MELK: a potential novel therapeutic target for TNBC and other aggressive malignancies
出版年份 2017 全文链接
标题
MELK: a potential novel therapeutic target for TNBC and other aggressive malignancies
作者
关键词
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出版物
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 21, Issue 9, Pages 849-859
出版商
Informa UK Limited
发表日期
2017-08-02
DOI
10.1080/14728222.2017.1363183
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Development of small molecular compounds targeting cancer stem cells
- (2017) Jae-Hyun Park et al. MedChemComm
- CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials
- (2017) Ann Lin et al. eLife
- Coordinate Activation of Redox-Dependent ASK1/TGF-β Signaling by a Multiprotein Complex (MPK38, ASK1, SMADs, ZPR9, and TRX) Improves Glucose and Lipid Metabolism in Mice
- (2016) Hyun-A Seong et al. ANTIOXIDANTS & REDOX SIGNALING
- Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight
- (2016) B. Barry Touré et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival
- (2016) Yubao Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stathmin involvement in the maternal embryonic leucine zipper kinase pathway in glioblastoma
- (2016) Suely Kazue Nagahashi Marie et al. Proteome Science
- Effective growth-suppressive activity of maternal embryonic leucine-zipper kinase (MELK) inhibitor against small cell lung cancer
- (2016) Hiroyuki Inoue et al. Oncotarget
- Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor
- (2016) Suyoun Chung et al. Oncotarget
- OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases
- (2016) Wenbin Ji et al. PLoS One
- CCR 20th Anniversary Commentary: Gene-Expression Signature in Breast Cancer--Where Did It Start and Where Are We Now?
- (2015) I. Gingras et al. CLINICAL CANCER RESEARCH
- Triple-negative breast cancer: new perspectives for targeted therapies
- (2015) Silverio Tomao et al. OncoTargets and Therapy
- Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in gastric cancer
- (2015) Shen Li et al. Oncotarget
- Is the future of personalized therapy in triple-negative breast cancer based on molecular subtype?
- (2015) Fanny Le Du et al. Oncotarget
- Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer
- (2015) Suyoun Chung et al. Oncotarget
- Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia
- (2015) Houda Alachkar et al. Oncotarget
- Copy number alterations and neoplasia-specific mutations inMELK,PDCD1LG2, TLN1, andPAX5at 9p in different neoplasias
- (2014) Virinder Kaur Sarhadi et al. GENES CHROMOSOMES & CANCER
- Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β–dependent cancer metastasis
- (2014) Jianfei Xue et al. JOURNAL OF CLINICAL INVESTIGATION
- Molecular mechanisms of epithelial–mesenchymal transition
- (2014) Samy Lamouille et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Multi-Kinase Inhibitor C1 Triggers Mitotic Catastrophe of Glioma Stem Cells Mainly through MELK Kinase Inhibition
- (2014) Mutsuko Minata et al. PLoS One
- Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase
- (2014) Christopher N. Johnson et al. ACS Medicinal Chemistry Letters
- MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells
- (2014) Yubao Wang et al. eLife
- The structures of the kinase domain and UBA domain of MPK38 suggest the activation mechanism for kinase activity
- (2014) Yong-Soon Cho et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Structural Insight into Maternal Embryonic Leucine Zipper Kinase (MELK) Conformation and Inhibition toward Structure-Based Drug Design
- (2013) Giulia Canevari et al. BIOCHEMISTRY
- Thioredoxin inhibits MPK38-induced ASK1, TGF‐β, and p53 function in a phosphorylation-dependent manner
- (2013) Ravi Manoharan et al. FREE RADICAL BIOLOGY AND MEDICINE
- Structural Basis for the Regulation of Maternal Embryonic Leucine Zipper Kinase
- (2013) Lu-Sha Cao et al. PLoS One
- MELK-Dependent FOXM1 Phosphorylation is Essential for Proliferation of Glioma Stem Cells
- (2013) Kaushal Joshi et al. STEM CELLS
- Tumor-Specific Activation of the C-JUN/MELK Pathway Regulates Glioma Stem Cell Growth in a p53-Dependent Manner
- (2013) Chunyu Gu et al. STEM CELLS
- Cell-cycle dependent localization of MELK and its new partner RACK1 in epithelial versus mesenchyme-like cells in Xenopus embryo
- (2013) I. Chartrain et al. Biology Open
- Optimal strategies for the treatment of metastatic triple-negative breast cancer with currently approved agents
- (2012) F. Andre et al. ANNALS OF ONCOLOGY
- FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair
- (2012) Yun-Yong Park et al. CARCINOGENESIS
- PDK1 Protein Phosphorylation at Thr354by Murine Protein Serine-Threonine Kinase 38 Contributes to Negative Regulation of PDK1 Protein Activity
- (2012) Hyun-A Seong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer
- (2012) Ruprecht Kuner et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression
- (2011) Seungho Choi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Candidate tumour suppressor Fau regulates apoptosis in human cells: An essential role for Bcl-G
- (2011) Mark R. Pickard et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Serine/threonine kinase, Melk, regulates proliferation and glial differentiation of retinal progenitor cells
- (2011) Rika Saito et al. CANCER SCIENCE
- Positive Regulation of Apoptosis Signal-regulating Kinase 1 Signaling by ZPR9 Protein, a Zinc Finger Protein
- (2011) Hyun-A Seong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A functional analysis of MELK in cell division reveals a transition in the mode of cytokinesis during Xenopus development
- (2011) Y. Le Page et al. JOURNAL OF CELL SCIENCE
- Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
- (2011) Brian D. Lehmann et al. JOURNAL OF CLINICAL INVESTIGATION
- Maternal Embryonic Leucine Zipper Kinase Is Upregulated and Required in Mammary Tumor-Initiating Cells In vivo
- (2010) L. W. Hebbard et al. CANCER RESEARCH
- Prognostic and Therapeutic Implications of Distinct Kinase Expression Patterns in Different Subtypes of Breast Cancer
- (2010) G. Bianchini et al. CANCER RESEARCH
- Kinase Associated-1 Domains Drive MARK/PAR1 Kinases to Membrane Targets by Binding Acidic Phospholipids
- (2010) Katarina Moravcevic et al. CELL
- Murine Protein Serine/Threonine Kinase 38 Stimulates TGF-β Signaling in a Kinase-dependent Manner via Direct Phosphorylation of Smad Proteins
- (2010) Hyun-A Seong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Triple-Negative Breast Cancer
- (2010) William D. Foulkes et al. NEW ENGLAND JOURNAL OF MEDICINE
- FoxM1, a Forkhead Transcription Factor Is a Master Cell Cycle Regulator for Mouse Mature T Cells but Not Double Positive Thymocytes
- (2010) Ling Xue et al. PLoS One
- The regulation and function of mammalian AMPK-related kinases
- (2009) N. J. Bright et al. Acta Physiologica
- TGF-β-induced epithelial to mesenchymal transition
- (2009) Jian Xu et al. CELL RESEARCH
- Biology, Metastatic Patterns, and Treatment of Patients with Triple-Negative Breast Cancer
- (2009) Carey K. Anders et al. Clinical Breast Cancer
- Identification of Novel Kinase Targets for the Treatment of Estrogen Receptor-Negative Breast Cancer
- (2009) C. Speers et al. CLINICAL CANCER RESEARCH
- Reciprocal Negative Regulation of PDK1 and ASK1 Signaling by Direct Interaction and Phosphorylation
- (2009) Hyun-A Seong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sixteen-Kinase Gene Expression Identifies Luminal Breast Cancers with Poor Prognosis
- (2008) P. Finetti et al. CANCER RESEARCH
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- Murine Protein Serine/Threonine Kinase 38 Activates Apoptosis Signal-regulating Kinase 1 via Thr838Phosphorylation
- (2008) Haiyoung Jung et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Response to Neoadjuvant Therapy and Long-Term Survival in Patients With Triple-Negative Breast Cancer
- (2008) Cornelia Liedtke et al. JOURNAL OF CLINICAL ONCOLOGY
- Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells
- (2007) Ichiro Nakano et al. JOURNAL OF NEUROSCIENCE RESEARCH
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