Design of Radioiodinated Pharmaceuticals: Structural Features Affecting Metabolic Stability towards in Vivo Deiodination

Bial incident raises FAAH suspicions

(2016) Eva von Schaper   NATURE BIOTECHNOLOGY

Synthesis of radioiodinated probes to evaluate the biodistribution of a potent TRPC3 inhibitor

(2016) Masayori Hagimori et al.   MedChemComm

Prediction of cytochrome P450 mediated metabolism

(2015) Lars Olsen et al.   ADVANCED DRUG DELIVERY REVIEWS

Predicting drug metabolism: experiment and/or computation?

(2015) Johannes Kirchmair et al.   NATURE REVIEWS DRUG DISCOVERY

Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents

(2014) Maria V. Papadopoulou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dynamic PET and SPECT imaging with radioiodinated, amyloid-reactive peptide p5 in mice: A positive role for peptide dehalogenation

(2014) Emily B. Martin et al.   PEPTIDES

The strength and directionality of a halogen bond are co-determined by the magnitude and size of the σ-hole

(2014) Michal Kolář et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism

(2014) U. Schweizer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis and evaluation of radioiodinated phenoxyquinazoline and benzylaminoquinazoline derivatives as new EGF receptor tyrosine kinase imaging ligands for tumor diagnosis using SPECT

(2012) Masahiko Hirata et al.   ANNALS OF NUCLEAR MEDICINE

Regioselective Deiodination of Thyroxine by Iodothyronine Deiodinase Mimics: An Unusual Mechanistic Pathway Involving Cooperative Chalcogen and Halogen Bonding

(2012) Debasish Manna et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel Mechanism for Dehalogenation and Glutathione Conjugation of Dihalogenated Anilines in Human Liver Microsomes: Evidence foripsoGlutathione Addition

(2011) Chenghong Zhang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Design, Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of Bridgehead Iodinated Analogues ofN-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as Potential SPECT Ligands for the 5-HT1AReceptor

(2011) Rana Al Hussainy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Halogen bond tunability I: the effects of aromatic fluorine substitution on the strengths of halogen-bonding interactions involving chlorine, bromine, and iodine

(2011) Kevin E. Riley et al.   JOURNAL OF MOLECULAR MODELING

Radiohalogenated nonnatural amino acids as PET and SPECT tumor imaging agents

(2011) Jonathan McConathy et al.   MEDICINAL RESEARCH REVIEWS

A Chemical Model for the Inner-Ring Deiodination of Thyroxine by Iodothyronine Deiodinase

(2010) Debasish Manna et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evaluation of radioiodinated quinazoline derivative as a new ligand for EGF receptor tyrosine kinase activity using SPECT

(2010) Masahiko Hirata et al.   ANNALS OF NUCLEAR MEDICINE

Efficient use and recycling of the micronutrient iodide in mammals

(2010) Steven E. Rokita et al.   BIOCHIMIE

Synthesis and characterization of novel phenylindoles as potential probes for imaging of β-amyloid plaques in the brain

(2010) Hiroyuki Watanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and in vitro/vivo Evaluation of Iodine-123/124 Labelled Hypericin Derivatives

(2010)   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Inhibition of the Type 2 Iodothyronine Deiodinase Underlies the Elevated Plasma TSH Associated with Amiodarone Treatment

(2010) Matthew L. Rosene et al.   ENDOCRINOLOGY

Is Halogen Bonding the Basis for Iodothyronine Deiodinase Activity?

(2010) Craig A. Bayse et al.   INORGANIC CHEMISTRY

Modeling of the 5′-Deiodination of Thyroxine by Iodothyronine Deiodinase: Chemical Corroboration of a Selenenyl Iodide Intermediate

(2009) Kei Goto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crystal Structure of Iodotyrosine Deiodinase, a Novel Flavoprotein Responsible for Iodide Salvage in Thyroid Glands

(2009) Seth R. Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Breast cancer brain metastases express the sodium iodide symporter

(2009) Corinne Renier et al.   JOURNAL OF NEURO-ONCOLOGY

A Mammalian Reductive Deiodinase has Broad Power to Dehalogenate Chlorinated and Brominated Substrates

(2009) Patrick M. McTamney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A radiotracer method to study efflux transport of iodide liberated from thyroid hormones via deiodination metabolism in the brain

(2009) Toshimitsu Okamura et al.   LIFE SCIENCES

Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH

(2008) Leonie wyffels et al.   BIOORGANIC & MEDICINAL CHEMISTRY