☆ 4.6 Article

Monoallelic expression and tissue specificity are associated with high crossover rates

TRENDS IN GENETICS (2009)

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TRENDS IN GENETICS
卷 25, 期 12, 页码 519-522

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ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2009.10.001

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Genetics & Heredity

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  1. Centre National de la Recherche Scientifique
  2. Agence Nationale de la Recherche [ANR-08-GENO-003-01]
  3. European Community
  4. Royal Society Wolfson Research Merit Award

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What determines the recombination rate of a gene? Following the observation that, in humans, imprinted genes have unusually high recombination levels, we ask whether increased recombination is seen for other monoallelically expressed genes and, more generally, how transcriptional properties relate to recombination. We find that monoallelically expressed genes do have high crossover rates and discover a striking negative correlation between within-gene crossover rate and expression breadth. We hypothesise that these findings are possibly symptomatic of a more general, adverse relationship between recombination and transcription in the human genome.

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