Review
Biochemistry & Molecular Biology
Celia Maria Curieses Andres, Jose Manuel Perez de la Lastra, Celia Andres Juan, Francisco J. Plou, Eduardo Perez-Lebena
Summary: This review focuses on the DNA damage caused by various oxidizing, alkylating, and nitrating species, which may play a crucial role in the pathophysiology of inflammation, cancer, and degenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Archana Molangiri, Saikanth Varma, M. Satyavani, Saikrishna Kambham, Asim K. Duttaroy, Sanjay Basak
Summary: Early exposure to bisphenol may result in adverse reproductive health issues in later life. This study investigated the effects of orally administered bisphenol S (BPS) and bisphenol A (BPA) on testicular development in rats. The results showed that prenatal exposure to BPS can lead to changes in plasma testosterone levels, testis histology, inflammation, oxidative stress, and sperm DNA damage, potentially affecting male reproductive functions.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Keyi Liu, Surekha Kadannagari, Jack Deruiter, Suhrud Pathak, Kodye L. Abbott, Julia M. Salamat, Satyanarayana R. Pondugula, Benson T. Akingbemi, Muralikrishnan Dhanasekaran
Summary: The current literature suggests that BPS, a substitute for BPA, may have negative effects on liver function. However, this study found that acute exposure to BPS had minimal impact on hepatocellular functions in newborn rats, and even showed hepatoprotective effects.
Article
Multidisciplinary Sciences
Rabia Azmat, Muhammad Umar Ijaz, Nazia Ehsan, Tayyaba Afsar, Ali Almajwal, Houda Amor, Nawaf W. Alruwaili, Suhail Razak
Summary: The study aimed to determine the therapeutic effects of Diosmetin (DIOS) against Nonylphenol (NP)-induced hepatotoxicity in rats. The results showed that DIOS significantly improved NP-induced hepatic toxicity through its antioxidant, anti-inflammatory, and anti-apoptotic potential. Therefore, DIOS may be an effective therapeutic agent for alleviating NP-induced hepatic toxicity.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Alberto Ruiz Priego, Emilio Gonzalez Parra, Sebastian Mas, Jose Luis Morgado-Pascual, Marta Ruiz-Ortega, Sandra Rayego-Mateos
Summary: This study demonstrates that chronic exposure to BPA can lead to inflammatory infiltration, tubular injury, and fibrosis in the kidneys of healthy mice, and exacerbation of renal lesions in SNX mice. BPA also modulates the autophagy process and redox protective mechanisms in the kidneys, suggesting potential harmful effects of BPA in the kidneys.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Mandana Lotfi, Amir Hosseyn Hasanpour, Ali Akbar Moghadamnia, Sohrab Kazemi
Summary: Nonylphenol (NP) is a chemical compound widely used in industry, known as an estrogen-like compound. It has destructive functions on various organs like brain. NP can disrupt brain homeostasis through multiple ways, leading to inflammatory factors activation, cell cycle disruption, morphology changes in neurons, dendrites and synapses, disturbance in calcium ion balance, and memory and learning disorders.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Urmi Mukherjee, Anwesha Samanta, Subhasri Biswas, Soumyajyoti Ghosh, Sambuddha Banerjee, Sudipta Maitra
Summary: The study investigates the impact of Nonylphenol (NP) on liver health and finds that NP exposure can lead to chronic liver injury through oxidative stress, metabolic disruption, and immune modulation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Environmental Sciences
Yao Chen, Maohua Miao, Ziliang Wang, Honglei Ji, Yan Zhou, Hong Liang, Gengsheng He, Wei Yuan
Summary: The study found that prenatal exposure to Bisphenol A (BPA) and its analogues can affect children's cognitive development, especially in boys. Specifically, prenatal exposure to BPA was associated with decreased IQ scores in boys, but not in girls.
Article
Pediatrics
Chao Xiong, Kai Chen, Lu-Li Xu, Yi-Ming Zhang, Hua Liu, Meng-Lan Guo, Zhi-Guo Xia, Yu-Ji Wang, Xiao-Feng Mu, Xiao-Xuan Fan, Jing-Quan Chen, Yu-Ru Liu, Yuan-Yuan Li, Wei Xia, You-Jie Wang, Ai-Fen Zhou
Summary: This study examined the relationship between prenatal bisphenol A and bisphenol F exposure and the BMI growth trajectory of offspring, finding an association between exposure to these chemicals and low-increasing BMI pattern in children during the first two years.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Environmental Sciences
Yuki Mizuno, Yohei Inaba, Hiroaki Masuoka, Mihoko Kibe, Satoko Kosaka, Kazumi Natsuhara, Kazuhiro Hirayama, Nouhak Inthavong, Sengchanh Kounnavong, Shinsuke Tomita, Masahiro Umezaki
Summary: This study investigated the determinants of oxidative stress in an indigenous population in Northern Laos by examining the associations of trace element exposures and dietary patterns with oxidative stress-related biomarkers. The results showed that urinary arsenic and cadmium concentrations were positively associated with urinary 8-isoprostane concentrations, while urinary selenium concentrations were positively associated with urinary 8-OHdG concentrations. Interaction terms between arsenic or cadmium and selenium showed negative associations with oxidative stress-related biomarkers. Urinary cadmium concentrations were negatively associated with telomere lengths.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Ixel Hernandez-Castro, Sandrah P. Eckel, Caitlin G. Howe, Zhongzheng Niu, Kurunthachalam Kannan, Morgan Robinson, Helen B. Foley, Tingyu Yang, Mario J. Vigil, Xinci Chen, Brendan Grubbs, Deborah Lerner, Nathana Lurvey, Laila Al-Marayati, Rima Habre, Genevieve F. Dunton, Shohreh F. Farzan, Max T. Aung, Carrie V. Breton, Theresa M. Bastain
Summary: The study suggests that prenatal exposure to organophosphate esters (OPEs) may be associated with child neurobehavior. The results show that specific OPE metabolites detected in maternal urine are positively correlated with externalizing, internalizing, and total problems in children. However, other OEP metabolites do not have a significant association with child neurobehavior. Gender may also have an influence on the relationship between OEP exposure and internalizing and total problems.
ENVIRONMENTAL HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Camila Aguilar Delgado, Tatiane Hammerschmidt, Jessica Lamberty Faverzini, Franciele Lopes, Roberto Giugliani, Guilherme Baldo, Carmen Regla Vargas
Summary: This study aimed to investigate the mechanisms of oxidative/nitrative stress and inflammation in MPS IVA patients under long-term enzyme replacement therapy (ERT). The results showed that there was no overproduction of reactive nitrogen species, protein damage, DNA/RNA oxidative damage, or alteration in non-enzymatic antioxidant capacity in these patients. Additionally, no significant difference was observed in the production of proinflammatory cytokines or the genic expression of factors involved in oxidative stress and inflammatory pathways. In conclusion, this study demonstrated the protective effect of long-term ERT in MPS IVA patients and emphasized the importance of early treatment.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Review
Pharmacology & Pharmacy
Barrett M. Welch, Erin E. McNell, Matthew L. Edin, Kelly K. Ferguson
Summary: Oxylipin production is associated with pregnancy outcomes and environmental exposures, with evidence suggesting different effects on pregnancy outcomes based on different biosynthetic pathways. Researchers reviewed the importance of oxylipins during pregnancy and provided recommendations for future epidemiologic studies.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biology
Sahar J. Melebary, Mariam S. AlGhamdi, Manal E. A. Elhalwagy, Soha A. Alsolmy, Al Jawaher A. Bin Dohaish
Summary: This study investigated the potential impacts of different doses of Bisphenol A (BPA) and Nonylphenol (NP) on biological activities in male albino rats. The results showed that high doses of BPA and NP significantly increased TNF Alpha, TNF Beta, and Caspase 3 serum levels. Additionally, there was histological damage in the testis and a decrease in spermatozoa. Overall, exposure to BPA and NP strongly affects antioxidants, immune-inflammatory mediators, and testicular tissue architecture.
Article
Reproductive Biology
Carolyn F. McCabe, Jaclyn M. Goodrich, Kelly M. Bakulski, Steven E. Domino, Tamara R. Jones, Justin Colacino, Dana C. Dolinoy, Vasantha Padmanabhan
Summary: The early-gestational fetal epigenome is influenced by environmental stressors, including chemical exposures. This study compared DNA methylation in different tissues and found tissue-specific differences in gene expression and associations between bisphenol exposures and DNA methylation in the placenta. These findings highlight the importance of studying multiple tissues in prenatal exposure research.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Food Science & Technology
Shi-Han Jian, Pei-Jou Yeh, Chung-Huang Wang, Hsin-Chang Chen, Sung-Fang Chen
JOURNAL OF FOOD AND DRUG ANALYSIS
(2019)
Article
Environmental Sciences
Chia-Huang Chang, Yu-Fang Huang, Pei-Wei Wang, Chun-Hao Lai, Li-Wei Huang, Hsin-Chang Chen, Meng-Han Lin, Winnie Yang, I-Fang Mao, Mei-Lien Chen
Correction
Multidisciplinary Sciences
Charlene Wu, Hsin-Chang Chen, Shu-Ting Chen, Su-Yin Chiang, Kuen-Yuh Wu
Article
Public, Environmental & Occupational Health
Chia-Huang Chang, Pei-Wei Wang, Hai-Wei Liang, Yu-Fang Huang, Li-Wei Huang, Hsin-Chang Chen, Wen-Chi Pan, Meng-Han Lin, Winnie Yang, I-Fang Mao, Mei-Lien Chen
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2019)
Article
Biochemical Research Methods
Han-Ju Chien, Yu-Ting Xue, Hsin-Chang Chen, Kuen-Yuh Wu, Chien-Chen Lai
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2020)
Article
Environmental Sciences
Po-Chin Huang, Alexander Waits, Hsin-Chang Chen, Wan-Ting Chang, Jouni J. K. Jaakkola, Han-Bin Huang
ENVIRONMENT INTERNATIONAL
(2020)
Article
Environmental Sciences
Alexander Waits, Hsin-Chang Chen, Pao-Lin Kuo, Chih-Wen Wang, Han-Bin Huang, Wei-Hsiang Chang, Shu-Fang Shih, Po-Chin Huang
ENVIRONMENTAL RESEARCH
(2020)
Article
Toxicology
Hsiao-Chi Chuang, Hsin-Chang Chen, Pei-Jui Chai, Ho-Tang Liao, Chang-Fu Wu, Chia-Ling Chen, Ming-Kai Jhan, Hui- Hsieh, Kuen-Yuh Wu, Ta-Fu Chen, Tsun-Jen Cheng
PARTICLE AND FIBRE TOXICOLOGY
(2020)
Article
Environmental Sciences
Chia-Huang Chang, Ching-Jung Yu, Jung-Chieh Du, Hsien-Chih Chiou, Jia-Woei Hou, Winnie Yang, Chian-Feng Chen, Hsin-Chang Chen, Ying-Sheue Chen, Betau Hwang, Mei-Lien Chen
Summary: This study reveals a potential link between organophosphate pesticide exposure and ADHD, related to oxidative stress and PON genetic polymorphisms. Children exposed to organophosphate pesticides may have higher levels of DMP and HNE-MA. The PON1 genetic polymorphism is associated with exposure levels and the risk of ADHD.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Po-Keng Cheng, Hsin-Chang Chen, Pao-Lin Kuo, Jung-Wei Chang, Wan-Ting Chang, Po-Chin Huang
Summary: This study investigated the association between oxidative and nitrosative stress and thyroid hormones, finding that an imbalance of oxidative and nitrosative stress may alter thyroid hormone homeostasis during pregnancy, which could affect embryonic and fetal development.
Article
Food Science & Technology
Mei-Lien Chen, Chih-Hsien Chen, Yu-Fang Huang, Hsin-Chang Chen, Jung-Wei Chang
Summary: Photoinitiators used in ultraviolet-cured ink may migrate from food packaging materials into food products. A dietary risk assessment was conducted to quantify the exposure to benzophenone-type photoinitiators and reduce associated uncertainties. The study found that the estimated daily dose of photoinitiators was below the toxicological concern threshold, indicating an acceptable level of cumulative toxicity. However, different results may occur if specific migration limits for unmeasured photoinitiator residues in other foodstuffs are followed.
Article
Environmental Sciences
Hsin-Chang Chen, Jung-Wei Chang, Yi-Chen Sun, Wan-Ting Chang, Po-Chin Huang
Summary: The development of a rapid and accurate analytical method for determining levels of antibacterial agents, plasticizers, and ultraviolet filters in biosamples is crucial for individual exposure assessment. This study developed an ID-UPLC-MS/MS method with SLE pretreatment to determine the levels of four parabens, triclosan, triclocarban, and benzophenone-3 in human urine. The method showed good performance and sensitivity in detecting these chemicals, making it valuable for human biomonitoring.
Article
Multidisciplinary Sciences
Vincent Laiman, Yu-Chun Lo, Hsin-Chang Chen, Tzu-Hsuen Yuan, Ta-Chih Hsiao, Jen-Kun Chen, Ching-Wen Chang, Ting-Chun Lin, Ssu-Ju Li, You-Yin Chen, Didik Setyo Heriyanto, Kian Fan Chung, Kai-Jen Chuang, Kin-Fai Ho, Jer-Hwa Chang, Hsiao-Chi Chuang
Summary: Air pollution is associated with respiratory diseases, and urban air pollution is caused by various sources of emissions. The particles and gases emitted are the main components of air pollution that enter the lungs through respiration. Particulate matter with an aerodynamic diameter of ≤ 2.5 μm (PM2.5) can penetrate deep into the respiratory tract through inhalation and has been suggested as a causative factor for adverse respiratory health. Additionally, the lung harbors a diverse microbial community (microbiome) that maintains normal balance but can be significantly altered in certain circumstances.
Article
Environmental Sciences
Hsiao-Chi Chuang, Yu-Ting Yang, Hsin-Chang Chen, Yaw-Huei Hwang, Kuen-Yuh Wu, Ta-Fu Chen, Chia-Ling Chen, Ming-Kai Jhan, Tsun-Jen Cheng
AEROSOL AND AIR QUALITY RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
Perng Yang Puah, Dexter Jiunn Herng Lee, Ken Hing Mak, Hui Jun Ang, Hsing-Chang Chen, Pak Yan Moh, Siat Yee Fong, Yee Soon Ling