamura, Natsuko Tanimura, Jun Kunisawa, Hiroshi Kiyono, Shizuo Akira, Toshio Kitamura, Jiro Kitaura, Satoshi Uematsu, Kensuke Miyake
INTERNATIONAL IMMUNOLOGY
(2012)
Article
Immunology
Takashi Kusu, Hisako Kayama, Makoto Kinoshita, Seong Gyu Jeon, Yoshiyasu Ueda, Yoshiyuki Goto, Ryu Okumura, Hiroyuki Saiga, Takashi Kurakawa, Kayo Ikeda, Yuichi Maeda, Jun-ichi Nishimura, Yasunobu Arima, Koji Atarashi, Kenya Honda, Masaaki Murakami, Jun Kunisawa, Hiroshi Kiyono, Meinoshin Okumura, Masahiro Yamamoto, Kiyoshi Takeda
JOURNAL OF IMMUNOLOGY
(2013)
Article
Immunology
Takashi Obata, Naoko Shibata, Yoshiyuki Goto, Izumi Ishikawa, Shintaro Sato, Jun Kunisawa, Hiroshi Kiyono
JOURNAL OF IMMUNOLOGY
(2013)
Article
Multidisciplinary Sciences
Yoshiyuki Goto, Takashi Obata, Jun Kunisawa, Shintaro Sato, Ivaylo I. Ivanov, Aayam Lamichhane, Natsumi Takeyama, Mariko Kamioka, Mitsuo Sakamoto, Takahiro Matsuki, Hiromi Setoyama, Akemi Imaoka, Satoshi Uematsu, Shizuo Akira, Steven E. Domino, Paulina Kulig, Burkhard Becher, Jean-Christophe Renauld, Chihiro Sasakawa, Yoshinori Umesaki, Yoshimi Benno, Hiroshi Kiyono
Article
Multidisciplinary Sciences
Jun Kunisawa, Masashi Gohda, Eri Hashimoto, Izumi Ishikawa, Morio Higuchi, Yuji Suzuki, Yoshiyuki Goto, Casandra Panea, Ivaylo I. Ivanov, Risa Sumiya, Lamichhane Aayam, Taichi Wake, So Tajiri, Yosuke Kurashima, Shiori Shikata, Shizuo Akira, Kiyoshi Takeda, Hiroshi Kiyono
NATURE COMMUNICATIONS
(2013)