Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma

The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD)

(2016) Olga F. Sarmento et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The transcription factor network in Th9 cells

(2016) Mark H. Kaplan   Seminars in Immunopathology

The Chromatin-Modifying Enzyme Ezh2 Is Critical for the Maintenance of Regulatory T Cell Identity after Activation

(2015) Michel DuPage et al.   IMMUNITY

The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway

(2015) Yusuke Endo et al.   IMMUNITY

DNA methylation and childhood asthma in the inner city

(2015) Ivana V. Yang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Spatial Interplay between Polycomb and Trithorax Complexes Controls Transcriptional Activity in T Lymphocytes

(2015) Atsushi Onodera et al.   MOLECULAR AND CELLULAR BIOLOGY

Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses

(2015) Timotheus Y F Halim et al.   NATURE IMMUNOLOGY

Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme

(2015) Norbert Krug et al.   NEW ENGLAND JOURNAL OF MEDICINE

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses

(2015) Ariane Hammitzsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The microbiota regulates type 2 immunity through ROR t+ T cells

(2015) C. Ohnmacht et al.   SCIENCE

Epigenetics of T cells regulated by Polycomb/Trithorax molecules

(2015) Atsushi Onodera et al.   TRENDS IN MOLECULAR MEDICINE

EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion

(2015) Xiang-Ping Yang et al.   Scientific Reports

Regulation of gene transcription by Polycomb proteins

(2015) S. Aranda et al.   Science Advances

Refractory asthma: mechanisms, targets, and therapy

(2014) J. L. Trevor et al.   ALLERGY

The polycomb repressive complex 2 governs life and death of peripheral T cells

(2014) Y. Zhang et al.   BLOOD

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

(2014) Timotheus Y.F. Halim et al.   IMMUNITY

Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma

(2014) Chaoyu Irvin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility

(2014) Grégory Seumois et al.   NATURE IMMUNOLOGY

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

A GM-CSF/IL-33 Pathway Facilitates Allergic Airway Responses to Sub-Threshold House Dust Mite Exposure

(2014) Alba Llop-Guevara et al.   PLoS One

Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells

(2014) Y. Watanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel subset of helper T cells promotes immune responses by secreting GM-CSF

(2013) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Interleukin-9 Is Required for Allergic Airway Inflammation Mediated by the Cytokine TSLP

(2013) Weiguo Yao et al.   IMMUNITY

The Polycomb Protein Ezh2 Regulates Differentiation and Plasticity of CD4+ T Helper Type 1 and Type 2 Cells

(2013) Damon J. Tumes et al.   IMMUNITY

Cutting Edge: Smad2 and Smad4 Regulate TGF- -Mediated Il9 Gene Expression via EZH2 Displacement

(2013) A. Wang et al.   JOURNAL OF IMMUNOLOGY

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Predicting Cell Types and Genetic Variations Contributing to Disease by Combining GWAS and Epigenetic Data

(2013) Anna Gerasimova et al.   PLoS One

Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity

(2013) H. Hosokawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenic memory type Th2 cells in allergic inflammation

(2013) Yusuke Endo et al.   TRENDS IN IMMUNOLOGY

Stable T-bet+GATA-3+ Th1/Th2 Hybrid Cells Arise In Vivo, Can Develop Directly from Naive Precursors, and Limit Immunopathologic Inflammation

(2013) Michael Peine et al.   PLOS BIOLOGY

The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years

(2013) Nelís Soto-Ramírez et al.   Clinical Epigenetics

Transcriptional and Epigenetic Control of T Helper Cell Specification: Molecular Mechanisms Underlying Commitment and Plasticity

(2012) Yuka Kanno et al.   Annual Review of Immunology

Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity

(2012) Jingli A. Zhang et al.   CELL

Activin A and TGF-β promote TH9 cell–mediated pulmonary allergic pathology

(2012) Carla P. Jones et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

DNA methylation of TH1/TH2 cytokine genes affects sensitization and progress of experimental asthma

(2012) Stephanie Brand et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-22 suppresses IFN-γ–mediated lung inflammation in asthmatic patients

(2012) Davide Pennino et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An epigenetic silencing pathway controlling T helper 2 cell lineage commitment

(2012) Rhys S. Allan et al.   NATURE

The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation

(2012) Makoto Kuwahara et al.   NATURE IMMUNOLOGY

Histone Deacetylases 6 and 9 and Sirtuin-1 Control Foxp3+ Regulatory T Cell Function Through Shared and Isoform-Specific Mechanisms

(2012) U. H. Beier et al.   Science Signaling

Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children

(2012) Arunima Kohli et al.   Clinical Epigenetics

Eomesodermin Controls Interleukin-5 Production in Memory T Helper 2 Cells through Inhibition of Activity of the Transcription Factor GATA3

(2011) Yusuke Endo et al.   IMMUNITY

Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes

(2011) Stephanie Brand et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation

(2011) Kentaro Takahashi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Changes in thymic regulatory T-cell maturation from birth to puberty: Differences in atopic children

(2011) Meri K. Tulic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rapid In Vivo Conversion of Effector T Cells into Th2 Cells during Helminth Infection

(2011) M. Panzer et al.   JOURNAL OF IMMUNOLOGY

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

(2011) Gregory F Sonnenberg et al.   NATURE IMMUNOLOGY

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

(2011) Margarita Dominguez-Villar et al.   NATURE MEDICINE

DNA methyltransferase 3a limits the expression of interleukin-13 in T helper 2 cells and allergic airway inflammation

(2011) Q. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orchestrating house dust mite-associated allergy in the lung

(2011) Lisa G. Gregory et al.   TRENDS IN IMMUNOLOGY

Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3+T-bet+ Cell Subset with Combined Th2 and Th1 Cell Functions

(2010) Ahmed N. Hegazy et al.   IMMUNITY

Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function

(2010) Bernhard Lehnertz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance ofGATA3expression in T helper type 2 cells

(2010) Atsushi Onodera et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A

(2010) Gregory F. Sonnenberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A novel subset of CD4+TH2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma

(2010) Yui-Hsi Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conditional Deletion of Histone Deacetylase 1 in T Cells Leads to Enhanced Airway Inflammation and Increased Th2 Cytokine Production

(2010) R. Grausenburger et al.   JOURNAL OF IMMUNOLOGY

Polycomb Group Gene Product Ring1B Regulates Th2-Driven Airway Inflammation through the Inhibition of Bim-Mediated Apoptosis of Effector Th2 Cells in the Lung

(2010) A. Suzuki et al.   JOURNAL OF IMMUNOLOGY

Importance of Cytokines in Murine Allergic Airway Disease and Human Asthma

(2010) Fred D. Finkelman et al.   JOURNAL OF IMMUNOLOGY

Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination

(2010) Ragnhild Eskeland et al.   MOLECULAR CELL

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

The many paths to asthma: phenotype shaped by innate and adaptive immunity

(2010) Hye Young Kim et al.   NATURE IMMUNOLOGY

Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells

(2009) Elena Ezhkova et al.   CELL

Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells

(2009) Gang Wei et al.   IMMUNITY

Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection

(2009) Guillaume Oldenhove et al.   IMMUNITY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma

(2009) Damon J. Tumes et al.   INTERNATIONAL IMMUNOLOGY

Altered epigenetic regulation and increasing severity of bronchial hyperresponsiveness in atopic asthmatic children

(2009) Ruey-Chyi Su et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The importance and features of the distal airways in children and adults

(2009) Erwin W. Gelfand et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Determinants of allergenicity

(2009) Claudia Traidl-Hoffmann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Histone modifications at human enhancers reflect global cell-type-specific gene expression

(2009) Nathaniel D. Heintzman et al.   NATURE

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

Polycomb Limits the Neurogenic Competence of Neural Precursor Cells to Promote Astrogenic Fate Transition

(2009) Yusuke Hirabayashi et al.   NEURON

Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory

(2009) Toshinori Nakayama et al.   SEMINARS IN IMMUNOLOGY

Human TSLP and TLR3 ligands promote differentiation of Th17 cells with a central memory phenotype under Th2-polarizing conditions

(2008) J. Tanaka et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Initiation and maintenance of Th2 cell identity

(2008) Toshinori Nakayama et al.   CURRENT OPINION IN IMMUNOLOGY

Unconventional Association of the Polycomb Group Proteins with Cytokine Genes in Differentiated T Helper Cells

(2008) Eyal Jacob et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bmi1 regulates memory CD4 T cell survival via repression of theNoxagene

(2008) Masakatsu Yamashita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Histone H2A Monoubiquitination Represses Transcription by Inhibiting RNA Polymerase II Transcriptional Elongation

(2008) Wenlai Zhou et al.   MOLECULAR CELL

Differential rates of apoptosis and recruitment limit eosinophil accumulation in the lungs of asthma-resistant CBA/Ca mice

(2008) Damon J. Tumes et al.   MOLECULAR IMMUNOLOGY

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

Epigenetic regulation of established human type 1 versus type 2 cytokine responses

(2007) Ruey-Chyi Su et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY