Article
Immunology
Ji-Xin Liu, Man Liu, Guo-Zhi Yu, Qian-Qian Zhao, Jian-Ling Wang, Yan-Hong Sun, Stephane Koda, Beibei Zhang, Qian Yu, Chao Yan, Ren-Xian Tang, Zhi-Hua Jiang, Kui-Yang Zheng
Summary: This study revealed that C. sinensis infection alters bioactive lipids and sphingolipid metabolic pathways in mice liver. Additionally, S1PR2 plays a predominant role in biliary epithelial cells affected by C. sinensis infection. The specific antagonist of S1PR2, JTE-013, effectively inhibits hepatobiliary pathological injuries caused by C. sinensis infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuliya Fakhr, Saloni Koshti, Yasaman Bahojb Habibyan, Kirsten Webster, Denise G. Hemmings
Summary: This study found that placental SphK1 levels are increased in PE patients, and TNF-alpha induces cell death, shedding, and specific cytokine release through SphK1 activity, affecting syncytial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yaeni Kim, Ji Hee Lim, Eun Nim Kim, Yu Ah Hong, Hun-Jun Park, Sungjin Chung, Bum Soon Choi, Yong-Soo Kim, Ji Yong Park, Hye Won Kim, Cheol Whee Park
Summary: This study found that AdipoRon improved cardiac lipid metabolism, hypertrophy, and functional parameters by increasing AdipoR expression, acid ceramidase activity, and activating AMPK-PPAR alpha/PGC-1 alpha and related downstream pathways.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Daniela Judith Romero, Lucila Gisele Pescio, Bruno Jaime Santacreu, Jazmin Maria Mosca, Norma Beatriz Sterin-Speziale, Nicolas Octavio Favale
Summary: Epithelial renal cells can adopt different cellular phenotypes through epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET). Sphingosine-1-phosphate (S1P) plays a crucial role in cell migration and differentiation, and its functions vary depending on the stage of cell differentiation and activation of S1P receptor 2 (S1PR2). Activation of S1PR2 promotes migration in fully differentiated cells but inhibits migration in non-differentiated cells. These findings provide new insights into the modulation of renal epithelial cell plasticity and have implications for research in various diseases.
Article
Immunology
Kei-ichi Uchiya, Saki Isono, Misa Yoshimura, Takeaki Wajima, Toshiaki Nikai
Summary: This study revealed the relationship between fimbrial gene clusters in Salmonella enterica serovar Typhimurium and COX-2 expression, and identified StcD as a pathogen-associated molecular pattern recognized by TLR4 that plays a significant role in the induction of COX-2 in macrophages.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Medicine, Research & Experimental
Caixia Zhou, Yashu Kuang, Qinyu Li, Yunhao Duan, Xiuxiang Liu, Jinnan Yue, Xiaoli Chen, Jie Liu, Yuzhen Zhang, Lin Zhang
Summary: This study demonstrates that EC-expressing S1pr2 tightly controls post-ischemic angiogenesis and blood flow perfusion recovery. The inhibition of S1pr2 can enhance post-ischemic angiogenesis and improve blood flow in peripheral artery disease, offering a novel therapeutic intervention.
Article
Immunology
Yingqin Wang, Chen Wang, Qiaolan He, Guannan Chen, Jie Yu, Jing Cang, Ming Zhong
Summary: Inhibition of S1PR3 attenuates NLRP3 inflammasome activation by suppressing the expression of NLRP3 and pro-IL-1 beta during LPS priming and impeding the membrane trafficking of TWIK2 and potassium efflux induced by ATP. However, inhibition of S1PR3 leads to increased bacterial loads and mortality in CLP mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Na Wang, Jing-Yi Li, Bo Zeng, Gui-Lan Chen
Summary: Sphingosine-1-phosphate (S1P) is a crucial sphingolipid molecule that regulates cardiovascular functions through binding and activating multiple G protein-coupled receptors in different cell types. It affects cell proliferation, migration, differentiation, and apoptosis through various downstream signaling pathways. Abnormal S1P levels are associated with cardiovascular disorders, and further research is needed to explore the potential therapeutic use of S1P in these diseases.
Article
Medicine, Research & Experimental
Hui Yan, Hu Zhao, Shao-wei Yi, Hang Zhuang, Dao-wen Wang, Jian-gang Jiang, Gui-fen Shen
Summary: The objective of this study was to investigate whether sphingosine-1-phosphate (S1P) could prevent cardiac remodeling and the associated mechanisms. The results demonstrated that S1P treatment improved cardiac function and reduced cardiac fibrosis in a mouse model of transverse aortic constriction (TAC). The study also identified sphingosine kinase 2 (SphK2) and the S1P receptor 2 (S1PR2)/extracellular regulated protein kinases (ERK) pathway as potential mediators of the anti-remodeling effect of S1P on the heart.
CURRENT MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Rachel S. Resop, Bradley Salvatore, Shawn J. Kim, Brent R. Gordon, Bianca Blom, Dimitrios N. Vatakis, Christel H. Uittenbogaart
Summary: HIV-1 infection leads to upregulation of S1P receptor 1 (S1PR1) in the human thymus, potentially increasing the number and speed of thymocyte egress. This may have implications for immune function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Kana Masuda-Kuroki, Shahrzad Alimohammadi, Anna Di Nardo
Summary: Psoriasis is a chronic skin condition that lacks a complete cure. Recent studies have identified sphingolipid metabolites as significant contributors to psoriasis, particularly ceramide and sphingosine-1-phosphate (S1P). The modulation of S1P and its receptor has shown potential in improving psoriasis inflammation.
Article
Oncology
Joy Sarkar, Hiroaki Aoki, Rongrong Wu, Masayo Aoki, Phillip Hylemon, Huiping Zhou, Kazuaki Takabe
Summary: This study found that conjugated bile acids (CBAs) accelerate the growth of S1PR2 predominant pancreatic cancer, suggesting that S1PR2 may be a potential therapeutic target for metastatic pancreatic cancer.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Joy Sarkar, Hiroaki Aoki, Rongrong Wu, Masayo Aoki, Phillip Hylemon, Huiping Zhou, Kazuaki Takabe
Summary: This study found that conjugated bile acids (CBAs) accumulated in cholestasis accelerate the growth of pancreatic cancer (PC) through S1PR2, indicating S1PR2 as a potential therapeutic target for metastatic pancreatic cancer.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yashu Kuang, Xiaolin Li, Xiuxiang Liu, Lu Wei, Xiaoli Chen, Jie Liu, Tao Zhuang, Jingjiang Pi, Yanfang Wang, Chenying Zhu, Xin Gong, Hao Hu, Zuoren Yu, Jiming Li, Ping Yu, Huimin Fan, Yuzhen Zhang, Zhongmin Liu, Lin Zhang
Summary: Loss of endothelial S1pr1 exacerbates post-MI cardiac remodelling and worsens cardiac dysfunction by reducing reparative macrophage accumulation. Activation of S1pr1 enhances Ly6c(low) macrophage proliferation and ameliorates cardiac remodelling after MI through the ERK/CSF1 pathway.
CARDIOVASCULAR RESEARCH
(2021)
Article
Chemistry, Medicinal
Molly Congdon, Russell G. Fritzemeier, Yugesh Kharel, Anne M. Brown, Vlad Serbulea, David R. Bevan, Kevin R. Lynch, Webster L. Santos
Summary: Elevated levels of Sphingosine 1-phosphate (S1P) and increased expression of Sphingosine kinase iso-forms (SphK1 and SphK2) are associated with various disease states. The development of selective inhibitors for SphK1 and SphK2 has become a focus of drug discovery, with studies focusing on optimizing binding in the SphK2 substrate binding site. The identification of indole-based compounds with 1,5-disubstitution as potent inhibitors highlights the potential for targeting SphK2 with improved potency and selectivity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Medicine, Research & Experimental
Shuni Duan, Xiaojiaoyang Li, Guifang Fan, Runping Liu
Summary: Liver diseases and related complications are major causes of morbidity and mortality worldwide. Effective treatments are limited, highlighting the need for novel therapies. Bile acids (BAs) play important roles in regulating energy and immune homeostasis in various liver diseases, making them attractive therapeutic targets. This review summarizes recent progress in understanding the enterohepatic circulation of BAs, potential targets of BAs signaling, and the development of treatments. The protective effects, molecular mechanisms, and outcomes of clinical trials are discussed, along with future perspectives for the development of these candidates. In conclusion, pharmacological therapies targeting BAs signaling hold promise for the treatment of complex liver disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Zhi Ma, Xiaoyong Xue, Jinzhao Bai, Yajie Cai, Xuejing Jin, Kexin Jia, Mingning Ding, Xiangjun Lyu, Xiaojiaoyang Li
Summary: Si-Wu-Tang (SWT) has been found to improve liver fibrosis by modulating the immune microenvironment. It repairs the imbalanced immune microenvironment by regulating the biological functions of different immune cells, especially macrophages, neutrophils, and CD8+ T cells. SWT inhibits the release of profibrotic cytokines and promotes the apoptosis of activated hepatic stellate cells. This research provides insights into the mechanisms of SWT's hepatoprotective activities and offers a novel therapeutic strategy for liver fibrosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Engineering, Biomedical
Fei Zhou, Xiaojiaoyang Li, Xiaoyong Xue, Shuo Li, Guifang Fan, Yajie Cai, Zihao Chang, Jiaorong Qu, Runping Liu
Summary: Immunotherapy has revolutionized cancer treatment, but the low response rate remains a challenge, especially in cold tumors. A study introduces a tri-functional liposomal system, DOX-SAR-JY4(LIPO), which combines doxorubicin, a VPS34 inhibitor, and an anti-PD-L1 peptide for targeted delivery. This system effectively increases immune cell infiltration in lung cancer xenografts, inhibiting tumor growth and metastasis by reshaping the tumor microenvironment. The study demonstrates the potential of inhibiting autophagy and presents a promising approach to enhance cancer immunotherapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yi-jie Li, Rui-yu Wu, Run-ping Liu, Kai-yi Wu, Ming-ning Ding, Rong Sun, Yi-qing Gu, Fei Zhou, Jian-zhi Wu, Qi Zheng, Shu-ni Duan, Rong-rong Li, Yin-hao Zhang, Fang-hong Li, Xiaojiaoyang Li
Summary: Obesity is associated with various chronic diseases and reduced life expectancy. Aurantio-obtusin (AO), a bioactive compound found in Chinese traditional medicine, can stimulate the growth and activation of brown adipose tissue (BAT) to increase energy expenditure and limit weight gain. AO achieves this by enhancing mitochondrial metabolism and UCP1 expression through the activation of PPARa.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Pathology
Kaitlyn G. Jackson, Grayson W. Way, Jing Zeng, Marissa K. Lipp, Huiping Zhou
Summary: Chronic liver disease is a global public health threat, and chronic activation of endoplasmic reticulum stress is recognized as an important factor in its progression. Abnormal protein folding leads to endoplasmic reticulum stress and unfolded protein response, and maladaptive responses cause inflammation and cell death.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Plant Sciences
Qi Zheng, Xiaojiaoyang Li, Nana Huang, Fanghong Li, Junde Ge, Daijie Wang, Rong Sun, Runping Liu
Summary: This study demonstrated that Saikosaponins (SSs) from traditional Chinese medicine have therapeutic effects on hyperlipidemia by reducing the levels of cholesterol and triglyceride, improving the imbalance of lipid metabolism, and reducing oxidative stress and inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Yajie Cai, Xiaojiaoyang Li, Qi Han, Jinzhao Bai, Qi Zheng, Rong Sun, Runping Liu
Summary: This study aimed to investigate the effect of Si-Ni-San (SNS) on acute murine colitis and the underlying mechanisms involving gut microbiota. The results demonstrated that SNS significantly inhibited acute inflammatory responses induced by DSS through improving gut microbiota dysbiosis, and specifically favoring the growth of beneficial bacteria Akkermansia genus, thus providing a potential therapeutic strategy against colitis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jing Zeng, Jiangao Fan, Huiping Zhou
Summary: Chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), gradually progress to liver fibrosis, cirrhosis, and failure. Disruption of bile acid metabolism and intrahepatic circulation plays a crucial role in accelerating the progression of cholestatic liver diseases. Bile acids not only act as detergents for nutrition absorption but also function as key signaling molecules that regulate hepatic metabolism and immune responses. This review focuses on the role of bile acid-mediated signaling in cholestatic liver disease.
CELL AND BIOSCIENCE
(2023)
Review
Cell Biology
Sayed Obaidullah Aseem, Phillip B. Hylemon, Huiping Zhou
Summary: Biliary fibrosis is the key pathological process in cholangiopathies, and cholestasis worsens with biliary fibrosis. Dysregulation of bile acid levels and composition is observed in PBC and PSC. Recent studies have shown that bile acids play a crucial role in the progression of biliary fibrosis, and the identification of bile acid receptors has advanced our understanding of related signaling pathways. Further understanding of bile acid signaling may lead to new therapeutic approaches for cholangiopathies.
Review
Chemistry, Medicinal
Kexin Jia, Yijie Li, Tiegang Liu, Xiaohong Gu, Xiaojiaoyang Li
Summary: COVID-19, caused by SARS-CoV-2, is a highly pathogenic and infectious pandemic with no specific drug treatment available. Traditional Chinese medicine (TCM), especially three Chinese patent medicines and three Chinese medicine formulas, has been proven effective in alleviating COVID-19 symptoms. This review provides a comprehensive analysis of the pathogenesis, clinical practice, active ingredients investigation, network pharmacology prediction, and mechanism verification of these TCM treatments, offering guidance for the development of new drugs against COVID-19.
CHINESE HERBAL MEDICINES
(2023)
Article
Chemistry, Medicinal
Mingning Ding, Fei Zhou, Yijie Li, Chuanyang Liu, Yiqing Gu, Jianzhi Wu, Guifang Fan, Yajing Li, Xiaojiaoyang Li
Summary: This study aimed to investigate the anti-steatosis effect and underlying mechanism of Cassiae Semen (CS) against non-alcoholic fatty liver disease (NAFLD). Five compounds were identified in CS extract. The results showed that CS improved diet-induced hepatic steatosis and attenuated lipid accumulation in hepatocytes, which might be attributed to the inhibition of fatty acid synthase (FASN) and the activation of autophagy-related signaling. CS could be a promising therapeutic strategy for relieving NAFLD.
CHINESE HERBAL MEDICINES
(2023)
Review
Biochemistry & Molecular Biology
Yanyan Wang, Jing Zeng, Weidong Chen, Jiangao Fan, Phillip B. Hylemon, Huiping Zhou
Summary: Liver cancer is a major cause of cancer-related death worldwide and has limited treatment options. Recent studies have revealed the significant role of long noncoding RNAs (lncRNAs) in the development of liver cancers, particularly the oncogene H19. H19 affects crucial biological processes like cell proliferation, apoptosis, invasion, and metastasis through epigenetic modifications, the H19/miR-675 axis, miRNA sponging, drug resistance, and downstream pathway regulation. This review focuses on the molecular mechanisms and regulation of H19 in hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), providing perspectives on its potential as a diagnostic marker and therapeutic target for liver cancer.
Article
Chemistry, Multidisciplinary
Xiao-jiao-yang Li, Fei Zhou, Ya-jing Li, Xiao-yong Xue, Jiao-rong Qu, Gui-fang Fan, Jia Liu, Rong Sun, Jian-zhi Wu, Qi Zheng, Run-ping Liu
Summary: Liver fibrosis is a wound-healing process characterized by excess formation of extracellular matrix (ECM) from activated hepatic stellate cells (HSCs). Previous studies show that EZH2 and long non-coding RNA H19 are highly correlated with fibrogenesis. In the current study, the mechanisms underlying this correlation were investigated, and it was found that EZH2 was upregulated and correlated with H19 and fibrotic markers expression in liver fibrosis models. The administration of EZH2 inhibitor 3-DZNeP showed protective effects in these models.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Chemistry, Medicinal
Yijie Li, Ranyun Chen, Jianzhi Wu, Xiaoyong Xue, Tiegang Liu, Guiying Peng, Ruiyu Wu, Lei Wang, Kexin Jia, Yajie Cai, Xiaojiaoyang Li
Summary: This study found that salvianolic acid B can significantly alleviate pulmonary fibrosis and cellular senescence, and halt lung cell senescence. The results showed that salvianolic acid B inhibits the release of senescence-associated secretory phenotype from lung macrophages and alveolar type II epithelial cells, thereby reducing lung fibroblast activation.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kexin Jia, Jianzhi Wu, Yijie Li, Jia Liu, Runping Liu, Yajie Cai, Yinhao Zhang, Xiaojiaoyang Li
Summary: This study successfully established a mouse model of AE-IPF that recapitulated the clinical features and pathological changes observed in AE-IPF patients, providing an appropriate experimental platform for investigating the underlying mechanisms of liver injury in AE-IPF.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2023)