Article
Oncology
Kimberly D. Miller, Quinn T. Ostrom, Carol Kruchko, Nirav Patil, Tarik Tihan, Gino Cioffi, Hannah E. Fuchs, Kristin A. Waite, Ahmedin Jemal, Rebecca L. Siegel, Jill S. Barnholtz-Sloan
Summary: Brain and other CNS tumors are highly fatal cancers in the United States, with different incidence rates and survival rates among different races and age groups. Survival disparities, especially in childhood tumors, highlight the importance of providing more resources to advance research and understand the reasons behind differences in brain tumor occurrence, especially among rarer subtypes and understudied populations.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Review
Physiology
Sera Nakisli, Alfonso Lagares, Corinne M. M. Nielsen, Henar Cuervo
Summary: Previously considered passive support cells, mural cells-pericytes and vascular smooth muscle cells-have started to garner more attention in disease research, as more subclassifications, based on morphology, gene expression, and function, have been discovered. Central nervous system (CNS) arteriovenous malformations (AVMs) represent a neurovascular disorder in which mural cells have been shown to be affected, both in animal models and in human patients. In this review, we summarize the observed perturbations to mural cells in human CNS AVM samples and CNS AVM animal models, and we discuss various potential mechanisms relating mural cell pathologies to AVMs.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ko-Ting Chen, Kuo-Chen Wei, Hao-Li Liu
Summary: Focused ultrasound combined with microbubbles enables precise, transient, reversible, and noninvasive opening of the blood-brain barrier. This technology enhances the penetration of therapeutic agents in the central nervous system, while also modulating local immunity and neuronal activity.
Review
Cell Biology
Sara Gonzalez-Hernandez, Yoh-suke Mukouyama
Summary: The central nervous system is considered an immune privilege organ due to its limited capacity for an immune response. While recent discoveries have challenged this view by identifying lymphatic-like vessels in the eye and meninges, the presence of lymphatic vessels in the CNS parenchyma has not been reported. This article discusses the potential reasons for the dearth of lymphatic vessels specifically in the CNS parenchyma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Immunology
Tiarne van de Walle, Alessandra Vaccaro, Mohanraj Ramachandran, Ilkka Pietila, Magnus Essand, Anna Dimberg
Summary: Glioblastoma is an aggressive brain tumor with a low prevalence of tumor-reactive T cells, and recent data suggest that naive T cells may be activated within brain tumor-associated tertiary lymphoid structures. Promoting tertiary lymphoid structures could enhance priming of tumor antigen-targeted T cells and sensitize glioblastomas to cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Behavioral Sciences
Juliet L. Kroll, Thomas Ritz
Summary: Accumulating behavioral evidence suggests that asthma is associated with cognitive deficits. A literature review was conducted to identify studies examining potential central nervous system (CNS) contributions to cognition in asthma. The review discusses the general understanding of the CNS in asthma, proposes a working model linking neural influences of asthma pathology with cognition, and highlights the clinical significance of CNS and neurocognitive sequelae in asthma.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Immunology
Yerly Useche, Ana Rosa Perez, Juliana de Meis, Adriana Bonomo, Wilson Savino
Summary: The involvement of the central nervous system (CNS) in human acute and chronic Chagas disease (CD) has been widely reported. Meningoencephalitis is common during acute infection, while cognitive and behavioral impairments often accompany CNS involvement during the chronic phase. Studies on rodents infected with Trypanosoma cruzi (T. cruzi) have shown abnormal behavior, brain inflammation, production of pro-inflammatory cytokines, and parasitism in various brain areas involving microglia, macrophages, astrocytes, and neurons. However, the mechanisms the parasite uses to reach the brain are largely unknown.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Ning Ji, Fuxiao Wang, Miaomiao Wang, Wencai Zhang, Han Liu, Jiacan Su
Summary: With the increasing aging population, there is a rising prevalence of central nervous system (CNS) diseases. The blood-brain barrier (BBB) poses a challenge for drug delivery to the CNS due to various obstacles. Recent studies have shown that the gut microbiota (GM) plays a crucial role in CNS diseases. GM can modulate host signaling pathways and regulate distant organ functions by delivering bioactive substances through bacterial extracellular vesicles (BEVs). Researchers are exploring the use of BEVs as a promising platform for treating CNS diseases, considering their nanostructure, ability to penetrate the BBB, low toxicity, high biocompatibility, ease of modification, and scalability.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Mathematics
Mohammed Balubaid, Osman Taylan, Mustafa Tahsin Yilmaz, Ehsan Eftekhari-Zadeh, Ehsan Nazemi, Mohammed Alamoudi
Summary: The Central Nervous System (CNS) is a vital part of the nervous system that comprises the brain and spinal cord. Researchers have proposed a modified version of a neuronal model using a quadratic-based modeling called Digital Spiking Silicon Neuron (DSSN), which can imitate the basic behaviors of the original model. The hardware implementation of the new model shows high similarity with the original model in terms of neuronal behaviors, as well as achieving higher frequency and lower cost conditions.
Review
Nanoscience & Nanotechnology
Tianyou Liu, Qinglian Xie, Zaiquan Dong, Qiang Peng
Summary: The treatment of central nervous system disorders is challenging due to the presence of the blood-brain barrier (BBB). Nanoparticles-based drug delivery systems have shown great potential in overcoming the BBB and treating CNS diseases. This article summarizes the recent progress in nanoparticles-based systems for CNS delivery and discusses the prerequisites, drawbacks, and challenges of nanocarriers in this field, such as protein corona formation.
Review
Virology
Arash Hellysaz, Marie Hagbom
Summary: This qualitative review examines the relationship between rotavirus infection and CNS complications, indicating the involvement of gut-brain mechanisms in symptoms driven by the CNS. Rotavirus can affect the CNS through various pathways, including neural gut-brain communication and systemic spread, requiring further research to elucidate the underlying mechanisms.
Article
Nanoscience & Nanotechnology
Han Li, Yinan Ding, Jiayan Huang, Yanyan Zhao, Wei Chen, Qiusha Tang, Yanli An, Rong Chen, Chunmei Hu
Summary: In this study, we loaded rifampin (RIF) into exosomes and modified the exosomes with a brain-targeting peptide to improve the blood-brain barrier (BBB) permeability. The results showed that the modified exosomes exhibited high targeting capacity and permeability in vitro and in vivo, and had high anti-tuberculosis activity and biocompatibility, providing hope for an effective treatment of CNS-TB.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Engineering, Biomedical
Xun Zhang, Jie Zhou, Zhongwei Gu, Hu Zhang, Qiyong Gong, Kui Luo
Summary: Despite advancements in medical services and lifespan, there has been a sharp increase in CNS disorders, posing challenges in diagnosis and delivery of diagnostic agents, especially across the blood-brain barrier. The use of nanomaterials is seen as a promising strategy to address these challenges, but further development is needed to overcome current obstacles in CNS diagnostics.
Review
Nutrition & Dietetics
Adriano E. Lima-Silva, Gislaine Cristina-Souza, Marcos D. Silva-Cavalcante, Romulo Bertuzzi, David J. Bishop
Summary: Caffeine is widely consumed as an ergogenic aid for exercise performance, with its stimulatory effect on the central nervous system being a key mechanism. However, caffeine may also have direct effects on other physiological systems like the pulmonary, cardiovascular, and muscular systems during high-intensity whole-body exercise. Understanding these multiple effects of caffeine could potentially expand its use in different sporting contexts and aid in the treatment of certain diseases.
Review
Clinical Neurology
Svetlana Blitshteyn
Summary: Postural orthostatic tachycardia syndrome (POTS) should not only be considered as a disorder of the peripheral nervous system, but also as a central nervous system (CNS) disorder. This is supported by significant CNS symptom burden in patients with POTS, structural and functional differences found on neuroimaging in patients with POTS, evidence of cerebral hypoperfusion and alteration in cerebrospinal fluid volume, and positive response to medications targeting the CNS and non-pharmacologic CNS therapies. Redefining POTS as a CNS disorder may open up new possibilities for pharmacotherapy and non-pharmacologic therapeutic interventions for patients affected by this disabling syndrome.
JOURNAL OF NEUROLOGY
(2022)
Review
Food Science & Technology
Rachel Kimble, Katherine Jones, Glyn Howatson
Summary: Anthocyanins have potential to facilitate exercise recovery by improving antioxidant capacity, reducing inflammation, and enhancing strength and muscle soreness. The effects are dose-dependent.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Adam Field, Liam David Corr, Hugo Sarmento, Robert Naughton, Tom Clifford, Matthew Haines, Richard Michael Page, Liam David Harper
Summary: The aim of this study was to assess muscle damage recovery following 90- and 120-min of simulated soccer match-play. The results showed that recovery of creatine kinase (CK) was delayed up to 72 hours after 120 minutes of simulated match-play. However, 120 minutes of simulated soccer had no additional impact on functional recovery and perceived muscle soreness compared to 90 minutes.
RESEARCH QUARTERLY FOR EXERCISE AND SPORT
(2023)
Editorial Material
Sport Sciences
Adam C. Field, Liam D. Harper, Jeffrey W. F. Aldous, Richard M. Page
Summary: Soccer is a rapidly growing area of research, with a large increase in the number of articles published. The activity profile and data collection techniques of soccer match-play are varied. Soccer-specific simulations have been developed to provide a reproducible exercise stimulus for researchers and practitioners. These simulations can be used to investigate the effects of nutrition and environmental stress on performance, as well as assess physiological and biomechanical responses to match-play representations. A scoring system was used to evaluate the research and practical applications of different simulation designs.
SCIENCE AND MEDICINE IN FOOTBALL
(2023)
Review
Hospitality, Leisure, Sport & Tourism
James Andrew Fleming, Adam Field, Steve Lui, Robert Joseph Naughton, Liam David Harper
Summary: This study systematically reviewed the available literature on training and match-play demands in an elite and highly trained junior tennis population. The results showed that training sessions failed to replicate the demands of tournament match-play, and matches played on clay courts were more challenging. Multiple matches per day negatively impacted performance and physical well-being of the players.
INTERNATIONAL JOURNAL OF SPORTS SCIENCE & COACHING
(2023)
Article
Sport Sciences
Sarah E. Costello, Jack R. W. Rossiter, Glyn Howatson, Phillip G. Bell, Barry O'Neill, Ken van Someren, Crystal F. Haskell-Ramsay
Summary: This study investigated the effects of intensified training on cognitive function, psychological state, and performance in trained cyclists. The findings showed that two weeks of intensified training resulted in overreaching, as demonstrated by decreased peak and mean power output, increased total mood disturbance, and disruption to recovery-stress balance. However, cognitive function remained unaffected during the training period, suggesting caution in using it as an early indicator of overreaching.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Nutrition & Dietetics
Noppadol Kietsiriroje, Hanya Shah, Marios Zare, Lauren L. O'Mahoney, Daniel J. West, Sam M. Pearson, Ramzi A. Ajjan, Matthew D. Campbell
Summary: This study aimed to investigate the relationship between dietary intake and insulin resistance (IR), as well as vascular biomarkers, in individuals with Type 1 Diabetes (T1D). The results showed that higher fat intake was associated with increased IR and an adverse vascular profile, while higher carbohydrate intake did not show any association.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Review
Sport Sciences
Richard Michael Page, Adam Field, Ben Langley, Liam David Harper, Ross Julian
Summary: This systematic review aims to assess the effects of fixture congestion on injuries during professional soccer.
Article
Psychology, Clinical
Anna Wippich, Glyn Howatson, Georgia Allen-Baker, Derek Farrell, Matthew Kiernan, Andrea Scott-Bell
Summary: This study conducted experiments on low socioeconomic status individuals and refugees in Lebanon, proving the effectiveness of eye movement desensitization reprocessing (EMDR) in treating posttraumatic stress disorder (PTSD), anxiety, and depression symptoms. These findings contribute to the research base for under-researched populations.
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2023)
Article
Sport Sciences
Natalie Dyas, David Green, Kevin Thomas, Esme Matthew, Glyn Howatson
Summary: This study aimed to assess the relationship between physical floor based performance measures and maximum Time of Flight (ToF) in elite gymnasts. The results showed that there were very large and large positive correlations between CMJ F-0 and ToF for seniors and juniors respectively, and very large positive correlations between CMJ height and total ToF for both seniors and juniors. Multiple regression analyses revealed that CMJ F-0 predicted 72% of ToF variability in seniors, while CMJ height, 10 to 5 Reactive Strength Index (RSI), and CMJ F-0 predicted 82% of ToF variability in juniors.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
Daniel M. Over, Nicola Arjomandkhah, Jordan D. Beaumont, Stuart Goodall, Martin J. Barwood
Summary: The study found that menthol applied topically to the skin improves perception and increases force generation. Nine trained male subjects were tested after spraying menthol on their legs during different weightlifting tasks. The results showed an improved performance in the isometric and dynamic lifting tasks after the application of menthol.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2023)
Article
Sport Sciences
Sean Hudson, Michael Fish, Matthew Haines, Liam Harper
Summary: This study investigates the practices and perspectives of rugby league practitioners in monitoring the physical demands of training through an online survey. The findings suggest that improving performance is considered the most important factor for monitoring training demands, with practitioners using time motion analysis (e.g., GPS) or accelerometers. The current practices are mostly supported by research evidence, with a preference for internal load monitoring tools such as RPE.
SCIENCE AND MEDICINE IN FOOTBALL
(2023)
Article
Nutrition & Dietetics
Emily James, Tom Butler, Simon Nichols, Stuart Goodall, Alasdair F. O'Doherty
Summary: This study investigated the provision of dietary education in cardiac rehabilitation centers in the UK. The findings showed that nurses and dietitians were the primary providers of dietary education, and most services used credible resources to support their education. However, a significant proportion of practitioners did not have nutrition-related qualifications. The cardiac rehabilitation programs were mostly community-based, lasting 8 weeks, and included two diet sessions. The services primarily focused on the Mediterranean diet, with less attention given to topics such as malnutrition and protein intake.
BRITISH JOURNAL OF NUTRITION
(2023)
Editorial Material
Sport Sciences
Justin W. Andrushko, Joshua C. Carr, Jonathan P. Farthing, Lindsey K. Lepley, Jason M. Defreitas, Stuart Goodall, Ashlee M. Hendy, Glyn Howatson, Dustin R. Grooms, Tjerk Zult, Tibor Hortobagyi, Gulcan Harput, Maria Papandreou, Kazunori Nosaka, Richard G. Carson, Andrea Manca, Franca Deriu, David George Behm, Dawson J. Kidgell, Nicholas C. Clark, Lara A. Boyd
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Physiology
Gonzalo Gomez-Guerrero, Paul Ansdell, Glyn Howatson, Janne Avela, Simon Walker
Summary: This study investigated spinal excitability during the transcranial magnetic stimulation (TMS) silent period (SP) at different time delays in m.rectus femoris. The results showed that reduced spinal excitability was extended during 50% and 75% of maximum voluntary contraction (MVC). In the future, paired TMS-lumbar stimulation (LS) could be a valuable method for studying changes in spinal excitability during SP and testing various neurophysiological phenomena.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Sport Sciences
Danny Lum, Glyn Howatson
Summary: This study compared the acute effects of isometric strength training and heavy resistance training on sprinting, jumping, and isometric strength performance. The results showed that acute heavy resistance training led to a greater reduction in sprinting strength performance and lower perceived recovery.
JOURNAL OF SCIENCE IN SPORT AND EXERCISE
(2023)