EP2 Receptor Signaling Pathways Regulate Classical Activation of Microglia

Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation

(2013) Jianxiong Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP

(2012) Haijun Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2

(2012) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High glucose stimulates TNFα and MCP-1 expression in rat microglia via ROS and NF-κB pathways

(2011) Yi Quan et al.   ACTA PHARMACOLOGICA SINICA

Ablation of Cyclooxygenase-2 in Forebrain Neurons is Neuroprotective and Dampens Brain Inflammation after Status Epilepticus

(2011) G. E. Serrano et al.   JOURNAL OF NEUROSCIENCE

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

The Prostaglandin E2 E-Prostanoid 4 Receptor Exerts Anti-Inflammatory Effects in Brain Innate Immunity

(2010) J. Shi et al.   JOURNAL OF IMMUNOLOGY

Cyclooxygenase (COX)-1 Activity Precedes the COX-2 Induction in Aβ-Induced Neuroinflammation

(2010) Leila Dargahi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Differential Roles of PKA and Epac on the Production of Cytokines in the Endotoxin-Stimulated Primary Cultured Microglia

(2010) Jian Liu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor

(2010) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice

(2009) Kevin Chen et al.   Brain Structure & Function

Chemokines and Chemokine Receptors: Standing at the Crossroads of Immunobiology and Neurobiology

(2009) Richard M. Ransohoff   IMMUNITY

Enhanced Rap1 Activation and Insulin Secretagogue Properties of an Acetoxymethyl Ester of an Epac-selective Cyclic AMP Analog in Rat INS-1 Cells

(2009) Oleg G. Chepurny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imipramine, in Part through Tumor Necrosis Factor   Inhibition, Prevents Cognitive Decline and  -Amyloid Accumulation in a Mouse Model of Alzheimer's Disease

(2009) F. Chavant et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Chronic expression of low levels of tumor necrosis factor-α in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia/macrophage activation

(2009) Ana Laura De Lella Ezcurra et al.   NEUROBIOLOGY OF DISEASE

Regulation of Fcγ receptors and immunoglobulin G-mediated phagocytosis in mouse microglia

(2009) Yi Quan et al.   NEUROSCIENCE LETTERS

Cell death mechanisms in the early stages of acute glutamate neurotoxicity

(2009) Alok Kumar et al.   NEUROSCIENCE RESEARCH

Cyclic AMP

(2008) Carlos H. Serezani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The prostaglandin E2EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis

(2008) Xibin Liang et al.   ANNALS OF NEUROLOGY

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

8-pCPT-2′-O-Me-cAMP-AM: An Improved Epac-Selective cAMP Analogue

(2008) Marjolein J. Vliem et al.   CHEMBIOCHEM

Therapeutic Targets in Prostaglandin E2 Signaling for Neurologic Disease

(2008) P. Cimino et al.   CURRENT MEDICINAL CHEMISTRY

Thrombin-Induced Regulation of CD95(Fas) Expression in the N9 Microglial Cell Line: Evidence for Involvement of Proteinase-Activated Receptor1 and Extracellular Signal-Regulated Kinase 1/2

(2008) Jonathan R. Weinstein et al.   NEUROCHEMICAL RESEARCH