Short- and Long-Term Protective Effects of Melatonin in a Mouse Model of Sepsis-Associated Encephalopathy

Melatonin Attenuates Pain Hypersensitivity and Decreases Astrocyte-Mediated Spinal Neuroinflammation in a Rat Model of Oxaliplatin-Induced Pain

(2017) Ye-song Wang et al.   INFLAMMATION

Melatonin antagonizes interleukin-18-mediated inhibition on neural stem cell proliferation and differentiation

(2017) Zheng Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The effect of melatonin on early postoperative cognitive decline in elderly patients undergoing hip arthroplasty: A randomized controlled trial

(2017) Yunxia Fan et al.   JOURNAL OF CLINICAL ANESTHESIA

Decrease of glial cell-derived neurotrophic factor contributes to anesthesia- and surgery-induced learning and memory dysfunction in neonatal rats

(2017) Lingli Gui et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Melatonin inhibits neuronal dysfunction-associated with neuroinflammation by atopic psychological stress in NC/Nga atopic-like mouse models

(2017) Gunhyuk Park et al.   JOURNAL OF PINEAL RESEARCH

Melatonin restores hippocampal neural precursor cell proliferation and prevents cognitive deficits induced by jet lag simulation in adult mice

(2017) Deetje Iggena et al.   JOURNAL OF PINEAL RESEARCH

Pre-ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting endoplasmic reticulum stress-dependent autophagy via PERK and IRE1 signalings

(2017) Dayun Feng et al.   JOURNAL OF PINEAL RESEARCH

Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis

(2017) Amanda Della Giustina et al.   NEUROCHEMISTRY INTERNATIONAL

Maternal administration of melatonin prevents spatial learning and memory deficits induced by developmental ethanol and lead co-exposure

(2017) Elham Soleimani et al.   PHYSIOLOGY & BEHAVIOR

Melatonin ameliorates restraint stress-induced oxidative stress and apoptosis in testicular cells via NF-κB/iNOS and Nrf2/ HO-1 signaling pathway

(2017) Ying Guo et al.   Scientific Reports

Melatonin rescues cardiac thioredoxin system during ischemia-reperfusion injury in acute hyperglycemic state by restoring Notch1/Hes1/Akt signaling in a membrane receptor-dependent manner

(2016) Liming Yu et al.   JOURNAL OF PINEAL RESEARCH

Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse

(2015) Seán T. Anderson et al.   BRAIN BEHAVIOR AND IMMUNITY

Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Potential Therapeutic Implications for Increased Light-Dark Contrast and Melatonin Therapy in an ICU Environment

(2015) Carlos Madrid-Navarro et al.   CURRENT PHARMACEUTICAL DESIGN

Sepsis-induced selective parvalbumin interneuron phenotype loss and cognitive impairments may be mediated by NADPH oxidase 2 activation in mice

(2015) Mu-Huo Ji et al.   Journal of Neuroinflammation

Combined melatonin and exendin-4 therapy preserves renal ultrastructural integrity after ischemia-reperfusion injury in the male rat

(2015) Hon-Kan Yip et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling

(2015) Lei Zhao et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates intestinal ischemia–reperfusion-induced lung injury in rats by upregulating N-myc downstream-regulated gene 2

(2015) Bo Yang et al.   JOURNAL OF SURGICAL RESEARCH

Chronic Melatonin Treatment Prevents Memory Impairment Induced by Chronic Sleep Deprivation

(2015) Karem H. Alzoubi et al.   MOLECULAR NEUROBIOLOGY

Beneficial effects of melatonin in a rat model of sporadic Alzheimer’s disease

(2014) Ekaterina A. Rudnitskaya et al.   BIOGERONTOLOGY

Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis

(2014) Lingling Liu et al.   BRAIN RESEARCH

Acute Neuroinflammation Impairs Context Discrimination Memory and Disrupts Pattern Separation Processes in Hippocampus

(2014) J. Czerniawski et al.   JOURNAL OF NEUROSCIENCE

Long-term cerebral consequences of sepsis

(2014) Catherine N Widmann et al.   LANCET NEUROLOGY

Mitochondria-Targeted Peptide Reverses Mitochondrial Dysfunction and Cognitive Deficits in Sepsis-Associated Encephalopathy

(2014) Jing Wu et al.   MOLECULAR NEUROBIOLOGY

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

(2013) D.A. Lowes et al.   BRITISH JOURNAL OF ANAESTHESIA

Melatonin suppresses markers of inflammation and oxidative damage in a human daytime endotoxemia model

(2013) Mahdi Alamili et al.   JOURNAL OF CRITICAL CARE

Developmental Changes in Structural and Functional Properties of Hippocampal AMPARs Parallels the Emergence of Deliberative Spatial Navigation in Juvenile Rats

(2013) M. G. Blair et al.   JOURNAL OF NEUROSCIENCE

Ulinastatin Alleviates Neuroinflammation but Fails to Improve Cognitive Function in Aged Rats Following Partial Hepatectomy

(2013) Ma Li et al.   NEUROCHEMICAL RESEARCH

Class I Histone Deacetylase Inhibitor Valproic Acid Reverses Cognitive Deficits in a Mouse Model of Septic Encephalopathy

(2013) Jing Wu et al.   NEUROCHEMICAL RESEARCH

Long-Term Cognitive Impairment after Critical Illness

(2013) P.P. Pandharipande et al.   NEW ENGLAND JOURNAL OF MEDICINE

Circadian rhythm disruption in severe sepsis: the effect of ambient light on urinary 6-sulfatoxymelatonin secretion

(2012) Avelino C. Verceles et al.   INTENSIVE CARE MEDICINE

Melatonin improved rat cardiac mitochondria and survival rate in septic heart injury

(2012) Hongmin Zhang et al.   JOURNAL OF PINEAL RESEARCH

Sepsis-associated encephalopathy

(2012) Teneille E. Gofton et al.   Nature Reviews Neurology

Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsis

(2011) D.A. Lowes et al.   BRITISH JOURNAL OF ANAESTHESIA

Delirium as a predictor of long-term cognitive impairment in survivors of critical illness

(2010) Timothy D. Girard et al.   CRITICAL CARE MEDICINE

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Melatonin in septic shock: Some recent concepts

(2010) Venkataramanujan Srinivasan et al.   JOURNAL OF CRITICAL CARE

BDNF expression in perirhinal cortex is associated with exercise-induced improvement in object recognition memory

(2010) Michael E. Hopkins et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Melatonin provides neuroprotection by reducing oxidative stress and HSP70 expression during chronic cerebral hypoperfusion in ovariectomized rats

(2009) Veysel H. Ozacmak et al.   JOURNAL OF PINEAL RESEARCH

Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB

(2008) Steve C. Danzer et al.   HIPPOCAMPUS

Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice

(2008) Ertugrul Kilic et al.   JOURNAL OF PINEAL RESEARCH

Cranial irradiation-induced inhibition of neurogenesis in hippocampal dentate gyrus of adult mice: attenuation by melatonin pretreatment

(2008) Kailash Manda et al.   JOURNAL OF PINEAL RESEARCH

Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia

(2007) Ming-Wai Hung et al.   JOURNAL OF PINEAL RESEARCH