Review
Environmental Sciences
Zengli Yu, Xiaoan Zhang, Junxi Zhang, Yang Feng, Han Zhang, Zhongxiao Wan, Chenglong Xiao, Huanhuan Zhang, Qiong Wang, Cunrui Huang
Summary: This study reviewed the long-term and short-term effects of particulate matter exposure on preterm birth. The results showed that both long-term and short-term exposure to particulate matter increased the risk of preterm birth.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Ran Li, Jing Peng, Wenhui Zhang, Yunlu Wu, Renjie Hu, Rucheng Chen, Weijia Gu, Lu Zhang, Li Qin, Mianhua Zhong, Lung-Chi Chen, Qinghua Sun, Cuiqing Liu
Summary: Recent studies have found that gestational exposure to ambient fine particulate matter (PM2.5) is associated with adverse pregnancy outcomes, particularly intrauterine growth restriction (IUGR). However, the underlying mechanism is still unclear. In this study, pregnant mice were exposed to either filtered air or ambient PM2.5, and it was found that PM2.5 exposure during gestation resulted in reduced fetal body weight and crown-rump length. Moreover, the placental blood sinusoid and expression of placental nutrient transporters and growth hormone were also affected by PM2.5 exposure. Additional tests revealed that PM2.5 exposure inhibited autophagy and activated the AMPK/mTOR signaling pathway in the placenta. These findings suggest that autophagy inhibition leading to placental developmental disorder might be an important mechanism for PM2.5-induced growth restriction.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Engineering, Environmental
Yankai Xia, Xu Wang, Mingzhi Zhang, Xu Yang, Yuqing Zhang, Tianyu Dong, Francis Manyori Bigambo, Danrong Chen, Heidi Aase
Summary: This study investigated the relationship between maternal exposure to PM2.5 and fetal immune system development. The results showed both negative and positive associations between maternal PM2.5 exposure and neonatal cytokines. The findings suggest that gestational exposure to PM2.5 could alter neonatal cytokine levels and highlight the importance of certain components.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Article
Environmental Sciences
Juan Chen, Shaowei Wu, Junkai Fang, Ziquan Liu, Xuejun Shang, Xinbiao Guo, Furong Deng, Liqiong Guo
Summary: This study found that exposure to PM2.5 waves may increase the risk of adverse birth outcomes, especially during early pregnancy. The intensity of the risk is associated with factors such as the concentration of PM2.5 and the duration of exposure.
ENVIRONMENTAL RESEARCH
(2022)
Article
Engineering, Environmental
Hongxu Bao, Benying Li, Qing You, Xinyu Dun, Zhen Zhang, Yanan Liang, Yahui Li, Qixiao Jiang, Rong Zhang, Rui Chen, Wen Chen, Yuxin Zheng, Daochuan Li, Lianhua Cui
Summary: This study elucidated the potential role of platelet-derived growth factor receptor beta (PDGFR beta) in particulate matter-induced vascular toxicity. PDGFR beta induced vascular hypertrophy through the activation of the JAK2/STAT3 pathway, which might serve as a biological target for the vascular toxic effects caused by exposure to particulate matter.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Nelson Gouveia, Josiah L. Kephart, Iryna Dronova, Leslie McClure, Jose Tapia Granados, Ricardo Morales Betancourt, Andrea Cortinez O'Ryan, Jose Luis Texcalac-Sangrador, Kevin Martinez-Folgar, Daniel Rodriguez, Ana Diez-Roux
Summary: The study found that a significant proportion of the population in Latin American cities live in areas with air pollution levels above WHO standards. Larger cities, higher GDP, higher motorization rate, and congestion tend to have higher PM2.5 levels. On the other hand, areas with higher population density tend to have lower levels of PM2.5.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Geriatrics & Gerontology
Kevin J. Sullivan, Xinhui Ran, Fan Wu, Chung-Chou H. Chang, Ravi Sharma, Erin Jacobsen, Sarah Berman, Beth E. Snitz, Akira Sekikawa, Evelyn O. Talbott, Mary Ganguli
Summary: This study examined the association between ambient PM2.5 levels and the risk of incident MCI and dementia in an older population, finding that higher estimated PM2.5 levels were associated with increased risk of both conditions, particularly with longer-term exposure.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Engineering, Environmental
Xiaole Zhang, Xi Chen, Yang Yue, Shuxiao Wang, Bin Zhao, Xinmei Huang, Tiantian Li, Qinghua Sun, Jing Wang
Summary: There is a variation in mortality risk associated with different sources of PM2.5, with industrial and residential combustion sources closely correlated with lung cancer and circulatory diseases.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kendrick Lee, Daniel B. Hardy
Summary: Consumption of cannabis during pregnancy by 18-24-year-old pregnant women can lead to fetal growth restriction and increased risk of obesity, type II diabetes, and cardiovascular disease in the offspring. The doubling concentration of Δ9-THC in cannabis over the past decade can readily cross the placenta and negatively impact fetal development via the eCB system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Yunfei Xing, Xiangyang Gao, Qin Li, Xueying Li, Youxin Wang, Yifan Yang, Shuhan Yang, Patrick W. C. Lau, Qiang Zeng, Hui Wang
Summary: This study found a link between long-term exposure to ambient particulate matter (PM) and advanced liver fibrosis (ALF) in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). Higher levels of PM1, PM2.5, and PM10 were associated with an increased risk of ALF. PM2.5 had a stronger impact on ALF compared to PM1 and PM10.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Zhang Hehua, Chang Qing, Zhao Yuhong
Summary: Long-term exposure to PM2.5 increases platelet counts in adults in Northeast China, with stronger effects observed in male participants, Han ethnicity individuals, and those without diabetes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Zhennan Lin, Shufeng Chen, Fangchao Liu, Jianxin Li, Jie Cao, Keyong Huang, Fengchao Liang, Jichun Chen, Hongfan Li, Jianfeng Huang, Dongsheng Hu, Chong Shen, Yingxin Zhao, Xiaoqing Liu, Ling Yu, Xiangfeng Lu, Dongfeng Gu
Summary: Long-term exposure to high levels of PM2.5 is associated with increased blood pressure and hypertension risk. In China, for each 10μg/m3 increase in PM2.5 concentration, systolic and diastolic blood pressure increased by 1.67mmHg and 0.45mmHg, respectively, and the prevalence of hypertension increased by 29%. The relationship between PM2.5 and blood pressure may be non-linear.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Qi Sun, Yuanmei Chen, Fang Ye, Jing Liu, Die Liu, Bo Ao, Qin Hui, Qi Zhang
Summary: This study aimed to investigate the association between preconception exposure to ambient particulate matter (PM) and hypothyroidism. The results showed that exposure to PM2.5 and PM10 during the 60-day period before the last menstrual period month, 30-day period before the last menstrual period month, and last menstrual period was associated with an increased risk of hypothyroidism.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Infectious Diseases
Zhongqi Li, Bilin Tao, Zhiliang Hu, Yongxiang Yi, Jianming Wang
Summary: The study found that short-term exposure to outdoor particulate matter (PM) is positively associated with the risk of severe COVID-19. Reducing air pollution may contribute to the control of COVID-19 transmission.
JOURNAL OF INFECTION
(2022)
Article
Biochemistry & Molecular Biology
Xuanyou Liu, Aimin Wang, Zhiheng Chen, Yuqi Cui, Hong Hao, Timothy L. Domeier, Qinghua Sun, Zhenguo Liu
Summary: Exposure to ambient fine particulate matter (PM) is associated with an increased risk of cardiovascular diseases (CVDs). There are major sex differences between males and females in the epidemiology, pathophysiology, and outcome of CVDs. Endothelial progenitor cells (EPCs) play a vital role in the development and progression of CVDs. This study found that PM exposure-induced reduction of EPCs is observed in male, not female, mice with increased reactive oxygen species (ROS) production and oxidative stress.
Article
Environmental Sciences
Jamie S. Church, Fiona Chace-Donahue, Jason L. Blum, Jill R. Ratner, Judith T. Zelikoff, Jared J. Schwartzer
ENVIRONMENTAL HEALTH PERSPECTIVES
(2020)
Review
Food Science & Technology
Joanna A. Ruszkiewicz, Ziyan Zhang, Filipe Marques Goncalves, Yousef Tizabi, Judith T. Zelikoff, Michael Aschner
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Article
Toxicology
Mitchell D. Cohen, Colette Prophete, Lori Horton, Maureen Sisco, Sung-Hyun Park, Hyun-Wook Lee, Judith Zelikoff, Lung-Chi Chen
INHALATION TOXICOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Qixin Wang, Isaac K. Sundar, Jason L. Blum, Jill R. Ratner, Joseph H. Lucas, Tsai-Der Chuang, Ying Wang, Jie Liu, Virender K. Rehan, Judith T. Zelikoff, Irfan Rahman
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Article
Cell Biology
Lun Li, Yi Liu, Chin Chiu, Yang Jin, Weixun Zhou, Min Peng, Lung-Chi Chen, Qinghua Sun, Jinming Gao
Summary: The study revealed the important role of CXCR3 in chronic obstructive pulmonary disease, potentially influencing disease progression through MMP9 production. Additionally, genetic analysis showed that a CXCR3 single nucleotide polymorphism is associated with COPD susceptibility and levels of MMP-9 in patients.
Article
Food Science & Technology
Jason L. Blum, Melissa Ellis, Jayson X. Chen, Odete Mendes, Sarah Sylla, Sara Perez Ojalvo, James Komorowski
Summary: Magnesium biotinate (MgB) was evaluated for general and genetic toxicity through a series of toxicologic tests, which showed no mutagenic effects. The acute oral toxicity study indicated a safe LD50 >= 5000 mg MgB/kg. A 90-day oral toxicity study found a NOAEL of 600 mg MgB/kg/day, equivalent to 39 g biotin/day for a 70 kg human. Based on these findings, MgB may be considered safe for long-term human use.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Environmental Sciences
Nicole A. Potter, Gabriella Y. Meltzer, Oyemwenosa N. Avenbuan, Amna Raja, Judith T. Zelikoff
Summary: Particulate air pollution, especially ultrafine and fine-size particles, can have serious health impacts, including neurological and behavioral effects, and premature death. Studies have shown that exposure to PM and PM-associated metals may negatively affect neurological health, highlighting the need for further research to inform future policy decisions and interventions.
Article
Environmental Sciences
Shannon Doherty Lyons, Jason L. Blum, Carol Hoffman-Budde, Pamela B. Tijerina, M. Isabel Fiel, Daniel J. Conklin, Francesca Gany, Joseph A. Odin, Judith T. Zelikoff
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Review
Toxicology
Oyemwenosa N. Avenbuan, Judith T. Zelikoff
CURRENT OPINION IN TOXICOLOGY
(2020)
Review
Public, Environmental & Occupational Health
Gabriella Y. Meltzer, Beverly-Xaviera Watkins, Dorice Vieira, Judith T. Zelikoff, Bernadette Boden-Albala
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2020)
Article
Health Policy & Services
Gabriella Meltzer, Oyemwenosa Avenbuan, Fen Wu, Krina Shah, Yu Chen, Vincent Mann, Judith T. Zelikoff
JOURNAL OF COMMUNITY HEALTH
(2020)