Article
Chemistry, Multidisciplinary
Benjamin L. Cline, Wen Jiang, Chaebin Lee, Zhengwei Cao, Xueyuan Yang, Shuyue Zhan, Harrison Chong, Tao Zhang, Zhaoguo Han, Xuedan Wu, Li Yao, Hui Wang, Weizhong Zhang, Zibo Li, Jin Xie
Summary: The team synthesized PMAO-KI NPs that can slowly release iodide into cancer cells, enhancing the production of reactive oxygen species induced by radiation therapy. This promotes radiotherapy against breast cancer by causing DNA damage and lipid peroxidation in cancer cells, ultimately leading to tumor eradication in 80% of treated animals without additional toxicity.
Article
Multidisciplinary Sciences
Jin Hee Lee, Kyung-Ho Jung, Kim Mina, Kyung-Han Lee
Summary: This study found that extracellular vesicles (EVs) can efficiently deliver sodium iodide symporter (NIS) protein to cancer cells, increasing the uptake of radioiodine and significantly enhancing the antitumor effects of radiotherapy.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Zhifang Zhang, Annie Yang, Shyambabu Chaurasiya, Anthony K. Park, Sang-In Kim, Jianming Lu, Tove Olafsen, Susanne G. Warner, Yuman Fong, Yanghee Woo
Summary: CF33-hNIS-antiPDL1 has anti-pancreatic adenocarcinoma activity and can infect, detect, and kill peritoneal tumors.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Biochemistry & Molecular Biology
Jiancang Ma, Xin Huang, Jinkai Xu, Zongyu Li, Jingyue Lai, Yawei Shen, Jun Zhao, Xuejun Sun, Lieting Ma
Summary: The study found that SBP1 promotes tumorigenesis and dedifferentiation of thyroid cancer through positively regulating TXN.
MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yoon Ju Choi, Jae-Eon Lee, Hyun Dong Ji, Bo-Ra Lee, Sang Bong Lee, Kil Soo Kim, In-Kyu Lee, Jungwook Chin, Sung Jin Cho, Jaetae Lee, Sang-Woo Lee, Jeoung-Hee Ha, Yong Hyun Jeon
Summary: The study demonstrates that Tunicamycin can restore the sensitivity of radioiodine refractory anaplastic thyroid cancer cells to radioiodine therapy by upregulating iodide-handling gene expression and NIS protein expression. Furthermore, TM also promotes redifferentiation of ATC cells by blocking multiple signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Ri Sa, Rui Liang, Xian Qiu, Ziyan He, Zhiyan Liu, Libo Chen
Summary: In this study, it was found that IGF2BP2 plays a role in promoting the dedifferentiation of RR-PTC by binding to the m6A modification site of the RUNX2 gene and enhancing its stability. High expression of IGF2BP2 is associated with I-131 nonavidity in metastatic PTCs. Targeting IGF2BP2 can increase I-125 uptake and enhance the expression of the sodium/iodide symporter (NIS) in RR-PTC cells. Therefore, IGF2BP2 can serve as a diagnostic marker for RR-PTC and may be targeted for differentiation therapy.
Article
Biochemistry & Molecular Biology
Kensuke Suzuki, Hiroshi Iwai, Keita Utsunomiya, Yumiko Kono, Tadashi Watabe, Yoshiki Kobayashi, Dan Van Bui, Shunsuke Sawada, Yasutaka Yun, Akitoshi Mitani, Kenta Fukui, Haruka Sakai, Hanh Hong Chu, Nguyen Manh Linh, Noboru Tanigawa, Akira Kanda
Summary: This study investigated the antitumor effects of combination therapy with lenvatinib and I-131 in differentiated thyroid cancer (DTC) cells with different sodium iodide symporter (NIS) status. The results demonstrated that lenvatinib treatment increased radioiodine uptake in NIS-expressing cells, but decreased uptake in non-expressing cells. The combination therapy synergistically inhibited colony formation and cell migration, especially in NIS-expressing cells. Furthermore, the treatment effectively inhibited tumor growth in a NIS-expressing thyroid cancer xenograft model. These findings suggest that lenvatinib should be administered after I-131 treatment for optimal efficacy in DTC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Suphalak Khamruang Marshall, Nutnicha Kaewpradit, Tavadee Mudmarn, Jirassaya Buathong, Palmuk Sriwirote
Summary: Combination chemotherapy is the standard treatment for triple-negative breast cancer, but the uptake of sodium iodide symporter (NIS) in TNBC has introduced the potential of NIS as a molecular target for radioiodine theranostic treatments. Researchers developed radiolabeled poly(lactic-co-glycolic) acid nanocarrier (NINP) to deliver I-131 to MDA-MB-231 cells, enhancing uptake and reducing clearance. The fractionated-dose NINPs were more effective than single-dose NINP and (NaI)-I-131 in causing cell death and reducing cell viability.
Article
Biochemistry & Molecular Biology
Aleksandra K. Gladysz, Jan Stepniak, Malgorzata Karbownik-Lewinska
Summary: The study aimed to investigate the potential protective effects of known antioxidants, such as melatonin and indole-3-propionic acid (IPA), against the oxidative damage caused by sodium/iodide symporter (NIS) inhibitors. Melatonin was found to prevent oxidative damage to membrane lipids in the thyroid caused by certain NIS inhibitors.
Article
Biochemistry & Molecular Biology
Jing Zhang, Aomei Zhao, Xi Jia, Xinru Li, Yiqian Liang, Yan Liu, Xin Xie, Xijie Qu, Qi Wang, Yuemin Zhang, Rui Gao, Yan Yu, Aimin Yang
Summary: Sinomenine hydrochloride (SH) shows therapeutic potential in the treatment of papillary thyroid cancer (PTC). It inhibits cell proliferation, induces apoptosis, promotes cell redifferentiation, and enhances the efficacy of radioactive iodine (RAI) therapy in PTC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Carlos Eduardo Bernal Barquero, Romina Celeste Geysels, Virginie Jacques, Gerardo Hernan Carro, Mariano Martin, Victoria Peyret, Maria Celeste Abregu, Patricia Papendieck, Ana Maria Masini-Repiso, Frederique Savagner, Ana Elena Chiesa, Cintia E. Citterio, Juan Pablo Nicola
Summary: In this study, genetic analysis of pediatric patients suspected of having congenital iodide transport defect revealed novel gene variants associated with congenital hypothyroidism. The findings suggest the existence of undiscovered mechanisms involved in thyroid hormone synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Mehmet Fatih Cengiz, Fatih Sen, Ayse Kevser Bilgin, Cennet Pelin Boyaci-Gunduz
Summary: Goiter, an abnormal enlargement of the thyroid gland, is a significant global public health issue primarily caused by iodine deficiency. This study aims to investigate the exposure levels to I- uptake inhibitors in drinking waters in five different districts in Antalya, Turkey.
ENVIRONMENTAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Reona Sakemura, Michelle J. Cox, Aditya Bansal, Claudia Manriquez Roman, Mehrdad Hefazi, Cynthia J. Vernon, Dianna L. Glynn, Mukesh K. Pandey, Timothy R. DeGrado, Elizabeth L. Siegler, Saad S. Kenderian
Summary: The support for the CDU/CSU alliance, led by German Chancellor Merkel, has been declining, with the latest polls showing that its popularity has reached its lowest level since the mid-1960s. The unclear policy positions and stance on social issues may have contributed to this decline in support.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Immunology
Elena Skourti, Alessia Volpe, Cameron Lang, Preeth Johnson, Fani Panagaki, Gilbert O. Fruhwirth
Summary: MicroRNAs play a crucial role in physiology and disease, especially in cancer development and progression. In this study, a novel in vivo microRNA detector platform was developed, allowing non-invasive quantification of microRNA changes in tumor models. The platform was found to accurately report on microRNA presence and revealed immune-mediated phenotypic changes in breast cancer tumors as they progressed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Guo-Qiang Zhang, Chuang Xi, Chen-Tian Shen, Hong-Jun Song, Quan-Yong Luo, Zhong-Ling Qiu
Summary: IL-6 inhibits the transcription of NIS in PTC cells by activating signaling pathways, which affects the efficacy of papillary thyroid cancer treatment.
ENDOCRINE-RELATED CANCER
(2023)
Article
Oncology
Xiao-Ping Liu, Xiaoqing Jin, Saman Seyed Ahmadian, Xu Yang, Su-Fang Tian, Yu-Xiang Cai, Kuldeep Chawla, Antoine M. Snijders, Yankai Xia, Paul J. van Diest, William A. Weiss, Jian-Hua Mao, Zhi-Qiang Li, Hannes Vogel, Hang Chang
Summary: By developing and validating cellular morphometric subtypes (CMS), personalized diagnosis and therapy for LGG patients can be achieved. These subtypes can predict patient prognosis and treatment response based on molecular alterations and immune microenvironment, and also have translational impact on glioblastoma.
Article
Biology
Joshua R. Wheeler, Oscar N. Whitney, Thomas O. Vogler, Eric D. Nguyen, Bradley Pawlikowski, Evan Lester, Alicia Cutler, Tiffany Elston, Nicole Dalla Betta, Kevin R. Parker, Kathryn E. Yost, Hannes Vogel, Thomas A. Rando, Howard Y. Chang, Aaron M. Johnson, Roy Parker, Bradley B. Olwin
Summary: This research reveals that the timing of RNA-binding protein (RBPs) expression can specify the fate transitions of muscle stem cells, playing a crucial role in skeletal muscle regeneration.
Article
Clinical Neurology
Carmen Barba, Ingmar Blumcke, Melodie R. Winawer, Till Hartlieb, Hoon-Chul Kang, Laura Grisotto, Mathilde Chipaux, Christian G. Bien, Barbora Hermanovska, Brenda E. Porter, Hart G. W. Lidov, Valentina Cetica, Friedrich G. Woermann, Javier A. Lopez-Rivera, Peter D. Canoll, Irina Mader, Ludovico D'Incerti, Sara Baldassari, Edward Yang, Ahmed Gaballa, Hannes Vogel, Barbora Straka, Letizia Macconi, Tilman Polster, Gerald A. Grant, Lenka Krskova, Hui Jin Shin, Ara Ko, Peter B. Crino, Pavel Krsek, Jeong Ho Lee, Dennis Lal, Stephanie Baulac, Annapurna Poduri, Renzo Guerrini
Summary: This study describes the clinical, genetic, neuroimaging, EEG, and histopathologic findings in patients with refractory epilepsy and brain somatic SLC35A2 gene variants. It also assesses possible predictors of postoperative seizure and cognitive outcomes.
Article
Clinical Neurology
Esther H. Nie, Saman S. Ahmadian, Sushma N. Bharadwaj, Lehi Acosta-Alvarez, Zachary D. Threlkeld, Matthew J. Frank, David B. Miklos, Michelle Monje, Brian J. Scott, Hannes Vogel
Summary: Immune effector cell-associated neurotoxicity syndrome (ICANS) is a common condition following CAR T therapy and other cancer cell therapies, but its underlying pathophysiology and neuropathology are not fully understood. This study presents the cellular and tissue neuropathologic analysis of a patient with severe ICANS after anti-CD19 CAR T therapy, revealing a pattern of multifocal demyelinating leukoencephalopathy associated with severe ICANS. The loss of region-specific oligodendrocyte lineage cells is proposed as a potential cellular and pathophysiologic factor in severe ICANS. Elucidation of the mechanistic processes underlying ICANS is crucial for minimizing neurotoxicity in CAR T-cell and immunotherapy treatments.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Xueqin Sun, Olaf Klingbeil, Bin Lu, Caizhi Wu, Carlos Ballon, Meng Ouyang, Xiaoli S. Wu, Ying Jin, Yon Hwangbo, Yu-Han Huang, Tim D. D. Somerville, Kenneth Chang, Jung Park, Taemoon Chung, Scott K. K. Lyons, Junwei Shi, Hannes Vogel, Michael Schulder, Christopher R. R. Vakoc, Alea A. A. Mills
Summary: Research uncovers a GBM-specific epigenetic mechanism where the chromatin regulator BRD8 inhibits p53 transactivation by maintaining H2AZ occupancy at p53 target loci, leading to sustained proliferation in TP53 wild-type GBM.
Article
Biochemistry & Molecular Biology
Daniel Dan Liu, Joy Q. He, Rahul Sinha, Anna E. Eastman, Angus M. Toland, Maurizio Morri, Norma F. Neff, Hannes Vogel, Nobuko Uchida, Irving L. Weissman
Summary: The human brain undergoes rapid development during mid-gestation, and neural stem and progenitor cells (NSPCs) play a key role in this process. However, the lack of precise purification methods has hindered the functional study of NSPCs. In this study, researchers developed a method to isolate ten distinct NSPC types from the developing human brain using cell-surface markers. These isolated cells were able to differentiate into various neural lineages, providing a valuable framework for studying the functions of different cell types in human neurodevelopment.
Letter
Hematology
Ekin Guney, Calixto-Hope G. Lucas, Kunwar Singh, Melike Pekmezci, Sebastian Fernandez-Pol, Kanish Mirchia, Angus Toland, Hannes Vogel, Serguei Bannykh, Kristian T. Schafernak, Sanda Alexandrescu, Bret C. Mobley, Suzanne Powell, Christian J. Davidson, Janna Neltner, Daniel R. Boue, Eyas Hattab, Sean P. Ferris, Robert S. Ohgami, James L. Rubenstein, Andrew W. Bollen, Tarik Tihan, Arie Perry, David A. Solomon, Kwun Wah Wen
Article
Cell Biology
Aisling M. Chaney, Haley C. Cropper, Poorva Jain, Edward Wilson, Federico Simonetta, Emily M. Johnson, Israt S. Alam, Ian T. J. Patterson, Michelle Swarovski, Marc Y. Stevens, Qian Wang, Carmen Azevedo, Sydney C. Nagy, Javier Ramos Benitez, Emily M. Deal, Hannes Vogel, Katrin I. Andreasson, Michelle L. James
Summary: Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system, and imaging strategies using TREM1-PET have the potential to aid in the diagnosis and monitoring of therapeutic responses. In this study, the effectiveness of TREM1 PET imaging in the EAE mouse model of MS was validated, and it was found to be more sensitive than the established TSPO-PET imaging method. TREM1-PET imaging has the potential to play a role in the diagnosis of MS and monitoring of therapeutic responses to drug treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biochemical Research Methods
Francisco Carrillo-Perez, Marija Pizurica, Michael G. Ozawa, Hannes Vogel, Robert B. West, Christina S. Kong, Luis Javier Herrera, Jeanne Shen, Olivier Gevaert
Summary: In this study, a novel approach using deep generative models, infused with gene expression profiles, is proposed to generate high-quality whole-slide image (WSI) tiles. The RNA-GAN model showed superior performance compared to traditional GANs, with preference by expert pathologists and shorter training time. Moreover, RNA-GAN demonstrated the ability to generalize to unknown gene expression profiles.
CELL REPORTS METHODS
(2023)
Review
Oncology
Betty Yao, Alberto Delaidelli, Hannes Vogel, Poul H. Sorensen
Summary: Despite advances in tumour molecular subtyping, pediatric brain tumours (PBTs) still pose a significant challenge and cause high mortality rates. Tumour immunotherapy has emerged as a promising approach for treating childhood tumours, including PBTs, by leveraging the immune landscape of the developing brain. This review focuses on understanding the immune microenvironments of common PBTs and how they shape responses to immunotherapy, with the goal of informing future treatment designs.
Article
Oncology
Dana Tlais, Maria Isabel Barros Guinle, Joshua Riley Wheeler, Laura M. Prolo, Hannes Vogel, Sonia Partap
Summary: This study reviewed 3 pediatric patients with CNS tumors having CHEK2 mutations. Germline testing in 1 case confirmed the hereditary nature of CHEK2 mutation. The study suggests that CHEK2 may contribute to carcinogenesis and reporting similar cases may help identify a new molecular driver in pediatric CNS tumors.
NEURO-ONCOLOGY ADVANCES
(2023)
Article
Medicine, Research & Experimental
Sandra Steyaert, Yeping Lina Qiu, Yuanning Zheng, Pritam Mukherjee, Hannes Vogel, Olivier Gevaert
Summary: Steyaert, Qiu et al. developed a deep learning framework for multimodal data fusion in brain tumors. Combining histopathology imaging and gene expression data, the multimodal data models outperformed single data models in predicting prognosis.
COMMUNICATIONS MEDICINE
(2023)
Article
Medical Laboratory Technology
Rebecca Rojansky, Iny Jhun, Alex M. Dussaq, Steven M. Chirieleison, Jeffrey J. Nirschl, Don Born, Jennifer Fralick, William Hetherington, Alison M. Kerr, Jonathan Lavezo, Daniel B. Lawrence, Seth Lummus, Ronald Macasaet, Thomas J. Montine, Emily Ryan, Jeanne Shen, Jonathan Shoemaker, Brent Tan, Hannes Vogel, Puneet Singh Waraich, Eric Yang, April Young, Ann Folkins
Summary: Validation and implementation of whole slide imaging (WSI) at a large academic medical center for various subspecialties showed high diagnostic concordance rates and improved patient care during the COVID-19 pandemic. Flexible workflows and tailored solutions were necessary for successful adoption of WSI at scale.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Article
Clinical Neurology
Carmen Barba, Ingmar Blumcke, Melodie R. Winawer, Till Hartlieb, Hoon-Chul Kang, Laura Grisotto, Mathilde Chipaux, Christian G. Bien, Barbora Hermanovska, Brenda E. Porter, Hart G. W. Lidov, Valentina Cetica, Friedrich G. Woermann, Javier A. Lopez-Rivera, Peter D. Canoll, Irina Mader, Ludovico D'Incerti, Sara Baldassari, Edward Yang, Ahmed Gaballa, Hannes Vogel, Barbora Straka, Letizia Macconi, Tilman Polster, Gerald A. Grant, Lenka Krskova, Hui Jin Shin, Ara Ko, Peter B. Crino, Pavel Krsek, Jeong Ho Lee, Dennis Lal, Stephanie Baulac, Annapurna Poduri, Renzo Guerrini
Summary: Brain somatic SLC35A2 gene variants are associated with two main clinical phenotypes, early epileptic encephalopathy (EE) and drug-resistant focal epilepsy (DR-FE). Most patients showed unchanged cognitive performances after surgery, with better postoperative seizure control outcomes seen in cases where postoperative EEG was normal or improved.
Article
Radiology, Nuclear Medicine & Medical Imaging
Quan Zhou, Nynke S. Van den Berg, Wenying Kang, Jacqueline Pei, Naoki Nishio, Stan Van Keulen, Myrthe A. Engelen, Yu-Jin Lee, Marisa Hom, Johana C. M. Vega Leonel, Zachary Hart, Hannes Vogel, Romain Cayrol, Brock A. Martin, Mark Roesner, Glenn Shields, Natalie Lui, Melanie Hayden Gephart, Roan C. Raymundo, Grace Yi, Monica Granucci, Gerald A. Grant, Gordon Li, Eben L. Rosenthal
Summary: In this study, the clinical imaging performance of a fluorescent antibody was compared across three types of cancer. The results showed that tumor size, resection margin, and imaging settings significantly influenced macroscopic tumor contrast.
JOURNAL OF NUCLEAR MEDICINE
(2022)