mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity

Adaptive Capacity to Bacterial Diet Modulates Aging in C. elegans

(2014) Shanshan Pang et al.   Cell Metabolism

Effects ofCaenorhabditis elegans sgk-1mutations on lifespan, stress resistance, and DAF-16/FoxO regulation

(2013) Albert Tzong-Yang Chen et al.   AGING CELL

Diet-Induced Developmental Acceleration Independent of TOR and Insulin in C. elegans

(2013) Lesley T. MacNeil et al.   CELL

A Genetic Program Promotes C. elegans Longevity at Cold Temperatures via a Thermosensitive TRP Channel

(2013) Rui Xiao et al.   CELL

Duration of Rapamycin Treatment Has Differential Effects on Metabolism in Mice

(2013) Yimin Fang et al.   Cell Metabolism

Fertility and Germline Stem Cell Maintenance under Different Diets Requires nhr-114/HNF4 in C. elegans

(2013) Xicotencatl Gracida et al.   CURRENT BIOLOGY

TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development

(2013) Vanessa Ruf et al.   DEVELOPMENTAL BIOLOGY

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Integration of the Unfolded Protein and Oxidative Stress Responses through SKN-1/Nrf

(2013) Kira M. Glover-Cutter et al.   PLoS Genetics

Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses

(2012) Justine A. Melo et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Regulation of ion channels by the serum- and glucocorticoid-inducible kinase SGK1

(2012) Florian Lang et al.   FASEB JOURNAL

LST8 Regulates Cell Growth via Target-of-Rapamycin Complex 2 (TORC2)

(2012) T. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Activation of mTORC2 by Association with the Ribosome

(2011) Vittoria Zinzalla et al.   CELL

EAK-7 Controls Development and Life Span by Regulating Nuclear DAF-16/FoxO Activity

(2010) Hena Alam et al.   Cell Metabolism

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Enhanced neuronal RNAi in C. elegans using SID-1

(2010) Andrea Calixto et al.   NATURE METHODS

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

A Neuromedin U Receptor Acts with the Sensory System to Modulate Food Type-Dependent Effects on C. elegans Lifespan

(2010) Wolfgang Maier et al.   PLOS BIOLOGY

Condition-adapted stress and longevity gene regulation byCaenorhabditis elegansSKN-1/Nrf

(2009) Riva P. Oliveira et al.   AGING CELL

Regulation of the Longevity Response to Temperature by Thermosensory Neurons in Caenorhabditis elegans

(2009) Seung-Jae Lee et al.   CURRENT BIOLOGY

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

(2009) A. A. Soukas et al.   GENES & DEVELOPMENT

Rictor/TORC2 Regulates Caenorhabditis elegans Fat Storage, Body Size, and Development through sgk-1

(2009) Kevin T Jones et al.   PLOS BIOLOGY

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL