CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

(2017) Yunjong Lee et al.   Cell Reports

Small molecule compounds that induce cellular senescence

(2016) Nadezhda V. Petrova et al.   AGING CELL

Activation of tyrosine kinase c-Abl contributes to α-synuclein–induced neurodegeneration

(2016) Saurav Brahmachari et al.   JOURNAL OF CLINICAL INVESTIGATION

Mouse models of ageing and their relevance to disease

(2016) Sulev Kõks et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Rs2853677 modulates Snail1 binding to the TERT enhancer and affects lung adenocarcinoma susceptibility

(2016) Xiaoting Li et al.   Oncotarget

Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model

(2016) Annika Scheffold et al.   Acta Neuropathologica Communications

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

PGC-1α Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases

(2015) Shiqin Xiong et al.   Cell Reports

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species

(2014) Priscila Britto Campos et al.   Frontiers in Aging Neuroscience

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

Telomere shortening in human diseases

(2013) Chiou Mee Kong et al.   FEBS Journal

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss

(2013) Yunjong Lee et al.   NATURE NEUROSCIENCE

Animal Models of Parkinson's Disease: Vertebrate Genetics

(2013) Y. Lee et al.   Cold Spring Harbor Perspectives in Medicine

Animal Models of Alzheimer Disease

(2013) F. M. LaFerla et al.   Cold Spring Harbor Perspectives in Medicine

Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria

(2012) Ilaria Chiodi et al.   Frontiers in Oncology

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide

(2011) Seth W. Perry et al.   BIOTECHNIQUES

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Telomeres in cancer and ageing

(2010) L. E. Donate et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

(2010) H. S. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction in Parkinson's disease

(2009) Konstanze F. Winklhofer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Benefits of Caloric Restriction on Brain Aging and Related Pathological States: Understanding Mechanisms to Devise Novel Therapies

(2008) Antonio Contestabile   CURRENT MEDICINAL CHEMISTRY

Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1

(2008) Sascha Beneke et al.   NUCLEIC ACIDS RESEARCH

Telomeres and Aging

(2008) Geraldine Aubert et al.   PHYSIOLOGICAL REVIEWS