Article
Chemistry, Multidisciplinary
Chenju Liang, Hsuan-Ying Chou, Siang Chen Wu
Summary: Guava leaf extract shows potential as a natural reducing agent for chlorinated solvents like carbon tetrachloride. It can degrade CT in aqueous phase, especially under alkaline conditions and in the presence of iron salts or minerals. Trichloromethane is a major intermediate in the degradation process.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Yu Ra Lee, Hye-Bin Lee, Mi-Jin Oh, Yoonsook Kim, Ho-Young Park
Summary: This study found that thyme extract can alleviate obesity and gut derangements caused by a high-fat diet. It can reduce weight gain and body fat percentage, regulate serum biomarkers associated with obesity, and improve intestinal barrier function and colon shortening. Additionally, thyme extract can alter the levels of metabolites.
Article
Chemistry, Applied
Thiet Anh Dinh, Yen Nhi Le, Nhat Quyen Pham, Phu Ton-That, Thinh Van-Xuan, Thanh Gia-Thien Ho, Tri Nguyen, Ha Huynh Ky Phuong
Summary: This study aimed to produce environmentally friendly and antibacterial edible films for packaging applications. Chitosan-based films were produced using the casting technique, and guava leaf extract was incorporated at different concentrations. The results showed that increasing the concentration of guava leaf extract improved the antioxidant properties and biodegradation of the films.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Agriculture, Multidisciplinary
Yuanyuan Li, Jialin Xu, Dongli Li, Hang Ma, Yu Mu, Dan Zheng, Xueshi Huang, Liya Li
Summary: A standardized triterpenoid-enriched extract of guava leaves showed hepatoprotective effects by modulating Nrf2 and MAPK signaling pathways to alleviate acetaminophen-induced oxidative and inflammatory stress in the liver. This supports its potential nutraceutical application in liver disease management.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Titeyut Wongsanao, Wipavadee Leemingsawat, Vipaporn Panapisal, Thanomwong Kritpet
Summary: The guava leaf extract-menthol toner significantly reduces post-exercise perspiration, while having no significant effects on skin temperature and heart rate. It may offer better hygiene after a workout through astringent effects.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Environmental Sciences
Baizhou Lu, Zhanqiang Fang, Pokeung Eric Tsang, Jinhua Wu
Summary: In this study, guava leaf extract (GLE) was used as a green promoter to enhance the traditional zero-valent iron Fenton-like (ZVI/H2O2) process. The removal rate and k(obs) of norfloxacin by the ZVI/H2O2/GLE system were significantly increased compared to the ZVI/H2O2 system. Mechanism investigation showed that the attack of reactive oxygen species and the promotion of reactive oxygen species generations were the main factors contributing to the improved reactivity. This study provides an important reference for the practical application of guava leaf in promoting the ZVI/H2O2 process in environmental pollution control.
Article
Plant Sciences
Warintorn Ruksiriwanich, Chiranan Khantham, Anurak Muangsanguan, Yuthana Phimolsiripol, Francisco J. Barba, Korawan Sringarm, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Pensak Jantrawut, Chuda Chittasupho, Romchat Chutoprapat, Korawinwich Boonpisuttinant, Sarana Rose Sommano
Summary: The study found that guava leaf extract has anti-androgen properties, possibly by inhibiting the synthesis of androgens and reducing hair loss. The main components of the extract are phenolic substances, which have antioxidant and metal chelating abilities. This research provides new insights for the development of guava leaf extract as an alternative or adjuvant treatment for hair loss.
Article
Agriculture, Multidisciplinary
Dingfa Wang, Luli Zhou, Hanlin Zhou, Haichao Hu, Guanyu Hou
Summary: The study revealed that guava leaf extract supplementation can reduce diarrhea incidence, enhance antioxidant capacity in the serum, decrease inflammatory factors levels, improve intestinal health, and attenuate diarrhea in piglets challenged by ETEC.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Chemistry, Multidisciplinary
William Xaveriano Waresindo, Halida Rahmi Luthfianti, Dhewa Edikresnha, Tri Suciati, Fatimah Arofiati Noor, Khairurrijal Khairurrijal
Summary: The study successfully fabricated a polyvinyl alcohol hydrogel containing guava leaf extract, adjusting its physical properties by varying the extract concentration. Addition of the extract decreased cross-linking and increased pore size of the hydrogel, leading to increased swelling and decreased mechanical strength. Increasing extract concentration widened absorbance peaks in FTIR, indicating hydrogen bond formation, and transformed the crystalline phase into an amorphous phase based on XRD spectra. The PVA/GLE hydrogel showed increased antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa.
Article
Chemistry, Multidisciplinary
Nguyen Ngoc Son, Vu Minh Thanh, Nguyen Thi Huong
Summary: This study reports on the green synthesis, characterization, and anticancer activity of zinc oxide nanoparticles (ZnO NPs) prepared using extracts of guava leaves. The synthesized ZnO NPs showed significant anticancer activity against different cancer cell lines, with relatively low toxicity towards normal human dermal fibroblast (HDF) cells. These findings highlight the potential of ZnO NPs synthesized using guava leaf extract as promising candidates for biomedical applications, particularly in cancer therapy.
Article
Fisheries
Novi Rosmala Dewi, Huai-Ting Huang, Yu-Sheng Wu, Zhen-Hao Liao, Yu-Ju Lin, Po-Tsang Lee, Fan-Hua Nan
Summary: The study found that guava leaf extract (GLE) can enhance immune responses, growth performance, and reduce infection of Vibrio parahaemolyticus in white shrimp.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shuzhou Chu, Feng Zhang, Huiying Wang, Lijun Xie, Zhinan Chen, Weimin Zeng, Zhiguang Zhou, Fang Hu
Summary: This study assessed the potential therapeutic effects of guava leaf extract on type 2 diabetes and found that it can alleviate hyperglycemia and insulin resistance by regulating liver glucose metabolism and restoring gut microbiota.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Ingrid Beatriz de Melo Morais, Denise Brentan Silva, Carlos Alexandre Carollo, Marcos Luiz Ferreira-Neto, Patricia Fidelis-de-Oliveira, Luiz Borges Bispo-da-Silva
Summary: Campomanesia xanthocarpa leaf extract (CXLE) reduces blood pressure through various mechanisms, with nitric oxide playing a role in maintaining the hypotensive effect.
NATURAL PRODUCT RESEARCH
(2021)
Article
Endocrinology & Metabolism
Prateek Sharma, Jayachandran Nair, Anurag Sinh, Shivangi, Thirumurthy Velpandian, Ruchi Tripathi, Rajani Mathur
Summary: The hydroethanolic extract of Guava leaves has the potential to suppress hepatic metabolic alterations in pediatric non-alcoholic fatty liver disease (NAFLD). It can inhibit multiple signaling pathways involved in the pathogenesis of NAFLD and improve insulin sensitivity. The results suggest that Guava leaf extract could be a potential therapeutic option for managing pediatric NAFLD.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Food Science & Technology
Nashi K. Alqahtani, Tareq M. Alnemr, Fahad Al-Asmari, Salim A. Ali
Summary: The use of natural preservatives such as lactic acid and guava leaf extract can significantly improve the quality parameters of Khalal Barhi dates. These natural preservatives can reduce moisture content, increase total soluble solids, inhibit microbial growth, and maintain higher color and firmness values of the dates.
Article
Clinical Neurology
Teresa Vezza, Jose Alberto Molina-Tijeras, Rafael Gonzalez-Cano, Alba Rodriguez-Nogales, Federico Garcia, Julio Galvez, Enrique J. Cobos
Summary: Abdominal pain is a common symptom in patients with inflammatory bowel disease (IBD) and has a significant impact on their quality of life. Minocycline, a broad-spectrum tetracycline antibiotic, has been identified as a potential therapy for managing visceral pain in IBD-induced colitis in mice.
Article
Biochemistry & Molecular Biology
Jose D. D. Puentes-Pardo, Sara Moreno-SanJuan, Jorge Casado, Julia Escudero-Feliu, David Lopez-Perez, Paula Sanchez-Uceta, Paula Gonzalez-Novoa, Julio Galvez, Angel Carazo, Josefa Leon
Summary: Poly(ADP-ribose) polymerase-1 (PARP-1) is involved in various physiological processes. Elevated PARP-1 expression is found in several tumors, associated with stemness and tumorigenesis. In colorectal cancer patients, PARP-1 expression correlated with differentiation grade, with a significant association only in tumors with wild-type p53. Additionally, PARP-1 and cancer stem cell markers were positively correlated in these tumors. In vitro studies showed that PARP-1 regulates cancer stem cell phenotype depending on p53 status, with overexpression increasing marker expression and sphere forming ability in wild-type p53 cells, while reducing these features in mutated p53 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Elixabet Diaz-de-Cerio, Francisco Giron, Alfonso Perez-Garrido, Andreia S. P. Pereira, Jose Antonio Gabaldon-Hernandez, Vito Verardo, Antonio Segura Carretero, Horacio Perez-Sanchez
Summary: This study identified 73 phenolic compounds from Spanish guava leaves and found that some of these compounds interact with diabetes-related proteins, suggesting their potential anti-diabetic activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Enrique Guillamon, Nuria Mut-Salud, Maria Jesus Rodriguez-Sojo, Antonio Jesus Ruiz-Malagon, Antonio Cuberos-Escobar, Antonio Martinez-Ferez, Alba Rodriguez-Nogales, Julio Galvez, Alberto Banos
Summary: This study demonstrates the potential anti-proliferative and anti-inflammatory effects of onion-derived metabolites PTS and PTSO on various human tumor lines. These compounds have the ability to induce apoptosis and reduce the levels of pro-inflammatory cytokines, suggesting their promising role in cancer prevention and/or treatment.
Article
Nutrition & Dietetics
Jorge Garcia-Garcia, Carlos Gracian, Alberto Banos, Enrique Guillamon, Julio Galvez, Alba Rodriguez-Nogales, Juristo Fonolla
Summary: This study aimed to evaluate the impact of a garlic and onion extract concentrate on the incidence of respiratory tract infections in elderly patients. The results showed that the extract is safe to use and significantly reduces the occurrence of respiratory infections, as well as the duration and number of associated symptoms.
Article
Biochemistry & Molecular Biology
Sebastien Dilly, Miguel Romero, Stephanie Solier, Olivier Feron, Chantal Dessy, Anny Slama Schwok
Summary: ROS in cancer cells play a crucial role in regulating cell death, stemness maintenance, and metabolic reprogramming, which are associated with resistance to chemo/immunotherapy. This paper introduces new inhibitors of NADPH oxidase (NOX), which is important in the tumor microenvironment. One of the inhibitors, called Nanoshutter-1 (NS1), decreases tumor-promoting M2 macrophages in human blood monocytes. NS1 disrupts the NOX2 complex in the macrophages' membrane and mitochondria, leading to vasodilation of blood vessels and potential reduction of hypoxia. By targeting specific cells, NOX2-specific inhibitors could provide precision therapies.
Article
Biochemistry & Molecular Biology
Maria Jesus Rodriguez-Sojo, Antonio Jesus Ruiz-Malagon, Laura Hidalgo-Garcia, Jose Alberto Molina-Tijeras, Patricia Diez-Echave, Laura Lopez-Escanez, Lucrezia Rosati, Elena Gonzalez-Lozano, Laura Cenis-Cifuentes, Jorge Garcia-Garcia, Federico Garcia, Inaki Robles-Vera, Miguel Romero, Juan Duarte, Jose Luis Cenis, Antonio Abel Lozano-Perez, Julio Galvez, Maria Elena Rodriguez-Cabezas, Alba Rodriguez-Nogales
Summary: Morus alba L. leaf extract has beneficial effects on high-fat diet-induced obesity in mice by reducing weight gain, attenuating lipid accumulation, increasing glucose sensitivity, and improving obesity-associated inflammation. These effects are possibly due to the extract's antioxidant properties. Moreover, the extract also mitigates gut dysbiosis, as evidenced by the restoration of the Firmicutes/Bacteroidota ratio and the decrease in plasma lipopolysaccharide levels.
Article
Infectious Diseases
Jorge Garcia-Garcia, Patricia Diez-Echave, Maria Eugenia Yuste, Natalia Chueca, Federico Garcia, Jose Cabeza-Barrera, Emilio Fernandez-Varon, Julio Galvez, Manuel Colmenero, Maria Elena Rodriguez-Cabezas, Alba Rodriguez-Nogales, Rocio Moron
Summary: The number of ICU patients and antibiotic treatments has increased due to SARS-CoV-2 infection, leading to a rise in multi-drug resistant bacteria (MDRB) colonization. As these bacteria mainly come from gut microbiota, studying its composition is crucial. This pilot study aims to identify bacteria biomarkers for predicting MDRB colonization risk in SARS-CoV-2 patients in ICUs.
Editorial Material
Nutrition & Dietetics
Carmen del Rio, Antonio Segura-Carretero
Editorial Material
Nutrition & Dietetics
Miguel Romero, Juan Duarte
Article
Gastroenterology & Hepatology
Javier Moleon, Cristina Gonzalez-Correa, Inaki Robles-Vera, Sofia Minano, Nestor de la Visitacion, Antonio Manuel Barranco, Natividad Martin-Morales, Francisco O'Valle, Laura Mayo-Martinez, Antonia Garcia, Marta Toral, Rosario Jimenez, Miguel Romero, Juan Duarte
Summary: This study aims to examine whether consuming dietary fiber can prevent vascular and renal damage in a genetic mouse model of systemic lupus erythematosus (SLE), and whether gut microbiota contributes to these protective effects. The results showed that fiber treatments, especially resistant starch (RS), can prevent hypertension and renal injury, improve aortic relaxation, and reduce vascular oxidative stress. The study also found that fiber treatments can modify the gut microbiota composition, reduce colonic inflammation and endotoxemia, and decrease the proportion of helper T (Th) 17 cells in the immune system of SLE mice.
Article
Medicine, Research & Experimental
Xando Diaz-Villamarin, Emilio Fernandez-Varon, Michelle Carolina Rojas Romero, Jose Luis Callejas-Rubio, Jose Cabeza-Barrera, Alba Rodriguez-Nogales, Julio Galvez, Rocio Moron
Summary: This study assesses the clinical impact of azathioprine dose tailoring based on TPMT genotyping and finds that dose reduction in TPMT intermediate metabolizer patients is associated with lower toxicity events and fewer dose adjustments.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Food Science & Technology
Yonghong Ye, Songyan Zheng, Yuanxing Wang
Summary: In this study, the changes of aroma components in Gannan navel orange during growth were systematically studied using HS-SPME-GC-MS. Key aroma components and markers were identified. These findings contribute to a better understanding of the dynamic variation of aroma compounds during navel orange growth and have potential for industrial applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Jia Xu, Yayuan Zhang, Mengke Zhang, Xinlin Wei, Yiming Zhou
Summary: This study evaluated the effects of glucosamine selenium on summer-autumn tea, showing that it can enhance nutritional quality, improve sensory characteristics, and increase plant adaptation to environmental changes and abiotic stresses.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yuanming Chu, Zhaoyang Ding, Jing Xie
Summary: This study investigated the use of ice glazing containing D-sodium erythorbate (DSE) and vacuum packaging to maintain the quality of large yellow croaker during frozen storage. The results showed that vacuum packaging effectively inhibited ice crystal growth and minimized water loss, while the combination of vacuum packaging and 0.3% DSE-infused ice glazing maintained freshness indicators at low levels throughout the 300-day storage period. This combination was considered the most effective in preserving the quality of the fish.
FOOD RESEARCH INTERNATIONAL
(2024)
Review
Food Science & Technology
Md. Ashikur Rahman, Shirin Akter, Md. Ashrafudoulla, Md. Anamul Hasan Chowdhury, A. G. M. Sofi Uddin Mahamud, Si Hong Park, Sang-Do Ha
Summary: This comprehensive review aims to provide insights into the mechanisms and key factors influencing biofilm formation by A. hydrophila in the food industry. It explores the molecular processes involved in various stages of biofilm formation and investigates the impact of intrinsic factors and environmental conditions on biofilm architecture and resilience. The article also highlights the potential of bibliometric analysis in conceptualizing the research landscape and identifying knowledge gaps in A. hydrophila biofilm research.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Chujing Wang, Wenni Tian, Zengliu Song, Qun Wang, Yong Cao, Jie Xiao
Summary: Solid lipid ratio in emulsions has significant effects on colloidal stability, mucus permeability, and bioavailability in vivo. Higher solid lipid ratio improves intestinal stability but reduces mucus permeability.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Dacai Zhong, Liping Kang, Juan Liu, Xiang Li, Li Zhou, Luqi Huang, Zidong Qiu
Summary: In this study, a novel online extraction electrospray ionization mass spectrometry method was developed to comprehensively characterize complex foods. Meanwhile, a characteristic marker screening method and chemometrics modeling were used for the accurate authentication of highly-similar foods. This research has significant implications for ensuring food quality and safety.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Qiannan Zhao, Jinyi Yang, Jiahui Li, Lei Zhang, Xiaohai Yan, Tianli Yue, Yahong Yuan
Summary: This study investigated the transport and hypoglycemic effects of phenolics in mulberry leaves using an in vitro digestion model. The results showed that digested phenolics had higher absorbability and could inhibit glucose digestion and absorption. Phenolics also regulated glucose metabolism. Luteoforol and p-coumaric acid were found to be the primary phenolics strongly correlated with the hypoglycemic ability of mulberry leaves.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yanyun Cao, Qingling Wang, Jinou Lin, Yin-Yi Ding, Jianzhong Han
Summary: This study investigated the effects of gallic acid (GA) and epigallocatechin gallate (EGCG) at different ratios on the gel properties of calcium induced-whey protein emulsion gel. It was found that GA and EGCG could promote gel formation, increase gel strength, and delay the release of emulsified oil droplets.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Monique Martins Strieder, Vitor Lacerda Sanches, Mauricio Ariel Rostagno
Summary: This study proposed an integrated and automated procedure for extracting, separating, and quantifying bioactive compounds from coffee co-products. By optimizing the extraction, separation, and analysis method, real-time analysis was achieved. The results suggest that coupling different techniques can efficiently extract, separate, and analyze phenolic compounds, providing an integrated method to produce high-added value ingredients for various applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Kyu Sang Sim, Hyoyoung Kim, Suel Hye Hur, Tae Woong Na, Ji Hye Lee, Ho Jin Kim
Summary: Geographical origin plays a crucial role in determining the quality and safety of agricultural products. In this study, ICP analysis was used to determine the inorganic elemental content of onions and identify their geographical origin. Chemometric methods were applied to analyze the ICP results, and the accuracy of distinguishing between Korean and Chinese onions was found to be excellent. The findings suggest that this method can be beneficial for identifying agricultural products.
FOOD RESEARCH INTERNATIONAL
(2024)
