Article
Polymer Science
Xu Yang, Baolong Wang, Di Sha, Yonggang Liu, Jiuduo Xu, Kai Shi, Cong Yu, Xiangling Ji
Summary: The injectable and antibacterial hydrogels based on c-poly (L-lysine)-modified poly (vinyl alcohol)/chitosan/silver complexes displayed excellent bactericidal properties, biocompatibility, and accelerated wound healing effects.
Article
Nanoscience & Nanotechnology
Honglin Zhu, Tiangang Yang, Sunni Chen, Xinhao Wang, Jie He, Yangchao Luo
Summary: In this study, chitosan-based double-network antibacterial hydrogels with excellent mechanical and antibacterial properties were developed. The hydrogels exhibited high compression resistance and excellent shape recovery, and showed significant antibacterial efficacy against both Gram-positive and Gram-negative bacteria.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Yanhui Liu, Ting Dong, Yuhang Chen, Na Sun, Qi Liu, Zhenkai Huang, Yafeng Yang, Hao Cheng, Kan Yue
Summary: This study proposes an antibiotics-free strategy to address implant-associated infection (IAI) challenges by using a biodegradable and cytocompatible hydrogel coating. The developed GelMA-octylQAS hydrogel exhibits good mechanical properties, biodegradability, excellent bactericidal activity against various types of bacteria, and high cytocompatibility. When coated onto the implant, it demonstrates superior antimicrobial ability in the infective model of femoral fracture of rats. The GelMA-octylQAS hydrogel might provide a promising platform for preventing and treating IAI.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Yanzhen Zhao, Liu Yang, Meirong Xu, Huifang Wang, Xianghua Gao, Baolong Niu, Wenfeng Li
Summary: In this study, silver nanoparticles were reduced and immobilized in situ using gallic acid-functionalized chitosan to achieve a long-lasting and stable controlled release of silver ions. The CG/PVA/AgNPs composite film demonstrated persistent antibacterial effects and improved freshness preservation, showing potential as an effective and safe packaging material to extend the shelf life of food products.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Paper & Wood
Bo-Nan Jiang, Dan Li, Xue-Na Zou, Hui-Ge Wei, Cheng Zhong, Li-Qiang Chu
Summary: Biopolymer-based injectable hydrogels with antibacterial activity have great potential for biomedical applications. In this study, a double network hydrogel was successfully prepared, which exhibited excellent injectability and antibacterial activity.
Article
Biochemistry & Molecular Biology
Zhaoyu Zhang, Yurong Zhao, Zhang Hu, Zhenyu Si, Ziming Yang
Summary: This study developed antibacterial PCA-CS-Ag complexes by grafting 2-pyridinecarboxaldehyde onto chitosan and coordinating with silver ions. The optimized preparation conditions resulted in a high silver content of 13.27 mg/g. The complexes showed strong antibacterial activity against both Gram-positive and Gram-negative bacteria, making them potential candidates for various applications, including food films, packaging, and medical dressings.
Article
Biotechnology & Applied Microbiology
Yuxuan Pang, Lin Guan, Yanlin Zhu, Ruijuan Niu, Song Zhu, Quan Lin
Summary: A composite hydrogel, CGH/PDA@HAP, with excellent mechanical properties and enhanced cellular affinity was synthesized. The introduction of PDA@HAP promoted the differentiation of BMSCs into osteoblasts, leading to enhanced bone regeneration. Moreover, the grafting of gallic acid onto chitosan effectively inhibited the growth of bacteria.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Composites
Qiaoyun Wu, Ling Wang, Peng Ding, Yaling Deng, Oseweuba Valentine Okoro, Amin Shavandi, Lei Nie
Summary: In this study, medical hydrogels with good swelling rate and cytocompatibility were successfully fabricated using the Thiol-Michael addition reaction, showing potential for wound healing applications.
COMPOSITES COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Cristina Ardean, Corneliu Mircea Davidescu, Nicoleta Sorina Nemes, Adina Negrea, Mihaela Ciopec, Narcis Duteanu, Petru Negrea, Daniel Duda-Seiman, Virgil Musta
Summary: Chitosan and its derivatives have significant biomedical and therapeutic potential due to their natural origin, biocompatibility, biodegradability, and antibacterial properties. The antibacterial effect of chitosan is influenced by various factors, including its source, structure, chemical modifications, and target bacteria species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wenbo Li, Yujia Zhao, Wuliang Sun, Tungalag Dong, Marleny D. A. Saldana, Wenxiu Sun
Summary: In this study, a nanocomposite hydrogel with pH, temperature, and salt ion responsiveness was successfully synthesized using free radical polymerization. Thymol was embedded in the hydrogel and the nanoparticles could be adsorbed on a chitosan film. The loaded thymol nanoparticles exhibited longer release time and stronger antibacterial activity, indicating their potential applications in food packaging.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Jelena Krstic, Aleksandra Radosavljevic, Jelena Spasojevic, Nikolina Nikolic, Uros Jovanovic, Nadica Abazovic, Zorica Kacarevic-Popovic
Summary: Hydrogels consisting of radiation-degraded chitosan, poly(vinyl alcohol), and Ag nano-filler were synthesized using two-stage and single-stage procedures. The study found that hydrogels synthesized using the single-stage procedure exhibited stronger antibacterial activity, possibly due to the higher mobility of radiation-modified chitosan in the network.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Polymer Science
Julia Radwan-Praglowska, Lukasz Janus, Marek Piatkowski, Aleksandra Sierakowska, Tomasz Galek, Ernest Szajna, Dariusz Bogdal, Miroslaw Tupaj
Summary: The study focuses on the preparation and evaluation of chitosan-derived natural biomaterials containing Kalanchoe pinnata extract, with potential application as a blood-clotting agent. These materials were obtained under microwave-assisted conditions in two different forms (granules/dressing) and their chemical structure and morphology were studied. The chitosan-derived hemostatic agents showed superior blood sorption abilities and were non-cytotoxic to L929 mouse fibroblasts, with differences in biological properties depending on their preparation method.
Article
Biochemistry & Molecular Biology
Fan-Xuan Xu, Chien Wei Ooi, Bing-Lan Liu, Cher Pin Song, Chen-Yaw Chiu, Chi-Yun Wang, Yu-Kaung Chang
Summary: Under optimized synthesis conditions, P-COOH-CS-Dye-PHMB showed highly effective disinfection against a high concentration of Escherichia coli, with an antibacterial efficacy of approximately 100%. Furthermore, P-COOH-CS-Dye-PHMB exhibited outstanding wash durability, with only a 5%-7% reduction in antibacterial efficacy after 5 repeated cycles of treatment. Overall, the experimental results suggest that P-COOH-CS-Dye-PHMB is a promising antibacterial nanofiber membrane for applications in the food, pharmaceutical, and textile industries.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Xiaoxiang Han, Zhehao Zheng, Chen Yu, Yunli Deng, Qing Ye, Fuge Niu, Qing Chen, Weichun Pan, Yanbo Wang
Summary: In this study, ionized chitosan (ICS) was successfully synthesized from chitosan through methylation and sulfonation reactions. The modified ICS showed improved water solubility and antibacterial activity, indicating its potential as a water-soluble antibacterial agent.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Chen Zhou, Hai-Yong Ao, Xiao Han, Wen-Wen Jiang, Zhi-Fei Yang, Le Ma, Xiao-Yan Deng, Yi-Zao Wan
Summary: PA-g-HACC is an antibacterial agent with broad-spectrum antibacterial properties and pharmacological activities, showing antibacterial rates above 92% against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus, and increased antibacterial rate against E. coli with the amount of grafted PA. The cytocompatibility of PA-g-HACC can be improved by appropriate grafting ratio of PA, while excessive grafted PA may lead to toxicity.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Yanyan Xu, Qifeng Dang, Chengsheng Liu, Jingquan Yan, Bing Fan, Jinping Cai, Jingjing Li
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2015)
Article
Biochemistry & Molecular Biology
Jinping Cai, Qifeng Dang, Chengsheng Liu, Bing Fan, Jingquan Yan, Yanyan Xu, Jingjing Li
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2015)
Article
Agricultural Engineering
Teng Wang, Qifeng Dang, Chengsheng Liu, Jingquan Yan, Bing Fan, Dongsu Cha, Yanyan Yin, Yubei Zhang
BIORESOURCE TECHNOLOGY
(2016)
Article
Chemistry, Applied
Qifeng Dang, Chengsheng Liu, Yujie Wang, Jingquan Yan, Huiqin Wan, Bing Fan
CARBOHYDRATE POLYMERS
(2016)
Article
Chemistry, Applied
Feilong Yan, Qifeng Dang, Chengsheng Liu, Jingquan Yan, Teng Wang, Bing Fan, Dongsu Cha, Xiaoli Li, Shengnan Liang, Zhenzhen Zhang
CARBOHYDRATE POLYMERS
(2016)
Article
Chemistry, Physical
Endong Zheng, Qifeng Dang, Chengsheng Liu, Bing Fan, Jingquan Yan, Zhenzhen Yu, Haifeng Zhang
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2016)
Article
Biochemistry & Molecular Biology
Yanyan Yin, Qifeng Dang, Chengsheng Liu, Jingquan Yan, Dongsu Cha, Zhenzhen Yu, Yachan Cao, Yan Wang, Bing Fan
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2017)
Article
Chemistry, Applied
Shengnan Liang, Qifeng Dang, Chengsheng Liu, Yubei Zhang, Yan Wang, Wenjing Zhu, Guozhu Chang, Hantian Sun, Dongsu Cha, Bing Fan
CARBOHYDRATE POLYMERS
(2018)
Article
Chemistry, Applied
Qifeng Dang, Kai Liu, Chengsheng Liu, Tao Xu, Jingquan Yan, Feilong Yan, Dongsu Cha, Qianqian Zhang, Yachan Cao
CARBOHYDRATE POLYMERS
(2018)
Article
Nanoscience & Nanotechnology
Yan Wang, Qifeng Dang, Chengsheng Liu, Dejun Yu, Xiaoying Pu, Qiongqiong Wang, Hong Gao, Bainian Zhang, Dongsu Cha
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Engineering, Environmental
Haifeng Zhang, Qifeng Dang, Chengsheng Liu, Dejun Yu, Yan Wang, Xiaoying Pu, Yan Liu, Yuanyuan Liang, Dongsu Cha
JOURNAL OF HAZARDOUS MATERIALS
(2019)
Article
Chemistry, Applied
Zhenzhen Yu, Qifeng Dang, Chengsheng Liu, Dongsu Cha, Haifeng Zhang, Wenjing Zhu, Qianqian Zhang, Bing Fan
CARBOHYDRATE POLYMERS
(2017)
Article
Chemistry, Applied
Qifeng Dang, Kai Liu, Zhenzhen Zhang, Chengsheng Liu, Xi Liu, Ying Xin, Xiaoyu Cheng, Tao Xu, Dongsu Cha, Bing Fan
CARBOHYDRATE POLYMERS
(2017)
Article
Nanoscience & Nanotechnology
Haifeng Zhan, Qifeng Dang, Chengsheng Liu, Dongsu Cha, Zhenzhen Yu, Wenjing Zhu, Bing Fan
ACS APPLIED MATERIALS & INTERFACES
(2017)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)