Review
Oncology
Enzo M. Scutigliani, Yongxin Liang, Hans Crezee, Roland Kanaar, Przemek M. Krawczyk
Summary: Hyperthermia is a method of exposing tumors to elevated temperatures to enhance the effects of chemotherapy and radiotherapy. However, its efficacy is limited by factors such as heat stress response. Targeting this cellular defense mechanism may improve the effectiveness of hyperthermia-based therapies.
Article
Oncology
Mau-Shin Chi, Der-Chi Tien, Kwan-Hwa Chi
Summary: Combined radiotherapy and mild hyperthermia have been used clinically to improve local control, but long-lasting abscopal effects have not been commonly observed. A proposed hypothesis emphasizes the importance of the dose distribution peak-to-valley ratio within the tumor to induce immunogenic ferrroptosis while avoiding nonimmunogenic ferroptosis. To increase the peak-to-valley ratio, possible implications include using nanoparticles with conventional therapy, high modulation depth hyperthermia, or spatially fractionated radiotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Enzo M. Scutigliani, Yongxin Liang, Marloes IJff, Hans Rodermond, Xionge Mei, Miriam P. Korver, Vaneesha S. Orie, Ron A. Hoebe, Daisy Picavet, Arlene Oei, Roland Kanaar, Przemek M. Krawczyk
Summary: Summary Hyperthermia can improve the effects of radio- and chemotherapy, but its efficacy is limited by the heat stress response (HSR). In this study, we evaluated the HSP90 inhibitor ganetespib in promoting the effects of radiotherapy or cisplatin combined with hyperthermia. Our results showed that ganetespib could enhance the efficacy of hyperthermia when combined with radiation.
Review
Genetics & Heredity
Sivasubramanian Ramani, Sungkwon Park
Summary: Doxorubicin, an anthracycline derivative anti-cancer drug, shows anti-cancer activity but can cause cardiotoxicity, which may be prevented by administering cardioprotectants. Hsp27 has shown potential as a cardioprotectant, but further research, particularly in primary cell lines and animal models, is needed to confirm its efficacy.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Multidisciplinary Sciences
Hiroyuki Omori, Masahiro Otsu, Haruo Nogami, Masayoshi Shibata
Summary: Cells have a regulatory mechanism called heat shock (HS) response, which is sensitive to both exogenous and endogenous factors, leading to both positive and negative effects on cells. The response of neural stem cells to heat shock is unclear, but studies have shown that extending the pre-culture period significantly affects the heat shock response and cell survival.
Article
Neurosciences
Abderrezak Bouchama, Mamoon Rashid, Shuja Shafi Malik, Saeed Al Mahri, Yara Yassin, Mashan Abdullah, Nour Abdulmalek, Fuad Maashi, Abdulaziz Mashi, Altaf Khan, Badriah Alotaibi, Cynthia Lehe, Sameer Mohammad, Haitham Alkadi, Deemah Al Waadani, Saber Yezli
Summary: An evolutionary heat shock response (HSR) protects most living species, including humans, from heat-induced macromolecular damage. However, its role in the pathogenesis of heat stroke is unknown. We examined the whole genome transcriptome in peripheral blood mononuclear cells of subjects who developed heat stroke versus those who did not. The findings reveal the molecular signature of heat stroke and suggest that a powerful HSR may not be sufficient to protect against heat injury.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Physiology
Aaron R. Caldwell, Kentaro Oki, Shauna M. Ward, Jermaine A. Ward, Thomas A. Mayer, Mark L. Plamper, Michelle A. King, Lisa R. Leon
Summary: The study found that mice undergoing repeated exertional heat injuries within a week of an initial heat injury appear to have protective adaptations. During the second exertional heat injury, mice were able to run longer and sustain higher body temperatures before collapse. However, despite this increased resilience to heat, the mice undergoing a second exertional heat injury showed lower levels of corticosterone, FABP2, MIP-1b, MIP-2, and IP-10, indicating potential adaptive processes providing acute heat resilience to subsequent conditions.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Engineering, Environmental
Hao Chen, Binbin Ding, Jia Tan, Pan Zheng, Ziyong Cheng, Ping'an Ma, Jun Lin
Summary: Traditional photothermal therapy is limited by high-temperature tolerance and weak immune responses. This study successfully synthesized PdHs nanoparticles with dendritic urchin structures and demonstrated their potential for photothermal immunotherapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Multidisciplinary Sciences
Tsukumi Miwa, Hideki Taguchi
Summary: Research has shown that IbpA down-regulates the expression of multiple heat shock proteins (Hsps) by repressing the translation of the heat shock transcription factor sigma(32), and plays a crucial role in shutting down the heat shock response. These findings reveal an unknown role of IbpA in regulating the heat shock response at the translational level.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Veterinary Sciences
Samuel A. Atkin, Abu Saleh Md Moin, Stephen L. Atkin, Alexandra E. Butler
Summary: This study investigated the effects of hypoglycemia on the heat shock-related protein pathway. The results showed that hypoglycemia significantly decreased the expression of HSP90, 70, 27, and ubiquitin proteins, which are important for the protective response against heat stress.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Plant Sciences
Quanquan Shen, Qian Chen, Yang Liu, Xiang Xue, Xiaogang Shen, Qiang He, Guokun Wang, Fei Han
Summary: Aspirin can partially alleviate vascular smooth muscle cell (VSMC) calcification by regulating the expression of heat shock protein 70 (HSP70) and heat shock protein 90 (HSP90). Blocking HSP70 or HSP90 inhibitors can partially weaken the anti-calcification effect of aspirin.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lingtian Wang, Ping Hu, Han Jiang, Jinhui Zhao, Jin Tang, Dajun Jiang, Jiaxing Wang, Jianlin Shi, Weitao Jia
Summary: This study applied mild magnetic hyperthermia therapy to improve the healing of bone defects. The use of core-shell structured magnetic iron oxide nanoparticles in a hydrogel composite promoted osteogenesis and angiogenesis, demonstrating great potential for clinical applications.
Review
Plant Sciences
Yunzhuan Zhou, Fuxiang Xu, Yanan Shao, Junna He
Summary: As global warming intensifies, the earth's average temperature continues to rise. Plants have developed two main mechanisms, the heat stress response and the thermomorphogenesis response, to cope with elevated temperatures. This review summarizes recent progress in understanding these heat-responsive molecular regulatory pathways in plants and discusses future perspectives in this field.
Review
Microbiology
Seongjoon Moon, Soojeong Ham, Juwon Jeong, Heechan Ku, Hyunhee Kim, Changhan Lee
Summary: Temperature is critical for the survival of all living organisms. Bacteria, being unicellular organisms, have evolved sensitive mechanisms to sense and defend against temperature changes. This review focuses on the molecular perspective of cellular changes and bacterial responses, particularly in Escherichia coli, when subjected to temperature shifts.
JOURNAL OF MICROBIOLOGY
(2023)
Article
Environmental Sciences
Shao-Shuai Bi, Milton Talukder, Xue-Tong Sun, Mei-Wei Lv, Jing Ge, Cong Zhang, Jin-Long Li
Summary: This study assessed the neurotoxic effects of chronic cadmium (Cd) exposure on the chicken cerebellum and investigated the expression of genes related to the heat-shock response. The results showed that Cd exposure led to clinical symptoms of ataxia in the chickens, decreased the number of Purkinje cells, and induced degeneration of Purkinje cells. Cd exposure also affected the expression of heat-shock factors and proteins. These findings shed light on the toxic effects of Cd on the cerebellum and provide evidence for the health risks posed by Cd exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Oncology
Anne Ernst, Heike Anders, Heidi Kapfhammer, Michael Orth, Roman Hennel, Karin Seidl, Nicolas Winssinger, Claus Belka, Steffen Unkel, Kirsten Lauber
Article
Oncology
Linda Kinzel, Anne Ernst, Michael Orth, Valerie Albrecht, Roman Hennel, Nikko Brix, Benjamin Frey, Udo S. Gaipl, Gabriele Zuchtriegel, Christoph A. Reichel, Andreas Blutke, Daniela Schilling, Gabriele Multhoff, Minglun Li, Maximilian Niyazi, Anna A. Friedl, Nicolas Winssinger, Claus Belka, Kirsten Lauber
Article
Immunology
R. Wunderlich, A. Ernst, F. Roedel, R. Fietkau, O. Ott, K. Lauber, B. Frey, U. S. Gaipl
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2015)
Article
Immunology
Matthias Rosenwald, Uwe Koppe, Hildegard Keppeler, Guido Sauer, Roman Hennel, Anne Ernst, Karin Erika Blume, Christoph Peter, Martin Herrmann, Claus Belka, Klaus Schulze-Osthoff, Sebastian Wesselborg, Kirsten Lauber
JOURNAL OF IMMUNOLOGY
(2012)
Review
Biology
Michael Orth, Kirsten Lauber, Maximilian Niyazi, Anna A. Friedl, Minglun Li, Cornelius Maihoefer, Lars Schuettrumpf, Anne Ernst, Olivier M. Niemoeller, Claus Belka
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2014)
Article
Oncology
Roman Hennel, Nikko Brix, Karin Seidl, Anne Ernst, Heike Scheithauer, Claus Belka, Kirsten Lauber
RADIATION ONCOLOGY
(2014)
Review
Oncology
Kirsten Lauber, Anne Ernst, Michael Orth, Martin Herrmann, Claus Belka
FRONTIERS IN ONCOLOGY
(2012)
Article
Oncology
Julia Krombach, Roman Hennel, Nikko Brix, Michael Orth, Ulrike Schoetz, Anne Ernst, Jessica Schuster, Gabriele Zuchtriegel, Christoph A. Reichel, Susanne Bierschenk, Markus Sperandio, Thomas Vogl, Steffen Unkel, Claus Belka, Kirsten Lauber
Article
Oncology
Yiren Xiao, Hongjuan Zhao, Lei Tian, Rosalie Nolley, Anh N. Diep, Anne Ernst, Katherine C. Fuh, Yu Rebecca Miao, Rie von Eyben, John T. Leppert, James D. Brooks, Donna M. Peehl, Amato J. Giaccia, Erinn B. Rankin
Article
Oncology
Anne Ernst, Roman Hennel, Julia Krombach, Heidi Kapfhammer, Nikko Brix, Gabriele Zuchtriegel, Bernd Uhl, Christoph A. Reichel, Benjamin Frey, Udo S. Gaipl, Nicolas Winssinger, Senji Shirasawa, Takehiko Sasazuki, Markus Sperandio, Claus Belka, Kirsten Lauber
FRONTIERS IN ONCOLOGY
(2020)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.