Article
Nanoscience & Nanotechnology
Soad A. Mohamad, Eman Maher Zahran, Maha Raafat Abdel Fadeel, Amgad Albohy, Mohamed A. Safwat
Summary: The study loaded acaciin into self-assembled nanofibers and found a significant antiviral effect against bovine coronavirus, offering a new avenue for herbal medicines in combating SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Virology
Sophakama Zabo, Kevin Alan Lobb
Summary: The main protease (M-pro) of SARS-CoV-2 is crucial for the virus's life cycle. It cleaves the polyproteins to form mature proteins, essential for virion formation. Molecular docking and molecular dynamics simulations were performed to study the recognition and cleavage of hexapeptides by M-pro. The results provided insights into M-pro's substrate recognition and its implications for developing small molecule inhibitors.
Article
Biochemistry & Molecular Biology
Ramakrishna Ungarala, Manne Munikumar, Sukesh Narayan Sinha, Dileshwar Kumar, R. Shyam Sunder, Suresh Challa
Summary: This study evaluated the therapeutic effects of oxidised Epigallocatechin Gallate (O-EGCG) compared to native EGCG, finding improved antioxidant capacity and anti-inflammatory properties. The O-EGCG showed significant inhibitory action against SARS-CoV-2, suggesting its potential as a treatment for COVID-19. Further in vivo studies and human clinical trials are needed to understand the mechanism of action and confirm its efficacy.
Review
Chemistry, Medicinal
Guillem Macip, Pol Garcia-Segura, Julia Mestres-Truyol, Bryan Saldivar-Espinoza, Maria Jose Ojeda-Montes, Aleix Gimeno, Adria Cereto-Massague, Santiago Garcia-Vallve, Gerard Pujadas
Summary: This review critically evaluates 61 peer-reviewed manuscripts that use a docking step in virtual screening to predict SARS-CoV-2 M-pro inhibitors. The study finds that most manuscripts do not validate their methodology or results, and the docking scores do not effectively predict the potency of M-pro inhibitors or differentiate between active and inactive compounds. The correlation between pIC(50) and docking scores is not strong, indicating limitations in using docking scores as a cutoff value for selecting new M-pro inhibitors or predicting relative bioactivity.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Chemistry, Physical
Heba T. Abdel-Mohsen, Ahmed Mostafa, Mohamed A. Omar, Omnia Kutkat, Ahmed M. El Kerdawy, Alaa A. Osman, Mohamed GabAllah, Mohamed A. Ali, Hoda I. El Diwani
Summary: In this study, two novel series of (tetrahydro)thioquinazoline-N-arylacetamides and (tetrahydro)thioquinazoline-N-arylacetohydrazides were designed, synthesized, and evaluated for their antiviral activity against SARS-CoV-2. Compounds 17g, 18c, and 18f exhibited potent antiviral activity with IC50 values of 21.4, 38.45, and 26.4 μM, respectively. Moreover, compounds 18c and 18f showed selectivity towards SARS-CoV-2 with SI values of 10.67 and 16.04, respectively. Mechanistic studies revealed that compounds 17g, 18c, and 18f inhibited the virus at both the adsorption and replication stages, and possessed favorable physicochemical and drug-likeness properties for further optimization as novel antiviral agents.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Heba T. Abdel-Mohsen, Mohamed A. Omar, Omnia Kutkat, Ahmed M. El Kerdawy, Alaa A. Osman, Mohamed GabAllah, Ahmed Mostafa, Mohamed A. Ali, Hoda I. El Diwani
Summary: In this study, two novel series of compounds were designed, synthesized, and evaluated for their antiviral activity against SARS-CoV-2. Compound 17g and compounds 18c and 18f showed potent antiviral activity, with IC50 values of 21.4, 38.45, and 26.4 μM, respectively. They also exhibited selective inhibition against SARS-CoV-2 with satisfactory physicochemical and drug-likeness properties.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biology
Alaa M. Elgohary, Abdo A. Elfiky, Florbela Pereira, Tarek Mohamed Abd El-Aziz, Mansour Sobeh, Reem K. Arafa, Amr El-Demerdash
Summary: This paper presents a virtual screening and molecular modeling study on 15 batzelladine marine alkaloids against the main protease (M-pro) of the novel coronavirus. Through molecular docking and simulations, two promising compounds, batzelladines H-I (8-9) and batzelladines F-G (6-7), were identified with high affinity to the M-pro and demonstrated good stability in molecular dynamics simulations. The study also revealed the structural and pharmacophoric features important for efficient protein-ligand interaction.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Medicinal
V. Alagarsamy, P. Shyam Sundar, B. Narendhar, M. T. Sulthana, Vishaka S. Kulkarni, A. Dharshini Aishwarya, V. Raja Solomon, S. Murugesan, S. Jubie, K. Rohitha, Sangeeta Dhanwar
Summary: This study used computational screening to identify two promising small molecules, sennoside-B and isotrilobine, from Ayurvedic medicinal plants, which showed lower binding energies to the SARS-CoV-2 Mpro target. These molecules can be further investigated and utilized as parent core molecules for the development of novel lead compounds for preventing COVID-19.
MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Nelson H. Morgon, Giulia S. Grandini, Mauricio I. Yoguim, Caio M. Porto, Lucas C. Santana, Srijit Biswas, Aguinaldo R. de Souza
Summary: The study investigated the interaction between (R and S)-Linezolid and the SARS-CoV-2 spike protein, and found that only (S)-Linezolid had a stable binding energy, indicating potential biological activity.
JOURNAL OF MOLECULAR MODELING
(2021)
Article
Microbiology
Maria I. Zapata-Cardona, Lizdany Florez-alvarez, Wildeman Zapata-Builes, Ariadna L. Guerra-Sandoval, Carlos M. Guerra-Almonacid, Jaime Hincapie-Garcia, Maria T. Rugeles, Juan C. Hernandez
Summary: This article evaluates the in vitro antiviral effect of atorvastatin (ATV) against SARS-CoV-2 and identifies its interaction affinity with two SARS-CoV-2 proteins. The results show that ATV demonstrates antiviral activity against different treatment strategies and variants, with a favorable binding affinity with viral proteins. Considering the extensive clinical experience of ATV use, it could be valuable in the treatment of COVID-19.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei Wei, Ni Kong, Meng-Zhen Liu, Ting Han, Jun-Feng Xu, Chong Liu
Summary: This study found that anisodamine suppressed SARS-CoV-2 infection in Vero E6 cells and reduced SARS-CoV-2 pseudovirus entry in HEK293/hACE2 cells. Molecular docking studies suggested that anisodamine may target SARS-CoV-2 main protease (Mpro) with a docking score of -6.63 kcal/mol and form three hydrogen bonds at the predicted active site of Mpro.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Shiv Bharadwaj, Esam Ibraheem Azhar, Mohammad Amjad Kamal, Leena Hussein Bajrai, Amit Dubey, Kanupriya Jha, Umesh Yadava, Sang Gu Kang, Vivek Dhar Dwivedi
Summary: The recent COVID-19 pandemic has led to global concern for public health. This study identified 1051 FDA-approved drugs with potential to target the main protease responsible for SARS-CoV-2 replication. Among these drugs, R428, Teniposide, VS-5584, and Setileuton showed stronger stability and affinity, and further validation is recommended.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Pharmacology & Pharmacy
Dina B. Mahmoud, Walaa M. Ismail, Yassmin Moatasim, Omnia Kutkat, Aliaa N. ElMeshad, Shahira M. Ezzat, Kadriya S. El Deeb, Ahlam M. El-Fishawy, Mokhtar R. Gomaa, Ahmed Kandeil, Ahmed A. Al-Karmalawy, Mohamed A. Ali, Ahmed Mostafa
Summary: The study found that polyphenol-rich Cuphea ignea extract has the potential to combat SARS-CoV-2, and a self-nanoemulsifying formulation can enhance solubility and enable combined delivery, offering a new direction for antiviral treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yury A. Gubarev, Natalya Sh Lebedeva, Elena S. Yurina, Sergey A. Syrbu, Aleksey N. Kiselev, Mikhail A. Lebedev
Summary: The study demonstrates that hetaryl-substituted porphyrins can interact with proteins of SARS-CoV-2 virus, inhibiting the functions of S protein, N protein, and nsp13, thereby preventing viral replication and processing. Additionally, hetaryl-substituted porphyrins can produce oxidants to assist in deactivating the virus's RBM structure.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Article
Pharmacology & Pharmacy
Saranya Nallusamy, Jayakanthan Mannu, Caroline Ravikumar, Kandavelmani Angamuthu, Bharathi Nathan, Kumaravadivel Nachimuthu, Gnanam Ramasamy, Raveendran Muthurajan, Mohankumar Subbarayalu, Kumar Neelakandan
Summary: The study explores the potential of phytochemicals and antiviral molecules from various plant species in inhibiting SARS-CoV-2, highlighting the need for discovering novel drugs. Some plant compounds, such as cyanin from ginger, showed promising inhibitory activity against main proteases of SARS-CoV-2, SARS-CoV, and MERS-CoV. Identified herbal plants, including Mangifera indica and Vitex negundo, were suggested as potential sources of phytochemicals for combating COVID-19. Overall, the study emphasizes the importance of herbal medicines in drug discovery and development for treating viral diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Aerospace
Xuewen Liu, Xinxi Zeng, Changbao Shao, Yuanjing Xu, Jincheng Hu, Pengxuan Liu, Hongwei Yang, Shuang Li
Summary: The paper presents the method and results of the team ASTL-NUAA from NUAA for solving the problem of GTOC 11. The problem is decomposed into three parts: optimization of multiple targets flyby sequence for Mother Ships, construction of a station-building database for asteroid transfer arcs, and mission planning for station-building. A three-step optimization framework is proposed to solve the problem. The optimal solutions are obtained by analyzing and selecting candidate asteroids, applying a genetic algorithm for asteroid flyby sequence determination, constructing a station-building database with less computation burden, and using a branch-and-bound algorithm for maximizing minimal mass among stations. The final score of the solution is 4315.6663, achieved after the competition.
Article
Engineering, Aerospace
Baichun Gong, Yuquan Ma, Weifu Zhang, Shuang Li, Xianqiang Li
Summary: This study develops a simple and fast algorithm to address the angles-only relative orbit determination problem by utilizing a deep neural network (DNN). The proposed algorithm is effective in estimating the relative position and shows better accuracy than the estimation of relative velocity.
Article
Mathematics
Xuxing Huang, Bin Yang, Shuang Li, Jinglang Feng, Josep J. Masdemont
Summary: This study considers the relative orbit of Ganymede with respect to Europa to accurately capture the perturbation potential caused by Ganymede. The orbital evolution behaviors of the Europa probe are studied under the non-spherical gravitation of Europa and the third-body gravitation of Jupiter and Ganymede. The initial orbital conditions of the Ganymede-synchronous frozen orbit are developed, and a station-keeping maneuver is performed, showing acceptable energy consumption for orbital maintenance.
Review
Engineering, Aerospace
Baichun Gong, Sha Wang, Shuang Li, Xianqiang Li
Summary: This article reviews the current status and solutions of space relative navigation based on angles-only measurements, and briefly reviews the flight demonstration results in two projects.
Article
Engineering, Aerospace
Yingjie Zhao, Hongwei Yang, Shuang Li, Yirong Zhou
Summary: This paper proposes an intelligent inversion method using Hopfield neural networks (HNNs) to rapidly model the gravity field near elongated asteroids and estimate on-orbit simplified model parameters. The method includes a rotating mass dipole model, a stepped parameter estimation model, a dynamic parameter linearization technique, and a Lyapunov function matching. Simulation results on natural elongated asteroids demonstrate that this method can quickly estimate the parameters and provide a good approximation of the gravity field.
Article
Engineering, Aerospace
Hongchen Jiao, Hailiang Li, Liangbo Zhao, Pengfei Xiao, Yan Li, Tao Wang, Chi Zhang, Zhongkai Wen, Huan Zhang, Qingjun Zhang, Beichao Wang, Shuang Li
Summary: This paper proposes and verifies an optimal estimation method for satellite attitude deviation in orbit using the frequency domain features of microwave remote sensing data. The method is applied to the Gaofen-3B (GF-3B) satellite and involves obtaining Synthetic Aperture Radar (SAR) imaging results and Doppler center deviation inversions. A model is established between the Doppler center deviation and satellite attitude deviation, allowing for the separation and estimation of attitude deviations in different dimensions. The proposed method successfully suppresses attitude deviation and improves image quality of SAR satellites.
Article
Engineering, Aerospace
Jun Sun, Yizhen Meng, Jing Huang, Fucheng Liu, Shuang Li
Summary: This article investigates an adaptive, distributed, and cooperative control strategy for the problem of spacecraft swarm reconfiguration, which involves assembling the spacecraft at a close distance to one another while avoiding collisions and keeping spacecraft far from an obstacle. The proposed control strategy is inspired by the actor-critic framework of reinforcement learning (RL) algorithms and utilizes a combination of critic neural network (NN) and artificial potential field (APF) to address the soft and hard constraints. The adaptive, distributed, and cooperative controller is devised using an actor NN of the RL algorithm, an APF, and Backstepping control technology.
Article
Engineering, Aerospace
Jincheng Hu, Hongwei Yang, Shuang Li, Yingjie Zhao
Summary: To address the issue of time-consuming training in reinforcement learning caused by sparse reward functions, an efficient dense reward framework is proposed for robust low-thrust trajectory optimization. The framework includes dense reward functions designed separately for deterministic and uncertain scenarios, and incorporates exponential acceleration terms to improve training efficiency in rendezvous missions. Empirical forbidden zones and exponential terms are also introduced to design a dense reward function for the deterministic scenario. The method is demonstrated to be effective and efficient in Earth-Mars and Earth-Venus missions.
ADVANCES IN SPACE RESEARCH
(2023)
Article
Engineering, Aerospace
Wenhao Xue, Beichao Wang, Xuxing Huang, Bin Yang, Zhongkai Wen, Huan Zhang, Shuang Li
Summary: This paper proposes an improved RRT* algorithm to obtain discrete quaternion path nodes that satisfy the pointing constraints of multiple sensors. Trapezoidal path planning method is used to define the temporal properties of these path nodes, and bounded constraints on angular velocity and control moment are introduced. Continuous quaternion curves are calculated through segmented cubic spline interpolation function. The method is verified to be feasible and capable of satisfying complex constraints, obtaining attitude optimization path, and alleviating large control moment variations during maneuver.
ADVANCES IN SPACE RESEARCH
(2023)
Article
Engineering, Aerospace
Xu Liu, Shuang Li, Ming Xin
Summary: This article presents a pseudospectral convex optimization-based model predictive static programming (PCMPSP) for the constrained guidance problem. The sensitivity relation between the state increment and control correction is reformulated using Legendre-Gauss and Legendre-Gauss-Radau pseudospectral transcriptions. Modifications to the initial guess solution and reference trajectory update are introduced to enhance the accuracy and robustness of the algorithm. The simulation results demonstrate that the PCMPSP has better performance compared to existing convex programming methods in terms of sensitivity, accuracy, and convergence speed.
IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS
(2023)
Article
Engineering, Aerospace
Xu Liu, Shuang Li, Ming Xin
Summary: This article introduces a method called Indirect Sequential Convex Programming (ISCP), which combines the Uniform Trigonometrization Method (UTM) and Sequential Convex Programming (SCP) to solve difficulties in the Mars entry problem. The ISCP method eliminates the need for evaluating two possible solutions through Pontryagin's minimum principle (PMP) and solves the nonlinear two-point boundary value problem (TPBVP) by relaxing it into a convex programming problem. Simulations show the effectiveness and efficiency of the ISCP method for Mars entry missions.
Article
Engineering, Aerospace
Baichun Gong, Linhai Jiang, Xin Ning, Shuang Li
Summary: This study developed a mission-planning algorithm for multi-target tracking in high altitude orbits using a passive optical sensor. It also addressed the distributed estimation problem and achieved the resolution of mission planning and conflict in multi-target tracking through the developed algorithm.
AEROSPACE SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Aerospace
Xuxing Huang, Josep J. Masdemont, Shuang Li
JOURNAL OF GUIDANCE CONTROL AND DYNAMICS
(2023)
Article
Environmental Sciences
Zhongkai Wen, Huan Zhang, Weiping Shu, Liqiang Zhang, Lei Liu, Xiang Lu, Yashi Zhou, Jingjing Ren, Shuang Li, Qingjun Zhang
Summary: This paper proposes a universal DNN model architecture and corresponding training scheme, and provides different SSR brightness temperature increment models for different relative permittivity models utilizing DNN based on offshore experiment data, and compares them with the existing models. The results show that the DNN models perform significantly better than the existing models, and that their calculation accuracy is close to the detection accuracy of a radiometer. Therefore, this study effectively solves the problem of SSR brightness temperature correction under different relative permittivity models, and provides a theoretical support for high-precision SSS inversion research.
Article
Engineering, Aerospace
Kai Cao, Renyuan Xie, Jianmin Zhou, Xiaowei Zhang, Jingji Wang, Shuang Li
Summary: This paper presents a rigid-flexible electromechanical coupling dynamic model for optimizing the placement of actuators on an asymmetric spacecraft continuum system. The model considers the effects of installation position and physical characteristics of the piezoelectric actuator. A genetic algorithm with a hybrid optimization criterion is employed to optimize the installation location of the actuators. Numerical simulations demonstrate that utilizing the actuator with the optimized position allows for effective vibration suppression and energy consumption reduction.
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
