Article
Oncology
Hao Li, Jia-Yi Ding, Meng-Jie Zhang, Hai-Jun Yu, Zhi-Jun Sun
Summary: Tertiary lymphoid structures (TLSs) are organized aggregates of lymphocytes and antigen-presenting cells that develop in non-lymphoid tissues during chronic inflammation, resembling the structure and features of secondary lymphoid organs. TLSs have been shown to play a crucial role in antitumor immunity within solid tumors, facilitating T cell and B cell differentiation and the production of antitumor antibodies. The formation of TLSs is driven by the cytokine signaling network between various cell populations, and this review comprehensively describes the mechanisms and therapeutic potential of exploiting these mechanisms to induce or enhance intratumoral TLSs for immunotherapy.
Article
Cell Biology
Xingwang Zhou, Wenyan Li, Jie Yang, Xiaolan Qi, Yimin Chen, Hua Yang, Liangzhao Chu
Summary: This study identified heterogeneity of TLS in gliomas through consensus clustering of TLS gene profiles, leading to the classification of three subtypes. These subtypes showed significant differences in clinical characteristics, immune infiltration, and biological functions, with subtype C associated with poorer prognosis, higher levels of immune cells, and enrichment in specific immune-related diseases.
Review
Immunology
Shuaiwei Wang, Serge A. van de Pavert
Summary: Immune cells within the central nervous system, particularly innate lymphoid cells, play important roles in neurological inflammation and disease. This review discusses the presence of innate lymphoid cells in the central nervous system and their involvement in major neurological diseases such as ischemic stroke, Alzheimer's disease, and Multiple Sclerosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Xinlei Zou, Canghai Guan, Jianjun Gao, Wujiang Shi, Yunfu Cui, Xiangyu Zhong
Summary: Pancreatic cancer is highly malignant and has limited response to immunotherapies due to its hypoxic and immunosuppressive tumor microenvironment. The formation of tertiary lymphoid structures (TLSs) induced by immune cells can be found in both intra- and peritumor tissues of pancreatic cancer. Intratumoral TLSs are associated with a good prognosis and can be used as an indicator to assess treatment effectiveness. Targeted induction of TLS formation may open up new possibilities for immunotherapy of pancreatic cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Shota Aoyama, Ryosuke Nakagawa, James J. Mule, Adam W. Mailloux
Summary: Tertiary lymphoid structures (TLS) are ectopically formed aggregates of organized lymphocytes and antigen-presenting cells in solid tissues, functioning as centers of antigen presentation and adaptive immune activation. Their presence in cancer confers positive prognostic value, leading to interest in their artificial induction as a new form of immunotherapy. Approaches for inducible TLS (iTLS) utilize chemokines, inflammatory factors, or cellular analogues, while facing challenges in clinical translation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zhenghao Wu, Junjie Zhou, Yunxiao Xiao, Jie Ming, Jing Zhou, Fang Dong, Xiaoqi Zhou, Zhuoshuo Xu, Xiangwang Zhao, Ping Lei, Tao Huang
Summary: In this study, the authors identified a subset of B cells called B-IR cells that have a memory phenotype and promote the response to immune checkpoint inhibitor (ICI) therapy. These cells were present in cancer-associated tertiary lymphoid structures and their gene signatures correlated with positive outcomes in patients treated with ICI therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Angeliki Datsi, Ruediger V. Sorg
Summary: Dendritic cell vaccination (DCV) is a promising immunotherapy for treating glioblastomas, with numerous trials showing potential but some controlled studies failing to detect a survival benefit. Further exploration is needed to fully understand the potential of this therapeutic approach.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Wenjie Zhang, Yuan Chen, Hui Pei
Summary: C1q is an essential component of the complement system, performing non-specific immune functions and playing a crucial role in immune homeostasis and normal physiological functions. In the developing central nervous system, C1q is involved in synapse formation, pruning, and the development of neuronal networks. C1q has a close relationship with microglia and astrocytes and may contribute to the development of CNS disorders. Clinical trials are already underway for CNS disorders, highlighting the potential therapeutic target of C1q.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Alessandra Vaccaro, Tiarne van de Walle, Mohanraj Ramachandran, Magnus Essand, Anna Dimberg
Summary: Tertiary lymphoid structures (TLS) are lymph node-like aggregates that form in association with chronic inflammation or cancer. They have been shown to have a positive prognosis and increased sensitivity to cancer immunotherapy. However, a comprehensive understanding of their role in anti-tumor immunity and the mechanisms involved in their formation and function is still lacking. Further research in relevant cancer models is needed to evaluate the impact of TLS on cancer therapies and develop new treatment approaches that promote their formation in cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Dominique Figarella-Branger, Carole Colin, Nathalie Baeza-Kallee, Aurelie Tchoghandjian
Summary: This review focuses on the expression of A2B5 in the central nervous system and gliomas. A2B5 is found in neural stem cells during brain development and in neurogenic areas and white matter in adults, where it identifies oligodendrocyte precursor cells and cells with neural stem cell properties. A2B5 has been identified as an accurate marker to identify glioma cancer stem cells and its expression is positively correlated with stemness and tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Boyuan Huang, Xuesong Li, Yuntao Li, Jin Zhang, Zhitao Zong, Hongbo Zhang
Summary: Glioblastoma multiforme (GBM) is the most common and aggressive malignant tumor in the central nervous system. Immunotherapy has shown promising results in the treatment of GBM, but future developments will require an integrated approach with various treatment modalities and specific targeted therapies for the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Nanda Horeweg, Hagma H. Workel, Dominik Loiero, David N. Church, Lisa Vermij, Alicia Leon-Castillo, Ricki T. Krog, Stephanie M. de Boer, Remi A. Nout, Melanie E. Powell, Linda R. Mileshkin, Helen MacKay, Alexandra Leary, Naveena Singh, Ina M. Juergenliemk-Schulz, Vincent T. H. B. M. Smit, Carien L. Creutzberg, Viktor H. Koelzer, Hans W. Nijman, Tjalling Bosse, Marco de Bruyn
Summary: B-cells and tertiary lymphoid structures (TLS) play critical roles in endometrial cancer (EC). L1CAM is identified as a marker for mature TLS and the presence of TLS is associated with favorable prognosis in EC patients.
NATURE COMMUNICATIONS
(2022)
Review
Neurosciences
Yadaly Gassama, Alexandre Favereaux
Summary: Extracellular vesicles play a crucial role in intercellular communication, especially in the central nervous system, and may serve as important biomarkers and therapeutic agents in clinical research in the future.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Clinical Neurology
Angela N. Viaene, Cunfeng Pu, Arie Perry, Marilyn M. Li, Minjie Luo, Mariarita Santi
Summary: Congenital brain tumors are rare and unique, accounting for a small percentage of all pediatric brain tumors. They have distinct characteristics different from brain tumors in older pediatric patients and adults.
Review
Immunology
Steven K. Yarmoska, Ali M. Alawieh, Stephen Tomlinson, Kimberly B. Hoang
Summary: The complement system is a crucial component of innate immunity involved in recognizing and responding to pathogens. Neoplastic diseases often manipulate the complement system to evade the immune system and promote tumor growth within the central nervous system, where both innate and adaptive immunity play active roles. Research has primarily focused on adaptive immunity, but innate immunity remains critical in the progression of central nervous system neoplasms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yuan Xie, Anders Sundstrom, Naga P. Maturi, E-Jean Tan, Voichita D. Marinescu, Malin Jarvius, Malin Tirfing, Chuan Fin, Lei Chen, Magnus Essand, Fredrik J. Swartling, Sven Nelander, Yiwen Jiang, Lene Uhrbom
JOURNAL OF PATHOLOGY
(2019)
Review
Oncology
Miika Martikainen, Magnus Essand
Article
Hematology
Barbara Depreter, Karin E. Weening, Karl Vandepoele, Magnus Essand, Barbara De Moerloose, Maria Themeli, Jacqueline Cloos, Diana Hanekamp, Ine Moors, Inge D'hont, Barbara Denys, Anne Uyttebroeck, An Van Damme, Laurence Dedeken, Sylvia Snauwaert, Glenn Goetgeluk, Stijn De Munter, Tessa Kerre, Bart Vandekerckhove, Tim Lammens, Jan Philippe
Article
Cell & Tissue Engineering
Matko Cancer, Sonja Hutter, Karl O. Holmberg, Gabriela Rosen, Anders Sundstrom, Jignesh Tailor, Tobias Bergstrom, Alexandra Garancher, Magnus Essand, Robert J. Wechsler-Reya, Anna Falk, Holger Weishaupt, Fredrik J. Swartling
Article
Cell Biology
Jing Ma, Mohanraj Ramachandran, Chuan Jin, Clara Quijano-Rubio, Miika Martikainen, Di Yu, Magnus Essand
CELL DEATH & DISEASE
(2020)
Article
Immunology
Jinar Rostami, Grammatiki Fotaki, Julien Sirois, Ropafadzo Mzezewa, Joakim Bergstrom, Magnus Essand, Luke Healy, Anna Erlandsson
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Chemistry, Multidisciplinary
Siyuan Deng, Alessandra Iscaro, Giorgia Zambito, Yimin Mijiti, Marco Minicucci, Magnus Essand, Clemens Lowik, Munitta Muthana, Roberta Censi, Laura Mezzanotte, Piera Di Martino
Summary: A redox responsive nanohydrogel based on hyaluronic acid was developed as a delivery system for oncolytic viruses, showing rapid degradation in a reductive environment and good oncolytic activity. Due to its hydrophilic and porous nature, the nanohydrogel is considered a promising carrier for viral drugs.
Article
Cardiac & Cardiovascular Systems
Evelina Vagesjo, Kristel Parv, David Ahl, Cedric Seignez, Carmen Herrera Hidalgo, Antoine Giraud, Catarina Leite, Olle Korsgren, Hakan Wallen, Greta Juusola, Harri H. Hakovirta, Helene Rundqvist, Magnus Essand, Lena Holm, Randall S. Johnson, Charlotte Thalin, Petra Korpisalo, Gustaf Christoffersson, Mia Phillipson
Summary: This study reveals a novel role of macrophages in regulating blood flow by releasing iNOS in ischemic muscles to improve tissue perfusion and repair. Depletion of iNOS in macrophages compromised blood flow regulation and exacerbated ischemic damage in the muscles.
CIRCULATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Luuk van Hooren, Alessandra Vaccaro, Mohanraj Ramachandran, Konstantinos Vazaios, Sylwia Libard, Tiarne van de Walle, Maria Georganaki, Hua Huang, Ilkka Pietilae, Joey Lau, Maria H. Ulvmar, Mikael C. I. Karlsson, Maria Zetterling, Sara M. Mangsbo, Asgeir S. Jakola, Thomas Olsson Bontell, Anja Smits, Magnus Essand, Anna Dimberg
Summary: This study demonstrates that the use of immunostimulatory CD40 antibodies in glioma models promotes the formation of tertiary lymphoid structures but does not improve survival and impairs the response to immune checkpoint blockade.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Miika Martikainen, Mohanraj Ramachandran, Roberta Lugano, Jing Ma, Minttu-Maria Martikainen, Anna Dimberg, Di Yu, Andres Merits, Magnus Essand
Summary: The study constructed an IFN-I-resistant SFV-AM6 virus that induced immunogenic apoptosis in GL261 cells and showed therapeutic potency against glioma. Additionally, combination therapy with SFV-AM6-124T and antiPD1 immunotherapy promoted an inflammatory response and increased tumor-reactive CD8(+) cells in the GL261 glioma model.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Nanoscience & Nanotechnology
Alessandra Iscaro, Christian Jones, Neil Forbes, Amina Mughal, Faith Nutter Howard, Haider Al Janabi, Secil Demiral, Yvonne Perrie, Magnus Essand, Aleksandra Weglarz, Luis J. Cruz, Claire E. Lewis, Munitta Muthana
Summary: This study demonstrates that encapsulating oncolytic adenovirus into CCL2-coated liposomes can effectively target tumors by recruiting circulating monocytes expressing CCR2. The nanomedicine approach significantly reduces tumor size and metastasis, providing a potential strategy for treating inaccessible tumors.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Mohiemen Anwar, Maja-Louise Arendt, Mohanraj Ramachandran, Anette Carlsson, Magnus Essand, Goran Akusjarvi, Ghasan Alusi, Daniel Oberg
Summary: This research describes a novel oncolytic adenovirus, Ixovex-1, which selectively replicates within cancer cells by modulating the level of expression of different E1B mRNA isoforms. The study demonstrates the characteristics and anti-tumor efficacy of Ixovex-1 in both in vitro and in vivo experiments, showing its superiority compared to other viruses with multiple deletions.
CANCER GENE THERAPY
(2022)
Article
Engineering, Biomedical
Chuan Jin, Jing Ma, Mohanraj Ramachandran, Di Yu, Magnus Essand
Summary: CAR T cells expressing NAP from Helicobacter pylori can trigger endogenous bystander T-cell responses against solid cancers, improving tumor growth and survival rates.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Oncology
Maria Georganaki, Mohanraj Ramachandran, Sander Tuit, Nicolas Gonzalo Nunez, Alexandros Karampatzakis, Grammatiki Fotaki, Luuk van Hooren, Hua Huang, Roberta Lugano, Thomas Ulas, Aura Kaunisto, Eric C. Holland, Peter Ellmark, Sara M. Mangsbo, Joachim Schultze, Magnus Essand, Sonia Tugues, Anna Dimberg