Progesterone Attenuates Microglial-Driven Retinal Degeneration and Stimulates Protective Fractalkine-CX3CR1 Signaling

The synthetic progesterone Norgestrel is neuroprotective in stressed photoreceptor-like cells and retinal explants, mediating its effects via basic fibroblast growth factor, protein kinase A and glycogen synthase kinase 3β signalling

(2016) Alice C. Wyse Jackson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa

(2016) Matthew K. Zabel et al.   GLIA

Alterations to retinal architecture prior to photoreceptor loss in a mouse model of retinitis pigmentosa

(2016) Sarah L. Roche et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina

(2015) Sandra M. Cardona et al.   ASN Neuro

Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration

(2015) L. Zhao et al.   EMBO Molecular Medicine

Progesterone receptor signalling in retinal photoreceptor neuroprotection

(2015) Alice C. Wyse Jackson et al.   JOURNAL OF NEUROCHEMISTRY

Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injury

(2015) Heidi Y. Febinger et al.   Journal of Neuroinflammation

Chemokine-mediated inflammation in the degenerating retina is coordinated by Müller cells, activated microglia, and retinal pigment epithelium

(2015) Matt Rutar et al.   Journal of Neuroinflammation

Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration

(2015) Rebecca Scholz et al.   Journal of Neuroinflammation

Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration

(2015) Rebecca Scholz et al.   Journal of Neuroinflammation

Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases

(2015) Maria H. Madeira et al.   MEDIATORS OF INFLAMMATION

Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity

(2015) Jenny Dworzak et al.   PLoS One

Adalimumab Reduces Photoreceptor Cell Death in A Mouse Model of Retinal Degeneration

(2015) Cristina Martínez-Fernández de la Cámara et al.   Scientific Reports

Fractalkine receptor regulates microglial neurotoxicity in an experimental mouse glaucoma model

(2014) Ke Wang et al.   GLIA

Cutting Edge: IL-1α Is a Crucial Danger Signal Triggering Acute Myocardial Inflammation during Myocardial Infarction

(2014) Jérôme Lugrin et al.   JOURNAL OF IMMUNOLOGY

Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis

(2014) Marcus Karlstetter et al.   Journal of Neuroinflammation

Suppression of Microglial Activation Is Neuroprotective in a Mouse Model of Human Retinitis Pigmentosa

(2014) B. Peng et al.   JOURNAL OF NEUROSCIENCE

Macroglia-Microglia Interactions via TSPO Signaling Regulates Microglial Activation in the Mouse Retina

(2014) M. Wang et al.   JOURNAL OF NEUROSCIENCE

Microglial NADPH oxidase activation mediates rod cell death in the retinal degeneration in rd mice

(2014) H. Zeng et al.   NEUROSCIENCE

CX3CL1 (Fractalkine) Protein Expression in Normal and Degenerating Mouse Retina: In Vivo Studies

(2014) Marina Zieger et al.   PLoS One

Suppressed pro-inflammatory response of microglia in CX3CR1 knockout mice

(2013) Hayley A. Mattison et al.   JOURNAL OF NEUROIMMUNOLOGY

Total Protein Analysis as a Reliable Loading Control for Quantitative Fluorescent Western Blotting

(2013) Samantha L. Eaton et al.   PLoS One

Minocycline selectively inhibits M1 polarization of microglia

(2013) K Kobayashi et al.   Cell Death & Disease

Activation of survival pathways in the degenerating retina of rd10 mice

(2012) Marijana Samardzija et al.   EXPERIMENTAL EYE RESEARCH

Knockout of ccr2 alleviates photoreceptor cell death in a model of retinitis pigmentosa

(2012) Congrong Guo et al.   EXPERIMENTAL EYE RESEARCH

Laboratory Evidence of Sustained Chronic Inflammatory Reaction in Retinitis Pigmentosa

(2012) Noriko Yoshida et al.   OPHTHALMOLOGY

Role of Fractalkine/CX3CR1 Interaction in Light-Induced Photoreceptor Degeneration through Regulating Retinal Microglial Activation and Migration

(2012) Meng Zhang et al.   PLoS One

An ADIOL-ERβ-CtBP Transrepression Pathway Negatively Regulates Microglia-Mediated Inflammation

(2011) Kaoru Saijo et al.   CELL

Enhancing survival of photoreceptor cells in vivo using the synthetic progestin Norgestrel

(2011) Francesca Doonan et al.   JOURNAL OF NEUROCHEMISTRY

Microglia in the healthy and degenerating retina: Insights from novel mouse models

(2010) Marcus Karlstetter et al.   IMMUNOBIOLOGY

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Constitutive Endocytosis of the Chemokine CX3CL1 Prevents Its Degradation by Cell Surface Metalloproteases

(2009) Yi-Wei Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activationin vivoandin vitro

(2009) Anthony Lyons et al.   JOURNAL OF NEUROCHEMISTRY

CCL2 is a key mediator of microglia activation in neuropathic pain states

(2008) Michael A. Thacker et al.   EUROPEAN JOURNAL OF PAIN

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Functional and structural modifications during retinal degeneration in the rd10 mouse

(2008) R. Barhoum et al.   NEUROSCIENCE

Microglial clearance function in health and disease

(2008) I. Napoli et al.   NEUROSCIENCE