Review
Infectious Diseases
Firzan Nainu, Ayu Masyita, Muh. Akbar Bahar, Muhammad Raihan, Shajuthi Rahman Prova, Saikat Mitra, Talha Bin Emran, Jesus Simal-Gandara
Summary: Bee products have been traditionally used for treating various disorders, including cancer and microbial-related diseases. Compounds found in bee products show potential in anticancer, antibacterial, antiviral, and antiparasitic activity, making them promising for cancer and infectious disease management.
Review
Engineering, Biomedical
Manisha Malani, Prerana Salunke, Shraddha Kulkarni, Gaurav K. Jain, Afsana Sheikh, Prashant Kesharwani, Jayabalan Nirmal
Summary: The limited time and large number of deaths due to COVID-19 present a challenge in finding appropriate therapeutic approaches. Drug repositioning and pharmaceutical excipients show promise as fast and effective treatment options, but further verification of their safety and efficacy is required. Meanwhile, alternative methods such as home remedies and phytotherapies are being explored for prevention and therapy in the absence of specific treatments for COVID-19.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Article
Agronomy
Shichao Lan, Wei Zhang, Xiuhai Gan
Summary: The authors designed and synthesized a series of novel 1-indanone derivatives and systematically evaluated their antiviral activities. The results showed that most compounds exhibited good protective activities against cucumber mosaic virus (CMV), tomato spotted wilt virus (TSWV), and pepper mild mottle virus (PMMoV). Compound 27 showed the best protective effects against PMMoV with an EC50 value of 140.5 mg/L, superior to ninanmycin (245.6 mg/L). Compound 27 induced immunity responses through multilayered regulation on mitogen-activated protein kinase, plant hormone signal transduction, and phenylpropanoid biosynthesis pathways. Therefore, these 1-indanone derivatives, especially compound 27, can be considered as potential immune activators to resist plant viruses.
PEST MANAGEMENT SCIENCE
(2023)
Article
Multidisciplinary Sciences
Maqusood Ahamed, Mohd Javed Akhtar, M. A. Majeed Khan
Summary: This study describes a method for manufacturing MgO nanoparticles using garlic extract to minimize environmental impact. The results show that these nanoparticles exhibit high effectiveness against various microorganisms and cancer cells.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Alyce J. Mayfosh, Zoe Day, Nathan B. Unsworth, Chun-Qiang Liu, Ruchi Gupta, Soraya Haynes, Rebecca Abraham, Sam Abraham, Zo L. Shaw, Sumeet Walia, Aaron Elbourne, Mark D. Hulett, Thomas F. Rau
Summary: GS-2 is a novel water-soluble antimicrobial agent that demonstrates activity against bacteria, fungi, and viruses, and performs more effectively in surface testing. Its ingredients are non-toxic to humans and animals, and when mixed with thymol, it can generate a bactericidal effect in a short period of time.
Review
Pharmacology & Pharmacy
Yijia Zhao, Huafeng Pan, Wei Liu, E. Liu, Yaobin Pang, Hongjin Gao, Qingying He, Wenhao Liao, Yejing Yao, Jinhao Zeng, Jing Guo
Summary: This study reviewed the anticancer activity and underlying mechanism of menthol, highlighting its safety profile and multiple pathways of action. Due to its excellent anticancer activity, further research is needed to develop menthol as a novel anticancer agent.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Materials Science, Paper & Wood
Mohammed Ibrahim Alghonaim, Sulaiman A. Alsalamah, Ahmed Alsolami, Tarek M. Abdel Ghany
Summary: The microconstituents of Ganoderma lucidum biomass were evaluated for their antimicrobial and anticancer activities. The study identified 12-octadecadienoic acid and n-hexadecanoic acid as important compounds in Ganoderma lucidum biomass, which exhibited inhibitory effects on breast cancer cell proliferation and antimicrobial activities. These compounds could be potential candidates for the development of new anticancer and antimicrobial agents.
Article
Biophysics
Emanuelle D. Freitas, Rogerio A. Rataglioli, Josephine Oshodi, Marisa M. Beppu
Summary: The coronavirus pandemic has highlighted the importance of bioactive materials in mitigating viral infections. Bioinspired antimicrobial peptides (AMPs) have emerged as suitable building blocks for antimicrobial coatings due to their versatile design and environmentally friendly features. This review discusses the advances and opportunities in using AMPs to create virucidal coatings, including the fundamental characteristics of peptide structure, advances in coating medical devices, and the role of different materials in designing antiviral coatings.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Pharmacology & Pharmacy
Seung Rim Hwang, Kushal Chakraborty, Jeong Man An, Jagannath Mondal, Hong Yeol Yoon, Yong-kyu Lee
Summary: Drug delivery to tumor sites using nanotechnology has shown promise in overcoming the drawbacks of traditional anticancer drugs, but challenges remain in the heterogeneity and blood flow in human cancer. To achieve targeted delivery and controlled release of drug molecules, smart nanocarriers combined with stimuli-responsive materials have been developed.
Article
Food Science & Technology
Bright Obeng, Christian M. Potts, Bailey E. West, John E. Burnell, Patrick J. Fleming, Juyoung K. Shim, Marissa S. Kinney, Emily L. Ledue, Suraj Sangroula, Alan Y. Baez Vazquez, Julie A. Gosse
Summary: Cetylpyridinium chloride (CPC) inhibits mast cell function by suppressing degranulation with antigen dose-dependence and at non-cytotoxic concentrations. It achieves this by disrupting phosphatidylinositol 4,5-bisphosphate and inhibiting store-operated Ca2+ entry (SOCE). Furthermore, CPC also inhibits microtubule polymerization.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Oncology
Ahmed. A. G. El-Shahawy, Esam M. Dief, S. I. El-Dek, A. A. Farghali, Fatma Abo I. El-Ela
Summary: This study demonstrates that Ni-gallate MOFs, synthesized by incorporating gallic acid as a linker, exhibit antimicrobial and anticancer activity through their mesoporous nanostructures. The synthesized Ni-gallate MOFs show antibacterial activity against both Gram-positive and Gram-negative bacteria, and antifungal activity against two different strains of fungi species. Furthermore, Ni-gallate MOFs have a significant cytotoxic effect on rhabdomyosarcoma (RMS) cells compared to the standard anticancer drug, Doxorubicin.
CANCER NANOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mary E. Law, Bradley J. Davis, Amanda F. Ghilardi, Elham Yaaghubi, Zaafir M. Dulloo, Mengxiong Wang, Olga A. Guryanova, Coy D. Heldermon, Stephan C. Jahn, Ronald K. Castellano, Brian K. Law
Summary: Tranexamic Acid (TA) is not only an antifibrinolytic agent but also exhibits anticancer activity by blocking extracellular Plasmin formation. It reduces the viability of various cancer cell lines and inhibits tumor growth in vivo. In addition to blocking extracellular Plasmin production, it perturbs intracellular signaling pathways, inhibits protein synthesis, reduces activating phosphorylation of certain proteins, decreases expression of MYC oncoprotein, and suppresses Lys acetylation. It also inhibits the uptake of Lys and Arg by cancer cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Dongqin Xia, Wenjie Li, Ce Tang, Juan Jiang
Summary: Cancer is increasing in developing countries with unsatisfactory outcomes from traditional cancer treatments. Traditional Chinese medicine (TCM) components, such as Astragaloside IV (AS-IV), have shown significant anticancer activities. AS-IV has various effects, including modulation of enzyme activities, cell cycle arrest, apoptosis and autophagy induction, and suppression of cancer progression. This article reviews the bioavailability, anticancer activity, and mechanism of AS-IV and provides suggestions for further research.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biology
Edgar Yebran Villegas-Vazquez, Laura Itzel Quintas-Granados, Hernan Cortes, Manuel Gonzalez-Del Carmen, Gerardo Leyva-Gomez, Miguel Rodriguez-Morales, Lilia Patricia Bustamante-Montes, Daniela Silva-Adaya, Carlos Perez-Plasencia, Nadia Jacobo-Herrera, Octavio Daniel Reyes-Hernandez, Gabriela Figueroa-Gonzalez
Summary: Lithium, an anti-cancer agent, shows potential in inducing apoptosis, autophagy, and inhibiting tumor growth. It also plays a role in tumor regulation and synergizes with standard cancer therapies. Additionally, lithium has neuroprotective effects and enhances anti-tumor activities in nano-sized form. However, its therapeutic activities depend on various factors. This review emphasizes the importance of repurposing lithium as a therapeutic agent and highlights its molecular mechanisms.
Article
Biochemistry & Molecular Biology
Nesrin Korkmaz, Dursun Kisa, Ozlem Kaplan, Nazan Goksen Tosun, Aykut Ozgur, Rizvan Imamoglu, Ahmet Karadag
Summary: This study investigated the biological activity of the silver coordination compound K-22. The results showed that K-22 has selective inhibitory effects on cancer cell proliferation and also stimulates apoptosis. Additionally, K-22 exhibits antimicrobial activity against various microorganisms and inhibitory potential against the BChE enzyme, which is important in Alzheimer's disease progression. Overall, K-22 shows strong potential for medical use due to its anticancer, antibacterial, antifungal, and anti-Alzheimer properties.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)