Activation of EP2 receptor suppresses poly(I: C) and LPS-mediated inflammation in primary microglia and organotypic hippocampal slice cultures: Contributing role for MAPKs

Effects of early or late prenatal immune activation in mice on behavioral and neuroanatomical abnormalities relevant to schizophrenia in the adulthood

(2017) Vivian T. da Silveira et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Differential expression of E-type prostanoid receptors 2 and 4 in microglia stimulated with lipopolysaccharide

(2017) Ester Bonfill-Teixidor et al.   Journal of Neuroinflammation

Alleviation of Microglial Activation Induced by p38 MAPK/MK2/PGE2 Axis by Capsaicin: Potential Involvement of other than TRPV1 Mechanism/s

(2017) Harsharan S. Bhatia et al.   Scientific Reports

Untangling the Web: Toxic and Protective Effects of Neuroinflammation and PGE2 Signaling in Alzheimer’s Disease

(2016) Nathaniel S. Woodling et al.   ACS Chemical Neuroscience

Early effects of Aβ 1-42 oligomers injection in mice: Involvement of PI3K/Akt/GSK3 and MAPK/ERK1/2 pathways

(2016) Fabiana Morroni et al.   BEHAVIOURAL BRAIN RESEARCH

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice

(2016) Sabine Hellwig et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia replenished OHSC: A culture system to studyin vivolike adult microglia

(2016) Annette Masuch et al.   GLIA

Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia

(2016) Antonio Carlos Pinheiro de Oliveira et al.   Journal of Neuroinflammation

Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology

(2016) Nicole Maphis et al.   Alzheimers Research & Therapy

Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models

(2015) Saktimayee M. Roy et al.   ACS Chemical Neuroscience

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia

(2015) Helois Radford et al.   ACTA NEUROPATHOLOGICA

Prostaglandin E2 Receptor Subtype 2 Regulation of Scavenger Receptor CD36 Modulates Microglial Aβ42 Phagocytosis

(2015) Xianwu Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice

(2015) Qiong Zhou et al.   ANNALS OF NEUROLOGY

CD14 is a key organizer of microglial responses to CNS infection and injury

(2015) Hana Janova et al.   GLIA

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

The Poly(I:C)-induced maternal immune activation model in preclinical neuropsychiatric drug discovery

(2015) Sonali Reisinger et al.   PHARMACOLOGY & THERAPEUTICS

Therapeutic implications of the prostaglandin pathway in Alzheimer's disease

(2014) Eiron Cudaback et al.   BIOCHEMICAL PHARMACOLOGY

Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models

(2014) Jenny U. Johansson et al.   JOURNAL OF CLINICAL INVESTIGATION

Prenatal Poly(I:C) Exposure and Other Developmental Immune Activation Models in Rodent Systems

(2013) Urs Meyer   BIOLOGICAL PSYCHIATRY

Inhibition of Neuroinflammation in LPS-Activated Microglia by Cryptolepine

(2013) Olumayokun A. Olajide et al.   Evidence-based Complementary and Alternative Medicine

EP2 Receptor Signaling Pathways Regulate Classical Activation of Microglia

(2013) Yi Quan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of Inflammation with Conditional Deletion of the Prostaglandin E2 EP2 Receptor in Macrophages and Brain Microglia

(2013) J. U. Johansson et al.   JOURNAL OF NEUROSCIENCE

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

Chronic Stress Induced Remodeling of the Prefrontal Cortex: Structural Re-Organization of Microglia and the Inhibitory Effect of Minocycline

(2012) M. Hinwood et al.   CEREBRAL CORTEX

Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia

(2012) Jörg Scheffel et al.   GLIA

Role of Prostaglandins in Neuroinflammatory and Neurodegenerative Diseases

(2012) Isabel Vieira de Assis Lima et al.   MEDIATORS OF INFLAMMATION

Prenatal activation of Toll-like receptors-3 by administration of the viral mimetic poly(I:C) changes synaptic proteins, N-methyl-D-aspartate receptors and neurogenesis markers in offspring

(2012) Caroline M Forrest et al.   Molecular Brain

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Suppressed microglial E prostanoid receptor 1 signaling selectively reduces tumor necrosis factor alpha and interleukin 6 secretion from toll-like receptor 3 activation

(2011) Xianwu Li et al.   GLIA

Signaling via the prostaglandin E2 receptor EP4 exerts neuronal and vascular protection in a mouse model of cerebral ischemia

(2011) Xibin Liang et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

(2011) Adam D Bachstetter et al.   Journal of Neuroinflammation

PGE2 EP1 receptor exacerbated neurotoxicity in a mouse model of cerebral ischemia and Alzheimer's disease

(2011) Gehua Zhen et al.   NEUROBIOLOGY OF AGING

To poly(I:C) or not to poly(I:C): Advancing preclinical schizophrenia research through the use of prenatal immune activation models

(2011) Urs Meyer et al.   NEUROPHARMACOLOGY

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor

(2010) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting p38 MAPK pathway for the treatment of Alzheimer's disease

(2009) Lenka Munoz et al.   NEUROPHARMACOLOGY

Emerging roles of PGE2 receptors in models of neurological disease

(2009) Katrin Andreasson   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Therapeutic Targets in Prostaglandin E2 Signaling for Neurologic Disease

(2008) P. Cimino et al.   CURRENT MEDICINAL CHEMISTRY

Astrocytes recognize intracellular polyinosinic-polycytidylic acid via MDA-5

(2008) Joari De Miranda et al.   FASEB JOURNAL

Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: Evidence for uncoupled regulation of mPGES-1 and COX-2

(2008) Antonio Carlos Pinheiro de Oliveira et al.   GLIA