Article
Oncology
Juhyung Kim, Dong Won Baek, Jin Ho Baek, Byung Woog Kang, Seung Ho Song, Hye Jin Kim, Soo Yeun Park, Jun Seok Park, Gyu-Seog Choi, Jong Gwang Kim
Summary: The study found that vitamin D deficiency at one year after surgical resection was associated with increased disease relapse in patients with stages I to III of colon cancer. Additionally, age of 70 years or older and pathologic stage were unfavorable factors influencing disease-free survival.
ANTICANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Hamzah Adwan, Lars Hammann, Thomas J. Vogl
Summary: This study evaluated the efficacy and safety of microwave ablation (MWA) as a treatment for recurrent hepatocellular carcinoma (HCC) after initial surgical resection. The results showed that MWA treatment is effective and safe for recurrent HCC lesions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Chien-Yi Yang, Min-Hsuan Yen, Kee-Thai Kiu, Yu-Ting Chen, Tung-Cheng Chang
Summary: This study compared the outcomes of right-sided colon cancer (RCC) and left-sided colon cancer (LCC). The results showed no significant difference in overall survival or time to recurrence between patients with RCC and LCC. However, in stage II colon cancer patients, RCC was associated with shorter time to recurrence.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Songphol Malakorn, Akira Ouchi, Chung-Yuan Hu, Lakhbir Sandhu, Arvind Dasari, Yi-Qian Nancy You, E. Scott Kopetz, Lee M. Ellis, George J. Chang
Summary: This study found that the sidedness of colon cancer tumors was not associated with recurrence risk among patients who underwent curative resection, but was linked to unique recurrence patterns and inferior survival rates after recurrence. Therefore, treatment decisions for patients with localized disease should not be solely based on tumor sidedness.
CLINICAL COLORECTAL CANCER
(2021)
Article
Oncology
Mitsuru Ishizuka, Takayuki Shimizu, Norisuke Shibuya, Kazutoshi Takagi, Hiroyuki Hachiya, Yusuke Nishi, Kotaro Suda, Taku Aoki, Keiichi Kubota
Summary: This study explored the impact of primary tumor location (PTL) on survival after curative surgery for patients with colon cancer (CC) using propensity score-matching (PSM) studies. The meta-analysis showed that there was no significant difference in 5-year overall survival (OS) between patients with right-sided CC (RSCC) and those with left-sided CC (LSCC).
Article
Pharmacology & Pharmacy
Guoliang Liu, Min Wang, Hongyu He, Jiannan Li
Summary: This study developed tumor-targeting nanoparticles loaded with doxorubicin for the treatment of colorectal cancer. The nanoparticles utilize a peptide, VATANST (STP), to achieve tumor-targeting effects, have a core-shell structure, and are sensitive to the tumor microenvironment. In vivo experiments in mice demonstrated the nanoparticles' properties as drug delivery systems and their good antitumor effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kevin P. Labadie, Donald K. Hamlin, Aimee Kenoyer, Sara K. Daniel, Alan F. Utria, Andrew D. Ludwig, Heidi L. Kenerson, Lily Li, Jonathan G. Sham, Delphine L. Chen, Johnnie J. Orozco, Raymond S. Yeung, Chris Orvig, Yawen Li, D. Scott Wilbur, James O. Park
Summary: This study describes the development and efficacy of a Th-227-labeled GPC3-targeting antibody conjugate (Th-227-octapa-alpha GPC3) for treating HCC. The results show that the treatment is stable in vitro, exhibits high specificity for GPC3, and significantly reduces tumor burden in an orthotopic murine model of HCC without causing acute off-target toxicity.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Medicine, General & Internal
Yutong Yao, Junjie Xiong, Ziyao Wang, Xing Wang, Xubao Liu, Nengwen Ke
Summary: This paper describes a new surgical technique, using a no-touch principle for laparoscopic pancreaticoduodenectomy, which can help with the in situ resection of tumors. This technique is safe and feasible, but further research is needed to elucidate its oncological benefits.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Yoshiyuki Shibata, Kenichiro Uemura, Tatsuaki Sumiyoshi, Kenjiro Okada, Hiroyuki Otsuka, Masahiro Serikawa, Yasutaka Ishii, Yoshiaki Murakami, Koji Arihiro, Shinya Takahashi
Summary: The study evaluated the clinical significance of surgical resection for liver recurrence in patients with curatively resected pancreatic ductal adenocarcinoma. The medical records of patients with liver recurrence after curative pancreatectomy were reviewed, and the clinical impact of liver resection was analyzed. In selected patients with solitary liver recurrence, liver resection may be a treatment option.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Long-Bin Jeng, Tsai-Chung Li, Wen-Ling Chan, Chiao-Fang Teng
Summary: This study aimed to identify independent prognostic biomarkers from 75 HBV-related HCC patients and validate their potential as a combination biomarker for HCC recurrence with pre-S2 gene deletion mutation. The study found that patients with both pre-S2 gene deletion mutation and TNM stage IIIA-IIIC had a higher risk of HCC recurrence. Furthermore, the combination of pre-S2 gene deletion mutation and TNM stage had better performance in predicting HCC recurrence than either factor alone. In conclusion, the study proposed that TNM stage holds significance as a combination biomarker with pre-S2 gene deletion mutation for predicting HCC recurrence after curative surgical resection.
Article
Oncology
Xiaoju Shi, Conor O'Neill, Xingtong Wang, Yujia Chen, Youxi Yu, Min Tan, Guoyue Lv, Yan Li, Robert C. Martin
Summary: The combination of IRE and immunotherapy enhances tumor necrosis and immune responses, not only in the IRE-treated tumor but also in the off-target tumor, suggesting a potential for broader impact in cancer treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Thinzar M. Lwin, Michael A. Turner, Siamak Amirfakhri, Hiroto Nishino, Pieterjan Debie, Bard C. Cosman, Robert M. Hoffman, Sophie Hernot, Michael Bouvet
Summary: This study demonstrates the rapid and specific labeling of colon cancer tumors using fluorescent anti-CEA nanobodies in both cell-line-based and patient-derived orthotopic xenograft models. The kinetics of nanobodies allow for same-day administration and imaging, making the anti-CEA-nb-800 a promising and practical molecule for fluorescence-guided surgery of colon cancer.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lillian L. Tsai, Danielle M. Fitzgerald, Rong Liu, Jenny T. Korunes-Miller, Eliza Neal, Yin P. Hung, Samantha Bilton, Aaron Hata, Mark W. Grinstaff, Yolonda L. Colson
Summary: A PDX surgical resection model of non-small cell lung cancer was established in mice, and it was found that intraoperative placement of drug-loaded meshes significantly improved local disease treatment, suggesting a potential improvement in recurrence-free survival for early-stage non-small cell lung cancer patients.
ANNALS OF THORACIC SURGERY
(2023)
Article
Oncology
Tzong-Yun Tsai, Jeng-Fu You, Yu-Jen Hsu, Jing-Rong Jhuang, Yih-Jong Chern, Hsin-Yuan Hung, Chien-Yuh Yeh, Pao-Shiu Hsieh, Sum-Fu Chiang, Cheng-Chou Lai, Jy-Ming Chiang, Reiping Tang, Wen-Sy Tsai
Summary: This study developed a prediction model to assess individual mPC risk in patients with pT4 colon cancer, categorizing patients into low-risk or high-risk groups based on tumor location, preoperative carcinoembryonic antigen value, histologic type, T stage, and nodal stage. The model showed high predictive accuracy (prediction error <= 5%) and good discrimination ability (area under the curve >0.7), making it feasible for selecting high-risk pT4 colon cancer patients for targeted interventions.
Article
Oncology
Raquel Ramos, Eduard Cabre, Antonia Vinyals, Daniel Lorenzo, Josep R. Ferreres, Mar Varela, Montse Goma, Maria Jose Paules, Cristina Gutierrez, Josep M. Piulats, Angels Fabra, Jose M. Caminal
Summary: This study describes a model of spontaneous metastatic uveal melanoma based on the orthotopic injection of human uveal melanoma cells into immunodeficient NSG mice, which can develop spontaneous liver metastasis. This model reproduces the organ-specificity of metastasis observed in uveal melanoma patients and may be useful for preclinical testing of targeted therapies with potential uveal melanoma antimetastatic activity and for studying the mechanisms involved in liver metastasis.
Article
Oncology
Aziz Zaanan, Claire Calmel, Julie Henriques, Magali Svrcek, Helene Blons, Christele Desbois-Mouthon, Fatiha Merabtene, Claire Goumard, Yann Parc, Brice Gayet, Julien Taieb, Pierre Validire, Christophe Louvet, Jean-Francois Flejou, Yves Le Bouc, Francoise Praz
Review
Biochemistry & Molecular Biology
Manon Ruffin, Julia Mercier, Claire Calmel, Julie Mesinele, Jeanne Bigot, Erika N. Sutanto, Anthony Kicic, Harriet Corvol, Loic Guillot
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Review
Respiratory System
M. Ruffin, J. Mercier, C. Calmel, J. Mesinele, H. Corvol, L. Guillot
REVUE DES MALADIES RESPIRATOIRES
(2020)
Article
Pathology
Jeremy Augustin, Caroline Gabignon, Aurelie Scriva, Laetitia Menu, Claire Calmel, Olivier Scatton, Francois Paye, Jean-Francois Flejou, Francoise Praz, Pascale Cervera, Dominique Wendum
Article
Cell Biology
Yuanhui Liu, Claire Calmel, Christele Desbois-Mouthon, Joelle Sobczak-Thepot, Anthi Karaiskou, Francoise Praz
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Rania Harati, Marc Vandamme, Benoit Blanchet, Christophe Bardin, Francoise Praz, Rifat Akram Hamoudi, Christele Desbois-Mouthon
Summary: This study found that simultaneous administration of metformin and sorafenib was more effective in inhibiting the growth of hepatocellular carcinoma compared to administering metformin before sorafenib. In vitro experiments confirmed that pretreatment with metformin reduced the effects of sorafenib on liver cancer cells. Transcriptomic analysis showed significant differences between xenografted tumors obtained under different dosing regimens.
MOLECULAR PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Catalina Lodillinsky, Laetitia Fuhrmann, Marie Irondelle, Olena Pylypenko, Xiao-Yan Li, Helene Bonsang-Kitzis, Fabien Reyal, Sophie Vacher, Claire Calmel, Olivier De Wever, Ivan Bieche, Marie-Lise Lacombe, Ana Maria Eijan, Anne Houdusse, Anne Vincent-Salomon, Stephen J. Weiss, Philippe Chavrier, Mathieu Boissan
Summary: The study reveals that NME1 plays a crucial role in the in situ-to-invasive transition of breast cancer, showing a negative correlation with MT1-MMP and impacting the invasive potential of breast cancer cells.
Article
Biochemistry & Molecular Biology
Amr Amin, Aaminah Farrukh, Chandraprabha Murali, Akbar Soleimani, Francoise Praz, Grazia Graziani, Hassan Brim, Hassan Ashktorab
Summary: The study revealed that saffron has a significant anti-proliferative effect on colorectal cancer cells with deficient MMR, which may have therapeutic implications for MSI CRC patients who are generally not recommended for 5-fluorouracil-based treatment.
Article
Biology
Marie-Lise Lacombe, Frederic Lamarche, Olivier De Wever, Teresita Padilla-Benavides, Alyssa Carlson, Imran Khan, Anda Huna, Sophie Vacher, Claire Calmel, Celine Desbourdes, Cecile Cottet-Rousselle, Isabelle Hininger-Favier, Stephane Attia, Beatrice Nawrocki-Raby, Joel Raingeaud, Christelle Machon, Jerome Guitton, Morgane Le Gall, Guilhem Clary, Cedric Broussard, Philippe Chafey, Patrice Therond, David Bernard, Eric Fontaine, Malgorzata Tokarska-Schlattner, Patricia Steeg, Ivan Bieche, Uwe Schlattner, Mathieu Boissan
Summary: The study reveals that mitochondrial nucleoside diphosphate kinase plays a suppressive role in metastatic cancer by promoting mitochondrial alterations leading to metastasis. Results suggest that NME4 expression could serve as a favorable prognostic indicator for cancer patients.
Article
Immunology
Manon Ruffin, Jeanne Bigot, Claire Calmel, Julia Mercier, Maelle Givelet, Justine Oliva, Andres Pizzorno, Manuel Rosa-Calatrava, Harriet Corvol, Viviane Balloy, Olivier Terrier, Loic Guillot
Summary: In this study, it was found that Pseudomonas aeruginosa increases the expression of TMPRSS2 in airway epithelial cells and Calu-3 cells, potentially enhancing susceptibility to SARS-CoV-2 infection. The mechanism is through the activation of Toll-like receptor-5 and p38 MAPK. This result may have clinical significance for cystic fibrosis patients who are frequently infected with P. aeruginosa.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Julia Mercier, Claire Calmel, Julie Mesinele, Erika Sutanto, Fatiha Merabtene, Elisabeth Longchampt, Edouard Sage, Anthony Kicic, Pierre-Yves Boelle, Harriet Corvol, Manon Ruffin, Loic Guillot
Summary: This study found an association between the SNP rs3788766 in the SLC6A14 gene and lung disease severity in cystic fibrosis patients. The minor allele G was found to be deleterious. Further experiments showed that this SNP reduces SLC6A14 promoter activity and affects the mTOR signaling pathway and airway epithelial repair.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Cell Biology
Alexander Kyumurkov, Anne-Pascale Bouin, Mathieu Boissan, Sandra Manet, Francesco Baschieri, Mathilde Proponnet-Guerault, Martial Balland, Olivier Destaing, Myriam Regent-Kloeckner, Claire Calmel, Alice Nicolas, Francois Waharte, Philippe Chavrier, Guillaume Montagnac, Emmanuelle Planus, Corinne Albiges-Rizo
Summary: ICAP-1 regulates integrin endocytosis by interacting with NME2, a key regulator of dynamin-dependent clathrin-coated pits fission. The control of clathrin-mediated integrin endocytosis by an integrin inhibitor is a unique mechanism to finely tune physical forces at focal adhesions. The impact of internalization on cellular mechanics and its mechanism remains elusive.
JOURNAL OF CELL BIOLOGY
(2023)