期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2014, 期 24, 页码 5153-5157出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201402404
关键词
Synthetic methods; Cross-coupling; Water chemistry; Microwave chemistry; Palladium; Tin
资金
- Beijing Forestry University National College Innovative Program [201310022066]
A simple and highly efficient one-pot approach has been developed for the Pd(PPh3)(4)-catalyzed cross-coupling of two different aryl or heteroaryl bromides/iodides. This method involves the combined use of microwave irradiation and water as a single solvent to achieve sequential stannylation and Stille cross-coupling reactions, which allows rapid access to a wide variety of biaryls in good to high yields. Furthermore, utilizing this step-economical protocol, 2,5-dibromopyridine was iteratively diarylated and the Boscalid intermediate was also synthesized in a one-pot manner.
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