Integrated genome analysis of uterine leiomyosarcoma to identify novel driver genes and targetable pathways

Spectrum of mutations in leiomyosarcomas identified by clinical targeted next-generation sequencing

(2017) Paul J Lee et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Uterine leiomyosarcoma: Epidemiology, contemporary treatment strategies and the impact of uterine morcellation

(2017) Stephanie Ricci et al.   GYNECOLOGIC ONCOLOGY

Uterine leiomyosarcoma - incidence, treatment, and the impact of morcellation. A nationwide cohort study

(2016) Mette Skorstad et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

Olaratumab and doxorubicin versus doxorubicin alone for treatment of soft-tissue sarcoma: an open-label phase 1b and randomised phase 2 trial

(2016) William D Tap et al.   LANCET

PRDM16 Suppresses MLL1r Leukemia via Intrinsic Histone Methyltransferase Activity

(2016) Bo Zhou et al.   MOLECULAR CELL

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

(2016) Bernard Thienpont et al.   NATURE

Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12

(2016) Netta Mäkinen et al.   PLoS Genetics

Clinically Relevant Molecular Subtypes in Leiomyosarcoma

(2015) X. Guo et al.   CLINICAL CANCER RESEARCH

MED12 and uterine smooth muscle oncogenesis: State of the art and perspectives

(2015) Sabrina Croce et al.   EUROPEAN JOURNAL OF CANCER

Laminin C1 expression by uterine carcinoma cells is associated with tumor progression

(2015) Hiroyasu Kashima et al.   GYNECOLOGIC ONCOLOGY

Characterization of patient-derived tumor xenograft models of endometrial cancer for preclinical evaluation of targeted therapies

(2015) Jeroen Depreeuw et al.   GYNECOLOGIC ONCOLOGY

The human gene damage index as a gene-level approach to prioritizing exome variants

(2015) Yuval Itan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Subtypes of Uterine Leiomyosarcoma and Correlation with Clinical Outcome

(2015) Joyce N. Barlin et al.   NEOPLASIA

Discovery of 14-3-3 Protein-Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693

(2014) Mattia Mori et al.   ChemMedChem

Dystrophin is a tumor suppressor in human cancers with myogenic programs

(2014) Yuexiang Wang et al.   NATURE GENETICS

Reliable Identification of Genomic Variants from RNA-Seq Data

(2013) Robert Piskol et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Uterine Leiomyosarcoma Management, Outcome, and Associated Molecular Biomarkers: A Single Institution’s Experience

(2013) Kristelle Lusby et al.   ANNALS OF SURGICAL ONCOLOGY

Gene expression signatures of primary and metastatic uterine leiomyosarcoma

(2013) Ben Davidson et al.   HUMAN PATHOLOGY

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Genomic Signatures Predict Poor Outcome in Undifferentiated Pleomorphic Sarcomas and Leiomyosarcomas

(2013) Sara Martoreli Silveira et al.   PLoS One

Identification of Candidate Driver Genes in Common Focal Chromosomal Aberrations of Microsatellite Stable Colorectal Cancer

(2013) George J. Burghel et al.   PLoS One

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

DIAPH3 governs the cellular transition to the amoeboid tumour phenotype

(2012) Martin H. Hager et al.   EMBO Molecular Medicine

MuSiC: Identifying mutational significance in cancer genomes

(2012) N. D. Dees et al.   GENOME RESEARCH

Analysis of molecular cytogenetic alterations in uterine leiomyosarcoma by array-based comparative genomic hybridization

(2012) Mohammad Raish et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial

(2012) Winette TA van der Graaf et al.   LANCET

Absolute quantification of somatic DNA alterations in human cancer

(2012) Scott L Carter et al.   NATURE BIOTECHNOLOGY

14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma

(2012) C.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

(2012) L. Pilotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA replication timing and long-range DNA interactions predict mutational landscapes of cancer genomes

(2011) Subhajyoti De et al.   NATURE BIOTECHNOLOGY

deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data

(2011) Andrew McPherson et al.   PLoS Computational Biology

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

Loss of pRB causes centromere dysfunction and chromosomal instability

(2010) A. L. Manning et al.   GENES & DEVELOPMENT

Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomes

(2010) C. L. Chen et al.   GENOME RESEARCH

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

(2010) Jordi Barretina et al.   NATURE GENETICS

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

Role of VPAC1 and VPAC2 in VIP mediated inhibition of rat pulmonary artery and aortic smooth muscle cell proliferation

(2010) Rose-Claire St. Hilaire et al.   PEPTIDES

Allele-specific copy number analysis of tumors

(2010) P. Van Loo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stage-Specific Outcomes of Patients With Uterine Leiomyosarcoma: A Comparison of the International Federation of Gynecology and Obstetrics and American Joint Committee on Cancer Staging Systems

(2009) Oliver Zivanovic et al.   JOURNAL OF CLINICAL ONCOLOGY

Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling

(2009) A H Beck et al.   ONCOGENE

Involvement of Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) and its Receptors in the Mechanism of Antidepressant Action

(2008) Michal Reichenstein et al.   JOURNAL OF MOLECULAR NEUROSCIENCE