Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression

Essential role for the TRF2 telomere protein in adult skin homeostasis

(2014) Paula Martínez et al.   AGING CELL

miR-155 Drives Telomere Fragility in Human Breast Cancer by Targeting TRF1

(2014) R. Dinami et al.   CANCER RESEARCH

miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase

(2014) L Chen et al.   Cell Death & Disease

High levels of oncomiR-21 contribute to the senescence-induced growth arrest in normal human cells and its knock-down increases the replicative lifespan

(2013) Hanna Dellago et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

(2013) Ylli Doksani et al.   CELL

Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway

(2013) Irmina Diala et al.   EMBO REPORTS

MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma

(2013) Ning Wang et al.   Molecular Cancer

The Telomere Deprotection Response Is Functionally Distinct from the Genomic DNA Damage Response

(2013) Anthony J. Cesare et al.   MOLECULAR CELL

Large-Scale Screens of miRNA-mRNA Interactions Unveiled That the 3′UTR of a Gene Is Targeted by Multiple miRNAs

(2013) Peng Zhou et al.   PLoS One

MicroRNA Regulation of Cbx7 Mediates a Switch of Polycomb Orthologs during ESC Differentiation

(2012) Ana O'Loghlen et al.   Cell Stem Cell

Signalling the end of the line

(2012) John van Tuyn et al.   NATURE CELL BIOLOGY

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-β signalling pathway

(2012) Yan Zhang et al.   NUCLEIC ACIDS RESEARCH

Sp1 upregulates expression of TRF2 and TRF2 inhibition reduces tumorigenesis in human colorectal carcinoma cells

(2011) Wenjie Dong et al.   CANCER BIOLOGY & THERAPY

Role of telomeres and telomerase in cancer

(2011) Jerry W. Shay et al.   SEMINARS IN CANCER BIOLOGY

MicroRegulators come of age in senescence

(2011) Myriam Gorospe et al.   TRENDS IN GENETICS

Role of shelterin in cancer and aging

(2010) Paula Martínez et al.   AGING CELL

Histone deacetylase regulates high mobility group A2-targeting microRNAs in human cord blood-derived multipotent stem cell aging

(2010) Seunghee Lee et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence

(2010) Kaori Fujita et al.   NATURE CELL BIOLOGY

Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3′ untranslated region

(2010) S Wu et al.   ONCOGENE

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Evolution under canalization and the dual roles of microRNAs--A hypothesis

(2009) C.-I Wu et al.   GENOME RESEARCH

In VivoStoichiometry of Shelterin Components

(2009) Kaori K. Takai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs

(2009) Hyeung Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Upregulation of miR-23a∼27a∼24-2 Cluster Induces Caspase-Dependent and -Independent Apoptosis in Human Embryonic Kidney Cells

(2009) Ravindresh Chhabra et al.   PLoS One

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes

(2008) Sahn-ho Kim et al.   JOURNAL OF CELL BIOLOGY

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

The telosome/shelterin complex and its functions

(2008) Huawei Xin et al.   GENOME BIOLOGY