PERM Hypothesis: The Fundamental Machinery Able to Elucidate the Role of Xenobiotics and Hormesis in Cell Survival and Homeostasis

ROS Are Good

(2017) Ron Mittler   TRENDS IN PLANT SCIENCE

Mitochondrial dynamics during cell cycling

(2016) Rostyslav Horbay et al.   APOPTOSIS

Inhibition of autophagy enhances heat-induced apoptosis in human non-small cell lung cancer cells through ER stress pathways

(2016) Wen-Yue Xie et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

SHP-2 phosphatase controls aryl hydrocarbon receptor-mediated ER stress response in mast cells

(2016) Hsueh-Chun Wang et al.   ARCHIVES OF TOXICOLOGY

Apoptosis Inducing Factor Binding Protein PGAM5 Triggers Mitophagic Cell Death That Is Inhibited by the Ubiquitin Ligase Activity of X-Linked Inhibitor of Apoptosis

(2016) Audrey M. Lenhausen et al.   BIOCHEMISTRY

Emerging role of Lon protease as a master regulator of mitochondrial functions

(2016) Marcello Pinti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Regulation of Mitofusin1 by Mahogunin Ring Finger-1 and the proteasome modulates mitochondrial fusion

(2016) Rukmini Mukherjee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Atypical profiles and modulations of heme-enzymes catalyzed outcomes by low amounts of diverse additives suggest diffusible radicals' obligatory involvement in such redox reactions

(2016) Kelath Murali Manoj et al.   BIOCHIMIE

The peroxisomal Lon protease LonP2 in aging and disease: functions and comparisons with mitochondrial Lon protease LonP1

(2016) Laura C. D. Pomatto et al.   BIOLOGICAL REVIEWS

The Roles of Mitochondria in Autophagic Cell Death

(2016) Zongyan Chen et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Hormesis running hot and cold

(2016) Arturo Bujarrabal et al.   CELL CYCLE

Synchronization of mobile chaotic oscillator networks

(2016) Naoya Fujiwara et al.   CHAOS

ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction underlie apoptosis induced by resveratrol and arsenic trioxide in A549 cells

(2016) Shiyan Gu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Associations between autophagy, the ubiquitin-proteasome system and endoplasmic reticulum stress in hypoxia-deoxygenation or ischemia-reperfusion

(2016) Tao Fan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Understanding genistein in cancer: The “good” and the “bad” effects: A review

(2016) Maria Russo et al.   FOOD CHEMISTRY

Tricin, flavonoid from Njavara reduces inflammatory responses in hPBMCs by modulating the p38MAPK and PI3K/Akt pathways and prevents inflammation associated endothelial dysfunction in HUVECs

(2016) V. Shalini et al.   IMMUNOBIOLOGY

Crosstalk between autophagy and intracellular radiation response (Review)

(2016) Lelin Hu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Ubiquitin-mediated regulation of the E3 ligase GP78 by MGRN1 in trans affects mitochondrial homeostasis

(2016) Rukmini Mukherjee et al.   JOURNAL OF CELL SCIENCE

Beneficial action of resveratrol: How and why?

(2016) Gustavo Tomas Diaz-Gerevini et al.   NUTRITION

ROS and ROS-Mediated Cellular Signaling

(2016) Jixiang Zhang et al.   Oxidative Medicine and Cellular Longevity

Preconditioning is hormesis part II: How the conditioning dose mediates protection: Dose optimization within temporal and mechanistic frameworks

(2016) Edward J. Calabrese   PHARMACOLOGICAL RESEARCH

Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations

(2016) Edward J. Calabrese   PHARMACOLOGICAL RESEARCH

Prooxidant Activity of Polyphenols, Flavonoids, Anthocyanins and Carotenoids: Updated Review of Mechanisms and Catalyzing Metals

(2016) Samira Eghbaliferiz et al.   PHYTOTHERAPY RESEARCH

The Roles of Mitochondrial Reactive Oxygen Species in Cellular Signaling and Stress Response in Plants

(2016) Shaobai Huang et al.   PLANT PHYSIOLOGY

Dietary phytochemicals as epigenetic modifiers in cancer: Promise and challenges

(2016) Eswar Shankar et al.   SEMINARS IN CANCER BIOLOGY

PARL: The mitochondrial rhomboid protease

(2016) Marco Spinazzi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Are Organisms Adapting to Ionizing Radiation at Chernobyl?

(2016) Anders Pape Møller et al.   TRENDS IN ECOLOGY & EVOLUTION

Apigenin suppresses colorectal cancer cell proliferation, migration and invasion via inhibition of the Wnt/β-catenin signaling pathway

(2016) MIN XU et al.   Oncology Letters

Flavonoids in Inflammatory Bowel Disease: A Review

(2016) Teresa Vezza et al.   Nutrients

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis

(2016) Jorge Iván Castillo-Quan et al.   Cell Reports

Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges

(2016) Sergio Davinelli et al.   Immunity & Ageing

Functioning of Microsomal Cytochrome P450s: Murburn Concept Explains the Metabolism of Xenobiotics in Hepatocytes

(2016) Kelath Murali Manoj et al.   Frontiers in Pharmacology

CODAS Syndrome Is Associated with Mutations of LONP1, Encoding Mitochondrial AAA+ Lon Protease

(2015) Kevin A. Strauss et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Peroxisomes sense and respond to environmental cues by regulating ROS and RNS signalling networks

(2015) L. M. Sandalio et al.   ANNALS OF BOTANY

Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy

(2015) Cathrin Meissner et al.   Autophagy

Flavonoids at the pharma-nutrition interface: Is a therapeutic index in demand?

(2015) Ilaria Peluso et al.   BIOMEDICINE & PHARMACOTHERAPY

Review of nut phytochemicals, fat-soluble bioactives, antioxidant components and health effects

(2015) Cesarettin Alasalvar et al.   BRITISH JOURNAL OF NUTRITION

Calcium signaling and cell proliferation

(2015) Mauro Cunha Xavier Pinto et al.   CELLULAR SIGNALLING

The daily rhythms of mitochondrial gene expression and oxidative stress regulation are altered by aging in the mouse liver

(2015) Changxia Gong et al.   CHRONOBIOLOGY INTERNATIONAL

Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure–activity/property relationship-based approach in the study of bioavailability and bioactivity

(2015) Gerard Bryan Gonzales et al.   DRUG METABOLISM REVIEWS

Hormesis depends upon the life-stage and duration of exposure: Examples for a pesticide and a nanomaterial

(2015) William Tyne et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

The switch from ER stress-induced apoptosis to autophagy via ROS-mediated JNK/p62 signals: A survival mechanism in methotrexate-resistant choriocarcinoma cells

(2015) Yun Shen et al.   EXPERIMENTAL CELL RESEARCH

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

(2015) Thomas M. Durcan et al.   GENES & DEVELOPMENT

Routes of Ca2+Shuttling during Ca2+Oscillations

(2015) László Pecze et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of Inflammatory Responses by Dihydromyricetin, a Flavonoid from Ampelopsis grossedentata, via Inhibiting the Activation of NF-κB and MAPK Signaling Pathways

(2015) X. L. Hou et al.   JOURNAL OF NATURAL PRODUCTS

Polypeptide from Chlamys farreri suppresses ultraviolet-B irradiation-induced apoptosis through restoring ER redox homeostasis, scavenging ROS generation, and suppressing the PERK-eIF2a-CHOP pathway in HaCaT cells

(2015) Feng Zhong et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Mitochondrial Lon protease controls ROS-dependent apoptosis in cardiomyocyte under hypoxia

(2015) Chan-Yen Kuo et al.   MITOCHONDRION

The mechanisms of action of flavonoids in the brain: Direct versus indirect effects

(2015) Catarina Rendeiro et al.   NEUROCHEMISTRY INTERNATIONAL

Flavonoids isolated from Citrus platymamma induce mitochondrial-dependent apoptosis in AGS cells by modulation of the PI3K/AKT and MAPK pathways

(2015) HO JEONG LEE et al.   ONCOLOGY REPORTS

p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner

(2015) Carlotta Giorgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Review of the Cognitive Effects Observed in Humans Following Acute Supplementation with Flavonoids, and Their Associated Mechanisms of Action

(2015) Lynne Bell et al.   Nutrients

iRhom1 regulates proteasome activity via PAC1/2 under ER stress

(2015) WonJae Lee et al.   Scientific Reports

Calcium and ROS: A mutual interplay

(2015) Agnes Görlach et al.   Redox Biology

Autophagy-Regulated ROS from Xanthine Oxidase Acts as an Early Effector for Triggering Late Mitochondria-Dependent Apoptosis in Cathepsin S-Targeted Tumor Cells

(2015) Chien-Chang Huang et al.   PLoS One

Pathogenesis of Human Mitochondrial Diseases Is Modulated by Reduced Activity of the Ubiquitin/Proteasome System

(2014) Alexandra Segref et al.   Cell Metabolism

The role of phytochemicals as micronutrients in health and disease

(2014) Melanie-Jayne R. Howes et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells

(2014) XIU CHENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Proanthocyanidins protect against early diabetic peripheral neuropathy by modulating endoplasmic reticulum stress

(2014) Ye Ding et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

(2014) Michael Ristow   NATURE MEDICINE

Modeling the intracellular organization of calcium signaling

(2014) Geneviève Dupont   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Reversible 26S Proteasome Disassembly upon Mitochondrial Stress

(2014) Nurit Livnat-Levanon et al.   Cell Reports

Molecular chaperones and proteostasis regulation during redox imbalance

(2014) Katerina Niforou et al.   Redox Biology

Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention

(2013) Xin Tong et al.   Anti-Cancer Agents in Medicinal Chemistry

Editorial (Hot Topic: Inhibition of PI3K/Akt/mTOR Signaling by Natural Products)

(2013) Shile Huang   Anti-Cancer Agents in Medicinal Chemistry

Potential Targets for Prevention of Colorectal Cancer: a Focus on PI3K/Akt/mTOR and Wnt Pathways

(2013) Ashok Kumar Pandurangan   Asian Pacific Journal of Cancer Prevention

The endoplasmic reticulum–mitochondria connection: One touch, multiple functions

(2013) Saverio Marchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The mitochondrial rhomboid protease: Its rise from obscurity to the pinnacle of disease-relevant genes

(2013) Eliana Y.L. Chan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

HIV protease inhibitors and onset of cardiovascular diseases: A central role for oxidative stress and dysregulation of the ubiquitin–proteasome system

(2013) Kathleen M.S.E. Reyskens et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells

(2013) Bo Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Eupafolin, a skin whitening flavonoid isolated from Phyla nodiflora, downregulated melanogenesis: Role of MAPK and Akt pathways

(2013) Horng-Huey Ko et al.   JOURNAL OF ETHNOPHARMACOLOGY

Regulation of mitophagy by the Gp78 E3 ubiquitin ligase

(2013) Min Fu et al.   MOLECULAR BIOLOGY OF THE CELL

IRE1: ER stress sensor and cell fate executor

(2013) Yani Chen et al.   TRENDS IN CELL BIOLOGY

Strange attractors: DAMPs and autophagy link tumor cell death and immunity

(2013) W Hou et al.   Cell Death & Disease

Mahogunin ring finger-1 (MGRN1) Suppresses Chaperone-Associated Misfolded Protein Aggregation and Toxicity

(2013) Deepak Chhangani et al.   Scientific Reports

Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging

(2013) Jenny K. Ngo et al.   Redox Biology

Chronic mild stress alters circadian expressions of molecular clock genes in the liver

(2012) Kei Takahashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Oxidation matters: The ubiquitin proteasome system connects innate immune mechanisms with MHC class I antigen presentation

(2012) Annika Warnatsch et al.   MOLECULAR IMMUNOLOGY

Parkin Promotes Degradation of the Mitochondrial Pro-Apoptotic ARTS Protein

(2012) Stav Kemeny et al.   PLoS One

Parkin uses the UPS to ship off dysfunctional mitochondria

(2011) Nickie C. Chan et al.   Autophagy

Role of peroxisomes in ROS/RNS-metabolism: Implications for human disease

(2011) Marc Fransen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeting the Ubiquitin-Proteasome Pathway: An Emerging Concept in Cancer Therapy

(2011) Michael Frezza et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Oxidative Stress-Mediated Regulation of Proteasome Complexes

(2011) Charity T. Aiken et al.   MOLECULAR & CELLULAR PROTEOMICS

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2011) N. D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

ROS signaling: the new wave?

(2011) Ron Mittler et al.   TRENDS IN PLANT SCIENCE

Upregulation of nuclear-encoded mitochondrial LON protease in HAART-treated HIV-positive patients with lipodystrophy: implications for the pathogenesis of the disease

(2010) Marcello Pinti et al.   AIDS

Flavonoids and alkenylbenzenes: New concepts in bioactivation studies

(2010) Ivonne M.C.M. Rietjens et al.   CHEMICO-BIOLOGICAL INTERACTIONS

PI3K/Akt/mTOR Pathway Inhibitors in Cancer: A Perspective on Clinical Progress

(2010) P. Wu et al.   CURRENT MEDICINAL CHEMISTRY

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Regulation of the 26S Proteasome Complex During Oxidative Stress

(2010) X. Wang et al.   Science Signaling

Spices, herbal xenobiotics and the stomach: Friends or foes?

(2010) Ibrahim Abdulkarim Al Mofleh   WORLD JOURNAL OF GASTROENTEROLOGY

Calcium Oscillations

(2010) G. Dupont et al.   Cold Spring Harbor Perspectives in Biology

A Reaction-Diffusion Model of ROS-Induced ROS Release in a Mitochondrial Network

(2010) Lufang Zhou et al.   PLoS Computational Biology

SR/ER–mitochondrial local communication: Calcium and ROS

(2009) György Csordás et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Reactive oxygen species and peroxisomes: Struggling for balance

(2009) Nina A. Bonekamp et al.   BIOFACTORS

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Divergent Effects of PERK and IRE1 Signaling on Cell Viability

(2009) Jonathan H. Lin et al.   PLoS One

Food flavonoid aryl hydrocarbon receptor-mediated agonistic/antagonistic/synergic activities in human and rat reporter gene assays

(2008) Edwige Van der Heiden et al.   ANALYTICA CHIMICA ACTA