Article
Environmental Sciences
Rania Samir, Ekrami A. Hassan, Abdullah A. Saber, David S. A. Haneen, Eman M. Saleh
Summary: This study investigated the cardioprotective effects of thermally treated sodium alginate (TTSA) in treating doxorubicin-induced cardiotoxicity. The results showed that TTSA improved cardiac dysfunction and alleviated doxorubicin-induced myocardial apoptosis. Furthermore, TTSA exhibited antioxidant properties and rebalanced the redox state of cardiomyocytes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Plant Sciences
Wei Huang, Wan-yi Liu, Lu-yao Chen, Lin Ni, Xiao-xing Zou, Min Ye, Zhong-yi Zhang, Shuang-quan Zou
Summary: The study evaluated the chemical composition of the extract from E. konishii leaves and investigated its hepatoprotective effects using an alcoholic liver injury mice model. The results showed that the extract contained flavonoids and chromones that exhibited strong antioxidant activity in vitro and effectively protected against alcoholic liver injury by reducing liver enzymes, oxidative stress, inflammation, apoptosis, and histological alterations. The extract also restored mitochondrial function and suppressed ER-induced apoptosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Yang Zhang, Shan Liu, Jiu-Long Ma, Chen Chen, Peng Huang, Jia-Hua Ji, Di Wu, Li-Qun Ren
Summary: Apocynum venetum L. leaf extract alleviates doxorubicin-induced cardiomyocyte apoptosis by suppressing oxidative stress and apoptosis through the AKT/Bcl-2 signaling pathway.
Article
Nutrition & Dietetics
Abdullah F. AlAsmari, Nemat Ali, Metab Alharbi, Faleh Alqahtani, Fawaz Alasmari, Daad Almoqbel, Mohammed AlSwayyed, Abdulrahman Alshammari, Mohammed M. Alanazi, Ali Alhoshani, Naif O. Al-Harbi
Summary: Pre-treatment with geraniol can alleviate doxorubicin-induced kidney damage in rats, improving kidney function, antioxidant parameters, and tissue structure. Geraniol also affects the expression of inflammatory and apoptosis-related genes and proteins, protecting the kidneys from doxorubicin-induced harm.
Article
Environmental Sciences
Dandan Gao, Hongping Liao, Muhammad Junaid, Xikun Chen, Chunmiao Kong, Qiuping Wang, Ting Pan, Guanglong Chen, Xu Wang, Jun Wang
Summary: Polystyrene nanoparticles (80 nm) have negative effects on the growth and antioxidant defense system of water spinach, but have no significant impact on chlorophyll concentration. These results provide a fresh perspective to examine the implications of polystyrene nanoparticles on edible aquatic plants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biotechnology & Applied Microbiology
Peng An, Di Fan, Zhen Guo, Fang-Yuan Liu, Chen-Fei Li, Dan Yang, Ming-Yu Wang, Zheng Yang, Qi-Zhu Tang
Summary: This study found that BMP10 has a cardioprotective effect in DOX-induced cardiac injury, reducing oxidative stress and cardiac apoptosis, and improving cardiac function. This protective effect is achieved by activating STAT3.
Article
Biochemistry & Molecular Biology
Ewa Florek, Marta Szukalska, Katarzyna Markiewicz, Izabela Miechowicz, Justyna Gornowicz-Porowska, Anna Jelinska, Joanna Kasprzyk-Pochopien, Joanna Nawrot, Agnieszka Sobczak, Malgorzata Horoszkiewicz, Wojciech Piekoszewski, Gerard Nowak
Summary: The extract from the leaves of Cynara scolymus L. has been found to have a high antioxidative potential and exhibits protective and regenerative effects on the liver, making it beneficial for reducing hepatocellular damage caused by xenobiotics.
Article
Environmental Sciences
Fangming Yu, Mingyue Fu, Chijian Tang, Cuiju Mo, Songying Li, Shiyu Luo, Peiqing Qin, Yinjun Zhao, Yi Li
Summary: Microplastic contamination in agroecosystems has attracted a lot of attention. This study focused on the impact of polyethylene microplastic (PE) on the physiological and biochemical variations of I. aquatica F. The results showed that PE addition had significant effects on soil properties, enzyme activities, and the diversity and structure of microbial communities.
Article
Plant Sciences
Mohammed Abu Tayab, Kazi Ashfak Ahmed Chowdhury, Md Jabed, Syed Mohammed Tareq, A. T. M. Mostafa Kamal, Mohammad Nazmul Islam, A. M. Kafil Uddin, Mohammad Adil Hossain, Talha Bin Emran, Jesus Simal-Gandara
Summary: Extracts from Woodfordia fruticosa leaves demonstrate strong potential in antioxidative, antidiabetic, and antidepressant effects, offering potential dietary supplements for mitigating hyperglycemia, cellular toxicity, and depressive disorder.
Article
Chemistry, Multidisciplinary
Burcu Ozdamar, Yusuf Surmeli, Gulsah Sanli-Mohamed
Summary: The olive leaf extract (OLE) was immobilized with chitosan nanoparticles (CNPs) through optimized conditions. The physicochemical characteristics of OLE-loaded CNPs were analyzed using SEM, FT-IR spectroscopy, DLS, and AFM. OLE-CNPs exhibited a spherical morphology with an average diameter of approximately 100 nm. In vitro cytotoxic assays showed that OLE-CNPs had an IC50 of 540 μg/mL for A549 cells and 810 μg/mL for MCF-7 cells. Treatment with OLE-CNPs caused cell cycle arrest and different apoptosis stages in A549 and MCF-7 cells, suggesting the potential of OLE-CNPs as an adjunct to cancer therapy.
Article
Environmental Sciences
Salwa A. Elgendy, Mohamed Mohamed Soliman, Heba I. Ghamry, Mustafa Shukry, Lina Abdelhady Mohammed, Hend Elsayed Nasr, Badriyah S. Alotaibi, Ibrahim Jafri, Samy Sayed, Amira Osman, Heba A. Elnoury
Summary: This study investigated the effects of Rhodiola rosea (RHO) on tilmicosin (TIL)-induced cardiac injury and the regulation of inflammatory, antioxidant, apoptotic, and anti-apoptotic signaling pathways. The results showed that pretreatment with RHO and CARV significantly reduced TIL-induced cardiac injury markers and inflammation, while improving antioxidant capacity.
Article
Plant Sciences
Siqiniseko S. Ndlovu, Anil A. Chuturgoon, Terisha Ghazi
Summary: The World Health Organization (WHO) reported that there are 37 million individuals living with HIV worldwide, with the majority in South Africa. This study investigated the toxicity of ARV drugs on mitochondria and the NRF2 antioxidant pathway and its possible amelioration using Moringa oleifera Lam (MO) leaf extracts.
Article
Horticulture
Xin Wang, Muhammad Ahsan Altaf, Yuanyuan Hao, Zhiwei Wang, Guopeng Zhu
Summary: Crop productivity is suffering from adverse environmental conditions, specifically high temperature stress. The study investigates the physiological response of water spinach to high temperature stress. The results show that HT stress reduces growth and alters various physiological and biochemical parameters of water spinach.
Article
Medicine, Research & Experimental
Chaoling Wen, Chunhong Liu, Yetian Li, Taibao Xia, Xiaohai Zhang, Shuangtao Xue, Opeyemi Joshua Olatunji
Summary: This study investigated the cardioprotective role of Lycium chinense leaf extract (LCME) in diabetic rats. LCME significantly improved blood glucose levels and cardiac function in diabetic rats, while suppressing oxidative stress, inflammation, apoptosis, and fibrosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Karim Samy El-Said, Ahmed S. Haidyrah, Maysa A. Mobasher, Arwa Ishaq A. Khayyat, Afnan Shakoori, Noorah Saleh Al-Sowayan, Ibrahim Omar Barnawi, Reham A. Mariah
Summary: Artemisia annua leaf extract (AALE) can attenuate the hepatic toxicity induced by Doxorubicin (DOX) through activation of the PI-3K/Akt/Nrf-2 signaling pathway, inducing antioxidant agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Dibyendu Das, Sanjib Sarkar, Sawlang Borsingh Wann, Jatin Kalita, Prasenjit Manna
Summary: Fermented soy foods have gained attention for their promising health benefits, particularly for their potential therapeutic effects against inflammation and related complications. Studies suggest that extracts from fermented soy foods possess anti-inflammatory properties by regulating the expression and activity of various inflammatory factors. These findings suggest that fermented soy foods have the potential to be used as anti-inflammatory agents in the future.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Dibyendu Das, Mir Ekbal Kabir, Sanjib Sarkar, Sawlang Borsingh Wann, Jatin Kalita, Prasenjit Manna
Summary: Soy protein has anti-diabetic properties and can prevent and control abnormalities related to diabetes, with a significant correlation between soy protein intake and lower prevalence of diabetes. Soy-derived peptides can also trigger anti-diabetic responses by modulating cell signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Environmental
Monikankana Saikia, Anupama Singh, Anjum Dihingia, Puja Khare, Jatin Kalita, Binoy K. Saikia
Summary: This study proposes a simplistic, innovative, sustainable, and economically scalable method for the formation of fluorescent nitrogen and sulphur co-doped carbon quantum dots (NS-CQDs) using subbituminous coal as feedstock. The NS-CQDs show promising opto-chemical characteristics and have potential applications in biomedicine, catalysis, and plant growth promotion.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Sanjib Sarkar, Pritam Sadhukhan, Dibyendu Das, Purashri Basyach, Joydeep Das, Manash R. Das, Lakshi Saikia, Sawlang Borsingh Wann, Jatin Kalita, Parames C. Sil, Prasenjit Manna
Summary: This study investigated the glucose-responsive delivery of vitamin K using dextran-capped mesoporous silica nanoparticles (MSNs) functionalized with 3-carboxyphenylboronic acid (CPBA). The results showed that the system not only delivered VK in a glucose-dependent manner but also significantly improved its bioavailability.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biology
Prateek Singh, Rajat Ujjainiya, Satyartha Prakash, Salwa Naushin, Viren Sardana, Nitin Bhatheja, Ajay Pratap Singh, Joydeb Barman, Kartik Kumar, Saurabh Gayali, Raju Khan, Birendra Singh Rawat, Karthik Bharadwaj Tallapaka, Mahesh Anumalla, Amit Lahiri, Susanta Kar, Vivek Bhosale, Mrigank Srivastava, Madhav Nilakanth Mugale, C. P. Pandey, Shaziya Khan, Shivani Katiyar, Desh Raj, Sharmeen Ishteyaque, Sonu Khanka, Ankita Rani, Promila, Jyotsna Sharma, Anuradha Seth, Mukul Dutta, Nishant Saurabh, Murugan Veerapandian, Ganesh Venkatachalam, Deepak Bansal, Dinesh Gupta, Prakash M. Halami, Muthukumar Serva Peddha, Ravindra P. Veeranna, Anirban Pal, Ranvijay Kumar Singh, Suresh Kumar Anandasadagopan, Parimala Karuppanan, Syed Nasar Rahman, Gopika Selvakumar, Subramanian Venkatesan, Malay Kumar Karmakar, Harish Kumar Sardana, Anamika Kothari, Devendra Singh Parihar, Anupma Thakur, Anas Saifi, Naman Gupta, Yogita Singh, Ritu Reddu, Rizul Gautam, Anuj Mishra, Avinash Mishra, Iranna Gogeri, Geethavani Rayasam, Yogendra Padwad, Vikram Patial, Vipin Hallan, Damanpreet Singh, Narendra Tirpude, Partha Chakrabarti, Sujay Krishna Maity, Dipyaman Ganguly, Ramakrishna Sistla, Narender Kumar Balthu, Kiran A. Kumar, Siva Ranjith, B. Vijay Kumar, Piyush Singh Jamwal, Anshu Wali, Sajad Ahmed, Rekha Chouhan, Sumit G. Gandhi, Nancy Sharma, Garima Rai, Faisal Irshad, Vijay Lakshmi Jamwal, Masroor Ahmad Paddar, Sameer Ullah Khan, Fayaz Malik, Debashish Ghosh, Ghanshyam Thakkar, S. K. Barik, Prabhanshu Tripathi, Yatendra Kumar Satija, Sneha Mohanty, Md Tauseef Khan, Umakanta Subudhi, Pradip Sen, Rashmi Kumar, Anshu Bhardwaj, Pawan Gupta, Deepak Sharma, Amit Tuli, Saumya Ray Chaudhuri, Srinivasan Krishnamurthi, L. Prakash, Ch Rao, B. N. Singh, Arvindkumar Chaurasiya, Meera Chaurasiya, Mayuri Bhadange, Bhagyashree Likhitkar, Sharada Mohite, Yogita Patil, Mahesh Kulkarni, Rakesh Joshi, Vaibhav Pandya, Sachin Mahajan, Amita Patil, Rachel Samson, Tejas Vare, Mahesh Dharne, Ashok Giri, Sachin Mahajan, Shilpa Paranjape, G. Narahari Sastry, Jatin Kalita, Tridip Phukan, Prasenjit Manna, Wahengbam Romi, Pankaj Bharali, Dibyajyoti Ozah, RaviKumar Sahu, Prachurjya Dutta, Moirangthem Goutam Singh, Gayatri Gogoi, Yasmin Begam Tapadar, Elapavalooru V. S. S. K. Babu, Rajeev K. Sukumaran, Aishwarya R. Nair, Anoop Puthiyamadam, Prajeesh Kooloth Valappil, Adrash Velayudhan Pillai Prasannakumari, Kalpana Chodankar, Samir Damare, Ved Varun Agrawal, Kumardeep Chaudhary, Anurag Agrawal, Shantanu Sengupta, Debasis Dash
Summary: Data science has played a crucial role in the COVID-19 pandemic response, and this study demonstrates how a statistical and machine learning approach can be used to discriminate between SARS-CoV-2 infection and immune response to a whole virion vaccine. By analyzing serial antibody data and incorporating an ensemble ML model, the researchers were able to accurately classify potential infections and validate their findings through neutralization assays. This study highlights the importance of real-world vaccine effectiveness assessments for whole virion vaccines.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Dibyendu Das, Nazim Uddin Afzal, Sawlang Borsingh Wann, Jatin Kalita, Prasenjit Manna
Summary: The present study investigated the antidiabetic potential of protein isolates from Hawaijar (HPI), a popular fermented soybean food of North-East India. Treatment with HPI significantly upregulated glucose uptake, glucose utilization, glucose-6-phosphate, and stimulated PI3K/AKT/GLUT4 pathway in high-glucose (HG) -treated myotubes. SDS-PAGE and immunoblotting analyses of HPI showed the reduction and/or absence of various subunits of 7S and 11S globulin protein and appearance of new proteins compared to respective non-fermented soy protein isolates.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Dibyendu Das, Sanjib Sarkar, Anjum Dihingia, Nazim Uddin Afzal, Sawlang Borsingh Wann, Jatin Kalita, Saikat Dewanjee, Prasenjit Manna
Summary: This study examined the antidiabetic efficacy of popular fermented soybean foods from Northeast India. Results showed that aqueous extract of Hawaijar significantly augmented glucose utilization and improved glucose metabolism in cultured myotubes and diabetic rats. Chemical profiling suggests the possible role of bioactive proteins/peptides and isoflavones underlying the antihyperglycemic potential of Hawaijar. These findings may contribute to the development of food-based prophylactics/therapeutics for managing hyperglycemia.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Sanjib Sarkar, Mir Ekbal Kabir, Jatin Kalita, Prasenjit Manna
Summary: Mesoporous silica nanoparticles (MSNs) are extensively used in biomedical applications such as drug delivery, diagnosis, bio-sensing, and cell tracking due to their unique properties. MSNs have been extensively studied in drug delivery field due to their highly ordered mesopores, high surface area, stability, and biocompatibility. MSN-based nanocomposites have been utilized for delivering therapeutic molecules for diabetes management. This review focuses on the delivery of antidiabetic therapeutics with emphasis on the functionalization of MSNs and stimuli-responsive delivery.
Article
Immunology
Romi Wahengbam, Pankaj Bharali, Prasenjit Manna, Tridip Phukan, Moirangthem Goutam Singh, Gayatri Gogoi, Yasmin Begam Tapadar, Anil Kumar Singh, Rituraj Konwar, Channakeshavaiah Chikkaputtaiah, Natarajan Velmurugan, Selvaraman Nagamani, Hridoy Jyoti Mahanta, Himakshi Sarma, Ravi Kumar Sahu, Prachurjya Dutta, Sawlang Borsingh Wann, Jatin Kalita, G. Narahari Sastry
Summary: Serological and genomic surveillance were conducted to investigate the spread of SARS-CoV-2 in Northeast (NE) India during the first and second waves of COVID-19. The study revealed that the test positivity rates (TPR) in NE India were 6.34% and 6.64% during the first and second waves, respectively, with similar patterns observed in other NE states. Seropositivity increased over time, and neutralizing antibody prevalence varied at different time points. The dominant variants during the first wave were normal variants, while B.1.617.2 and AY-sublineages dominated the second wave.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Purna K. Boruah, Priyakshree Borthakur, Gayatri Neog, Benjamin Le Ouay, Nazim Uddin Afzal, Prasenjit Manna, Manash R. Das
Summary: This article describes the synthesis of porous 3D nitrogen-doped crumpled graphene nanoparticles (CGNPs) and their use as a platform for the sensitive detection of dopamine (DA) in complex biological media such as blood serum. The CGNPs were prepared by doping graphene oxide (GO) using ammonium hydroxide in a hydrothermal treatment. The system selectively detected DA with a limit of detection of 1.15 μM and a linearity range of 1 to 20 μM, and it showed good selectivity in the presence of various interfering species and in human blood serum.
ACS APPLIED NANO MATERIALS
(2023)
Review
Chemistry, Medicinal
Bhuvi Sachdeva, Punya Sachdeva, Arvind Negi, Shampa Ghosh, Sungsoo Han, Saikat Dewanjee, Saurabh Kumar Jha, Rakesh Bhaskar, Jitendra Kumar Sinha, Ana Claudia Paiva-Santos, Niraj Kumar Jha, Kavindra Kumar Kesari
Summary: Chitin is a biopolymer derived from marine crustaceans and organisms like bacteria, fungi, and algae, which offers biodegradability and biocompatibility properties suitable for biomedical applications. Its deacetylated derivative, chitosan, also possesses similar properties and can be used as a support material in biomedical applications. Additionally, both chitin and chitosan have intrinsic material properties such as antioxidant, antibacterial, and antitumor activities. This paper focuses on the use of chitin and chitosan biopolymers in drug delivery strategies for cancer treatment.
Review
Biochemistry & Molecular Biology
Nilanjan Ghosh, Leena Chacko, Hiranmoy Bhattacharya, Jayalakshmi Vallamkondu, Sagnik Nag, Abhijit Dey, Tanushree Karmakar, P. Hemachandra Reddy, Ramesh Kandimalla, Saikat Dewanjee
Summary: Diabetes mellitus (DM) and cardiovascular complications often occur together, creating a challenging situation. The development of diabetic cardiomyopathy (DCM) involves complex pathophysiological pathways at the metabolic and molecular level, leading to structural and functional alterations of the heart. Glucagon-like peptide-1 (GLP-1) analogues and sodium-glucose cotransporter-2 (SGLT-2) inhibitors have shown promising results in improving cardiovascular outcomes in diabetes. This article highlights the pathways contributing to DCM and discusses potential future therapies.
Review
Biochemistry & Molecular Biology
Hafiza Padinharayil, Jinsu Varghese, Mithun Chacko John, Golgodu Krishnamurthy Rajanikant, Cornelia M. Wilson, Minnatallah Al-Yozbaki, Kaviyarasi Renu, Saikat Dewanjee, Rupa Sanyal, Abhijit Dey, Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Abilash Valsala Gopalakrishnan, Alex George
Summary: Continuous revision of the histologic and stage-wise classification of lung cancer by the World Health Organization (WHO) supports therapeutic advances and accurate diagnosis. Cancer epidemiologic data provide helpful information for cancer prevention and management. Global cancer mortality projections indicate that cancer will become the leading cause of death, particularly non-small cell lung cancer (NSCLC) which accounts for a significant portion of lung cancers. Early diagnosis and proper management play crucial roles in NSCLC therapies. Advanced techniques, such as immune checkpoint inhibitors (ICIs) and targeted molecular therapies, have improved the treatment of late-stage NSCLC. However, the improvement of cancer biomarkers and the development of prospective studies are needed for better therapeutic outcomes.
Review
Food Science & Technology
Richa Dhakal, Anjum Dihingia, Ruksana Sultana Ahmed, Dipanneeta Das Gupta, Ravi Kumar Sahu, Prachurjya Dutta, Pankaj Bharali, Prasenjit Manna, G. Narahari Sastry, Jatin Kalita
Summary: Amomum subulatum, a widely used herb in traditional medicine, possesses various therapeutic properties such as antioxidant, anti-inflammatory, and anti-nephrotoxic effects. It contains a wide range of secondary metabolites, but further research is needed to understand its molecular mechanisms in cell/animal models and clinical trials.
