FGFR2 mutations in bent bone dysplasia syndrome activate nucleolar stress and perturb cell fate determination

Ribosome biogenesis is dynamically regulated during osteoblast differentiation

(2017) Cynthia L. Neben et al.   GENE

Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress

(2016) Emilien Nicolas et al.   Nature Communications

The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome

(2016) Kristin E. Noack Watt et al.   PLoS Genetics

Ribosomopathies: how a common root can cause a tree of pathologies

(2015) Nadia Danilova et al.   Disease Models & Mechanisms

Fibroblast growth factor signaling in skeletal development and disease

(2015) David M. Ornitz et al.   GENES & DEVELOPMENT

Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation

(2015) Kazuho Nishimura et al.   Cell Reports

Bent bone dysplasia syndrome reveals nucleolar activity for FGFR2 in ribosomal DNA transcription

(2014) Cynthia L. Neben et al.   HUMAN MOLECULAR GENETICS

Downregulation of rRNA Transcription Triggers Cell Differentiation

(2014) Yuki Hayashi et al.   PLoS One

Changes in rRNA Transcription Influence Proliferation and Cell Fate Within a Stem Cell Lineage

(2014) Q. Zhang et al.   SCIENCE

Biosynthesis of Ribosomal RNA in Nucleoli Regulates Pluripotency and Differentiation Ability of Pluripotent Stem Cells

(2014) Kanako Watanabe-Susaki et al.   STEM CELLS

Ribosome biogenesis in skeletal development and the pathogenesis of skeletal disorders

(2013) Paul A. Trainor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Subnuclear partitioning of rRNA genes between the nucleolus and nucleoplasm reflects alternative epiallelic states

(2013) F. Pontvianne et al.   GENES & DEVELOPMENT

Cockayne syndrome: The expanding clinical and mutational spectrum

(2013) Vincent Laugel   MECHANISMS OF AGEING AND DEVELOPMENT

The Chromatin Remodeling Factor CSB Recruits Histone Acetyltransferase PCAF to rRNA Gene Promoters in Active State for Transcription Initiation

(2013) Meili Shen et al.   PLoS One

Translation initiation factor eIF3h targets specific transcripts to polysomes during embryogenesis

(2013) A. Choudhuri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

5S Ribosomal RNA Is an Essential Component of a Nascent Ribosomal Precursor Complex that Regulates the Hdm2-p53 Checkpoint

(2013) Giulio Donati et al.   Cell Reports

The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress

(2013) Katherine E. Sloan et al.   Cell Reports

Bent Bone Dysplasia-FGFR2 type, a Distinct Skeletal Disorder, Has Deficient Canonical FGF Signaling

(2012) Amy E. Merrill et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

(2012) Megan J. Bywater et al.   CANCER CELL

eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies

(2012) T. Alain et al.   CANCER RESEARCH

Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint

(2012) S. Fumagalli et al.   GENES & DEVELOPMENT

Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules

(2012) T. K. Kelly et al.   GENOME RESEARCH

A RUNX2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation

(2012) S. A. Ali et al.   JOURNAL OF CELL SCIENCE

Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion

(2012) S Wei et al.   ONCOGENE

The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions

(2012) W. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A comprehensive description of the severity groups in Cockayne syndrome

(2011) Valerie Natale   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

WSTF does it all: a multifunctional protein in transcription, repair, and replicationThis paper is one of a selection of papers published in a Special Issue entitled 31st Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer review process.

(2011) Chris Barnett et al.   Biochemistry and Cell Biology

A zebrafish model of dyskeratosis congenita reveals hematopoietic stem cell formation failure resulting from ribosomal protein-mediated p53 stabilization

(2011) T. C. Pereboom et al.   BLOOD

Dexamethasone and lenalidomide have distinct functional effects on erythropoiesis

(2011) A. Narla et al.   BLOOD

Defective ribosome assembly in Shwachman-Diamond syndrome

(2011) C. C. Wong et al.   BLOOD

Quantitative nucleolar proteomics reveals nuclear re-organization during stress- induced senescence in mouse fibroblast

(2011) Bishnupriya kar et al.   BMC CELL BIOLOGY

Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation

(2011) Alison M. Taylor et al.   EXPERIMENTAL HEMATOLOGY

The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells

(2011) G Donati et al.   ONCOGENE

The Chromatin Remodelling Complex B-WICH Changes the Chromatin Structure and Recruits Histone Acetyl-Transferases to Active rRNA Genes

(2011) Anna Vintermist et al.   PLoS One

Ontogeny-Driven rDNA Rearrangement, Methylation, and Transcription, and Paternal Influence

(2011) Yih-Horng Shiao et al.   PLoS One

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

(2010) Denis Drygin et al.   CANCER RESEARCH

Specific activation of the p53 pathway by low dose actinomycin D: A new route to p53 based cyclotherapy

(2010) Meng Ling Choong et al.   CELL CYCLE

Diamond Blackfan anemia 2008–2009: broadening the scope of ribosome biogenesis disorders

(2010) Jeffrey M Lipton et al.   CURRENT OPINION IN PEDIATRICS

The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats

(2010) Claudio Guetg et al.   EMBO JOURNAL

The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin

(2010) Elaine Sanij et al.   Epigenetics

Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits

(2010) Marie-Françoise O’Donohue et al.   JOURNAL OF CELL BIOLOGY

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation

(2010) Weijun Feng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway

(2010) C Deisenroth et al.   ONCOGENE

The nucleolus: structure/function relationship in RNA metabolism

(2010) Danièle Hernandez-Verdun et al.   Wiley Interdisciplinary Reviews-RNA

Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-α3 binding

(2009) N D Marchenko et al.   CELL DEATH AND DIFFERENTIATION

Diamond-Blackfan Anemia: Diagnosis, Treatment, and Molecular Pathogenesis

(2009) Jeffrey M. Lipton et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

(2009) Stefano Fumagalli et al.   NATURE CELL BIOLOGY

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q– syndrome

(2009) Jillian L Barlow et al.   NATURE MEDICINE

Nucleolus, Ribosomes, and Cancer

(2008) Lorenzo Montanaro et al.   AMERICAN JOURNAL OF PATHOLOGY

The Epigenetics of rRNA Genes: From Molecular to Chromosome Biology

(2008) Brian McStay et al.   Annual Review of Cell and Developmental Biology

UBF levels determine the number of active ribosomal RNA genes in mammals

(2008) Elaine Sanij et al.   JOURNAL OF CELL BIOLOGY

Truncated Cockayne Syndrome B Protein Represses Elongation by RNA Polymerase I

(2008) Anton Lebedev et al.   JOURNAL OF MOLECULAR BIOLOGY

Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation

(2008) Valentina Gandin et al.   NATURE

Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects

(2008) Kelly A McGowan et al.   NATURE GENETICS

Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function

(2008) Natalie C Jones et al.   NATURE MEDICINE

p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner

(2008) Alina Molchadsky et al.   PLoS One

Phenotypic transcription factors epigenetically mediate cell growth control

(2008) S. A. Ali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA