A highly efficient Suzuki–Miyaura methylation of pyridines leading to the drug pirfenidone and its CD3 version (SD-560)

Recent Advances in the Palladium Catalyzed Suzuki–Miyaura Cross-Coupling Reaction in Water

(2016) Anamitra Chatterjee et al.   CATALYSIS LETTERS

CHEM21 selection guide of classical- and less classical-solvents

(2016) Denis Prat et al.   GREEN CHEMISTRY

Modular Approaches to Diversified Soft Lewis Basic Complexants through Suzuki–Miyaura Cross-Coupling of Bromoheteroarenes with Organotrifluoroborates

(2016) Ai Lin Chin et al.   JOURNAL OF ORGANIC CHEMISTRY

Advances in the chemistry of organozinc reagents

(2016) Alexander D. Dilman et al.   TETRAHEDRON LETTERS

Recent Developments in Negishi Cross-Coupling Reactions

(2016) Diana Haas et al.   ACS Catalysis

Pirfenidone: A Review of Its Use in Idiopathic Pulmonary Fibrosis

(2015) Esther S. Kim et al.   DRUGS

Regioselective Synthesis of 6-Vinyl-3,6-dihydropyridine-2(1H)-ones through Simple Addition of a Vinylmagnesium “Ate” Complex to 2-Pyridones

(2015) Jacek G. Sośnicki et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Overcoming barriers to green chemistry in the pharmaceutical industry – the Green Aspiration Level™ concept

(2015) F. Roschangar et al.   GREEN CHEMISTRY

Organotrifluoroborates: Another Branch of the Mighty Oak

(2015) Gary A. Molander   JOURNAL OF ORGANIC CHEMISTRY

The modified trifluoromethylation protocol applicable to electronically deficient iodopyridinones

(2015) Tomoko Kawasaki-Takasuka et al.   TETRAHEDRON

Simple preparation of aryltributylstannanes and its application to one-pot synthesis of diaryl ketones

(2015) Asuka Oikawa et al.   TETRAHEDRON

3-Alkyl-1,2-cyclopentanediones by Negishi cross-coupling of a 3-bromo-1,2-cyclopentanedione silyl enol ether with alkylzinc reagents: an approach to 2-substituted carboxylic acid γ-lactones, homocitric and lycoperdic acids

(2015) Anne Paju et al.   TETRAHEDRON

A copper-catalyzed multi-component reaction accessing fused imidazo-heterocycles via C–H functionalization

(2015) G. Santosh Kumar et al.   RSC Advances

Efficient One-Pot Cross-Coupling of Two Aryl Halides by Stannylation/Stille Reaction in Water under Microwave Irradiation

(2014) Xin Tan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Scope and limitations of the synthesis of functionalized quinolizidinones and related compounds by a simple precursor approach via addition of lithium allylmagnesates to 2-pyridones and RCM as key steps

(2014) Jacek G. Sośnicki et al.   TETRAHEDRON

Negishi coupling reactions as a valuable tool for [11C]methyl-arene formation; first proof of principle

(2013) S. Kealey et al.   CHEMICAL COMMUNICATIONS

Seven Important Elements for an Effective Green Chemistry Program: An IQ Consortium Perspective

(2013) David K. Leahy et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Sanofi’s Solvent Selection Guide: A Step Toward More Sustainable Processes

(2013) Denis Prat et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Pirfenidone structural isosteres: design, synthesis and spectral study

(2012) Kamelia F. Abd El Kader et al.   HETEROCYCLIC COMMUNICATIONS

Discovery of 2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (Perampanel): A Novel, Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropanoic Acid (AMPA) Receptor Antagonist

(2012) Shigeki Hibi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regioselective reactions of 3,4-pyridynes enabled by the aryne distortion model

(2012) Adam E. Goetz et al.   Nature Chemistry

Synthesis and evaluation of pyridone-phenoxypropyl-R-2-methylpyrrolidine analogues as histamine H3 receptor antagonists

(2011) Nadine C. Becknell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Expanding GSK's solvent selection guide – embedding sustainability into solvent selection starting at medicinal chemistry

(2011) Richard K. Henderson et al.   GREEN CHEMISTRY

Ligand Effects on Negishi Couplings of Alkenyl Halides

(2011) Arkady Krasovskiy et al.   ORGANIC LETTERS

Cross-coupling reaction on N-(3,5-dibromo-2-pyridyl)piperazines: regioselective synthesis of 3,5-disubstituted pyridylpiperazines

(2010) Hidemasa Hikawa et al.   TETRAHEDRON

Green Chemistry: Principles and Practice

(2009) Paul Anastas et al.   CHEMICAL SOCIETY REVIEWS

Suzuki−Miyaura Cross-Coupling Reactions of Primary Alkyltrifluoroborates with Aryl Chlorides

(2009) Spencer D. Dreher et al.   JOURNAL OF ORGANIC CHEMISTRY

Nickel-Catalyzed Vinylation of Aryl Chlorides and Bromides with Vinyl ZnBr·MgBrCl

(2009) Tetsuya Yamamoto et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Suzuki−Miyaura Cross-Coupling Reactions Employing Dialkylbiaryl Phosphine Ligands

(2008) Ruben Martin et al.   ACCOUNTS OF CHEMICAL RESEARCH

Direct Vinylation and Difluorovinylation of Arylboronic Acids Using Vinyl- and 2,2-Difluorovinyl Tosylates via the Suzuki−Miyaura Cross Coupling

(2008) Thomas M. Gøgsig et al.   JOURNAL OF ORGANIC CHEMISTRY

Cross-Coupling of Cyclopropyl- and Cyclobutyltrifluoroborates with Aryl and Heteroaryl Chlorides

(2008) Gary A. Molander et al.   JOURNAL OF ORGANIC CHEMISTRY