Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets

Altered mitochondrial quality control signaling in muscle of old gastric cancer patients with cachexia

(2017) Emanuele Marzetti et al.   EXPERIMENTAL GERONTOLOGY

Plasma Exosome Profiling of Cancer Patients by a Next Generation Systems Biology Approach

(2017) Valeriy Domenyuk et al.   Scientific Reports

Enjoy the Trip: Calcium in Mitochondria Back and Forth

(2016) Diego De Stefani et al.   Annual Review of Biochemistry

Mammalian Autophagy: How Does It Work?

(2016) Carla F. Bento et al.   Annual Review of Biochemistry

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

“What makes some rats live so long?” The mitochondrial contribution to longevity through balance of mitochondrial dynamics and mtDNA content

(2016) Anna Picca et al.   EXPERIMENTAL GERONTOLOGY

Association between myocyte quality control signaling and sarcopenia in old hip-fractured patients: Results from the Sarcopenia in HIp FracTure (SHIFT) exploratory study

(2016) Emanuele Marzetti et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial ROS regulation of proliferating cells

(2016) Lauren Diebold et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The rise of mitochondria in medicine

(2016) Martin Picard et al.   MITOCHONDRION

The potential of endurance exercise-derived exosomes to treat metabolic diseases

(2016) Adeel Safdar et al.   Nature Reviews Endocrinology

Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity

(2015) Douglas R. Seals et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of mitochondrial biogenesis through TFAM–mitochondrial DNA interactions

(2015) Anna Picca et al.   MITOCHONDRION

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

New roles for mitochondrial proteases in health, ageing and disease

(2015) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand

(2014) D. A. Patten et al.   EMBO JOURNAL

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

(2014) Gian-Luca McLelland et al.   EMBO JOURNAL

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

(2014) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia

(2014) Jonathan P. Little et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

Evaluation of the Contribution of Multiple DAMPs and DAMP Receptors in Cell Death-Induced Sterile Inflammatory Responses

(2014) Hiroshi Kataoka et al.   PLoS One

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

(2014) J. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mitochondrial dysfunction and the inflammatory response

(2013) María J. López-Armada et al.   MITOCHONDRION

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Aging and Calorie Restriction Oppositely Affect Mitochondrial Biogenesis through TFAM Binding at Both Origins of Mitochondrial DNA Replication in Rat Liver

(2013) Anna Picca et al.   PLoS One

Chaperone–protease networks in mitochondrial protein homeostasis

(2012) Wolfgang Voos   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

(2012) Vincent Soubannier et al.   CURRENT BIOLOGY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Reconstitution of Mitochondria Derived Vesicle Formation Demonstrates Selective Enrichment of Oxidized Cargo

(2012) Vincent Soubannier et al.   PLoS One

Acetyl-l-Carnitine Activates the Peroxisome Proliferator-Activated Receptor-γ Coactivators PGC-1α/PGC-1β–Dependent Signaling Cascade of Mitochondrial Biogenesis and Decreases the Oxidized Peroxiredoxins Content in Old Rat Liver

(2012) Vito Pesce et al.   REJUVENATION RESEARCH

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Mitochondrial DNA and inflammatory diseases

(2011) Germaine Escames et al.   HUMAN GENETICS

Mitophagy Plays an Essential Role in Reducing Mitochondrial Production of Reactive Oxygen Species and Mutation of Mitochondrial DNA by Maintaining Mitochondrial Quantity and Quality in Yeast

(2011) Yusuke Kurihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin Interacts with Ambra1 to Induce Mitophagy

(2011) C. Van Humbeeck et al.   JOURNAL OF NEUROSCIENCE

Increased plasma levels of extracellular mitochondrial DNA during HIV infection: A new role for mitochondrial damage-associated molecular patterns during inflammation

(2011) Andrea Cossarizza et al.   MITOCHONDRION

Mitochondrial Network Determines Intracellular ROS Dynamics and Sensitivity to Oxidative Stress through Switching Inter-Mitochondrial Messengers

(2011) Junseong Park et al.   PLoS One

Mitochondrial protein quality control during biogenesis and aging

(2011) Brooke M. Baker et al.   TRENDS IN BIOCHEMICAL SCIENCES

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

Ubiquitin–Proteasome System and mitochondria — Reciprocity

(2010) Nurit Livnat-Levanon et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

The mitochondrial transcription factor A functions in mitochondrial base excision repair

(2010) Chandrika Canugovi et al.   DNA REPAIR

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

A Stress-Responsive System for Mitochondrial Protein Degradation

(2010) Jin-Mi Heo et al.   MOLECULAR CELL

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Role of Mitochondria in Apoptosis

(2009) Chunxin Wang et al.   Annual Review of Genetics

Transcriptional Control of Mitochondrial Biogenesis and Function

(2009) M. Benjamin Hock et al.   Annual Review of Physiology

An Update of the Oxidation-Inflammation Theory of Aging: The Involvement of the Immune System in Oxi-Inflamm-Aging

(2009) Monica Fuente et al.   CURRENT PHARMACEUTICAL DESIGN

SLP-2 is required for stress-induced mitochondrial hyperfusion

(2009) Daniel Tondera et al.   EMBO JOURNAL

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

(2009) Michele Guescini et al.   JOURNAL OF NEURAL TRANSMISSION

Region-specific changes in mitochondrial D-loop in aged rat CNS

(2009) Simone C. McInerny et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors

(2009) Corina Kohler et al.   Molecular Cancer

Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view

(2008) Gilad Twig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY