Article
Food Science & Technology
Liuya Wang, Kun Li, Yidan Cui, Haihai Peng, Ying Hu, Zhenyuan Zhu
Summary: In this study, a new intracellular polysaccharide component called P. ostreatus polysaccharide (POP-W) was obtained from the mycelium of P. ostreatus and its structure was analyzed. The results showed that POP-W had a molecular weight of Mw = 3.034 x 103 kDa and did not contain protein and nucleic acid. POP-W showed good thermal stability and significant antioxidant activity, and it protected PC12 cells from H2O2-induced oxidative damage through the PI3K/Akt signaling pathway and regulation of apoptosis-related pathway proteins.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Yun-Jeong Ji, Sujin Kim, Jwa-Jin Kim, Gwi Yeong Jang, Minho Moon, Hyung Don Kim
Summary: In this study, it was found that Platycodon grandiflorum saponins protect neurons from neurodegeneration caused by amyloid beta-induced oxidative stress by inhibiting ROS production and apoptosis, upregulating Nrf2-mediated antioxidant signaling, downregulating NF-kappa B-mediated inflammatory signaling, and regulating apoptosis-associated proteins. Additionally, P. grandiflorum saponins ameliorated A beta-mediated pathologies and attenuated nerve damage, suggesting their potential as a resource for developing Alzheimer's disease therapeutics.
Article
Biochemistry & Molecular Biology
Yali Wang, Dejuan Sun, Yanmei Chen, Jinyu Xu, Yang Xu, Xinyi Yue, Jingming Jia, Hua Li, Lixia Chen
Summary: Three new diterpenoid alkaloids and eight known alkaloids were isolated from Delphinium grandiflorum, with some compounds showing significant protective effects on H2O2-induced cardiomyocytes injury. Compound 6 was found to reduce oxidative damage by inhibiting cell death through the AMPK/AKT/mTOR signaling pathway in H2O2-induced H9C2 cells.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Juanjuan Tian, Qing Xu, Xiaomeng Wang, Xueliang Zhang, Xiaohong Chen, Xin Rui, Qiuqin Zhang, Mingsheng Dong, Wei Li
Summary: Oxidative stress is a crucial process in the development of neurodegenerative diseases, and there is a need to focus on screening natural antioxidants and exploring pharmacological mechanisms. Polysaccharides from natural products, which have no toxic side effects, exhibit strong antioxidant activity. Two purified intracellular polysaccharide fractions (IPS1 and IPS2) from Paecilomyces cicadae TJJ1213 were isolated. The neuroprotective role of IPS and its potential protection mechanism were investigated through a model of H2O2-induced oxidative stress in PC12 cells. Results showed that IPS1 and IPS2 reduced reactive oxygen species (ROS) production, inhibited lactate dehydrogenase (LDH) and Ca2+ leakage, and attenuated the expression of apoptotic proteins. Additionally, IPS1 and IPS2 significantly inhibited mitophagy induced by H2O2 in PC12 cells through the PINK/Parkin pathway. Therefore, further investigation of IPS1 and IPS2 as potential protective agents against neurodegenerative diseases is warranted.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Kun Li, Liuya Wang, Ying Hu, Zhenyuan Zhu
Summary: The novel polysaccharide LDP-CP was extracted and purified from mycelia of Lactarius deliciosus Gray, and it demonstrated protective effects against oxidative injury in PC12 cells. The polysaccharides in Lactarius deliciosus Gray mycelia exhibited great advantages in managing oxidative toxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Minyan Li, Sha Wang, Chunmei Fu, Hongyu Chen, Yuxia Su, Peng Wu, Xinhao Yan, Juanjuan Gao
Summary: Parkinson's disease (PD) is characterized by oxidative stress and this study investigated the neuroprotective effects of salidroside (Sal) on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in PC12 cells. Sal effectively regulated oxidative stress and prevented the transmission of pathologic α-synuclein in the cells. These findings provide insights into potential protective mechanisms against neurodegenerative diseases and synucleinopathies.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Siqiang Wang, Ximei Yang, Xuening Hou, Zhenyuan Zhu
Summary: A homogeneous polysaccharide, ICMP-1, was isolated from the cultured mycelia of Isaria cicadae Miquel. A zinc modification on ICMP-1 improved its antioxidant activity.
PROCESS BIOCHEMISTRY
(2022)
Article
Food Science & Technology
Li Feng, Yingmin Wu, Jiankang Wang, Yuting Han, Junrong Huang, Huaide Xu
Summary: In this study, the neuroprotective effects of SGGY on H2O2-induced oxidative stress in SH-SY5Y cells were investigated. Results showed that SGGY alleviated oxidative stress by reducing ROS levels and altering MMP, thereby promoting cell survival and inhibiting apoptosis. SGGY also restored antioxidant enzyme activities, suppressed the activation of MAPKs, and facilitated the nuclear translocation of Nrf2. Overall, these findings suggest that SGGY protects against oxidative stress by enhancing antioxidant defense and modulating MAPK and Nrf2 signaling pathways.
Article
Biochemistry & Molecular Biology
Mersedeh Shayan, Soghra Mehri, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: Arsenic is a naturally occurring metalloid that can cause acute and chronic toxicity in humans. Neurotoxicity is a serious manifestation of arsenic toxicity. This study found that minocycline, an antimicrobial agent with antioxidant properties and the ability to cross the blood-brain barrier, can significantly attenuate arsenic-induced neurotoxicity by reducing oxidative stress and apoptosis. These findings suggest that minocycline could be a promising treatment for arsenic toxicity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yuan-Feng Zou, Mengsi Chen, Yu-Ping Fu, Zhong-Kai Zhu, Yan-Yun Zhang, Berit Smestad Paulsen, Frode Rise, Yu-Long Chen, Yong-Zhi Yang, Ren-Yong Jia, Li-Xia Li, Xu Song, Hua-Qiao Tang, Bin Feng, Cheng Lv, Gang Ye, Ding-Tao Wu, Zhong-Qiong Yin, Chao Huang
Summary: The study extracted a pectic polysaccharide, PGP-I-I, from Platycodon grandiflorus roots, which was found to promote cellular antioxidant defense and protect against oxidative damage.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Xintong Ma, Shuai Shao, Fengqin Xiao, Hongyin Zhang, Rongrong Zhang, Miao Wang, Guangzhe Li, Mingming Yan
Summary: This study isolated and purified the whitening active extract of Platycodon grandiflorum (PGE) for the first time, and elucidated its whitening activity mechanism and chemical composition. The results demonstrated that PGE had significant anti-inflammatory effects and could enhance the whitening effect by inhibiting tyrosinase and melanin generation.
Article
Chemistry, Multidisciplinary
Ling Ma, Jing Liu, Anjun Liu, Yu Wang
Summary: A polysaccharide named Se-POP-1 was extracted and purified from selenium-enriched Pleurotus ostreatus. It showed potent antioxidant and biological activities, alleviating oxidative damage and apoptosis in cells.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Plant Sciences
Xianwei Gao, Shengnan Li, Xiaofei Liu, Chao Cong, Li Zhao, Huicong Liu, Lianwei Xu
Summary: TGD may attenuate oxidative injury and apoptosis via the Nrf2 and JNK signaling pathways, making it a potential therapeutic candidate for neurodegenerative diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Kaniz Fatima Binte Hossain, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasaki
Summary: The study confirmed that Zn pretreatment significantly improves Hg-induced cytotoxicity, mainly by enhancing cell viability, reducing cell membrane damage, decreasing DNA damage, replenishing glutathione levels, lowering ROS production, and reducing apoptotic cells. Furthermore, Zn pretreatment can activate the Nrf2-HO1 pathway, thereby suppressing cell apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Food Science & Technology
Jin Wang, Shuang Xiao, Qi Cai, Jing Miao, Jinyao Li
Summary: This study found that the ethyl acetate fraction from Brassica rapa exhibited strong antioxidant activity and could reduce apoptosis in PC12 cells caused by oxidative stress. This protective effect was achieved by reducing the production of intracellular reactive oxygen species and increasing the activities of antioxidant enzymes. The findings suggest that this fraction has potential as a natural antioxidant that can improve the body's defense against oxidative damage.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)