Article
Biotechnology & Applied Microbiology
Nhu Truong, Andrea L. Cottingham, Shruti Dharmaraj, Jacob R. Shaw, Jackline Joy Martin Lasola, Christopher C. Goodis, Steven Fletcher, Ryan M. Pearson
Summary: Excessive immune activation and immunosuppression are two opposing factors in severe inflammation and sepsis. A novel drug delivery method using iNP-SAHA nanoparticles showed promising results in controlling inflammatory responses, improving survival rate, and reducing organ toxicity. This holds potential significance in treating diseases similar to sepsis.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Hae Jin Kee, Inkyeom Kim, Myung Ho Jeong
Summary: This article provides an overview of the pathogenesis of hypertension, current anti-hypertensive drugs, and the need for novel drugs. It focuses on the role and regulatory mechanisms of HDACs in hypertension and discusses the progress in developing HDAC inhibitors as potential therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Svetlana Demyanenko, Valentina Dzreyan, Svetlana Sharifulina
Summary: Cerebral ischemia is the second leading cause of death worldwide, requiring multimodal stroke therapy. Histone deacetylase inhibitors have shown to be effective in protecting the brain from ischemic damage by inducing neurogenesis and angiogenesis in damaged brain areas, promoting functional recovery after stroke.
Article
Oncology
Mengyang Wang, Chenxiao Bi, Hong Li, Lizhen Lu, Tao Gao, Panpan Huang, Chengxia Liu, Bin Wang
Summary: This study reveals the dual role of SIRTs in gastric carcinogenesis and suggests that HMGs may play different roles at different stages of gastric cancer development. It provides new insights into gastric cancer prevention and therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
He-ming Huang, Shi-jie Fan, Xiao-ru Zhou, Yan-jun Liu, Xiao Li, Li-ping Liao, Jing Huang, Cui-cui Shi, Liang Yu, Rong Fu, Jian-gao Fan, Yuan-yuan Zhang, Cheng Luo, Guang-ming Li
Summary: Givinostat demonstrated therapeutic potential in treating nonalcoholic steatohepatitis (NASH) by alleviating inflammation and attenuating hepatic fibrosis, as shown in both in vivo and in vitro studies.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Chemistry, Medicinal
Yuqi Jiang, Jie Xu, Kairui Yue, Chao Huang, Mengting Qin, Dongyu Chi, Qixin Yu, Yue Zhu, Xiaohan Hou, Tongqiang Xu, Min Li, C. James Chou, Xiaoyang Li
Summary: The study focused on modifying HDAC inhibitors to deactivate the Michael reaction in order to improve their potency. Compound 11h showed significant improvements in both HDAC inhibitory activity and cell-based antitumor assay, demonstrating potential for clinical application and efficacy against AML.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Agricultural Engineering
Xuefeng Lu, Tae Kyung Hyun
Summary: Post-translational histone modifications, such as histone acetylation, play key roles in regulating gene expression in plant growth, development, and stress responses. The research found that HDAC inhibitors led to hyperacetylation of histone H3, enhancing MeJA-induced ginsenoside production in ginseng adventitious roots. Additionally, the study identified specific PgHDACs that may serve as crucial factors in controlling MeJA-induced ginsenoside production.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Review
Oncology
Fengyi Guo, Hongjing Wang
Summary: This review summarizes the classification and mechanisms of action of histone deacetylase and the clinical application of their inhibitors in ovarian cancer. Histone deacetylase inhibitors show promising potential as anti-cancer drugs, and combination therapy with other anticancer drugs for synergistic effects can improve efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Ana C. R. Ribeiro, Fay M. Jahr, Elisa Hawkins, Mohamad M. Kronfol, Rabha M. Younis, Joseph L. McClay, Laxmikant S. Deshpande
Summary: Exposure to organophosphate compounds in rats led to an increase in HDAC protein expression and enzyme activity in the hippocampus, as well as a decrease in H3K9ac and BDNF protein levels. Treatment with an HDAC inhibitor showed promising results in reducing immobility time in the Forced Swim Test for rats exposed to organophosphates, suggesting potential new targets for the treatment of GWI symptoms.
Review
Oncology
Amandine Badie, Christian Gaiddon, Georg Mellitzer
Summary: Our understanding of the identity of many cancers has greatly increased in recent years, leading to progress in early detection and treatment options. However, gastric cancer remains poorly treated with low survival rates. The lack of possibilities for early detection and the variations between tumors of gastric cancer patients are major challenges. Histone Deacetylases (HDACs) have been identified to be potentially related to gastric cancer. In this review, we summarize the current knowledge on the role of HDACs in gastric cancer development and their potential as early detection markers and targets for new treatment options.
Review
Pharmacology & Pharmacy
Meran Keshawa Ediriweera
Summary: Histone acetylation is a crucial epigenetic event and continues to be an area of great interest in biochemical research. The balance between histone acetyltransferases (HATs) and histone deacetylases (HDACs) is disrupted in various human cancers. Histone deacetylase inhibitors (HDACi) have shown promising results in restoring dysregulated histone acetylation profiles and are considered as potential anti-cancer therapeutics. Recent studies have identified odd-chain fatty acids as novel HDACi, further expanding the understanding of fatty acids in cancer therapy.
DRUG DISCOVERY TODAY
(2023)
Article
Multidisciplinary Sciences
William Villiers, Audrey Kelly, Xiaohan He, James Kaufman-Cook, Abdurrahman Elbasir, Halima Bensmail, Paul Lavender, Richard Dillon, Borbala Mifsud, Cameron S. Osborne
Summary: The PML-RARA gene fusion is the characteristic driver of Acute Promyelocytic Leukaemia (APL) and is known to bind to the genome. Here, the authors characterise the impact of PML-RARA on gene regulation in APL cell lines and patient samples using transcriptomics, epigenomics, and machine learning.
NATURE COMMUNICATIONS
(2023)
Review
Oncology
Robert Jenke, Nina Ressing, Finn K. Hansen, Achim Aigner, Thomas Buch
Summary: Epigenetic changes can drive cancer malignancy, while histone deacetylase inhibitors (HDACis) hold promise as anticancer drugs due to their ability to target multiple pathways relevant to the disease.
Review
Pharmacology & Pharmacy
Ekta Shirbhate, Ravichandran Veerasamy, Sai H. S. Boddu, Amit K. Tiwari, Harish Rajak
Summary: One significant obstacle in cancer treatment is the decrease in drug efficacy and occurrence of adverse effects. Oncolytic viruses (OVs) have gained interest as a potential method to treat cancer due to their specificity for cancerous tissue and reduced likelihood of adverse effects. Clinical trials have shown that OVs have an acceptable safety profile and are effective in treating certain types of cancer, despite their limited availability. However, further advancements are needed to enhance tumor permeation and improve virus delivery in order to make oncolytic virotherapy more effective.
DRUG DISCOVERY TODAY
(2022)
Article
Oncology
Zahra Souri, Aart G. Jochemsen, Annemijn P. A. Wierenga, Wilma G. M. Kroes, Rob M. Verdijk, Pieter A. van der Velden, Gregorius P. M. Luyten, Martine J. Jager
Summary: In Uveal Melanoma (UM), increased expression of several HDACs is associated with the loss of chromosome 3. This study found a positive correlation between the expression of HDACs 1, 3, and 8 and T-cell infiltrates, while HDACs 2 and 11 were negatively correlated with macrophages. Furthermore, stimulation with interferon-gamma induced an increase in certain HDACs, suggesting a potential link with the loss of chromosome 3/BAP1 and inflammation in UM.
Article
Biochemistry & Molecular Biology
Yangyang Shan, Panmiao Liu, Yanbo Zhou, Xin Ding, Hongtao Liu, Jianjun Yang
Summary: This study reveals the critical role of NLRP3 inflammasome and HMGB1 in sevoflurane-induced cognitive impairment. The results indicate that the HMGB1 inhibitor can suppress the activation of the NLRP3/ASC inflammasome and cognitive dysfunction caused by sevoflurane.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Hua Wei, Xinhui Du, Huaping Zhao, Peipei Sun, Jianjun Yang
Summary: The study aimed to assess the role of propofol on osteosarcoma and explore the possible mechanisms. The results showed that propofol could inhibit the proliferation and invasion of osteosarcoma and increase the sensitivity of doxorubicin. The experimental results also demonstrated that propofol could induce ER stress and exert an anti-tumor effect.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Jie Guo, Di Qiu, Han-wen Gu, Xing-ming Wang, Kenji Hashimoto, Guang-fen Zhang, Jian-jun Yang
Summary: The perioperative administration of ketamine reduces postoperative depression and pain scores but increases the risk of adverse effects.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Xingming Wang, Akifumi Eguchi, Yong Yang, Lijia Chang, Xiayun Wan, Jiajing Shan, Youge Qu, Li Ma, Chisato Mori, Jianjun Yang, Kenji Hashimoto
Summary: Multiple sclerosis (MS) is a common demyelinating disease that affects the central nervous system. This study investigated the effects of subdiaphragmatic vagotomy (SDV) on demyelination in cuprizone (CPZ)-treated mice and found that SDV significantly improved demyelination and microglial activation in the brain. Analysis of gut microbiota composition and blood metabolites revealed that SDV also improved the abnormal levels in CPZ-treated mice. These findings suggest a link between the gut microbiota-brain axis and demyelination in the brain.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Endocrinology & Metabolism
Xin-Miao Wu, Yu-Zhu Gao, Ting-Ting Zhu, Han-Wen Gu, Jian-Hua Tong, Jie Sun, Jian-Jun Yang, Mu-Huo Ji
Summary: This study investigated the potential molecular mechanisms of early life inflammation-induced cognitive impairment by conducting proteomic and phosphoproteomic analysis of the hippocampus. It was found that early life lipopolysaccharide (LPS) exposure led to cognitive impairment in male mice but not in female mice. The analysis also revealed that early life LPS exposure affected the glutamatergic synapse and neuroactive ligand-receptor interaction, which are associated with synaptic function and energy metabolism.
NEUROIMMUNOMODULATION
(2023)
Article
Chemistry, Medicinal
Jin-Jin Yang, Lei Lei, Di Qiu, Sai Chen, Jing-Wei Zhao, Yuan -Yuan Mao, Jian-Jun Yang
Summary: This randomized controlled trial aimed to evaluate the relationship between remimazolam and postoperative delirium in older adult patients undergoing orthopedic surgery. The incidence of postoperative delirium in the remimazolam group was 15.6%, while it was 12.4% in the propofol group, with no significant difference observed. Although patients in the remimazolam group had a lower incidence of hypotension and consumed fewer vasoactive drugs intraoperatively, they experienced longer postoperative extubation time and PACU stay.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Medical Informatics
Cheng-Mao Zhou, Ying Wang, Jian-Jun Yang, Yu Zhu
Summary: Machine learning can predict gastric cancer patients' prognosis, but no studies have explored predicting gastric cancer death based on machine learning using related inflammatory factor variables. In this study, six machine learning algorithms were applied to predict total gastric cancer death after surgery, and the neutrophil-lymphocyte ratio, platelet lymphocyte ratio, and age were found to be the most important factors.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2023)
Article
Clinical Neurology
Sai Chen, Jin-Jin Yang, Yue Zhang, Lei Lei, Di Qiu, Hui-Min Lv, Zhen-Tao Sun, Kenji Hashimoto, Jian-Jun Yang
Summary: This study investigated the effects of a single-dose of esketamine during anesthesia induction on emergence delirium (ED) in preschool children after minor surgery. The study found that the use of esketamine was associated with a higher incidence and score of ED, as well as a longer post-anesthesia care unit stay. However, there were no significant differences in other outcomes between the two groups. Therefore, the use of esketamine in preschool children for minor surgery should be noticed.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Xingming Wang, Akifumi Eguchi, Yuko Fujita, Xiayun Wan, Lijia Chang, Yong Yang, Jiajing Shan, Youge Qu, Li Ma, Yukihiko Shirayama, Chisato Mori, Jianjun Yang, Kenji Hashimoto
Summary: This study found that gut microbiota and microbiome-derived metabolites play important roles in susceptibility versus resilience in rats exposed to inescapable electric stress. The relative abundances of Asaccharobacter, Eisenbergiella, and Klebsiella in the gut microbiota of susceptible rats were significantly higher than that of resilient rats. Additionally, several microbiome and metabolites were found to be significantly altered between susceptible and resilient rats.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Immunology
Xiao-Yu Yin, Xiao-Hui Tang, Shi-Xu Wang, Yong-Chang Zhao, Min Jia, Jian-Jun Yang, Mu-Huo Ji, Jin-Chun Shen
Summary: This study found that in sepsis-associated encephalopathy, high mobility group box-1 protein (HMGB1) induces microglial activation-mediated neuroinflammation and cognitive impairment. Modulating HMGB1 secretion can reverse these changes, suggesting that HMGB1 may be a potential target for the treatment of brain diseases.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Neurosciences
Ling Zhang, Yu-Zhu Gao, Chun-Jie Zhao, Jiang-Yan Xia, Jian-Jun Yang, Mu-Huo Ji
Summary: This study reveals that active MMP-9 mediates PNN remodeling, leading to reduced synaptic input and abnormal gamma oscillations in hippocampal CA1, ultimately contributing to cognitive impairments in SAE induced by LPS injection. Treatment with the MMP-9 inhibitor SB-3CT can rescue most of these abnormalities.
Article
Multidisciplinary Sciences
Ya-Wei Ji, Zi-Lin Shen, Xue Zhang, Kairan Zhang, Tao Jia, Xiangying Xu, Huizhen Geng, Yu Han, Cui Yin, Jian-Jun Yang, Jun-Li Cao, Chunyi Zhou, Cheng Xiao
Summary: The study focuses on the role of ventral pallidum (VP)-derived cholinergic circuits in hyperalgesia and depression-like behavior in a chronic pain mouse model. The cholinergic circuits are activated by pain-like stimuli and become hyperactive during persistent pain. Acute stimulation of these circuits reduces pain threshold, while inhibition of the circuits elevates pain threshold. Modulation of the VP-derived cholinergic pathway for multiple days regulates depression-like behavior in chronic pain. Therefore, these circuits are implicated in comorbid hyperalgesia and depression-like behavior in a chronic pain mouse model.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Ting-ting Zhu, He Wang, Han-wen Gu, Ling-sha Ju, Xin-miao Wu, Wei-tong Pan, Ming-ming Zhao, Jian-jun Yang, Pan-miao Liu
Summary: Inflammatory depression is closely related to neuroinflammation. Melanin-like polydopamine nanoparticles (PDA NPs) were synthesized using nano-based drug delivery technology to overcome the low permeability of current anti-inflammatory drugs. PDA NPs, with abundant phenolic hydroxyl groups, showed excellent antioxidative properties and were effective in treating lipopolysaccharide-induced inflammatory depression in mice. PDA NPs reduced inflammation, restored synaptic loss, and exhibited good biocompatibility.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Letter
Anesthesiology
Penghui Wei, Min Jia, Pan-miao Liu, Liying Meng, Jianjun Li, Jian-jun Yang
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Anesthesiology
Wen Duan, Cheng-Mao Zhou, Jin-Jin Yang, Yue Zhang, Ze-Ping Li, Da-Qing Ma, Jian-Jun Yang
Summary: This study investigated the association between the duration of intraoperative hypotension and the incidence of postoperative delirium (POD) in elderly patients undergoing thoracic and orthopedic surgery. The results showed that a duration of hypotension of 5 minutes or longer was closely related to an increased incidence of POD.
JOURNAL OF CLINICAL ANESTHESIA
(2023)