期刊
GREEN CHEMISTRY
卷 19, 期 19, 页码 4509-4514出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7gc01783a
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资金
- National Science Foundation of China [21502101]
- Natural Science Foundation for Distinguished Young Scholars of Zhejiang Province [LR15H300001]
- Thousand-Talent Program of Zhejiang Province and Zhejiang University of Technology
A simple and efficient method was developed for the construction of the medicinally important 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivatives with readily available aniline derivatives as starting materials. This highly atom- and step-economical onepot protocol was carried out under metal-free base-mediated conditions through a novel oxidative annulation strategy with oxygen as the oxidant. The key intermediates were isolated and confirmed. A reasonable reaction pathway was proposed and supported by the preliminary experiments, and the computational studies were carried out to understand the energetics of the key rearrangement reaction.
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