Article
Medicine, General & Internal
Blazej Chermula, Wieslawa Kranc, Piotr Celichowski, Boguslawa Stelmach, Hanna Piotrowska-Kempisty, Paul Mozdziak, Leszek Pawelczyk, Robert Zygmunt Spaczynski, Bartosz Kempisty
Summary: This study analyzes the epithelial origin of cumulus and granulosa cells in ovarian follicles, and identifies genes associated with epithelialization processes. The results suggest that these cells originate from the ovarian surface epithelium, and some gene expression profiles may have tumorigenic properties.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yu-Chen Chen, Ju-Yueh Li, Chia-Jung Li, Kuan-Hao Tsui, Peng-Hui Wang, Zhi-Hong Wen, Li-Te Lin
Summary: In poor ovarian responders undergoing IVF cycles, there were differences in CC gene expression involving inflammation, oxidative phosphorylation, apoptosis, and metabolism between LPOS and FPOS groups. The LPOS group showed significantly higher progesterone levels but similar outcomes in terms of reproductive indicators compared to the FPOS group. Further large-scale randomized controlled trials are needed to confirm these findings.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Developmental Biology
Kaitlin R. Karl, Peter Z. Schall, Zaramasina L. Clark, Meghan L. Ruebel, Jose Cibelli, Robert J. Tempelman, Keith E. Latham, James J. Ireland
Summary: Excessive FSH doses during ovarian stimulation in heifers with small ovarian reserve can cause disruptions in cumulus cell and oocyte functions, leading to premature cumulus expansion and follicular hyperstimulation dysgenesis. These effects can impair the quality of cumulus-oocyte complexes and hinder successful fertilization.
MOLECULAR HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
C. Dell'Aversana, F. Cuomo, S. Longobardi, T. D'Hooghe, F. Caprio, G. Franci, M. Santonastaso, N. Colacurci, S. Barone, V Pisaturo, D. Valerio, L. Altucci
Summary: The miRNA expression in cumulus oophorus cells (COCs) is influenced by maternal age and gonadotropin treatment, with potential implications for ovarian dysfunction and fertility in older women. The study identified age- and MAR stimulation-dependent miRNA expression patterns in COCs, highlighting the importance of miRNAs in female infertility and assisted reproductive technologies.
HUMAN REPRODUCTION
(2021)
Article
Reproductive Biology
Xianrong Xiong, Hongchen Ma, Xinyu Min, Feng Su, Yan Xiong, Jian Li
Summary: The study investigated the expression and function of lysine-specific demethylase 4B (KDM4B) in yak cumulus cells (CCs) and found that KDM4B regulates biological characteristics and physiological function of CCs mainly through changing the methylation patterns of H3K9 and related gene expression levels, affecting cell proliferation, apoptosis, hormone secretion, and embryo development.
Article
Medicine, General & Internal
Piotr Jozef Olbromski, Piotr Pawlik, Anna Bogacz, Stefan Sajdak
Summary: Ovarian cancer is a common cause of death among women worldwide. The current diagnostic and prognostic procedures available for the treatment of ovarian cancer are either not specific or are very expensive. This study evaluated the expression of selected genes and found that KRAS, NOXA, PUMA, c-FOS, and c-JUN may be associated with poor prognosis in ovarian cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Jakub Kulus, Magdalena Kulus, Wieslawa Kranc, Karol Jopek, Maciej Zdun, Malgorzata Jozkowiak, Jedrzej M. Jaskowski, Hanna Piotrowska-Kempisty, Dorota Bukowska, Pawel Antosik, Paul Mozdziak, Bartosz Kempisty
Summary: The study focused on the gene expression profile of porcine granulosa cells during primary in vitro culture, particularly related to ECM formation and intercellular signaling. Most genes were upregulated, providing insight into molecular mechanisms within the ovary which can be used for assisted reproduction techniques and stemness potential of granulosa cells. The research may also serve as preliminary data for further studies on ovarian pathological processes using in vitro granulosa cell cultures.
Article
Cell Biology
Zhong-xin Jiang, Yi-ning Wang, Zi-yuan Li, Zhi-hui Dai, Yi He, Kun Chu, Jia-yi Gu, Yi-Xuan Ji, Ning-xia Sun, Fu Yang, Wen Li
Summary: The study demonstrates that m6A adenine regulates the function of GCs in female ovarian aging by modulating FTO demethylase, which in turn affects ovarian aging. FTO retards ovarian cell aging by regulating FOS expression.
CELL DEATH & DISEASE
(2021)
Article
Food Science & Technology
Nisreen Faizo, Chandrakala Aluganti Narasimhulu, Anna Forsman, Shibu Yooseph, Sampath Parthasarathy
Summary: The study utilized RNA sequencing to investigate the impact of exposure to peroxidized linoleic acid on cellular processes, uncovering alterations in lipid metabolic pathways, detoxification mechanisms, and suppression of oxidative phosphorylation. These findings provide insights into the effects of 13-HPODE on cellular processes and propose potential therapeutic strategies for LOOH-related pathologies.
Article
Endocrinology & Metabolism
Xiaodi Huang, Qi Yu
Summary: Endometriosis has negative impact on oocyte quality, and ovarian endometriosis (OEM) and peritoneal endometriosis (PEM) may have different effects on female fertility. This study discovered differences in circRNA expression profiles of cumulus cells (CCs) between patients with OEM and PEM infertility, providing new insights into the different effects of various endometriosis phenotypes on oocytes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Emily De Conto, Ursula Matte, Joao Sabino Cunha-Filho
Summary: This study found reduced expression of BMP-6 and SMAD4 in cumulus cells of women with peritoneal endometriosis compared with the control group, while other genes did not show altered gene expression in women with endometriosis.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Cell Biology
Qiqi Li, Yangan Huo, Siqi Wang, Liu Yang, Qifa Li, Xing Du
Summary: This study reveals that TGF-beta 1 alters the lncRNA transcriptome in a SMAD4-dependent manner, and shows that lncRNAs mediate the functions of TGF-beta 1 in granulosa cells, contributing to a better understanding of the epigenetic regulation of female fertility.
CELL PROLIFERATION
(2023)
Article
Endocrinology & Metabolism
Jane Alro Botkjaer, Stine Gry Kristensen, Hanna Ornes Olesen, Per Larsson, Bernadette Mannaerts, Claus Yding Andersen
Summary: CG beta supplementation during ovarian stimulation can enhance follicular steroidogenesis and modulate gene expression in cumulus cells.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
G. D. Catandi, D. R. Bresnahan, S. O. Peters, K. J. Fresa, L. J. Maclellan, C. D. Broeckling, E. M. Carnevale
Summary: Many age-related changes in metabolite abundance suggest impaired mitochondrial metabolic function and oxidative stress in oocytes and follicular cells. The results also indicate impaired transfer of carbohydrate and free fatty acid substrates from cumulus cells to the oocytes of old mares, potentially related to disruption of transzonal projections between the cell types. The identification of age-associated alterations in the abundance of specific metabolites and their correlations among cells contribute to our understanding of follicular dysfunction with maternal aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biology
Jeong Hyun Lee, Emily S. Park, Jane Ru Choi, Kerryn Matthews, Alice V. Lam, Xiaoyan Deng, Simon P. Duffy, Hongshen Ma
Summary: This paper presents a selective sequencing method called SeeN-Seq, which uses UV laser patterning of hydrogel porosity to link morphological phenotypes to single-cell RNAseq. The method allows for rapid screening of specific cells without physically extracting each cell, and has been used to associate transcriptomic data with specific functions and behaviors in single cells.
COMMUNICATIONS BIOLOGY
(2022)
Article
Genetics & Heredity
Panagiotis Drakopoulos, Juan Garcia-Velasco, Ernesto Bosch, Christophe Blockeel, Michel de Vos, Samuel Santos-Ribeiro, Antonis Makrigiannakis, Herman Tournaye, Nikolaos P. Polyzos
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2019)
Article
Obstetrics & Gynecology
D. Alecsandru, A. Pacheco, A. Guerrero-Mayo, A. Fabris, P. Aparicio, A. Barrio, A. Pellicer, Juan A. Garcia-Velasco
REPRODUCTIVE BIOMEDICINE ONLINE
(2020)
Article
Obstetrics & Gynecology
Maria Cruz, Diana Alecsandru, Juan Antonio Garcia-Velasco, Antonio Requena
REPRODUCTIVE BIOMEDICINE ONLINE
(2019)
Review
Obstetrics & Gynecology
Jose Bellver, Ernesto Bosch, Juan Jose Espinos, Francisco Fabregues, Juan Fontes, Juan Garcia-Velasco, Joaquin Llacer, Antonio Requena, Miguel Angel Checa
REPRODUCTIVE BIOMEDICINE ONLINE
(2019)
Article
Immunology
Diana Alecsandru, Natalia Lopez-Palacios, Mercedes Castano, Pilar Aparicio, Juan Antonio Garcia-Velasco, Concepcion Nunez
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2020)
Article
Environmental Sciences
Diana C. Santa-Cruz, Rafael A. Caparros-Gonzalez, Borja Romero-Gonzalez, Maria Isabel Peralta-Ramirez, Raquel Gonzalez-Perez, Juan Antonio Garcia-Velasco
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Medicine, General & Internal
Justin Tan, Maria Cerrillo, Maria Cruz, Gustavo Nardini Cecchino, Juan Antonio Garcia-Velasco
Summary: This study compared IVF outcomes in women with endometriosis undergoing fresh ET versus deferred ET after cryopreservation, finding no significant differences in patient characteristics and response to stimulation between the two groups. There were also no significant differences in implantation rate, clinical pregnancy rate, and miscarriage rate between fresh and deferred ET groups. Prospective studies are needed to further validate these findings and improve IVF protocols for women with endometriosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Alberto Pacheco, Arancha Blanco, Fernando Bronet, Maria Cruz, Jaime Garcia-Fernandez, Juan Antonio Garcia-Velasco
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Biology
Cristina Rodriguez-Varela, Giulia Mariani, Pilar Dolz, Juan Antonio Garcia-Velasco, Vicente Serra, Antonio Pellicer, Elena Labarta
Summary: The COVID-19 pandemic has had an impact on infertility treatments, resulting in a reduction in the total number of treatments performed but not significantly affecting pregnancy rates. The psychological status of pregnant women did not seem to affect their final pregnancy outcome.
Review
Nutrition & Dietetics
Ana Arnanz, Juan A. Garcia-Velasco, Jose Luis Neyro
Summary: The vitamin D endocrine system plays a crucial role in human fertility, and its deficiency can be related to various reproductive issues. This deficiency has been linked to in vitro fertilization outcomes, ovarian reserve and fertility, and endocrine disorders such as polycystic ovary disease. It may also be associated with uterine fibroids and pregnancy-related complications. The optimal dose of vitamin D supplementation for infertility or during pregnancy is still uncertain, and further clinical studies are needed to determine its benefits and appropriate dosage.
Editorial Material
Obstetrics & Gynecology
Juan A. Garcia-Velasco
FERTILITY AND STERILITY
(2022)
Letter
Obstetrics & Gynecology
Filippo Maria Ubaldi, Alberto Vaiarelli, Danilo Cimadomo, Maria Cerrillo, Laura Rienzi, Juan A. Garcia-Velasco
HUMAN REPRODUCTION
(2023)
Letter
Obstetrics & Gynecology
Juan A. Garcia-Velasco, Danilo Cimadomo, Maria Cerrillo, Alberto Vaiarelli, Filippo Maria Ubaldi
HUMAN REPRODUCTION
(2023)
Article
Biology
A. M. Portillo, E. Varela, J. A. Garcia-Velasco
Summary: This paper proposes a discrete model for the temporal evolution of a population of cells sorted according to their telomeric length. The model assumes asymmetric distribution of genetic material during cell division, with one daughter cell having the same telomere length as the mother and the other having shorter telomeres. The model takes into account telomerase activity, cell death, and the Hayflick limit. A partial differential equation with boundary conditions is derived to represent the continuous model. The model is applied to study the aging rate of human follicular growth.
MATHEMATICAL BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Barbara Herranz-Blanco, Elza Daoud, Paola Vigano, Juan Antonio Garcia-Velasco, Enrico Colli
Summary: Endometriosis affects more than 10% of women of reproductive age and significantly impacts their quality of life. Diagnosis often takes several years due to the invasive nature of the gold standard diagnostic method, laparoscopy. Two studies were conducted to develop a diagnostic test combining serum biomarkers and clinical variables, resulting in a specific and accurate test for early disease identification.
Article
Obstetrics & Gynecology
Tal Margaliot Kalifa, Hen Y. Sela, Jordanna Joseph, Sorina Grisaru-Granovsky, Fayez Khatib, Misgav Rottenstreich
Summary: Pregnancies following a second trimester uterine evacuation do not have an increased risk of preterm delivery or other adverse perinatal outcomes compared to pregnancies following a first trimester uterine evacuation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Dominique A. Badr, Mieke M. Cannie, Caroline Kadji, Xin Kang, Andrew Carlin, Jacques C. Jani
Summary: The objective of this study was to assess the influence of the test-to-delivery interval on the performance of ultrasound and MRI in predicting birthweight. The results showed that MRI performed best in predicting birthweight greater than gestational age if delivery occurred within two weeks of the examination, with a slight decrease thereafter, while ultrasound performance decreased drastically over time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Corina N. Schoen, Sami Backley, Lauren Orr, Amrita Roy, Tiffany Corlin, Alexander B. Knee
Summary: This retrospective cohort study aimed to evaluate whether induction of labor is associated with a lower risk of cesarean section in patients with isolated polyhydramnios. The study found that planned induction was associated with a lower rate of cesarean delivery compared to expectant management, but the difference was not statistically significant. Additionally, no differences were observed in maternal or fetal secondary outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Ohad Houri, Asaf Romano, Yossi Geron, Gil Zeevi, Eran Hadar, Shiri Barbash-Hazan, Shir Danieli-Gruber
Summary: Women with prior uterine rupture have good maternal and neonatal outcomes in subsequent pregnancies when managed at a tertiary medical center, with planned elective term cesarean delivery, or even earlier, at the onset of spontaneous preterm labor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Correction
Obstetrics & Gynecology
Laura E. Janssen, Marjon A. de Boer, Eline C. E. von Konigslow, Elisa Dal, Martijn A. Oudijk, Danielle Robbers-Visser, Christianne J. M. de Groot
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Review
Obstetrics & Gynecology
Natalia Rzewuska, Jacek Kunicki, Katarzyna Pieniak, Paulina Laskus, Bernadeta Zabielska, Roman Smolarczyk, Michal Kunicki
Summary: This systematic review examined the comorbidity of idiopathic intracranial hypertension (IIH) and polycystic ovarian syndrome (PCOS) and their impact on metabolism, hormone levels, and reproduction. The findings showed a high prevalence of comorbidity between the two conditions, which may have significant clinical implications for patient management.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)