Antifungal plant defensins: increased insight in their mode of action as a basis for their use to combat fungal infections

Nicotiana alata Defensin Chimeras Reveal Differences in the Mechanism of Fungal and Tumor Cell Killing and an Enhanced Antifungal Variant

(2016) Mark R. Bleackley et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The plant defensin NaD1 introduces membrane disorder through a specific interaction with the lipid, phosphatidylinositol 4,5 bisphosphate

(2016) Jennifer A.E. Payne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

How promising are combinatorial drug strategies in combating Candida albicans biofilms?

(2016) Karin Thevissen   Future Medicinal Chemistry

Why cellular communication during plant reproduction is particularly mediated by CRP signalling

(2016) Susanne Bircheneder et al.   JOURNAL OF EXPERIMENTAL BOTANY

The Defensins Consist of Two Independent, Convergent Protein Superfamilies

(2016) Thomas M. A. Shafee et al.   MOLECULAR BIOLOGY AND EVOLUTION

Antifungal mechanisms of a plant defensin MtDef4 are not conserved between the ascomycete fungiNeurospora crassaandFusarium graminearum

(2016) Kaoutar El-Mounadi et al.   MOLECULAR MICROBIOLOGY

The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilms

(2016) Kim Vriens et al.   PEPTIDES

The antifungal plant defensin AtPDF2.3 from Arabidopsis thaliana blocks potassium channels

(2016) Kim Vriens et al.   Scientific Reports

In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents

(2016) Ann M. Czyzewski et al.   PLoS One

Isolation, characterization and mechanism of action of an antimicrobial peptide fromLecythis pisonisseeds with inhibitory activity againstCandida albicans

(2015) Maria Eliza Brambila Vieira et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

PvD1 defensin, a plant antimicrobial peptide with inhibitory activity against Leishmania amazonensis

(2015) V. V. do Nascimento et al.   BIOSCIENCE REPORTS

Ixodes ricinus defensins attack distantly-related pathogens

(2015) Miray Tonk et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Combinatorial drug approaches to tackleCandida albicansbiofilms

(2015) Kaat De Cremer et al.   Expert Review of Anti-Infective Therapy

Peanut defensins: Novel allergens isolated from lipophilic peanut extract

(2015) Arnd Petersen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Maize EMBRYO SAC family peptides interact differentially with pollen tubes and fungal cells

(2015) Mayada Woriedh et al.   JOURNAL OF EXPERIMENTAL BOTANY

The Tomato Defensin TPP3 Binds Phosphatidylinositol (4,5)-Bisphosphate via a Conserved Dimeric Cationic Grip Conformation To Mediate Cell Lysis

(2015) Amy A. Baxter et al.   MOLECULAR AND CELLULAR BIOLOGY

Antimicrobial peptides: Possible anti-infective agents

(2015) Jayaram Lakshmaiah Narayana et al.   PEPTIDES

The Plant Peptidome: An Expanding Repertoire of Structural Features and Biological Functions

(2015) Patrizia Tavormina et al.   PLANT CELL

The antifungal plant defensin AhPDF1.1b is a beneficial factor involved in adaptive response to zinc overload when it is expressed in yeast cells

(2015) Oriane Mith et al.   MicrobiologyOpen

Synergistic Activity of the Plant Defensin HsAFP1 and Caspofungin against Candida albicans Biofilms and Planktonic Cultures

(2015) Kim Vriens et al.   PLoS One

Agp2p, the Plasma Membrane Transregulator of Polyamine Uptake, Regulates the Antifungal Activities of the Plant Defensin NaD1 and Other Cationic Peptides

(2014) M. R. Bleackley et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Psd1 binding affinity toward fungal membrane components as assessed by SPR: The role of glucosylceramide in fungal recognition and entry

(2014) Luciano Neves de Medeiros et al.   BIOPOLYMERS

The C-terminal propeptide of a plant defensin confers cytoprotective and subcellular targeting functions

(2014) Fung T Lay et al.   BMC PLANT BIOLOGY

How Does It Kill?: Understanding the Candidacidal Mechanism of Salivary Histatin 5

(2014) Sumant Puri et al.   EUKARYOTIC CELL

Experimental Conversion of a Defensin into a Neurotoxin: Implications for Origin of Toxic Function

(2014) Shunyi Zhu et al.   MOLECULAR BIOLOGY AND EVOLUTION

Specific domains of plant defensins differentially disrupt colony initiation, cell fusion and calcium homeostasis inNeurospora crassa

(2014) Alberto Muñoz et al.   MOLECULAR MICROBIOLOGY

Antifungal Plant Defensins: Mechanisms of Action and Production

(2014) Kim Vriens et al.   MOLECULES

Nitric Oxide-Mediated Antioxidative Mechanism in Yeast through the Activation of the Transcription Factor Mac1

(2014) Ryo Nasuno et al.   PLoS One

Synthesis and Biological Properties of Fungal Glucosylceramide

(2014) Maurizio Del Poeta et al.   PLoS Pathogens

Phosphoinositide-mediated oligomerization of a defensin induces cell lysis

(2014) Ivan KH Poon et al.   eLife

Antifungal defensins and their role in plant defense

(2014) Ariane F. Lacerda et al.   Frontiers in Microbiology

Identification and Mechanism of Action of the Plant Defensin NaD1 as a New Member of the Antifungal Drug Arsenal against Candida albicans

(2013) Brigitte M. E. Hayes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthetic biology: lessons from engineering yeast MAPK signalling pathways

(2013) Kentaro Furukawa et al.   MOLECULAR MICROBIOLOGY

Structural and Functional Studies of a Phosphatidic Acid-Binding Antifungal Plant Defensin MtDef4: Identification of an RGFRRR Motif Governing Fungal Cell Entry

(2013) Uma Shankar Sagaram et al.   PLoS One

Dimerization of Plant Defensin NaD1 Enhances Its Antifungal Activity

(2012) Fung T. Lay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans

(2012) Karin Thevissen et al.   MOLECULAR MICROBIOLOGY

Plant defensins: Common fold, multiple functions

(2012) Nicole L. van der Weerden et al.   Fungal Biology Reviews

Antibiotic activities of host defense peptides: more to it than lipid bilayer perturbation

(2011) Miriam Wilmes et al.   NATURAL PRODUCT REPORTS

Structure-Activity Determinants in Antifungal Plant Defensins MsDef1 and MtDef4 with Different Modes of Action against Fusarium graminearum

(2011) Uma Shankar Sagaram et al.   PLoS One

The Antifungal Plant Defensin HsAFP1 from Heuchera Sanguinea Induces Apoptosis in Candida Albicans

(2011) An M. Aerts et al.   Frontiers in Microbiology

Antifungal Activity of PvD1 Defensin Involves Plasma Membrane Permeabilization, Inhibition of Medium Acidification, and Induction of ROS in Fungi Cells

(2010) Erica O. Mello et al.   CURRENT MICROBIOLOGY

Ultra-high resolution crystal structure of a dimeric defensin SPE10

(2010) Xiaomin Song et al.   FEBS LETTERS

Permeabilization of Fungal Hyphae by the Plant Defensin NaD1 Occurs through a Cell Wall-dependent Process

(2010) Nicole L. van der Weerden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defensin-Like ZmES4 Mediates Pollen Tube Burst in Maize via Opening of the Potassium Channel KZM1

(2010) Suseno Amien et al.   PLOS BIOLOGY

Backbone dynamics of the antifungal Psd1 pea defensin and its correlation with membrane interaction by NMR spectroscopy

(2009) Luciano Neves de Medeiros et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The antifungal plant defensin RsAFP2 from radish induces apoptosis in a metacaspase independent way inCandida albicans

(2009) An M. Aerts et al.   FEBS LETTERS

Treatment with LL-37 Peptide Enhances Antitumor Effects Induced by CpG Oligodeoxynucleotides Against Ovarian Cancer

(2009) Chi-Mu Chuang et al.   HUMAN GENE THERAPY

In Vitro Activity of the Antifungal Plant Defensin RsAFP2 against Candida Isolates and Its In Vivo Efficacy in Prophylactic Murine Models of Candidiasis

(2008) P. M. Tavares et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Isolation and biochemical characterization of a novel leguminous defense peptide with antifungal and antiproliferative potency

(2008) Shaoyun Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Plant Defensin, NaD1, Enters the Cytoplasm ofFusarium OxysporumHyphae

(2008) Nicole L. van der Weerden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY