Systematic Analyses and Prediction of Human Drug Side Effect Associated Proteins from the Perspective of Protein Evolution

Relating Essential Proteins to Drug Side-Effects Using Canonical Component Analysis: A Structure-Based Approach

(2015) Tianyun Liu et al.   Journal of Chemical Information and Modeling

Determinants of the rate of protein sequence evolution

(2015) Jianzhi Zhang et al.   NATURE REVIEWS GENETICS

Targets of drugs are generally and targets of drugs having side effects are specifically good spreaders of human interactome perturbations

(2015) Áron R. Perez-Lopez et al.   Scientific Reports

Comprehensive prediction of drug-protein interactions and side effects for the human proteome

(2015) Hongyi Zhou et al.   Scientific Reports

IntSide: a web server for the chemical and biological examination of drug side effects

(2014) Teresa Juan-Blanco et al.   BIOINFORMATICS

Elucidating the Genotype–Phenotype Relationships and Network Perturbations of Human Shared and Specific Disease Genes from an Evolutionary Perspective

(2014) Tina Begum et al.   Genome Biology and Evolution

Dual-Targeted Proteins Tend to be More Evolutionarily Conserved

(2014) Irit Kisslov et al.   MOLECULAR BIOLOGY AND EVOLUTION

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

(2013) Jacqueline K. White et al.   CELL

Evolutionary Rate Heterogeneity of Core and Attachment Proteins in Yeast Protein Complexes

(2013) Sandip Chakraborty et al.   Genome Biology and Evolution

Evolutionary Survey of Druggable Protein Targets with Respect to Their Subcellular Localizations

(2013) Xiaotong Wang et al.   Genome Biology and Evolution

DrugBank 4.0: shedding new light on drug metabolism

(2013) Vivian Law et al.   NUCLEIC ACIDS RESEARCH

Yin and Yang of disease genes and death genes between reciprocally scale-free biological networks

(2013) Hyun Wook Han et al.   NUCLEIC ACIDS RESEARCH

Recent Adaptive Events in Human Brain Revealed by Meta-Analysis of Positively Selected Genes

(2013) Yue Huang et al.   PLoS One

Target Essentiality and Centrality Characterize Drug Side Effects

(2013) Xiujuan Wang et al.   PLoS Computational Biology

From Mouse to Human: Evolutionary Genomics Analysis of Human Orthologs of Essential Genes

(2013) Benjamin Georgi et al.   PLoS Genetics

Biological function through network topology: a survey of the human diseasome

(2012) V. Janjic et al.   Briefings in Functional Genomics

Characterization and prediction of the binding site in DNA-binding proteins: improvement of accuracy by combining residue composition, evolutionary conservation and structural parameters

(2012) Sucharita Dey et al.   NUCLEIC ACIDS RESEARCH

Ensembl 2013

(2012) Paul Flicek et al.   NUCLEIC ACIDS RESEARCH

Insights into the Evolutionary Features of Human Neurodegenerative Diseases

(2012) Arup Panda et al.   PLoS One

ProteinHistorian: Tools for the Comparative Analysis of Eukaryote Protein Origin

(2012) John A. Capra et al.   PLoS Computational Biology

When orthologs diverge between human and mouse

(2011) W. H. Gharib et al.   BRIEFINGS IN BIOINFORMATICS

Near-Neutrality, Robustness, and Epigenetics

(2011) Tomoko Ohta   Genome Biology and Evolution

Expression breadth and expression abundance behave differently in correlations with evolutionary rates

(2010) Seung Park et al.   BMC EVOLUTIONARY BIOLOGY

The interplay between evolution, regulation and tissue specificity in the Human Hereditary Diseasome

(2010) Shivashankar H Nagaraj et al.   BMC GENOMICS

Young proteins experience more variable selection pressures than old proteins

(2010) A. Vishnoi et al.   GENOME RESEARCH

Understanding the Effect of Secondary Structures and Aggregation on Human Protein Folding Class Evolution

(2010) Tina Begum et al.   JOURNAL OF MOLECULAR EVOLUTION

A Complex-based Reconstruction of theSaccharomyces cerevisiaeInteractome

(2009) Haidong Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

CORUM: the comprehensive resource of mammalian protein complexes—2009

(2009) Andreas Ruepp et al.   NUCLEIC ACIDS RESEARCH

Structural imperatives impose diverse evolutionary constraints on helical membrane proteins

(2009) A. Oberai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The universal distribution of evolutionary rates of genes and distinct characteristics of eukaryotic genes of different apparent ages

(2009) Y. I. Wolf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monoallelic expression and tissue specificity are associated with high crossover rates

(2009) Anamaria Necsulea et al.   TRENDS IN GENETICS

An Abundance of Ubiquitously Expressed Genes Revealed by Tissue Transcriptome Sequence Data

(2009) Daniel Ramsköld et al.   PLoS Computational Biology

An Ancient Evolutionary Origin of Genes Associated with Human Genetic Diseases

(2008) T. Domazet-Loso et al.   MOLECULAR BIOLOGY AND EVOLUTION

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE