Roflumilast Reduces Cerebral Inflammation in a Rat Model of Experimental Subarachnoid Hemorrhage

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

(2016) Tim Vanmierlo et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of rolipram and roflumilast, phosphodiesterase-4 inhibitors, on hypertension-induced defects in memory function in rats

(2015) Sobhana George Sugin Lal Jabaris et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Enhanced Therapeutic Potential of Nano-Curcumin Against Subarachnoid Hemorrhage-Induced Blood–Brain Barrier Disruption Through Inhibition of Inflammatory Response and Oxidative Stress

(2015) Zong-yong Zhang et al.   MOLECULAR NEUROBIOLOGY

Activation of mGluR5 Attenuates Microglial Activation and Neuronal Apoptosis in Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats

(2015) Zong-yong Zhang et al.   NEUROCHEMICAL RESEARCH

Cysteamine Alleviates Early Brain Injury Via Reducing Oxidative Stress and Apoptosis in a Rat Experimental Subarachnoid Hemorrhage Model

(2014) Zong-yong Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis

(2013) C González-García et al.   BRITISH JOURNAL OF PHARMACOLOGY

The phosphodiesterase-4 inhibitor rolipram protects from ischemic stroke in mice by reducing blood–brain-barrier damage, inflammation and thrombosis

(2013) Peter Kraft et al.   EXPERIMENTAL NEUROLOGY

The Therapeutic Profile of Rolipram, PDE Target and Mechanism of Action as a Neuroprotectant following Spinal Cord Injury

(2012) Sandra Marie Schaal et al.   PLoS One

Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease

(2011) Klaus F. Rabe   BRITISH JOURNAL OF PHARMACOLOGY

Metamorphosis of Subarachnoid Hemorrhage Research: from Delayed Vasospasm to Early Brain Injury

(2010) Fatima A. Sehba et al.   MOLECULAR NEUROBIOLOGY

Inflammation and Cerebral Vasospasm After Subarachnoid Hemorrhage

(2010) Gustavo Pradilla et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

(2010) Armin Hatzelmann et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs

(2009) Han-Ting Zhang   CURRENT PHARMACEUTICAL DESIGN