Article
Pharmacology & Pharmacy
Leah R. Benington, Gunesh Rajan, Cornelia Locher, Lee Yong Lim
Summary: This study aimed to develop stable formulations of FGF-2 using pharmaceutical excipients to withstand physical stressors encountered in processing and storage. Formulations containing MC and alanine (F5) or MC and HSA (F6) were the most effective in stabilizing FGF-2 against thermal and processing stressors. These stabilized solutions have potential applications in medicinal products or in more advanced forms for wound healing and tissue regeneration.
Review
Cell Biology
Alessio Ardizzone, Valentina Bova, Giovanna Casili, Alberto Repici, Marika Lanza, Raffaella Giuffrida, Cristina Colarossi, Marzia Mare, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti
Summary: Cancer, the leading cause of death worldwide, requires successful strategies for treatment. Growth factors like VEGF, bFGF, and TGF-beta play significant roles in tumor growth, activating essential signaling pathways and promoting cell proliferation, angiogenesis, and metastasis. Specifically, bFGF is secreted by tumor cells and interacts with its receptors (FGFRs), leading to tumor cell proliferation, invasion, and upregulation of pro-inflammatory and anti-apoptotic proteins. Studies have focused on developing therapeutic strategies targeting the bFGF/FGFR axis, considering its involvement in oncogenesis. This review comprehensively examines the biological mechanisms of bFGF in the tumor microenvironment, available anticancer therapies targeting FGFRs, and the prognostic value of bFGF.
Article
Biotechnology & Applied Microbiology
Hong Zhu, Jie Xu, Min Zhao, Hangqi Luo, Minjie Lin, Yuting Luo, Yuan Li, Huacheng He, Jiang Wu
Summary: A co-loaded polyvinyl alcohol (PVA) hydrogel containing fibroblast growth factor 21 (FGF21) and metformin was developed to promote diabetic wound healing by scavenging ROSs and recruiting EPCs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Zhao-yan Liu, Yan Luo, Ai-ping Fang, Maierhaba Wusiman, Tong-tong He, Xiao-zhan Liu, Dinuerguli Yishake, Si Chen, Xiao-ting Lu, Yao-jun Zhang, Hui-lian Zhu
Summary: The study concluded that higher serum FGF21 levels were associated with worse survival in HCC patients, suggesting that serum FGF21 may be used as a novel metabolism-related prognostic biomarker for HCC.
LIVER INTERNATIONAL
(2022)
Article
Reproductive Biology
Corrine F. Monaco, Michele R. Plewes, Emilia Przygrodzka, Jitu W. George, Fang Qiu, Peng Xiao, Jennifer R. Wood, Andrea S. Cupp, John S. Davis
Summary: During the regression of the ovarian corpus luteum, fibroblasts are responsible for rapid matrix remodeling. However, little is known about the role of fibroblasts in the functional or regressing corpus luteum. In this study, it was found that FGF2 activates luteal fibroblasts, leading to collagen production and cell proliferation.
BIOLOGY OF REPRODUCTION
(2023)
Article
Pharmacology & Pharmacy
Qing-Yun Xie, Lu-Ping Huang, Feng-Wei Gao, Da-Qing Liu, Xia Wang, Kang-Yi Jiang, Jie Gong, Xin Zhao, Ben-Jian Gao, Ze-Hua Lei
Summary: This study investigated the therapeutic efficacy of lenvatinib combined with sequential TACE on primary HCC and its effects on serum bFGF and VEGF. The results showed that the combination treatment group had a higher objective response rate, lower serum bFGF and VEGF levels, and better survival rates.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gherardo Baudo, Suhong Wu, Matteo Massaro, Haoran Liu, Hyunho Lee, Aijun Zhang, Dale J. Hamilton, Elvin Blanco
Summary: This study aimed to investigate whether improving mitochondrial function can attenuate fibroblast-to-myofibroblast transition (FMT) stimulated by transforming growth factor-beta (TGF-beta). The results demonstrated that administering Dex-TPP-coated mitochondria to TGF-beta-stimulated fibroblasts can inhibit the shift towards glycolysis, reduce reactive oxygen species (ROS) generation, and decrease the expression of FMT markers and extracellular matrix (ECM) proteins, as well as migration and proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Fenzan Wu, Penghui Wang, Xiaojie Wei, Yanhong Yang, Abdullah Al Mamun, Xie Zhang, Yunsen Zhu, Tingting Mo, Hongyu Zhang, Chang Jiang, Jie Hu, Jian Xiao
Summary: This study developed a dual-targeting liposome for delivering bFGF to treat spinal cord injury (SCI), with the ability to target the injury lesion and penetrate the blood-spinal cord barrier (BSCB). The results showed that the dual-targeted liposomes could effectively cross the BSCB and accumulate at the injury site. Continuous treatment with the liposomes promoted BSCB repair, facilitated M2 polarization of macrophages, enhanced angiogenesis, and improved motor function in SCI rats.
MATERIALS TODAY BIO
(2023)
Article
Multidisciplinary Sciences
Xu Zhou, Ruth A. Franklin, Miri Adler, Trevor S. Carter, Emily Condiff, Taylor S. Adams, Scott D. Pope, Naomi H. Philip, Matthew L. Meizlish, Naftali Kaminski, Ruslan Medzhitov
Summary: This article reports on the mechanisms controlling the population numbers of different cell types in animal tissues. The study shows that fibroblasts are limited in proliferation due to space availability, while macrophages are constrained by growth factor availability. The transcriptional coactivator YAP1 in fibroblasts directly regulates the expression of the macrophage-specific growth factor Csf1. The findings suggest that tissue environment sensing is a general strategy for controlling tissue composition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Gensuke Okamura, Kosuke Ebina, Makoto Hirao, Ryota Chijimatsu, Yasukazu Yonetani, Yuki Etani, Akira Miyama, Kenji Takami, Atsushi Goshima, Hideki Yoshikawa, Takuya Ishimoto, Takayoshi Nakano, Masayuki Hamada, Takashi Kanamoto, Ken Nakata
Summary: Adding basic fibroblast growth factor (bFGF) to the culture of synovial mesenchymal stem cells (SMSC) can significantly promote cartilage regeneration in vivo, leading to better cartilage repair outcomes and more obvious cartilage matrix formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Leidan Huang, Carole Quesada, Mitra Aliabouzar, J. Brian Fowlkes, Renny T. Franceschi, Zheng Liu, Andrew J. Putnam, Mario L. Fabiilli
Summary: Vascularization following tissue implantation is crucial for viability, and the ability to spatially control this process using acoustically responsive scaffolds has been demonstrated in this study. The study found that spatially-defined patterns of acoustic droplet vaporization can elicit spatially-defined patterns of angiogenesis.
ACTA BIOMATERIALIA
(2021)
Article
Cell & Tissue Engineering
I. Heggli, U. Blache, N. Herger, T. Mengis, P. K. Jaeger, R. Schuepbach, N. Farshad-Amacker, F. Brunner, J. G. Snedeker, M. Farshad, O. Distler, S. Dudli
Summary: The study found that the presence of FGF2 during the culture of BMSCs derived from MC1 did not detect pro-fibrotic genes and pathways, and significantly decreased cell-matrix adhesion.
EUROPEAN CELLS & MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Xinze Li, Guangliang Hong, Guangju Zhao, Hui Pei, Jie Qu, Changju Chun, Zhiwei Huang, Zhongqiu Lu
Summary: This study demonstrates the therapeutic potential of bFGF in sepsis-induced cardiac injury, using red blood cell membrane-camouflaged nanoparticles for targeted delivery. The results show the protective effects of bFGF against oxidative and inflammatory damage in cardiomyocytes, and its therapeutic benefits in treating myocardial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Hongqi Zhang, Gang Xiang, Jiong Li, Sihan He, Yunjia Wang, Ang Deng, Yuxiang Wang, Chaofeng Guo, Xiuyuan Hao
Summary: This study investigated the relationship between congenital scoliosis (CS) and fibroblast growth factor 23 (FGF23). The results showed that CS patients had increased FGF23 mRNA levels in the peripheral blood and decreased bone mineral density. Additionally, FGF23 may contribute to osteopenia in CS patients through the FGFr3/TNAP/OPN pathway.
CHINESE MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Hongqi Zhang, Gang Xiang, Jiong Li, Sihan He, Yunjia Wang, Ang Deng, Yuxiang Wang, Chaofeng Guo
Summary: The study investigates the relationship between congenital scoliosis (CS) and fibroblast growth factor 23 (FGF23). The results show that CS patients have increased peripheral blood FGF23 mRNA levels and decreased bone mineral density, suggesting that FGF23 may contribute to osteopenia in CS patients through the FGFr3/TNAP/OPN pathway.
CHINESE MEDICAL JOURNAL
(2023)
Article
Oncology
Eileen G. Russell, Jianfeng Guo, Elaine C. O'Sullivan, Caitriona M. O'Driscoll, Florence O. McCarthy, Thomas G. Cotter
INVESTIGATIONAL NEW DRUGS
(2016)
Article
Biochemistry & Molecular Biology
Alice C. Wyse Jackson, Sarah L. Roche, Ashleigh M. Byrne, Ana M. Ruiz-Lopez, Thomas G. Cotter
JOURNAL OF NEUROCHEMISTRY
(2016)
Review
Oncology
D. P. O'Leary, E. O'Leary, N. Foley, T. G. Cotter, J. H. Wang, H. P. Redmond
Article
Neurosciences
Alice C. Wyse-Jackson, Sarah L. Roche, Ana M. Ruiz-Lopez, Jennifer N. Moloney, Ashleigh M. Byrne, Thomas G. Cotter
EUROPEAN JOURNAL OF NEUROSCIENCE
(2016)
Article
Biochemistry & Molecular Biology
Ashleigh M. Byrne, Ana M. Ruiz-Lopez, Sarah L. Roche, Jennifer N. Moloney, Alice C. Wyse-Jackson, Thomas G. Cotter
Article
Neurosciences
Sarah L. Roche, Ana M. Ruiz-Lopez, Jennifer N. Moloney, Ashleigh M. Byrne, Thomas G. Cotter
Article
Oncology
Jennifer N. Moloney, Joanna Stanicka, Thomas G. Cotter
Article
Medicine, Research & Experimental
Jianfeng Guo, Eileen G. Russell, Raphael Darcy, Thomas G. Cotter, Sharon L. McKenna, Mary R. Cahill, Caitriona M. O'Driscoll
MOLECULAR PHARMACEUTICS
(2017)
Article
Oncology
Jennifer N. Moloney, Ashok Kumar Jayavelu, Joanna Stanicka, Sarah L. Roche, Rebecca L. O'Brien, Sebastian Scholl, Frank-D. Boehmer, Thomas G. Cotter
Article
Multidisciplinary Sciences
Lieve Temmerman, Marijke M. Westra, Ilze Bot, Bart J. M. van Vlijmen, Niek Van Bree, Martine Bot, Kim L. L. Habets, Tom G. H. Keulers, Johan van der Vlag, Thomas G. Cotter, Theo J. C. van Berkel, Erik A. L. Biessen
SCIENTIFIC REPORTS
(2017)
Review
Cell Biology
Jennifer N. Moloney, Thomas G. Cotter
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Sarah L. Roche, Alice C. Wyse-Jackson, Violeta Gomez-Vicente, Pedro Lax, Ana M. Ruiz-Lopez, Ashleigh M. Byrne, Nicolas Cuenca, Thomas G. Cotter
Article
Multidisciplinary Sciences
Sarah L. Roche, Alice C. Wyse-Jackson, Ana M. Ruiz-Lopez, Ashleigh M. Byrne, Thomas G. Cotter
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Ashleigh M. Byrne, Sarah L. Roche, Ana M. Ruiz-Lopez, Alice C. Wyse Jackson, Thomas G. Cotter