期刊
SCIENTIFIC REPORTS
卷 5, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep15918
关键词
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资金
- Core Research for Evolutional Science and Technology Program of the Japan Science and Technology Agency
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Global Center of Excellence (COE) Program Center of Education and Research for Advanced Genome-based Medicine
- Ministry of Health, Labour and Welfare of Japan
- Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries and Food Industry
- Kishimoto Foundation Research Grant
- Chugai Pharmaceutical Company, Inc.
- Grants-in-Aid for Scientific Research [26670241, 26293111] Funding Source: KAKEN
Fucosylated glycans on the surface of epithelial cells (ECs) regulate intestinal homeostasis by serving as attachment receptors and a nutrient source for some species of bacteria. We show here that epithelial fucosylation in the ileum is negatively regulated by IL-10-producing CD4(+) T cells. The number of fucosylated ECs was increased in the ileum of mice lacking T cells, especially those expressing alpha beta T cell receptor (TCR), CD4, and IL-10. No such effect was observed in mice lacking B cells. Adoptive transfer of alpha beta TCR+ CD4(+) T cells from normal mice, but not IL-10-deficient mice, normalized fucosylation of ECs. These findings suggest that IL-10-producing CD4(+) T cells contribute to the maintenance of the function of ECs by regulating their fucosylation.
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