Review
Immunology
Joanna Mackiewicz, Malwina Lisek, Tomasz Boczek
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by cognitive decline. It is associated with beta-amyloid plaques, tau tangles, and a sustained inflammatory response. The CaN/NFAT signaling pathway has been found to contribute to the progression of Alzheimer's disease and targeting this pathway may have therapeutic benefits.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Erin M. Lloyd, Gavin J. Pinniger, Miranda D. Grounds, Robyn M. Murphy
Summary: Dysferlinopathies are muscular dystrophies caused by a genetic deficiency of dysferlin protein, which leads to muscle wasting, inflammation, droplet accumulation, and adipose tissue replacement. This study found that dysferlin deficiency affects the function of skeletal muscles, as well as the abundance of proteins related to calcium handling and glucose/glycogen metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Ellert-Miklaszewska, Agata Szymczyk, Katarzyna Poleszak, Bozena Kaminska
Summary: NFAT transcription factors play a key role in controlling T cell activation and are overexpressed in various cancers, including gliomas. In this study, the effects of VIVIT-GFP on NFAT-driven activity were demonstrated, while Sim2-VIVIT and 11R-VIVIT did not show significant activity in inhibiting NFAT signaling in glioma cells.
Article
Genetics & Heredity
Ji Ye Lim, Eunju Kim, Collin M. Douglas, Marvin Wirianto, Chorong Han, Kaori Ono, Sun Young Kim, Justin H. Ji, Celia K. Tran, Zheng Chen, Karyn A. Esser, Seung-Hee Yoo
Summary: This study illustrates the pivotal role of the circadian E3 ligase FBXL21 in sarcomere structure and muscle differentiation by regulating MYOZ1 degradation and NFAT2 signaling, providing important insights into the regulatory mechanisms of the skeletal muscle biological clock.
Article
Neurosciences
Barbara Roman, Yusuf Mastoor, Yingfan Zhang, Dennis Gross, Danielle Springer, Chengyu Liu, Brian Glancy, Elizabeth Murphy
Summary: Loss of MICU3 in skeletal muscle leads to impaired exercise capacity and decreased time to fatigue when muscles are directly stimulated. Additionally, MICU3 ablation alters muscle fiber type composition and reduces Ca2+ uptake. These findings demonstrate the important role of MICU3 in skeletal muscle physiology.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Nutrition & Dietetics
Hui Zhou, Chen Xia, Yaqing Yang, Hasitha Kalhari Warusawitharana, Xiaohui Liu, Youying Tu
Summary: Theaflavin-3,3'-digallate (TF3), a compound found in black tea, has been found to have anti-coronary heart disease effect. In this study, TF3 was shown to reduce cell size and fetal gene mRNA level in a heart failure cell model, potentially preventing pathological cardiac hypertrophy. TF3 may be a promising natural compound for the treatment of heart failure.
Article
Biochemistry & Molecular Biology
Mario G. Pavez-Giani, Pablo I. Sanchez-Aguilera, Nils Bomer, Shigeki Miyamoto, Harmen G. Booij, Paula Giraldo, Silke U. Oberdorf-Maass, Kirsten T. Nijholt, Salva R. Yurista, Hendrik Milting, Peter van der Meer, Rudolf A. de Boer, Joan Heller Brown, Herman W. H. Sillje, B. Daan Westenbrink
Summary: IF1 is upregulated in the context of heart failure, contributing to mitochondrial dysfunction and pathological cardiac remodeling. Its effects on mitochondrial function are independent of ATP synthase binding and involve mitochondrial Ca2+ handling and nuclear crosstalk through CaMKII activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kerry C. Ryan, Jocelyn T. Laboy, Kenneth R. Norman
Summary: Mitochondrial dysfunction and oxidative stress are major contributors to neurodegenerative diseases. This study reveals that elevated mitochondrial calcium levels, rather than cytosolic calcium levels, lead to increased reactive oxygen species (ROS) production and subsequent neurodegeneration in sel-12 mutants. The study also identifies mTORC1 signaling as a critical factor in sustaining high ROS levels in sel-12 mutants.
Review
Physiology
Hiroaki Eshima
Summary: Obesity and diabetes can disrupt peripheral insulin resistance in skeletal muscle and lead to loss of muscle size, strength, and physical function, with contractile dysfunction being linked to impaired intracellular Ca2+ concentration regulation. Recent studies have shown that metabolic disorders affect interactions between the SR and mitochondrial networks, altering Ca2+ handling by these organelles. This review highlights the importance of understanding the impact of metabolic disorders on calcium regulation in skeletal muscle for potential therapeutic strategies.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Peihong Chen, Jie Yang, Quanlin Mei, Huayu Liu, Yunpeng Cheng, Fengwang Ma, Ke Mao
Summary: This study identified 11 MdCBL genes from the apple genome, showing that these genes could be divided into four groups. Functional identification in Na+-sensitive yeast mutant demonstrated that overexpression of 7 MdCBL genes enhanced salt stress resistance in transgenic yeast. The function of MdCBL10.1 in regulating salt tolerance was also verified in cisgenic apple calli and apple plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Ajuan Chen, Jian Jin, Shasha Cheng, Zezheng Liu, Cheng Yang, Qingjing Chen, Wenquan Liang, Kai Li, Dawei Kang, Zhicong Ouyang, Chenfeng Yao, Xiaochun Bai, Qingchu Li, Dadi Jin, Bin Huang
Summary: Senescence impairs preosteoblasts and mTORC1 accelerates this process, while Scn1a plays a role in membrane depolarization. Understanding these pathways could lead to potential treatments for age-related bone loss.
Article
Neurosciences
Thomas R. Tripp, Barnaby P. Frankish, Victor Lun, J. Preston Wiley, Jane Shearer, Robyn M. Murphy, Martin J. MacInnis
Summary: Sprint interval training (SIT) has been found to cause fragmentation of the sarcoplasmic reticulum calcium-release channel, ryanodine receptor 1 (RyR1), 24 hours after exercise, which may serve as a signal for mitochondrial biogenesis. This study examined the time course of RyR1 fragmentation in human whole muscle and pooled type I and type II skeletal muscle fibers following a single session of SIT. Full-length RyR1 protein content was significantly lower than pre-exercise by 6 hours post-SIT in whole muscle, and fragmentation was detectable in type II but not type I fibers, albeit to a lesser extent than in whole muscle. The peak in PGC1A mRNA expression occurred earlier than RyR1 fragmentation. The increased temporal resolution and fiber type-specific responses for RyR1 fragmentation provide insights into its importance to mitochondrial biogenesis in humans.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Geriatrics & Gerontology
Hamood AlSudais, Rashida Rajgara, Aisha Saleh, Nadine Wiper-Bergeron
Summary: C/EBPβ is a transcription factor associated with aggressiveness and poor outcomes in human cancers. It plays a key role in regulating tumor-derived cachexia-inducing factors, highlighting its potential as a therapeutic target for cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Cell Biology
Congcong Zhang, Jiangtao Cui, Leiqun Cao, Xiaoting Tian, Yayou Miao, Yikun Wang, Shiyu Qiu, Wanxin Guo, Lifang Ma, Jinjing Xia, Xiao Zhang
Summary: Abnormal nuclear structure caused by dysregulation of skeletal proteins is common in tumour cells. This study reveals that skeletal protein Emerin (EMD) promotes lung adenocarcinoma (LUAD) by promoting glucose metabolism and inhibiting aerobic oxidation through interacting with PDHA.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Nandaraj Taye, Mukti Singh, Clair Baldock, Dirk Hubmacher
Summary: Myogenesis is regulated by MYOD1 and involves ADAMTSL2, which acts as a signal hub to integrate WNT, TGF6, and potentially other signaling pathways in the dynamic microenvironment of differentiating myoblasts during skeletal muscle development and regeneration. ADAMTSL2 depletion leads to impaired myoblast differentiation and abnormal skeletal muscle architecture. Mechanistically, ADAMTSL2 enhances WNT signaling by binding to WNT ligands and receptors, and a WNT-binding ADAMTSL2 peptide is sufficient to promote myogenesis in vitro.
Article
Biochemistry & Molecular Biology
Aymeric Ravel-Chapuis, Ali Al-Rewashdy, Guy Belanger, Bernard J. Jasmin
HUMAN MOLECULAR GENETICS
(2018)
Article
Cell Biology
Tammy L. Pham, Marie-Eve St-Pierre, Aymeric Ravel-Chapuis, Tara E. C. Parks, Stephanie Langlois, Silvia Penuela, Bernard J. Jasmin, Kyle N. Cowan
JOURNAL OF CELLULAR PHYSIOLOGY
(2018)
Article
Multidisciplinary Sciences
Maneka Chitiprolu, Chantal Jagow, Veronique Tremblay, Emma Bondy-Chorney, Genevieve Paris, Alexandre Savard, Gareth Palidwor, Francesca A. Barry, Lorne Zinman, Julia Keith, Ekaterina Rogaeva, Janice Robertson, Mathieu Lavallee-Adam, John Woulfe, Jean-Francois Couture, Jocelyn Cote, Derrick Gibbings
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Tara E. Crawford Parks, Kristen A. Marcellus, Jonathan Langill, Aymeric Ravel-Chapuis, Jean Michaud, Kyle N. Cowan, Jocelyn Cote, Bernard J. Jasmin
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Nasim Haghandish, R. Mitchell Baldwin, Alan Morettin, Haben Tesfu Dawit, Hemanta Adhikary, Jean-Yves Masson, Rachid Mazroui, Laura Trinkle-Mulcahy, Jocelyn Cote
MOLECULAR BIOLOGY OF THE CELL
(2019)
Article
Biochemistry & Molecular Biology
Tara E. Crawford Parks, Kristen A. Marcellus, Christine Peladeau, Bernard J. Jasmin, Aymeric Ravel-Chapuis
HUMAN MOLECULAR GENETICS
(2020)
Article
Cell Biology
Alexis Osseni, Aymeric Ravel-Chapuis, Jean-Luc Thomas, Vincent Gache, Laurent Schaeffer, Bernard J. Jasmin
JOURNAL OF CELL BIOLOGY
(2020)
Article
Oncology
Shekoufeh Almasi, Tara E. Crawford Parks, Aymeric Ravel-Chapuis, Alex MacKenzie, Jocelyn Cote, Kyle N. Cowan, Bernard J. Jasmin
Summary: Recent studies have shown the therapeutic potential of targeting autophagy in various diseases, including cancer. The research demonstrated that STAU1 silencing reduces autophagy and increases apoptosis in ARMS cells, while activating mTOR-dependent autophagy without promoting apoptosis in non-transformed skeletal muscle cells.
Article
Biochemistry & Molecular Biology
Aymeric Ravel-Chapuis, Amir Haghandish, Nasibeh Daneshvar, Bernard J. Jasmin, Jocelyn Cote
Summary: This study investigates the molecular mechanisms involved in muscle defects in spinal muscular atrophy (SMA). The researchers found that the interaction between Carm1 and HuR regulates muscle differentiation and plasticity, and the absence of SMN in SMA muscle leads to aberrant regulation of this axis.
HUMAN MOLECULAR GENETICS
(2022)
Review
Neurosciences
Aymeric Ravel-Chapuis, Elise Duchesne, Bernard J. Jasmin
Summary: Myotonic dystrophy type 1 (DM1) is a multisystemic disorder caused by CUG repeats in DMPK mRNAs, leading to RNA foci formation and abnormal RNA-binding proteins. AMPK activation and exercise have shown beneficial effects on the DM1 pathophysiology.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Biochemistry & Molecular Biology
Naomi S. Misquitta, Aymeric Ravel-Chapuis, Bernard J. Jasmin
Summary: Combining AICAR and exercise is an effective treatment strategy for mitigating disease features and promoting muscle hypertrophy in DM1 mice. Importantly, this combination therapy produces greater benefits in female DM1 mice, highlighting sex differences in the response to AMPK-based therapeutic strategies.
HUMAN MOLECULAR GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Nafisa Neault, Aymeric Ravel-Chapuis, Stephen D. Baird, John A. Lunde, Mathieu Poirier, Emiliyan Staykov, Julio Plaza-Diaz, Gerardo Medina, Francisco Abadia-Molina, Bernard J. Jasmin, Alex E. MacKenzie
Summary: Myotonic dystrophy type 1 (DM1) is caused by an abnormal expansion of CTG repeats in the DMPK gene. This expansion leads to misregulation of proteins and aberrant alternative splicing of mRNAs, resulting in DM1 pathogenesis. Vorinostat, an HDAC inhibitor, has been identified as a promising therapy for DM1, as it reduces RNA foci and improves spliceopathy in patient cells and mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Huishan Guo, Maneka Chitiprolu, Luc Roncevic, Charlotte Javalet, Fiona J. Hemming, My Tran Trung, Lingrui Meng, Elyse Latreille, Christiano Tanese de Souza, Danielle McCulloch, R. Mitchell Baldwin, Rebecca Auer, Jocelyn Cote, Ryan Charles Russell, Remy Sadoul, Derrick Gibbings
DEVELOPMENTAL CELL
(2017)