BRD9 Inhibition, Alone or in Combination with Cytostatic Compounds as a Therapeutic Approach in Rhabdoid Tumors

Doxorubicin targets multiple players: A new view of an old problem

(2018) Donato Cappetta et al.   PHARMACOLOGICAL RESEARCH

Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma

(2017) Michael Olvedy et al.   JOURNAL OF CLINICAL INVESTIGATION

Bromodomain Histone Readers and Cancer

(2017) Abhinav K Jain et al.   JOURNAL OF MOLECULAR BIOLOGY

Atypical teratoid rhabdoid tumor in the first year of life: the Canadian ATRT registry experience and review of the literature

(2017) Mary Fossey et al.   JOURNAL OF NEURO-ONCOLOGY

Targeting chromatin defects in selected solid tumors based on oncogene addiction, synthetic lethality and epigenetic antagonism

(2016) D. Morel et al.   ANNALS OF ONCOLOGY

Microtubule destabilising agents: far more than just antimitotic anticancer drugs

(2016) Darcy Bates et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

(2016) Pascal D. Johann et al.   CANCER CELL

Platinum-based drugs: past, present and future

(2016) Shahana Dilruba et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformation

(2016) Angelina Stojanova et al.   CELL CYCLE

Progress in the Development of non-BET Bromodomain Chemical Probes

(2016) Natalie H. Theodoulou et al.   ChemMedChem

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

(2016) Laetitia J. Martin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition

(2016) Anja F Hohmann et al.   Nature Chemical Biology

Atypical teratoid/rhabdoid tumors—current concepts, advances in biology, and potential future therapies

(2016) Michael C. Frühwald et al.   NEURO-ONCOLOGY

Initial testing (stage 1) of tazemetostat (EPZ-6438), a novel EZH2 inhibitor, by the Pediatric Preclinical Testing Program

(2016) Raushan T. Kurmasheva et al.   PEDIATRIC BLOOD & CANCER

Prognostic relevance of SAMSN1 expression in gastric cancer

(2016) Mitsuro Kanda et al.   Oncology Letters

Suppression of SAMSN1 Expression is Associated with the Malignant Phenotype of Hepatocellular Carcinoma

(2015) Satoshi Sueoka et al.   ANNALS OF SURGICAL ONCOLOGY

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

(2015) Natalie H. Theodoulou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multimodal therapy in children and adolescents with newly diagnosed atypical teratoid rhabdoid tumor: individual pooled data analysis and review of the literature

(2015) D. Schrey et al.   JOURNAL OF NEURO-ONCOLOGY

A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications

(2015) E. Megan Flynn et al.   STRUCTURE

Loss of function of SWI/SNF chromatin remodeling genes leads to genome instability of human lung cancer

(2014) HAI-TAO HUANG et al.   ONCOLOGY REPORTS

A rationale to target the SWI/SNF complex for cancer therapy

(2014) Anja F. Hohmann et al.   TRENDS IN GENETICS

Rhabdoid tumors: integrating biological insights with clinical success

(2014) Franck Bourdeaut et al.   Cancer Genetics

SAMSN1 Is a Tumor Suppressor Gene in Multiple Myeloma

(2014) Jacqueline E. Noll et al.   NEOPLASIA

The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells

(2013) Kornelius Kerl et al.   BMC CANCER

DUSP6 regulates drug sensitivity by modulating DNA damage response

(2013) T V Bagnyukova et al.   BRITISH JOURNAL OF CANCER

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

(2013) Cigall Kadoch et al.   NATURE GENETICS

Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5

(2013) E L Mora-Blanco et al.   ONCOGENE

Intensive induction chemotherapy followed by myeloablative chemotherapy with autologous hematopoietic progenitor cell rescue for young children newly-diagnosed with central nervous system atypical teratoid/rhabdoid tumors: The head start III experience

(2013) Wafik Zaky et al.   PEDIATRIC BLOOD & CANCER

Fibroblast Growth Factor Receptors as Novel Therapeutic Targets in SNF5-Deleted Malignant Rhabdoid Tumors

(2013) Simon Wöhrle et al.   PLoS One

Histone deacetylases expression in atypical teratoid rhabdoid tumors

(2012) Simone Treiger Sredni et al.   CHILDS NERVOUS SYSTEM

Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity

(2012) Anbarasi Kothandapani et al.   EXPERIMENTAL CELL RESEARCH

Role of the Non-Receptor Tyrosine Kinase Fes in Cancer

(2011) F. Condorelli et al.   CURRENT MEDICINAL CHEMISTRY

FES/FER kinase signaling in hematopoietic cells and leukemias

(2011) Andrew et al.   Frontiers in Bioscience-Landmark

The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3

(2011) S. Rahman et al.   MOLECULAR AND CELLULAR BIOLOGY

Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation

(2010) Boris G. Wilson et al.   CANCER CELL

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

SLy2 targets the nuclear SAP30/HDAC1 complex

(2010) Simone Brandt et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway

(2010) Zainab Jagani et al.   NATURE MEDICINE

Initial testing of the aurora kinase a inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP)

(2010) John M. Maris et al.   PEDIATRIC BLOOD & CANCER

Oncogenesis Caused by Loss of the SNF5 Tumor Suppressor Is Dependent on Activity of BRG1, the ATPase of the SWI/SNF Chromatin Remodeling Complex

(2009) X. Wang et al.   CANCER RESEARCH