Review
Biochemistry & Molecular Biology
Anastasia Kariagina, Andrea I. Doseff
Summary: Flavones, natural phytochemicals found in our diet, possess anti-inflammatory properties that can effectively control the innate immune system and inflammation. They play a significant role in chronic inflammation, particularly in obesity and cancer, by influencing molecular mechanisms. Flavones restore immune landscape by impacting innate immune cell repertoire and reestablish immune homeostasis through NF-kappa B, STAT, COX-2, or NLRP3 inflammasome pathways. With no adverse side effects, flavones could be alternative opportunities for treating and preventing chronic inflammation associated with obesity and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Huan Xia, Yitong Liu, Guiyang Xia, Yi Liu, Sheng Lin, Lijia Guo
Summary: The study identified a novel isoquinoline alkaloid LA from Litsea cubeba, which significantly inhibited the activation of inflammatory macrophages by modulating the NF-kappa B pathway. LA showed high selectivity and effective anti-inflammatory properties, making it a potential pharmacophore for developing novel agents to regulate local macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Meiling Fan, Mengyao Shan, Xintian Lan, Xiaoxue Fang, Dimeng Song, Haoming Luo, Donglu Wu
Summary: This review summarizes the therapeutic effects and molecular mechanisms of ginsenosides in the treatment of breast cancer (BC). It also discusses the combination strategy of ginsenosides with other drugs for BC. Furthermore, it elucidates the role of ginsenosides in breast cancer treatment through epigenetic changes, particularly in microRNAs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pawel Bryniarski, Katarzyna Nazimek, Janusz Marcinkiewicz
Summary: Research shows that the combined use of diuretics with or without captopril affects the function of macrophages, modulating humoral immunity and potentially providing important insights for assessing the safety of antihypertensive therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Qingxuan Zeng, Hongbin Deng, Yinghong Li, Tianyun Fan, Yang Liu, Sheng Tang, Wei Wei, Xiaojia Liu, Xixi Guo, Jiandong Jiang, Yanxiang Wang, Danqing Song
Summary: Berberine directly targets the NEK7 protein via hydrogen bonding, inhibiting the NEK7-NLRP3 interaction and subsequent IL-1 beta release. NEK7 is considered a key target of BBR in the treatment of NLRP3-related inflammatory diseases, and the development of novel inhibitors targeting the NEK7-NLRP3 interaction may be achievable.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Quan-He Jin, Hyung-Keun Kim, Ju-Yong Na, Cheng Jin, Jong-Keun Seon
Summary: This study aims to investigate the anti-inflammatory effects of mesenchymal stem cells (MSCs) on macrophages and finds that the effect can be improved by interleukin (IL) 4 stimulation.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Giorgio Caratti, Ulrich Stifel, Bozhena Caratti, Ali J. M. Jamil, Kyoung-Jin Chung, Michael Kiehntopf, Markus H. H. Graeler, Matthias Blueher, Alexander Rauch, Jan P. P. Tuckermann
Summary: This study found that anti-inflammatory glucocorticoids can improve obesity-induced insulin resistance by regulating adipose tissue macrophages. Deletion of the glucocorticoid receptor in macrophages aggravates obesity-related insulin resistance, leading to increased adipose tissue inflammation, enhanced lipolysis, and severe hepatic steatosis. This suggests that glucocorticoids play an important role in macrophages by limiting adipose tissue inflammation and lipolysis to promote insulin sensitivity.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Lucas C. Wheeler, Joseph F. Walker, Julienne Ng, Rocio Deanna, Amy Dunbar-Wallis, Alice Backes, Pedro H. Pezzi, M. Virginia Palchetti, Holly M. Robertson, Andrew Monaghan, Loreta Brandao de Freitas, Gloria E. Barboza, Edwige Moyroud, Stacey D. Smith
Summary: The relationship between gene function and substitution rates is crucial for understanding molecular evolution. Our study on the flavonoid pigment pathway in the Petunieae clade of the Solanaceae family reveals that transcription factors evolve faster, with MYB genes exhibiting the highest evolutionary rates. Despite weak correlations with changes in coding regions, there is a strong relationship between floral pigmentation shifts and the presence/absence patterns of MYB transcripts.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Plant Sciences
Hassan Y. Ebrahim, Mohamed S. Mady, Hanaa B. Atya, Sahar A. Ali, Heba E. Elsayed, Fatma A. Moharram
Summary: This study investigated the metabolic profile of polyphenols in Melaleuca rugulosa, a species of the tea tree, and examined its anti-inflammatory, free radical scavenging, and anti-aging activities. The results showed that these polyphenols have the potential to treat conditions related to free radicals, inflammation, and skin aging.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Christian D. Ortiz-Robles, Vanessa Cortes-Montoya, Sandra S. Reyes-Aguilar, Arnulfo Albores, Emma S. Calderon-Aranda
Summary: Lead exposure alters functional outcomes and phenotypic markers of macrophages, especially the anti-inflammatory phenotype, with effects on specific pathways differing between inflammatory and anti-inflammatory cells.
Article
Chemistry, Medicinal
Yaoyao Yan, Chen Xing, Yun Xiao, Xiaobao Shen, Zhaoyan Zhang, Chuanbiao He, Jing-Bo Shi, Mingming Liu, Xinhua Liu
Summary: This study describes the complete discovery process of a novel CDK8 inhibitor as an anti-inflammatory agent. The inhibitor was able to upregulate IL-10 levels and exhibit effective anti-inflammatory activity in an animal model of IBD.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Muhammad Alamzeb, William N. Setzer, Saqib Ali, Behramand Khan, Mamoon-Ur-Rashid, Ihsanullah, Syed Muhammad Salman, Adnan, Muhammad Omer, Javed Ali, Asad Ullah
Summary: The study found that chondrofolinol possesses anti-inflammatory, anti-pyretic, and anti-leishmanial properties with minimal cytotoxicity against THP-1 monocytic cells. Further research is needed to explore their therapeutic potential.
FRONTIERS IN CHEMISTRY
(2021)
Article
Medicine, General & Internal
Melanie Uebelhoer, Cecile Lambert, Juliane Grisart, Kilian Guse, Stanislav Plutizki, Yves Henrotin
Summary: This manuscript provides a review of gene therapies for osteoarthritis, highlighting the potential of gene therapy as a promising treatment for the disease. However, further research and development are needed to bring more gene therapy targets to the clinical stage.
FRONTIERS IN MEDICINE
(2023)
Review
Immunology
Desheng Tang, Feng Cao, Changsheng Yan, Kun Fang, Jiamin Ma, Lei Gao, Bei Sun, Gang Wang
Summary: Extracellular vesicles can regulate the polarization of macrophages, influencing the development of inflammatory diseases. In some diseases, extracellular vesicles induce proinflammatory polarization of macrophages, promoting disease progression. In other diseases, extracellular vesicles induce anti-inflammatory polarization of macrophages, reducing disease severity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Nimsi Campos-Xolalpa, Ana Laura Esquivel-Campos, Rubria Marlen Martinez-Casares, Salud Perez-Gutierrez, Julia Perez-Ramos, Ernesto Sanchez-Mendoza
Summary: The study found that piquerol isolated from Piqueria trinervia has anti-inflammatory activity, can reduce ear edema and act by inhibiting pro-inflammatory mediators. Piquerol also has a protective effect on erythrocyte membrane.
Article
Biochemistry & Molecular Biology
Lucia Yepes-Molina, Maria Isabel Perez-Jimenez, Maria Martinez-Esparza, Jose A. Teruel, Antonio J. Ruiz-Alcaraz, Pilar Garcia-Penarrubia, Micaela Carvajal
Summary: There is a growing interest in finding new non-toxic anti-inflammatory drugs, and this study investigates the potential of sulforaphane, a compound derived from Brassica plants, loaded into membrane vesicles from broccoli plants. The results show that the sulforaphane-loaded vesicles exhibit anti-inflammatory properties and the vesicles themselves also have anti-inflammatory effects, indicating potential for further research and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alexandre Mery, Samir Jawhara, Nadine Francois, Marjorie Cornu, Julien Poissy, Maria Martinez-Esparza, Daniel Poulain, Boualem Sendid, Yann Guerardel
Summary: Early diagnosis of invasive candidiasis (IC) is crucial for patient survival. The current gold standard diagnostic test has limitations such as low positivity rate and delayed results. However, mass spectrometry-based detection of circulating glycans provides a reliable and cost-effective early diagnostic method. Furthermore, high resolution mass spectrometry improves the performance of IC diagnosis.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Medicine, Research & Experimental
Antonio Jose Ruiz-Alcaraz, Maria Antonia Martinez-Sanchez, Pilar Garcia-Penarrubia, Maria Martinez-Esparza, Bruno Ramos-Molina, Diego A. Moreno
Summary: The study found that phytochemicals from Brassica plants have significant anti-inflammatory activity in a human macrophage-like cell model, offering potential as therapeutic leads for treating or preventing human chronic inflammation and related diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Surgery
Jose Ignacio Martinez-Montoro, Maria Antonia Martinez-Sanchez, Andres Balaguer-Roman, Jose Gil-Martinez, Maria Jose Mesa-Lopez, Juan Egea-Valenzuela, Antonio Jose Ruiz-Alcaraz, Maria Isabel Queipo-Ortuno, Mercedes Ferrer, Jose Carlos Fernandez-Garcia, Bruno Ramos-Molina
Summary: This article reviews the role of the gut microbiota in complications of colorectal cancer surgery and explores the potential therapeutic modulation of the gut microbiome through nutritional intervention in patients with colorectal cancer undergoing surgery.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Maria Antonia Martinez-Sanchez, Maria Angeles Nunez-Sanchez, Andres Balaguer-Roman, Alba Oliva-Bolarin, Gabriel Pujante-Gilabert, Quiteria Hernandez-Aguera, Maria Jose Mesa-Lopez, Juan Egea-Valenzuela, Maria Isabel Queipo-Ortuno, Antonio Jose Ruiz-Alcaraz, Mercedes Ferrer-Gomez, Jose Gil-Martinez, Bruno Ramos-Molina
Summary: This study aims to evaluate the impact of a high-fiber diet intervention on the gut microbiota of CRC patients and its effect on reducing post-surgical complications. The results of this study will provide guidance for preoperative nutritional management in CRC patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Tamara Ramirez-Pavez, Andrea Garcia-Penaranda, Paula Garcia-Ibanez, Lucia Yepes-Molina, Micaela Carvajal, Antonio J. Ruiz-Alcaraz, Diego A. Moreno, Pilar Garcia-Penarrubia, Maria Martinez-Esparza
Summary: The study shows that broccoli compounds can reduce the activity of human macrophages and modulate cytokine production, potentially having opposite effects on different diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Noelia Maldonado-Perez, Maria Tristan-Manzano, Pedro Justicia-Lirio, Elena Martinez-Planes, Pilar Munoz, Kristina Pavlovic, Marina Cortijo-Gutierrez, Carlos Blanco-Benitez, Maria Castella, Manel Juan, Mathias Wenes, Pedro Romero, Francisco J. Molina-Estevez, Concepcion Maranon, Concha Herrera, Karim Benabdellah, Francisco Martin
Summary: This study investigated the safety and efficacy of knocking out the TCR gene in ARI-0001 CAR-T cells using CRISPR/Cas9. The results showed that TCR disruption efficiently prevented allogeneic responses without altering T cell phenotype and maintained a similar anti-tumor activity compared to unedited CAR-T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Angeles Nunez-Sanchez, Maria Antonia Martinez-Sanchez, Marina Verdejo-Sanchez, Paula Garcia-Ibanez, Alba Oliva Bolarin, Bruno Ramos-Molina, Diego A. Moreno, Antonio J. Ruiz-Alcaraz
Summary: This study analyzed the anti-leukemic activity of various phytochemicals from cruciferous foods. The results showed that sulforaphane, chlorogenic acid, and cyanidin-3-glucoside exhibited potential as anti-leukemic agents, specifically targeting AML cells. Additionally, these compounds activated the NRF2/KEAP1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Paula Garcia-Ibanez, Maria A. Nunez-Sanchez, Alba Oliva-Bolarin, Maria A. Martinez-Sanchez, Bruno Ramos-Molina, Antonio J. Ruiz-Alcaraz, Diego A. Moreno
Summary: Digestates from red cabbage sprouts and red radish sprouts, which are derived from cruciferous vegetables, have anti-inflammatory effects and could be used as dietary coadjuvants in the treatment of chronic inflammation. These findings were observed in an in vitro model, where the bioaccessible compounds from the sprouts significantly decreased the production of pro-inflammatory cytokines in stimulated cells.
Article
Pharmacology & Pharmacy
Antonio Jose Ruiz-Alcaraz, Maria Angeles Nunez-Sanchez, Maria Alejandra Asensio Ruiz, Maria Antonia Martinez-Sanchez, Alba Oliva-Bolarin, Teresa Martinez Martinez, Jose Julian Perez Cuadrado, Bruno Ramos-Molina, Antonio Abel Lozano-Perez
Summary: Silk fibroin nanoparticles (SFN) have excellent physicochemical characteristics and can enhance the antioxidant and anti-inflammatory effects of polyphenols in macrophages. In this study, we developed a reproducible and scalable method for the production of SFN using direct precipitation of non-dialyzed silk fibroin solutions. We also improved the loading efficiency of natural polyphenols in SFN using propylene glycol as a solvent. The loaded nanoparticles were fully characterized and demonstrated significant anti-inflammatory effects in human macrophage cells.
Article
Genetics & Heredity
Ma Luz Munoz-Megias, Ruth Sanchez-Fresneda, Francisco Solano, Sergi Maicas, Maria Martinez-Esparza, Juan-Carlos Arguelles
Summary: Disrupting the genes encoding trehalase activity in Candida parapsilosis increases susceptibility to Itraconazole. The fungicidal effect of Itraconazole can be counteracted by preincubating cells with rotenone and 2,4-Dinitrophenol. Itraconazole induces oxidative stress, which can be reduced in rotenone-treated cells. This study suggests that mitochondrial activity plays a role in the antifungal action of Itraconazole and highlights central metabolic pathways as potential antifungal targets.
Editorial Material
Obstetrics & Gynecology
Tamara N. Ramirez-Pavez, Francisco Machado-Linde, Pilar Garcia-Penarrubia, Lucia Nieto-Meca, Maria Martinez-Esparza, Pilar Marin-Sanchez
Summary: A standardized protocol for collecting peritoneal free fluid and leukocyte samples in women with endometriosis for biomedical research is proposed. The study found that the presence of free peritoneal fluid was scarce and not significantly related to hormonal treatment. The collected samples had high cell viability, but a certain proportion were contaminated with blood or had low cellularity. The number of leukocytes and macrophages recovered from peritoneal lavages was correlated with lavage volume, body mass index, and independent of patient age.
FERTILITY AND STERILITY
(2023)
Review
Nutrition & Dietetics
Julia Nino-Narvion, Marina Idalia Rojo-Lopez, Patricia Martinez-Santos, Joana Rossell, Antonio J. Ruiz-Alcaraz, Nuria Alonso, Bruno Ramos-Molina, Didac Mauricio, Josep Julve
Summary: NAD+ is crucial for cellular metabolism and plays a critical role in maintaining the integrity of the gut barrier. Its deficiency is associated with gut inflammation, leakage, and dysbiosis. NAD+-increasing therapies may protect against intestinal inflammation, potentially by modulating the composition of the intestinal microbiota. However, the mechanisms underlying these effects are not well understood.
Article
Pharmacology & Pharmacy
Xuezhi Zhuo, Vito Fodera, Per Larsson, Zarah Schaal, Christel A. S. Bergstrom, Korbinian Lobmann, Aleksei Kabedev
Summary: Our previous work demonstrated that beta-lactoglobulin-stabilized amorphous solid dispersion (ASD) loaded with 70 % indomethacin remains stable for over 12 months. We further investigated the stabilization mechanisms by testing five other drug molecules and using experimental techniques and molecular dynamics simulations. The results showed that steric confinement, hydrogen bonding, and the glass transition temperature of the drug molecule play important roles in stabilizing ASDs with high drug loadings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Sebastian Schmidt, Ulrike Holzgrabe
Summary: The binding of drugs to plasma proteins, such as human serum albumin (HSA), is crucial for determining pharmacokinetic parameters. This study investigated the enantioselective binding of S- and R-ketamine to HSA. It was found that ketamine has weak affinity to HSA, with no significant differences in binding behavior between the individual enantiomers and the racemate. The aromatic ring and N-methyl group were identified as the most strongly involved structural moieties in the binding of ketamine to HSA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Yuchen Zhao, Han Wang, Lin Jin, Ziwei Zhang, Lianghu Liu, Mengqi Zhou, Xianzheng Zhang, Lingling Zhang
Summary: Interleukins (ILs) are important for communication between immune cells and non-immune cells, but dysregulation of ILs expression is a characteristic of autoinflammatory diseases. Drugs targeting ILs have significant clinical benefits, but may also cause adverse reactions. Fusion protein technology, with its ability to enhance therapeutic efficacy, has been explored for developing anti-inflammatory drugs. This review discusses the efficacy of fusion protein drugs developed with ILs or their receptors in treating autoinflammatory diseases, highlighting the potential of this technology in future anti-inflammatory drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Serena Bertoni, Elena Simone, Stefano Sangiorgi, Beatrice Albertini, Nadia Passerini
Summary: This study investigated the correlation between the structure and release properties of solid lipid microparticles (MPs) with different liquid additives. The additives accelerated the conversion of the unstable alpha-form of tristearin to the stable beta-polymorph and caused structural modifications in the MPs. The presence of additives prolonged the drug release in water and resulted in higher release profiles in biorelevant media. The findings suggest that the release behavior can be influenced by the polymorphism and supramolecular-level structural modification of lipid formulations containing crystal modifiers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Juulia Jarvinen, Ahmed B. Montaser, Santosh Kumar Adla, Jukka Leppanen, Marko Lehtonen, Kati-Sisko Vellonen, Tuomo Laitinen, Aaro Jalkanen, William F. Elmquist, Juri Timonen, Kristiina M. Huttunen, Jarkko Rautio
Summary: This study attempted to alter the brain distribution pattern of Palbociclib by creating and assessing two novel prodrugs. Although the prodrug design did not significantly improve Palbociclib brain delivery, the study provides valuable insights for future prodrug development and drug delivery strategies targeting specific transporters.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Review
Pharmacology & Pharmacy
Miao Wang, Xinyu Ma, Shiyu Zong, Yaqiong Su, Rui Su, Hong Zhang, Yang Liu, Chunliu Wang, Ye Li
Summary: This article discusses the potential and limitations of nasal administration in central nervous system drug delivery. Nasal gel viscosity can alleviate the impact of nasal mucociliary clearance on drug delivery, and materials such as gellan gum, chitosan, carbomer, cellulose, and poloxamer can be used to prepare nasal gels.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Bjarke Strom Larsen, Eric Kissi, Liebert Parreiras Nogueira, Natalja Genina, Ingunn Tho
Summary: This study investigates the influence of drug load and polymer molecular weight on the structure of 3D printed tablets. The results show that drug load and polymer molecular weight have a significant impact on the porosity and size of the tablets, while the effect of drug load on the total porosity of the tablets is minimal.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Zhentao Qiao, Fuhang Wang, Dongjian Han, Yuansong Zhuang, Qingjiao Jiang, Yi Zhang, Miaomiao Liu, Quanxu An, Zhiwei Wang, Deliang Shen
Summary: In this study, it was demonstrated that periadventitial delivery of rapamycin-fibrin glue (RPM-FG) can inhibit intimal hyperplasia (IH) in a rat carotid artery injury model without compromising re-endothelialization. This provides a promising direction for the future development of a safe, effective, and minimally invasive perivascular drug delivery method to treat vascular disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Neele Puhlmann, Rodrigo Vidaurre, Klaus Kuemmerer
Summary: Active pharmaceutical ingredients and their metabolites and transformation products are pollutants that can harm human and environmental health. Designing greener APIs is an effective strategy to address this issue. The drug discovery and development process can incorporate environmental parameters to achieve this design, and this process is highly flexible.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)