Reaction phenotyping to assess victim drug-drug interaction risks

Utilization of Liver Microsomes to Estimate Hepatic Intrinsic Clearance of Monoamine Oxidase Substrate Drugs in Humans

(2017) Yusuke Masuo et al.   PHARMACEUTICAL RESEARCH

Impact of Probe Substrate Selection on Cytochrome P450 Reaction Phenotyping Using the Relative Activity Factor

(2016) Y. Amy Siu et al.   DRUG METABOLISM AND DISPOSITION

Regulatory aspects of human radiolabeled mass balance studies in oncology: concise review

(2016) C. M. Nijenhuis et al.   DRUG METABOLISM REVIEWS

CYP2C9 Genotype-Dependent Warfarin Pharmacokinetics: Impact of CYP2C9 Genotype on R- and S-Warfarin and Their Oxidative Metabolites

(2016) Darcy R. Flora et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Addressing the Challenges of Low Clearance in Drug Research

(2015) Li Di et al.   AAPS Journal

The effects of ketoconazole and rifampin on the single-dose pharmacokinetics of crizotinib in healthy subjects

(2015) Huiping Xu et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

(2015) Michael A. Brodney et al.   JOURNAL OF MEDICINAL CHEMISTRY

Application of 14C-Accelerator MS in pharmaceutical development

(2015) Graeme C Young et al.   Bioanalysis

The effect of pathophysiology on pharmacokinetics in the critically ill patient — Concepts appraised by the example of antimicrobial agents

(2014) Stijn I. Blot et al.   ADVANCED DRUG DELIVERY REVIEWS

Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device

(2014) Aurelie Vivares et al.   XENOBIOTICA

Metabolism, excretion and pharmacokinetics of [14C]crizotinib following oral administration to healthy subjects

(2014) Theodore R. Johnson et al.   XENOBIOTICA

Contribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: risk assessment of acylglucuronides using human hepatocytes

(2014) Norimasa Jinno et al.   XENOBIOTICA

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Using human recombinant UDP-glucuronosyltransferase isoforms and a relative activity factor approach to model total body clearance of laropiprant (MK-0524) in humans

(2013) Christopher R. Gibson et al.   XENOBIOTICA

Clinically Relevant Genetic Variations in Drug Metabolizing Enzymes

(2011) Navin Pinto et al.   CURRENT DRUG METABOLISM

Substrate inhibition kinetics in drug metabolism reactions

(2011) Baojian Wu   DRUG METABOLISM REVIEWS

Utility of Intersystem Extrapolation Factors in Early Reaction Phenotyping and the Quantitative Extrapolation of Human Liver Microsomal Intrinsic Clearance Using Recombinant Cytochromes P450

(2010) Y. Chen et al.   DRUG METABOLISM AND DISPOSITION

Characterization of Human Liver Enzymes Involved in the Biotransformation of Boceprevir, a Hepatitis C Virus Protease Inhibitor

(2010) A. Ghosal et al.   DRUG METABOLISM AND DISPOSITION

N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275

(2009) Michael Siu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Impact of Infectious and Inflammatory Disease on Cytochrome P450–Mediated Drug Metabolism and Pharmacokinetics

(2009) ET Morgan   CLINICAL PHARMACOLOGY & THERAPEUTICS

Comparison of Different Algorithms for Predicting Clinical Drug-Drug Interactions, Based on the Use of CYP3A4 in Vitro Data: Predictions of Compounds as Precipitants of Interaction

(2009) O. A. Fahmi et al.   DRUG METABOLISM AND DISPOSITION

Gender and interindividual variability in pharmacokinetics

(2009) Jean-Marie Nicolas et al.   DRUG METABOLISM REVIEWS

Application of CYP3A4 in vitro data to predict clinical drug–drug interactions; predictions of compounds as objects of interaction

(2008) Kuresh A. Youdim et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Modeling, Prediction, and in Vitro in Vivo Correlation of CYP3A4 Induction

(2008) M. Shou et al.   DRUG METABOLISM AND DISPOSITION

Enzyme Kinetics of Cytochrome P450-Mediated Reactions

(2005) Magang Shou et al.   CURRENT DRUG METABOLISM