期刊
AUTOPHAGY
卷 7, 期 7, 页码 771-772出版社
LANDES BIOSCIENCE
DOI: 10.4161/auto.7.7.15453
关键词
Parkinson disease; parkin; ubiquitin-proteasome system; mitophagy; mitochondria
类别
资金
- NIGMS NIH HHS [R01 GM062967] Funding Source: Medline
Parkin is a ubiquitin E3 ligase that is implicated in familial Parkinson disease (PD). Previous studies have established its role in mitophagy, a pathway whereby dysfunctional mitochondria are targeted for autophagic degradation. We recently reported that a major function of Parkin in dysfunctional mitochondria is to activate the ubiquitin-proteasome system (UPS) for proteolysis of multiple outer membrane proteins, and that such activation of the UPS is a critical step in Parkin-mediated mitophagy. Here, we discuss the possible roles of the UPS in mitophagy and the pathogenesis of PD.
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