Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction

A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer’s Pathogenesis—And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder

(2021) Mark F. McCarty et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

(2021) Henry Querfurth et al.   Molecular Neurodegeneration

The role of astrocytes in oxidative stress of central nervous system: A mixed blessing

(2020) Yaxing Chen et al.   CELL PROLIFERATION

Reversal of calcium dysregulation as potential approach for treating Alzheimer's Disease

(2020) Elena Popugaeva et al.   Current Alzheimer Research

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration

(2020) Anna Picca et al.   Antioxidants

Mitochondrial ROS generated at the complex-II matrix or intermembrane space microdomain have distinct effects on redox signaling and stress sensitivity in C. elegans.

(2019) Adam J Trewin et al.   ANTIOXIDANTS & REDOX SIGNALING

mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism

(2019) Huibin Tang et al.   AGING CELL

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

(2019) Anju Singh et al.   MOLECULES

Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in C. elegans

(2019) Yung-Chi Huang et al.   eLife

Corrupted ER‐mitochondrial calcium homeostasis promotes the collapse of proteostasis

(2019) Zahra Ashkavand et al.   AGING CELL

TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging

(2019) T. Keith Blackwell et al.   GENETICS

DYSREGULATION OF INTRACELLULAR CALCIUM SIGNALING IN ALZHEIMER’S DISEASE

(2018) Elena Popugaeva et al.   ANTIOXIDANTS & REDOX SIGNALING

Uncoupling of ER/Mitochondrial Oxidative Stress in mTORC1 Hyperactivation-Associated Skin Hypopigmentation

(2018) Fei Yang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Presenilin mutations deregulate mitochondrial Ca2+ homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans

(2018) Shaarika Sarasija et al.   eLife

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

(2018) Ziyun Wu et al.   BMC BIOLOGY

Are antibodies directed against amyloid-β (Aβ) oligomers the last call for the Aβ hypothesis of Alzheimer's disease?

(2018) Francesco Panza et al.   Immunotherapy

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

(2017) Ilija Melentijevic et al.   NATURE

Subcellular ROS imaging methods: Relevance for the study of calcium signaling

(2016) David M. Booth et al.   CELL CALCIUM

When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer’s Disease

(2016) Mario Agostini et al.   CELL CALCIUM

Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways

(2016) Stephen P. Duggan et al.   CELLULAR SIGNALLING

Neuroprotection Through Rapamycin-Induced Activation of Autophagy and PI3K/Akt1/mTOR/CREB Signaling Against Amyloid-β-Induced Oxidative Stress, Synaptic/Neurotransmission Dysfunction, and Neurodegeneration in Adult Rats

(2016) Abhishek Kumar Singh et al.   MOLECULAR NEUROBIOLOGY

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans

(2016) Caroline Heintz et al.   NATURE

Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition

(2016) M Dermit et al.   ONCOGENE

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

(2015) T. Keith Blackwell et al.   FREE RADICAL BIOLOGY AND MEDICINE

A  -Secretase Independent Role for Presenilin in Calcium Homeostasis Impacts Mitochondrial Function and Morphology in Caenorhabditis elegans

(2015) S. Sarasija et al.   GENETICS

Increased Mammalian Target of Rapamycin Signaling Contributes to the Accumulation of Protein Oxidative Damage in a Mouse Model of Down's Syndrome

(2015) Antonella Tramutola et al.   Neurodegenerative Diseases

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

C. elegans Epidermal Wounding Induces a Mitochondrial ROS Burst that Promotes Wound Repair

(2014) Suhong Xu et al.   DEVELOPMENTAL CELL

Hyperactivation of L-type voltage-gated Ca2+ channels in Caenorhabditis elegans striated muscle can result from point mutations in the IS6 or the IIIS4 segment of the  1 subunit

(2014) V. Laine et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

(2014) Sandra Weimer et al.   Nature Communications

Regulation of Synaptic nlg-1/Neuroligin Abundance by the skn-1/Nrf Stress Response Pathway Protects against Oxidative Stress

(2014) Trisha A. Staab et al.   PLoS Genetics

Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts

(2013) Chad Lerner et al.   AGING CELL

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reduced Sleep-Like Quiescence in Both Hyperactive and Hypoactive Mutants of the Galphaq Gene egl-30 during lethargus in Caenorhabditis elegans

(2013) Juliane Schwarz et al.   PLoS One

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The very many faces of presenilins and the γ-secretase complex

(2013) Michalina Smolarkiewicz et al.   PROTOPLASMA

Regulators of Calcium Homeostasis Identified by Inference of Kinetic Model Parameters from Live Single Cells Perturbed by siRNA

(2013) S. Bandara et al.   Science Signaling

Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response

(2013) Eva D. Runkel et al.   PLoS Genetics

Anoxia-Reoxygenation Regulates Mitochondrial Dynamics through the Hypoxia Response Pathway, SKN-1/Nrf, and Stomatin-Like Protein STL-1/SLP-2

(2013) Piya Ghose et al.   PLoS Genetics

A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans

(2013) Huanhu Zhu et al.   eLife

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

(2013) Sebastian Schmeisser et al.   Molecular Metabolism

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Mitochondrial SKN-1/Nrf Mediates a Conserved Starvation Response

(2012) Jennifer Paek et al.   Cell Metabolism

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

Neurite Sprouting and Synapse Deterioration in the Aging Caenorhabditis elegans Nervous System

(2012) M. L. Toth et al.   JOURNAL OF NEUROSCIENCE

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

(2012) Gawain McColl et al.   Molecular Neurodegeneration

Simple Microfluidic Devices for in vivo Imaging of C. elegans, Drosophila and Zebrafish

(2012) Sudip Mondal et al.   Jove-Journal of Visualized Experiments

Dynamic measurements of mitochondrial hydrogen peroxide concentration and glutathione redox state in rat pancreatic β-cells using ratiometric fluorescent proteins: confounding effects of pH with HyPer but not roGFP1

(2011) Leticia P. Roma et al.   BIOCHEMICAL JOURNAL

Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism

(2011) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spontaneous Age-Related Neurite Branching in Caenorhabditis elegans

(2011) E. M. H. Tank et al.   JOURNAL OF NEUROSCIENCE

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

(2011) William Mair et al.   NATURE

Genetic analysis of age-dependent defects of the Caenorhabditis elegans touch receptor neurons

(2011) C.-L. Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The dysregulation of intracellular calcium in Alzheimer disease

(2010) Charlene Supnet et al.   CELL CALCIUM

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

(2010) Seung-Jae Lee et al.   CURRENT BIOLOGY

Mitochondrial Fragmentation Leads to Intracellular Acidification in Caenorhabditis elegans and Mammalian Cells

(2010) David Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2010) Tao Ma et al.   PLoS One

Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease-Linked Presenilin Mutants in Human Cells and Mouse Neurons

(2010) K.-H. Cheung et al.   Science Signaling

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

(2009) Estela Area-Gomez et al.   AMERICAN JOURNAL OF PATHOLOGY

Real-time imaging of the intracellular glutathione redox potential

(2008) Marcus Gutscher et al.   NATURE METHODS

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response inCaenorhabditis elegans

(2007) Nate W. Kahn et al.   BIOCHEMICAL JOURNAL