MR-guided parenchymal delivery of adeno-associated viral vector serotype 5 in non-human primate brain

Titer and Product Affect the Distribution of Gene Expression after Intraputaminal Convection-Enhanced Delivery

(2017) Marina E. Emborg et al.   STEREOTACTIC AND FUNCTIONAL NEUROSURGERY

Axonal transport of AAV9 in nonhuman primate brain

(2016) F Green et al.   GENE THERAPY

Widespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington's disease

(2016) Piotr Hadaczek et al.   Molecular Therapy-Methods & Clinical Development

Transduction of antigen-presenting cells in the brain by AAV9 warrants caution in preclinical studies

(2015) John Forsayeth et al.   MOLECULAR THERAPY

Broad Therapeutic Benefit After RNAi Expression Vector Delivery to Deep Cerebellar Nuclei: Implications for Spinocerebellar Ataxia Type 1 Therapy

(2014) Megan S Keiser et al.   MOLECULAR THERAPY

Proteomics Analysis of Co-Purifying Cellular Proteins Associated with rAAV Vectors

(2014) Biao Dong et al.   PLoS One

Adeno-associated virus type 6 is retrogradely transported in the non-human primate brain

(2013) W San Sebastian et al.   GENE THERAPY

Strong Cortical and Spinal Cord Transduction After AAV7 and AAV9 Delivery into the Cerebrospinal Fluid of Nonhuman Primates

(2013) Lluis Samaranch et al.   HUMAN GENE THERAPY

Comparative Analysis of Adeno-Associated Virus Capsid Stability and Dynamics

(2013) V. Rayaprolu et al.   JOURNAL OF VIROLOGY

Viral Delivery of Antioxidant Genes as a Therapeutic Strategy in Experimental Models of Amyotrophic Lateral Sclerosis

(2013) Aikaterini Nanou et al.   MOLECULAR THERAPY

Long-distance Axonal Transport of AAV9 Is Driven by Dynein and Kinesin-2 and Is Trafficked in a Highly Motile Rab7-positive Compartment

(2013) Michael J Castle et al.   MOLECULAR THERAPY

AAV9-mediated Expression of a Non-self Protein in Nonhuman Primate Central Nervous System Triggers Widespread Neuroinflammation Driven by Antigen-presenting Cell Transduction

(2013) Lluis Samaranch et al.   MOLECULAR THERAPY

Efficient gene delivery and selective transduction of astrocytes in the mammalian brain using viral vectors

(2013) Nicolas Merienne et al.   Frontiers in Cellular Neuroscience

Generation and Characterization of Adeno-Associated Virus Producer Cell Lines for Research and Preclinical Vector Production

(2013) John Martin et al.   Human Gene Therapy Methods

Axonal transport of adeno-associated viral vectors is serotype-dependent

(2012) E A Salegio et al.   GENE THERAPY

Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates

(2012) Carmen Unzu et al.   Journal of Translational Medicine

Cerebral Infusion of AAV9 Vector-encoding Non-self Proteins Can Elicit Cell-mediated Immune Responses

(2012) Agnieszka Ciesielska et al.   MOLECULAR THERAPY

Adeno-Associated Virus Serotype 9 Transduction in the Central Nervous System of Nonhuman Primates

(2011) Lluis Samaranch et al.   HUMAN GENE THERAPY

Preclinical Differences of Intravascular AAV9 Delivery to Neurons and Glia: A Comparative Study of Adult Mice and Nonhuman Primates

(2011) Steven J Gray et al.   MOLECULAR THERAPY

Interventional MRI-guided Putaminal Delivery of AAV2-GDNF for a Planned Clinical Trial in Parkinson's Disease

(2011) R Mark Richardson et al.   MOLECULAR THERAPY

Glial-derived neurotrophic factor gene transfer for Parkinson's disease: Anterograde distribution of AAV2 vectors in the primate brain

(2011) Adrian P. Kells et al.   NEUROBIOLOGY OF DISEASE

Novel Platform for MRI-Guided Convection-Enhanced Delivery of Therapeutics: Preclinical Validation in Nonhuman Primate Brain

(2011) R. Mark Richardson et al.   STEREOTACTIC AND FUNCTIONAL NEUROSURGERY

Anterograde Axonal Transport of AAV2-GDNF in Rat Basal Ganglia

(2010) Agnieszka Ciesielska et al.   MOLECULAR THERAPY

Safe, Efficient, and Reproducible Gene Therapy of the Brain in the Dog Models of Sanfilippo and Hurler Syndromes

(2010) N Matthew Ellinwood et al.   MOLECULAR THERAPY

Manufacturing Recombinant Adeno-Associated Viral Vectors from Producer Cell Clones

(2009) Barbara A. Thorne et al.   HUMAN GENE THERAPY

Efficient gene therapy-based method for the delivery of therapeutics to primate cortex

(2009) A. P. Kells et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY

Real-time MR imaging of adeno-associated viral vector delivery to the primate brain

(2008) Massimo S. Fiandaca et al.   NEUROIMAGE

Image-guided convection-enhanced delivery platform in the treatment of neurological diseases

(2008) Massimo S. Fiandaca et al.   Neurotherapeutics